SIMILAR PATTERNS OF AMINO ACIDS FOR 1HO5_B_ADNB2604_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		5 SER A 354
GLY A 356
ARG A 410
ASN A 512
ASP A 342
 None
 1.14A 1ho5B-1advA:
undetectable		 1ho5B-1advA:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 379
SER A 405
GLY A 406
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
None
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.18A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		9 ARG A 379
SER A 405
GLY A 407
ARG A 410
PHE A 429
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.3A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.60A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 408
ARG A 410
PHE A 429
GLY A 406
PHE A 498
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
None
ATP  A 606 (-3.6A)
 1.24A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 SER A 405
GLY A 408
ARG A 410
PHE A 429
PHE A 498
ASP A 504
 ATP  A 606 ( 4.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.20A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ASN A 900
SER A1059
GLY A1063
GLY A1106
ASP A1105
 None
FMN  A2508 ( 3.9A)
FMN  A2508 (-3.1A)
FMN  A2508 (-3.4A)
FMN  A2508 (-3.0A)
 1.26A 1ho5B-1ofeA:
1.2		 1ho5B-1ofeA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siq GLUTARYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ARG A  88
SER A 261
GLY A 259
ARG A  84
ASN A 330
 None
 1.49A 1ho5B-1siqA:
undetectable		 1ho5B-1siqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 GLY A 405
ARG A 426
PHE A 424
GLY A 514
PHE A 511
 None
 1.32A 1ho5B-2aeyA:
undetectable		 1ho5B-2aeyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase) 		5 ASN A 432
SER A 154
GLY A 130
ARG A 358
GLY A 131
 None
GLN  A 501 (-2.9A)
GLN  A 501 (-3.2A)
GLN  A 501 (-2.5A)
GLN  A 501 ( 4.5A)
 1.36A 1ho5B-2f2aA:
undetectable		 1ho5B-2f2aA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgw OUTER MEMBRANE
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00691
(OmpA) 		5 ASN A 263
GLY A 259
ARG A 277
ASN A 318
GLY A 299
 None
 1.09A 1ho5B-2kgwA:
undetectable		 1ho5B-2kgwA:
13.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 349
GLY A 379
ASN A 404
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
None
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.30A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		8 ARG A 349
GLY A 380
ARG A 383
PHE A 402
ASN A 404
GLY A 432
PHE A 481
ASP A 487
 PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.73A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ASN A 181
GLY A 380
ARG A 383
GLY A 432
ASP A 487
 THM  A6510 (-4.1A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.85A 1ho5B-2z1aA:
37.9		 1ho5B-2z1aA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		5 GLY A 388
ARG A 391
PHE A 410
ASN A 412
PHE A 521
 None
FMT  A 607 (-2.7A)
None
None
None
 0.85A 1ho5B-3c9fA:
25.3		 1ho5B-3c9fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 GLY A 372
ARG A 375
PHE A 394
ASN A 396
PHE A 466
ASP A 472
 CTN  A 603 (-3.2A)
CTN  A 603 ( 3.0A)
CTN  A 603 (-3.5A)
CTN  A 603 (-3.0A)
CTN  A 603 (-3.8A)
CTN  A 603 (-2.7A)
 0.51A 1ho5B-3iveA:
37.3		 1ho5B-3iveA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 160
ASN A 475
GLY A 162
PHE A 447
ASP A 164
 None
 1.35A 1ho5B-3m07A:
1.5		 1ho5B-3m07A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 SER A 204
GLY A 180
PHE A 220
GLY A 206
PHE A 236
 None
 1.35A 1ho5B-3nqhA:
undetectable		 1ho5B-3nqhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ASN A 162
SER A 362
GLY A 311
PHE A 309
GLY A 315
 BNG  A 439 (-2.9A)
None
None
None
None
 1.46A 1ho5B-3o7qA:
undetectable		 1ho5B-3o7qA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		5 SER A 274
GLY A 272
ARG A 239
GLY A 271
ASP A 270
 EDO  A 414 ( 4.0A)
SO4  A 402 (-3.6A)
SO4  A 402 (-2.9A)
None
EDO  A 414 ( 4.7A)
 1.27A 1ho5B-3ohgA:
undetectable		 1ho5B-3ohgA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhy BETA-LACTAMASE

(Bacillus
anthracis) 		PF13354
(Beta-lactamase2) 		5 GLY A 143
PHE A 165
ASN A 136
GLY A 147
PHE A 139
 None
 1.36A 1ho5B-3qhyA:
undetectable		 1ho5B-3qhyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ASN A 438
SER A 155
GLY A 187
ARG A 142
PHE A 190
 None
 1.19A 1ho5B-3u0bA:
1.6		 1ho5B-3u0bA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.44A 1ho5B-3va7A:
undetectable		 1ho5B-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 397
GLY A 434
ARG A 437
ASN A 538
ASP A 546
 A12  A1598 (-3.0A)
A12  A1598 (-3.4A)
A12  A1598 (-2.6A)
A12  A1598 ( 4.4A)
A12  A1598 (-2.7A)
 1.17A 1ho5B-3zu0A:
34.2		 1ho5B-3zu0A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 397
GLY A 434
ARG A 437
PHE A 456
ASN A 458
GLY A 488
ASP A 546
 A12  A1598 (-3.0A)
A12  A1598 (-3.4A)
A12  A1598 (-2.6A)
A12  A1598 (-3.4A)
A12  A1598 (-3.1A)
A12  A1598 (-3.4A)
A12  A1598 (-2.7A)
 0.58A 1ho5B-3zu0A:
34.2		 1ho5B-3zu0A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		5 ASN A 447
SER A 191
GLY A 192
ASN A 445
GLY A 178
 None
 1.31A 1ho5B-4a1fA:
2.0		 1ho5B-4a1fA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ARG A 241
ARG A 238
PHE A 291
ASN A 288
ASP A 298
 None
 1.47A 1ho5B-4aj9A:
undetectable		 1ho5B-4aj9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		5 GLY A 340
ARG A  24
PHE A  21
GLY A 283
ASP A 186
 None
None
None
None
ZN  A 500 (-2.3A)
 1.49A 1ho5B-4bz7A:
undetectable		 1ho5B-4bz7A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		5 ASN A 158
SER A 153
GLY A  65
ARG A  66
GLY A  59
 None
 1.43A 1ho5B-4dqvA:
undetectable		 1ho5B-4dqvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 354
GLY A 391
GLY A 447
PHE A 500
ASP A 506
 PO4  A 604 (-2.8A)
None
None
None
None
 1.26A 1ho5B-4h1sA:
22.9		 1ho5B-4h1sA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 354
GLY A 392
ARG A 395
PHE A 417
GLY A 447
PHE A 500
ASP A 506
 PO4  A 604 (-2.8A)
None
PO4  A 604 (-2.9A)
None
None
None
None
 0.61A 1ho5B-4h1sA:
22.9		 1ho5B-4h1sA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 354
GLY A 392
PHE A 500
GLY A 447
PHE A 508
 PO4  A 604 (-2.8A)
None
None
None
None
 1.47A 1ho5B-4h1sA:
22.9		 1ho5B-4h1sA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jru THAUMATIN-LIKE
PROTEIN

(Vitis vinifera) 		PF00314
(Thaumatin) 		5 ASN A  81
GLY A  46
ARG A  71
PHE A  76
GLY A  45
 None
 1.50A 1ho5B-4jruA:
undetectable		 1ho5B-4jruA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 ASN A 424
SER A 791
GLY A 790
ASN A 438
GLY A 764
 None
 1.47A 1ho5B-4k3cA:
undetectable		 1ho5B-4k3cA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE

(Drosophila
melanogaster) 		PF05822
(UMPH-1) 		5 GLY A 125
PHE A  75
ASN A  79
GLY A 208
PHE A  78
 None
MG7  A 403 (-3.6A)
MG7  A 403 ( 4.7A)
None
None
 1.19A 1ho5B-4nv0A:
undetectable		 1ho5B-4nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 ASN A 287
SER A 247
GLY A 383
GLY A 378
ASP A 249
 None
 1.33A 1ho5B-4ojzA:
undetectable		 1ho5B-4ojzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq ANTIBODY FV FRAGMENT
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 GLY D  34
ARG D  73
PHE D  30
GLY D 100
PHE D  28
 None
 1.36A 1ho5B-4ybqD:
undetectable		 1ho5B-4ybqD:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 ASN A 466
SER A 404
GLY A 432
PHE A 443
GLY A 433
 None
 1.36A 1ho5B-5djwA:
undetectable		 1ho5B-5djwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ASN A  58
GLY A  38
PHE A  60
GLY A  35
PHE A  57
 None
 1.33A 1ho5B-5egwA:
undetectable		 1ho5B-5egwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv CH03 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY A  33
ARG A  71
PHE A  29
GLY A  95
PHE A  27
 None
 1.39A 1ho5B-5esvA:
undetectable		 1ho5B-5esvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		5 ASN A 165
GLY A 366
ARG A 281
ASN A 450
PHE A 448
 None
 1.27A 1ho5B-5fn4A:
undetectable		 1ho5B-5fn4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		5 SER A 446
GLY A  65
PHE A 353
GLY A  41
ASP A  42
 None
 1.46A 1ho5B-5g0aA:
undetectable		 1ho5B-5g0aA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ARG A 354
GLY A 391
GLY A 448
PHE A 501
ASP A 507
 None
 1.31A 1ho5B-5h7wA:
34.6		 1ho5B-5h7wA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 6 ARG A 354
GLY A 392
ARG A 395
PHE A 418
GLY A 448
ASP A 507
 None
 0.91A 1ho5B-5h7wA:
34.6		 1ho5B-5h7wA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 6 ARG A 354
GLY A 392
PHE A 418
GLY A 448
PHE A 501
ASP A 507
 None
 0.83A 1ho5B-5h7wA:
34.6		 1ho5B-5h7wA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 None
 1.46A 1ho5B-5i8iA:
undetectable		 1ho5B-5i8iA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		5 ASN A 799
ARG A 448
SER A 437
GLY A 438
ASP A 536
 None
 1.23A 1ho5B-5n8oA:
undetectable		 1ho5B-5n8oA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 5 ASN B 143
SER B 103
GLY B 104
PHE B 142
ASN B 144
 None
 1.41A 1ho5B-5nnzB:
undetectable		 1ho5B-5nnzB:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 GLY f 203
PHE f 217
GLY f 200
PHE f 221
ASP f 234
 None
 1.10A 1ho5B-5t0hf:
undetectable		 1ho5B-5t0hf:
19.85