SIMILAR PATTERNS OF AMINO ACIDS FOR 1HO5_A_ADNA1604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 287
GLY A 280
ASN A 314
GLY A 282
PHE A 401
 None
 1.38A 1ho5A-1e5mA:
undetectable		 1ho5A-1e5mA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ILE A 383
SER A 390
GLY A 388
PHE A 314
ASP A 269
 None
 1.38A 1ho5A-1exxA:
undetectable		 1ho5A-1exxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g6q HNRNP ARGININE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF06325
(PrmA) 		5 SER 1 329
GLY 1 334
GLY 1 331
PHE 1 327
ASP 1 301
 None
 1.45A 1ho5A-1g6q1:
undetectable		 1ho5A-1g6q1:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		5 ILE A 370
SER A 398
GLY A 394
GLY A 372
PHE A 196
 None
 1.29A 1ho5A-1hdiA:
undetectable		 1ho5A-1hdiA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 379
SER A 405
GLY A 406
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
None
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.20A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		9 ARG A 379
SER A 405
GLY A 407
ARG A 410
PHE A 429
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.3A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.60A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 410
PHE A 429
ASN A 431
GLY A 406
PHE A 498
 ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
None
ATP  A 606 (-3.6A)
 1.48A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLY A 408
ARG A 410
PHE A 429
GLY A 406
PHE A 498
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
None
ATP  A 606 (-3.6A)
 1.37A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 SER A 405
GLY A 408
ARG A 410
PHE A 429
PHE A 498
ASP A 504
 ATP  A 606 ( 4.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.28A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 ILE A 531
ASN A 479
GLY A 485
GLY A 207
PHE A 483
 None
NAI  A 920 ( 4.6A)
None
None
None
 1.44A 1ho5A-1o0sA:
undetectable		 1ho5A-1o0sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 ILE B  20
SER B  26
GLY B  25
ASN B 193
GLY B  22
 None
 1.31A 1ho5A-1qdlB:
undetectable		 1ho5A-1qdlB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 5 ASN A 475
SER A 416
GLY A 491
PHE A 478
GLY A 494
 None
VO4  A 600 (-2.8A)
None
None
None
 1.37A 1ho5A-1qi9A:
undetectable		 1ho5A-1qi9A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		5 ILE E  16
ASN E  78
ARG E 139
SER E 141
GLY E  19
 None
 1.27A 1ho5A-1sgqE:
undetectable		 1ho5A-1sgqE:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su3 INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 ILE A 415
GLY A 421
PHE A 447
GLY A 423
PHE A 438
 None
 1.45A 1ho5A-1su3A:
undetectable		 1ho5A-1su3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E

(Bacillus cereus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A  27
GLY A 435
GLY A  24
PHE A 432
ASP A  21
 None
 1.03A 1ho5A-1uokA:
2.3		 1ho5A-1uokA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		5 ILE A 546
SER A 550
ASN A 611
GLY A 548
ASP A 547
 None
 1.35A 1ho5A-1xhkA:
undetectable		 1ho5A-1xhkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cda GLUCOSE
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		5 ASN A 263
SER A 280
GLY A 255
GLY A 278
ASP A 252
 None
None
NAP  A1367 (-3.3A)
NAP  A1367 (-3.4A)
None
 1.30A 1ho5A-2cdaA:
undetectable		 1ho5A-2cdaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 156
GLY A  69
ARG A  62
GLY A 150
PHE A  32
 None
 0.98A 1ho5A-2fjaA:
undetectable		 1ho5A-2fjaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		5 ILE A 328
ARG A 370
ASN A 382
GLY A 414
ASP A 415
 None
 1.34A 1ho5A-2i3oA:
2.4		 1ho5A-2i3oA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paa PHOSPHOGLYCERATE
KINASE, TESTIS
SPECIFIC

(Mus musculus) 		PF00162
(PGK) 		5 ILE A 370
SER A 398
GLY A 394
GLY A 372
PHE A 196
 None
 1.26A 1ho5A-2paaA:
undetectable		 1ho5A-2paaA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 ILE A  28
GLY A 434
GLY A  25
PHE A 431
ASP A  22
 None
None
None
None
CA  A7001 (-3.0A)
 1.02A 1ho5A-2pwhA:
undetectable		 1ho5A-2pwhA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		5 ASN A 487
ARG A 526
PHE A 485
GLY A 369
PHE A 488
 None
 1.32A 1ho5A-2qzpA:
undetectable		 1ho5A-2qzpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 ILE A  96
GLY A 505
PHE A 471
ASN A 470
ASP A 179
 None
 1.37A 1ho5A-2rghA:
undetectable		 1ho5A-2rghA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 ILE A 251
SER A 214
GLY A 242
ASN A 236
GLY A 290
 None
 1.31A 1ho5A-2w48A:
undetectable		 1ho5A-2w48A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ASN A 203
ARG A 397
GLY A 196
GLY A 195
PHE A 201
 None
GOL  A 807 (-4.5A)
GOL  A 807 ( 4.8A)
None
None
 1.50A 1ho5A-2ww2A:
undetectable		 1ho5A-2ww2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 ASN A 198
ARG A 391
GLY A 191
GLY A 190
PHE A 196
 None
 1.49A 1ho5A-2wzsA:
undetectable		 1ho5A-2wzsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 ASN A 464
SER A 459
GLY A 458
GLY A 401
ASP A 397
 None
 1.49A 1ho5A-2x1iA:
undetectable		 1ho5A-2x1iA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xts SULFITE
DEHYDROGENASE

(Paracoccus
pantotrophus) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		5 ILE A 337
GLY A 333
ASN A 411
GLY A 335
ASP A 386
 None
 1.47A 1ho5A-2xtsA:
undetectable		 1ho5A-2xtsA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 349
GLY A 379
ASN A 404
GLY A 432
ASP A 487
 PO4  A5646 (-2.9A)
None
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 1.32A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 ASN A 181
ARG A 349
GLY A 380
PHE A 402
GLY A 432
ASP A 487
 THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
THM  A6510 (-3.7A)
THM  A6510 (-3.2A)
THM  A6510 (-2.4A)
 0.96A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ILE A 179
ARG A 349
GLY A 380
ARG A 383
ASN A 479
GLY A 432
PHE A 481
 THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 ( 4.7A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
 1.42A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		9 ILE A 179
ARG A 349
GLY A 380
ARG A 383
PHE A 402
ASN A 404
GLY A 432
PHE A 481
ASP A 487
 THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-4.1A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-3.0A)
THM  A6510 (-3.2A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 0.69A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 179
GLY A 381
ARG A 383
PHE A 481
ASP A 487
 THM  A6510 (-3.6A)
THM  A6510 (-3.6A)
PO4  A5646 (-2.9A)
THM  A6510 (-3.7A)
THM  A6510 (-2.4A)
 1.31A 1ho5A-2z1aA:
38.5		 1ho5A-2z1aA:
31.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 ILE A 131
ASN A 125
PHE A 112
GLY A 203
ASP A 132
 None
 1.12A 1ho5A-2z5xA:
undetectable		 1ho5A-2z5xA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A  27
GLY A 427
GLY A  24
PHE A 424
ASP A  21
 CA  A 552 (-4.7A)
None
None
None
CA  A 552 (-3.1A)
 1.03A 1ho5A-2ze0A:
undetectable		 1ho5A-2ze0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b59 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Novosphingobium
aromaticivorans) 		PF00903
(Glyoxalase) 		5 ASN A 235
GLY A 226
GLY A 280
PHE A 237
ASP A 275
 None
 1.22A 1ho5A-3b59A:
undetectable		 1ho5A-3b59A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9f 5'-NUCLEOTIDASE

(Candida
albicans) 		PF00149
(Metallophos) 		5 GLY A 388
ARG A 391
PHE A 410
ASN A 412
PHE A 521
 None
FMT  A 607 (-2.7A)
None
None
None
 0.98A 1ho5A-3c9fA:
25.6		 1ho5A-3c9fA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		5 ASN A 153
ARG A 172
SER A 160
GLY A 239
ARG A 240
 None
 1.35A 1ho5A-3eapA:
undetectable		 1ho5A-3eapA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		5 ILE A 201
SER A 164
GLY A 192
ASN A 186
GLY A 240
 None
 1.31A 1ho5A-3efbA:
undetectable		 1ho5A-3efbA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A  42
GLY A 449
GLY A  39
PHE A 446
ASP A  36
 None
 0.97A 1ho5A-3gbdA:
undetectable		 1ho5A-3gbdA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ive NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 GLY A 372
ARG A 375
PHE A 394
ASN A 396
PHE A 466
ASP A 472
 CTN  A 603 (-3.2A)
CTN  A 603 ( 3.0A)
CTN  A 603 (-3.5A)
CTN  A 603 (-3.0A)
CTN  A 603 (-3.8A)
CTN  A 603 (-2.7A)
 0.65A 1ho5A-3iveA:
37.3		 1ho5A-3iveA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6i T-CADHERIN

(Gallus gallus) 		PF00028
(Cadherin) 		5 ILE A  87
SER A  83
GLY A  84
ARG A  36
ASP A  81
 None
 1.50A 1ho5A-3k6iA:
undetectable		 1ho5A-3k6iA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 160
ASN A 475
GLY A 162
PHE A 447
ASP A 164
 None
 1.31A 1ho5A-3m07A:
undetectable		 1ho5A-3m07A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		5 ASN A 161
SER A 151
GLY A 147
GLY A 102
ASP A 103
 None
 1.11A 1ho5A-3mn8A:
undetectable		 1ho5A-3mn8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 ILE A 184
SER A  83
GLY A  85
ARG A 179
ASP A 185
 None
None
None
EDO  A 406 ( 2.9A)
None
 1.25A 1ho5A-3nfvA:
undetectable		 1ho5A-3nfvA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 ILE A 186
SER A  83
GLY A 167
GLY A 182
ASP A 185
 None
 1.34A 1ho5A-3nfvA:
undetectable		 1ho5A-3nfvA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 SER A 204
GLY A 180
PHE A 220
GLY A 206
PHE A 236
 None
 1.44A 1ho5A-3nqhA:
undetectable		 1ho5A-3nqhA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 GLY A  41
ARG A  15
PHE A 111
GLY A  40
ASP A  19
 None
 1.50A 1ho5A-3pl2A:
1.0		 1ho5A-3pl2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 ARG A 125
SER A  96
GLY A  97
ARG A 101
ASP A  52
 SO4  A 500 ( 2.9A)
SO4  A 500 ( 4.0A)
SO4  A 500 (-3.4A)
SO4  A 505 (-3.0A)
SO4  A 504 (-3.4A)
 1.47A 1ho5A-3rmtA:
undetectable		 1ho5A-3rmtA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sil SIALIDASE

(Salmonella
enterica) 		PF13859
(BNR_3) 		5 ARG A 246
SER A 248
GLY A 279
ARG A 309
ASN A 305
 PO4  A 499 (-2.7A)
None
None
PO4  A 499 (-3.0A)
None
 1.02A 1ho5A-3silA:
undetectable		 1ho5A-3silA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trd ALPHA/BETA HYDROLASE

(Coxiella
burnetii) 		PF00561
(Abhydrolase_1) 		5 ILE A  33
SER A 116
GLY A 112
PHE A  68
GLY A 108
 None
 1.48A 1ho5A-3trdA:
undetectable		 1ho5A-3trdA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ASN A 664
SER A 626
GLY A 641
GLY A 636
ASP A 624
 None
 1.37A 1ho5A-3txaA:
undetectable		 1ho5A-3txaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 URE  A1902 ( 4.9A)
BTI  A1901 ( 3.5A)
URE  A1902 (-3.0A)
BTI  A1901 (-3.8A)
BTI  A1901 (-4.6A)
 1.42A 1ho5A-3va7A:
undetectable		 1ho5A-3va7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		6 ARG A 397
GLY A 434
ARG A 437
ASN A 538
GLY A 488
ASP A 546
 A12  A1598 (-3.0A)
A12  A1598 (-3.4A)
A12  A1598 (-2.6A)
A12  A1598 ( 4.4A)
A12  A1598 (-3.4A)
A12  A1598 (-2.7A)
 1.14A 1ho5A-3zu0A:
34.3		 1ho5A-3zu0A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 397
GLY A 434
ARG A 437
PHE A 456
ASN A 458
GLY A 488
ASP A 546
 A12  A1598 (-3.0A)
A12  A1598 (-3.4A)
A12  A1598 (-2.6A)
A12  A1598 (-3.4A)
A12  A1598 (-3.1A)
A12  A1598 (-3.4A)
A12  A1598 (-2.7A)
 0.58A 1ho5A-3zu0A:
34.3		 1ho5A-3zu0A:
26.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF07679
(I-set)
PF13855
(LRR_8) 		5 ILE A 208
SER A 226
GLY A 227
ASN A 276
GLY A 204
 None
 1.42A 1ho5A-3zyiA:
undetectable		 1ho5A-3zyiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1s GLYCOSIDE HYDROLASE
FAMILY 76
MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF03663
(Glyco_hydro_76) 		5 ILE A 232
SER A 203
GLY A 201
GLY A 199
ASP A 266
 EDO  A1527 (-3.9A)
None
None
None
None
 1.27A 1ho5A-4c1sA:
undetectable		 1ho5A-4c1sA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7w HEMAGGLUTININ-ESTERA
SE

(Murine
coronavirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 ASN A 373
ARG A 330
GLY A 368
PHE A 370
ASN A  26
 None
 1.44A 1ho5A-4c7wA:
undetectable		 1ho5A-4c7wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		5 SER A  36
GLY A  41
ASN A  45
GLY A  40
ASP A 206
 None
 1.03A 1ho5A-4cs6A:
undetectable		 1ho5A-4cs6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		5 ILE A  89
ASN A  74
GLY A 380
ARG A  96
GLY A 379
 None
None
None
GLC  A1416 (-3.2A)
None
 1.47A 1ho5A-4d47A:
undetectable		 1ho5A-4d47A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 ILE A 516
ASN A 532
SER A 130
GLY A 504
ASP A 515
 None
 1.09A 1ho5A-4dwsA:
undetectable		 1ho5A-4dwsA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 ILE A  32
SER A  10
GLY A   9
GLY A   8
PHE A  45
 None
 1.33A 1ho5A-4e4yA:
undetectable		 1ho5A-4e4yA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frf INOSITOL
POLYPHOSPHATE
MULTIKINASE ALPHA

(Arabidopsis
thaliana) 		PF03770
(IPK) 		5 ILE A 258
ASN A 261
GLY A 254
ASN A 218
GLY A 256
 None
SO4  A 302 ( 4.8A)
None
SO4  A 302 (-4.2A)
None
 1.04A 1ho5A-4frfA:
undetectable		 1ho5A-4frfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ARG A 354
GLY A 391
GLY A 447
PHE A 500
ASP A 506
 PO4  A 604 (-2.8A)
None
None
None
None
 1.23A 1ho5A-4h1sA:
36.7		 1ho5A-4h1sA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		7 ARG A 354
GLY A 392
ARG A 395
PHE A 417
GLY A 447
PHE A 500
ASP A 506
 PO4  A 604 (-2.8A)
None
PO4  A 604 (-2.9A)
None
None
None
None
 0.61A 1ho5A-4h1sA:
36.7		 1ho5A-4h1sA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 ILE A  69
GLY A 476
GLY A  66
PHE A 473
ASP A  63
 None
None
None
None
CA  A 701 (-3.2A)
 1.03A 1ho5A-4hozA:
1.9		 1ho5A-4hozA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iia RAS
GTPASE-ACTIVATING
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF02136
(NTF2) 		5 ASN A  69
GLY A  43
PHE A  70
ASN A 100
GLY A  44
 None
 1.38A 1ho5A-4iiaA:
undetectable		 1ho5A-4iiaA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipn 6-PHOSPHO-BETA-GLUCO
SIDASE

(Streptococcus
pneumoniae) 		PF00232
(Glyco_hydro_1) 		5 ILE B 435
SER B 414
PHE B  79
GLY B 416
PHE B  76
 None
 1.42A 1ho5A-4ipnB:
undetectable		 1ho5A-4ipnB:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irq BETA-1,4-GALACTOSYLT
RANSFERASE 7

(Homo sapiens) 		PF02709
(Glyco_transf_7C)
PF13733
(Glyco_transf_7N) 		5 SER A 218
GLY A 286
ASN A 140
GLY A 285
ASP A 282
 None
 1.31A 1ho5A-4irqA:
undetectable		 1ho5A-4irqA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		5 ILE A  31
ASN A  28
GLY A 119
GLY A  33
ASP A  22
 None
None
None
None
LAT  A 201 (-2.8A)
 1.23A 1ho5A-4izxA:
undetectable		 1ho5A-4izxA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 ILE B 139
SER B  92
GLY B  91
PHE B  78
ASN B  64
 None
PYC  B 904 (-3.0A)
PYC  B 904 (-3.5A)
None
None
 1.42A 1ho5A-4k7gB:
2.4		 1ho5A-4k7gB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 ILE A  60
ASN A 270
GLY A  94
ASN A  69
GLY A  87
 None
 1.48A 1ho5A-4kgbA:
undetectable		 1ho5A-4kgbA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		5 ILE A 275
SER A 268
ARG A 326
ASN A 256
PHE A 258
 None
 1.24A 1ho5A-4lnfA:
undetectable		 1ho5A-4lnfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv0 7-METHYLGUANOSINE
PHOSPHATE-SPECIFIC
5'-NUCLEOTIDASE

(Drosophila
melanogaster) 		PF05822
(UMPH-1) 		5 GLY A 125
PHE A  75
ASN A  79
GLY A 208
PHE A  78
 None
MG7  A 403 (-3.6A)
MG7  A 403 ( 4.7A)
None
None
 1.27A 1ho5A-4nv0A:
undetectable		 1ho5A-4nv0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oal CYTOKININ
DEHYDROGENASE 4

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		5 ILE A 235
SER A 175
GLY A 177
ASN A 182
GLY A 146
 FAD  A 601 (-4.5A)
FAD  A 601 (-2.7A)
FAD  A 601 (-3.5A)
FAD  A 601 (-4.2A)
FAD  A 601 ( 4.2A)
 1.37A 1ho5A-4oalA:
undetectable		 1ho5A-4oalA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi) 		PF00561
(Abhydrolase_1) 		5 ILE A 237
SER A 242
GLY A 268
GLY A 239
ASP A 136
 None
 1.34A 1ho5A-4oseA:
undetectable		 1ho5A-4oseA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		5 ILE A 503
ASN A 358
SER A 519
GLY A 518
GLY A 517
 None
4NS  A 601 (-3.6A)
None
None
None
 1.46A 1ho5A-4p05A:
undetectable		 1ho5A-4p05A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D

(Homo sapiens) 		PF12706
(Lactamase_B_2) 		5 ILE A 306
SER A 269
PHE A 279
GLY A 283
PHE A 280
 None
 1.35A 1ho5A-4qn9A:
undetectable		 1ho5A-4qn9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zc0 REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 ASN A 447
SER A 191
GLY A 192
ASN A 445
GLY A 178
 None
 1.26A 1ho5A-4zc0A:
undetectable		 1ho5A-4zc0A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		5 ILE A 107
SER A 101
GLY A  72
GLY A 105
PHE A  79
 PGT  A 309 ( 4.8A)
None
None
BOG  A 303 ( 4.1A)
None
 0.91A 1ho5A-5azbA:
undetectable		 1ho5A-5azbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 ASN A 466
SER A 404
GLY A 432
PHE A 443
GLY A 433
 None
 1.31A 1ho5A-5djwA:
undetectable		 1ho5A-5djwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5egw CYSTEINE PROTEASE

(Ambrosia
artemisiifolia) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 ASN A  58
GLY A  38
PHE A  60
GLY A  35
PHE A  57
 None
 1.34A 1ho5A-5egwA:
undetectable		 1ho5A-5egwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa9 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Treponema
denticola) 		PF01625
(PMSR)
PF01641
(SelR) 		5 ASN A 287
SER A 261
GLY A 265
GLY A 264
ASP A 212
 None
 1.20A 1ho5A-5fa9A:
undetectable		 1ho5A-5fa9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		5 SER A 446
GLY A  65
PHE A 353
GLY A  41
ASP A  42
 None
 1.43A 1ho5A-5g0aA:
undetectable		 1ho5A-5g0aA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ARG A 354
GLY A 391
GLY A 448
PHE A 501
ASP A 507
 None
 1.25A 1ho5A-5h7wA:
34.7		 1ho5A-5h7wA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 6 ARG A 354
GLY A 392
ARG A 395
PHE A 418
GLY A 448
ASP A 507
 None
 0.96A 1ho5A-5h7wA:
34.7		 1ho5A-5h7wA:
30.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 6 ARG A 354
GLY A 392
PHE A 418
GLY A 448
PHE A 501
ASP A 507
 None
 0.74A 1ho5A-5h7wA:
34.7		 1ho5A-5h7wA:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A1610
SER A1609
GLY A1635
ASN A1330
PHE A1349
 None
 1.44A 1ho5A-5i8iA:
undetectable		 1ho5A-5i8iA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 SER A 390
GLY A 396
ASN A 399
GLY A 395
ASP A 391
 None
None
None
None
SO4  A 703 (-4.5A)
 1.40A 1ho5A-5ic7A:
undetectable		 1ho5A-5ic7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm2 CAPSID PROTEIN VP4B

(Nora virus) 		no annotation 5 ILE B 200
ASN B 195
SER B  66
PHE B 147
PHE B 194
 None
 1.46A 1ho5A-5mm2B:
undetectable		 1ho5A-5mm2B:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 5 SER A 218
GLY A 181
GLY A 183
PHE A  93
ASP A 264
 None
None
None
8U8  A 713 (-4.1A)
None
 1.47A 1ho5A-5ndxA:
2.7		 1ho5A-5ndxA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE

(Aspergillus
oryzae) 		no annotation 5 ASN B 472
GLY B 451
PHE B 473
ASN B 474
GLY B 449
 None
 1.39A 1ho5A-5oarB:
undetectable		 1ho5A-5oarB:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0h 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 2

(Homo sapiens) 		PF00004
(AAA) 		5 GLY f 203
PHE f 217
GLY f 200
PHE f 221
ASP f 234
 None
 1.09A 1ho5A-5t0hf:
undetectable		 1ho5A-5t0hf:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 ILE A 378
ASN A 369
SER A 403
GLY A 406
ASP A 380
 None
 1.46A 1ho5A-5u47A:
undetectable		 1ho5A-5u47A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ASN A 385
GLY A 373
ARG A 589
PHE A 382
GLY A 391
 None
 1.36A 1ho5A-5xh9A:
undetectable		 1ho5A-5xh9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xl6 HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 ILE A  63
SER A  69
GLY A  68
GLY A  65
PHE A  96
 None
 1.25A 1ho5A-5xl6A:
undetectable		 1ho5A-5xl6A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bnp UNCONVENTIONAL
MYOSIN-VI

(Sus scrofa) 		no annotation 5 ILE I 178
GLY I 173
PHE I 214
ASN I 215
GLY I 175
 None
 1.43A 1ho5A-6bnpI:
undetectable		 1ho5A-6bnpI:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 5 ILE A 383
SER A 390
GLY A 388
PHE A 314
ASP A 269
 PG4  A 502 ( 4.6A)
None
None
None
None
 1.24A 1ho5A-6fx0A:
undetectable		 1ho5A-6fx0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g43 PUTATIVE MAJOR
CAPSID PROTEIN

(Cafeteriavirus-dependent
mavirus) 		no annotation 5 ILE A 353
SER A 420
GLY A 392
PHE A 387
GLY A 351
 None
 1.29A 1ho5A-6g43A:
undetectable		 1ho5A-6g43A:
10.06