SIMILAR PATTERNS OF AMINO ACIDS FOR 1HMY_A_SAMA328_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahi 7
ALPHA-HYDROXYSTEROID
DEHYDROGENASE


(Escherichia
coli)
PF13561
(adh_short_C2)
4 ASP A  68
ILE A  69
THR A  70
LEU A 117
NAI  A 302 (-3.6A)
NAI  A 302 (-3.8A)
NAI  A 302 ( 4.0A)
None
0.83A 1hmyA-1ahiA:
2.2
1hmyA-1ahiA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)


(Proteus
vulgaris)
PF01555
(N6_N4_Mtase)
4 PHE A 273
GLU A 294
ASP A  34
PRO A  55
SAH  A 401 (-4.6A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
0.74A 1hmyA-1booA:
5.7
1hmyA-1booA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.)
PF00067
(p450)
4 ASP A 359
ILE A 360
THR A 361
LEU A 292
None
0.90A 1hmyA-1cptA:
undetectable
1hmyA-1cptA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dct PROTEIN
(MODIFICATION
METHYLASE HAEIII)


(Haemophilus
influenzae)
PF00145
(DNA_methylase)
6 PHE A   7
GLU A  29
ASP A  50
ILE A  51
PRO A  70
LEU A  90
None
0.76A 1hmyA-1dctA:
27.1
1hmyA-1dctA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
4 PHE A 209
ILE A 226
THR A 228
PRO A 292
None
0.86A 1hmyA-1ileA:
undetectable
1hmyA-1ileA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc6 VENOM BASIC PROTEASE
INHIBITORS IX AND
VIIIB


(Bungarus
fasciatus)
PF00014
(Kunitz_BPTI)
4 PHE A  23
ASP A  51
ILE A  50
PRO A  21
None
0.85A 1hmyA-1jc6A:
undetectable
1hmyA-1jc6A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
4 GLU A 232
ILE A 264
PRO A 278
LEU A 326
None
0.78A 1hmyA-1kcxA:
undetectable
1hmyA-1kcxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE


(Escherichia
coli)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
4 PHE A 213
ILE A 217
PRO A 209
LEU A 106
None
0.87A 1hmyA-1nylA:
undetectable
1hmyA-1nylA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqp CALTRACTIN

(Chlamydomonas
reinhardtii)
PF13499
(EF-hand_7)
4 PHE A 107
ASP A 122
ILE A 118
THR A 119
None
0.94A 1hmyA-1oqpA:
undetectable
1hmyA-1oqpA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3)
PF00693
(Herpes_TK)
4 GLU A 164
ILE A 213
THR A 212
LEU A 209
None
0.94A 1hmyA-1osnA:
undetectable
1hmyA-1osnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN


(Salmonella
enterica)
PF07487
(SopE_GEF)
5 PHE A 213
ILE A 114
THR A 110
PRO A 211
LEU A 212
None
1.43A 1hmyA-1r6eA:
undetectable
1hmyA-1r6eA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT


(Pseudomonas
putida)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 PHE B 442
ILE B 645
THR B 658
LEU B 456
None
0.86A 1hmyA-1t3qB:
undetectable
1hmyA-1t3qB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE


(Thermus
thermophilus)
PF00133
(tRNA-synt_1)
4 PHE A 209
THR A 228
PRO A 292
LEU A 234
None
0.82A 1hmyA-1ue0A:
undetectable
1hmyA-1ue0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE


(Thermotoga
maritima)
PF01634
(HisG)
4 ILE E  81
THR E  83
PRO E   7
LEU E  11
None
0.84A 1hmyA-1usyE:
undetectable
1hmyA-1usyE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
4 PHE A 275
GLU A 273
PRO A  40
LEU A 224
None
0.92A 1hmyA-1v2dA:
3.6
1hmyA-1v2dA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13


(Homo sapiens)
PF00102
(Y_phosphatase)
4 PHE A2459
ILE A2421
PRO A2382
LEU A2388
None
0.94A 1hmyA-1wchA:
undetectable
1hmyA-1wchA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
4 PHE A  34
GLU A  36
ILE A   5
LEU A  25
None
0.95A 1hmyA-1x0lA:
2.2
1hmyA-1x0lA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xru 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE


(Escherichia
coli)
PF04962
(KduI)
4 PHE A 126
ILE A  89
THR A  90
PRO A  52
None
0.90A 1hmyA-1xruA:
undetectable
1hmyA-1xruA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a81 CARB

(Pectobacterium
carotovorum)
PF00378
(ECH_1)
4 PHE A 110
GLU A 131
ILE A 157
LEU A 164
None
BCN  A 501 (-3.5A)
None
None
0.92A 1hmyA-2a81A:
undetectable
1hmyA-2a81A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eey MOLYBDOPTERIN
BIOSYNTHESIS


(Geobacillus
kaustophilus)
PF01967
(MoaC)
4 ASP A  17
ILE A  18
THR A  19
PRO A  78
None
0.93A 1hmyA-2eeyA:
undetectable
1hmyA-2eeyA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE


(Candida
tropicalis)
PF00106
(adh_short)
4 GLU A 538
ILE A 494
THR A 453
LEU A 475
None
0.94A 1hmyA-2et6A:
4.7
1hmyA-2et6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE


(Dictyostelium
discoideum)
PF01979
(Amidohydro_1)
4 GLU A 225
ILE A 257
PRO A 271
LEU A 319
None
0.86A 1hmyA-2ftwA:
undetectable
1hmyA-2ftwA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 ASP B 369
ILE B 298
PRO B 213
LEU B 211
None
0.90A 1hmyA-2hdnB:
undetectable
1hmyA-2hdnB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
4 ILE A 522
THR A 523
PRO A 537
LEU A 528
None
0.84A 1hmyA-2hnhA:
undetectable
1hmyA-2hnhA:
16.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2i9k MODIFICATION
METHYLASE HHAI


(Haemophilus
haemolyticus)
PF00145
(DNA_methylase)
8 PHE A  18
GLU A  40
TRP A  41
ASP A  60
ILE A  61
THR A  62
PRO A  80
LEU A 100
SAH  A 328 (-4.9A)
SAH  A 328 (-2.8A)
SAH  A 328 (-3.4A)
SAH  A 328 (-3.6A)
SAH  A 328 (-4.3A)
SAH  A 328 ( 4.3A)
SAH  A 328 (-4.0A)
SAH  A 328 ( 4.9A)
0.52A 1hmyA-2i9kA:
43.3
1hmyA-2i9kA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T


(Homo sapiens)
PF00102
(Y_phosphatase)
4 PHE A1157
ILE A1119
PRO A1078
LEU A1084
None
0.94A 1hmyA-2ooqA:
undetectable
1hmyA-2ooqA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozv HYPOTHETICAL PROTEIN
ATU0636


(Agrobacterium
fabrum)
PF05175
(MTS)
4 GLU A  75
ASP A 106
THR A 108
PRO A 132
None
0.80A 1hmyA-2ozvA:
8.8
1hmyA-2ozvA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 PHE A  37
ILE A 474
PRO A   9
LEU A 479
None
0.86A 1hmyA-2pq6A:
3.4
1hmyA-2pq6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE


(Trypanosoma
cruzi)
PF02685
(Glucokinase)
4 PHE A 104
ASP A  61
ILE A  62
THR A  63
None
0.62A 1hmyA-2q2rA:
undetectable
1hmyA-2q2rA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2


(Homo sapiens)
PF00102
(Y_phosphatase)
4 PHE A 997
ILE A 958
PRO A 917
LEU A 923
None
0.73A 1hmyA-2qepA:
undetectable
1hmyA-2qepA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr4 PEPTIDASE M3B,
OLIGOENDOPEPTIDASE F


(Enterococcus
faecium)
PF01432
(Peptidase_M3)
PF08439
(Peptidase_M3_N)
4 PHE A  30
ILE A  75
THR A  72
LEU A 102
None
0.90A 1hmyA-2qr4A:
undetectable
1hmyA-2qr4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w92 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D


(Streptococcus
pneumoniae)
PF03644
(Glyco_hydro_85)
4 PHE A 493
ILE A 514
PRO A 473
LEU A 470
None
0.94A 1hmyA-2w92A:
undetectable
1hmyA-2w92A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0q ALCALIGIN
BIOSYNTHESIS PROTEIN


(Bordetella
bronchiseptica)
PF04183
(IucA_IucC)
PF06276
(FhuF)
5 PHE A 289
GLU A 155
ASP A 150
PRO A 382
LEU A 383
None
1.37A 1hmyA-2x0qA:
undetectable
1hmyA-2x0qA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Methanocaldococcus
jannaschii)
PF01135
(PCMT)
4 GLU A 109
ASP A 136
THR A 138
LEU A 207
None
0.92A 1hmyA-2yxeA:
5.1
1hmyA-2yxeA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE


(Thermus
thermophilus)
PF01555
(N6_N4_Mtase)
4 PHE A 243
GLU A 264
ASP A  28
PRO A  49
None
0.83A 1hmyA-2zieA:
4.9
1hmyA-2zieA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 PHE A1148
GLU A1171
ASP A1193
PRO A1227
LEU A1250
SAM  A   1 (-4.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
None
SAM  A   1 (-4.6A)
1.42A 1hmyA-3av6A:
16.7
1hmyA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Mus musculus)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD)
5 PHE A1148
GLU A1171
ASP A1193
PRO A1228
LEU A1250
SAM  A   1 (-4.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
0.63A 1hmyA-3av6A:
16.7
1hmyA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae)
PF01653
(DNA_ligase_aden)
4 GLU A 300
ILE A  98
PRO A 106
LEU A 109
None
0.87A 1hmyA-3bacA:
undetectable
1hmyA-3bacA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE


(Bacillus cereus)
PF13489
(Methyltransf_23)
4 GLU A  60
ASP A  80
ILE A  81
LEU A 105
None
0.91A 1hmyA-3cc8A:
6.9
1hmyA-3cc8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyg UNCHARACTERIZED
PROTEIN


(Fervidobacterium
nodosum)
PF11738
(DUF3298)
PF13739
(DUF4163)
5 PHE A 227
ASP A 194
ILE A 191
PRO A 225
LEU A 217
None
1.28A 1hmyA-3cygA:
undetectable
1hmyA-3cygA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti)
PF01979
(Amidohydro_1)
4 GLU A 214
ILE A 246
PRO A 260
LEU A 307
None
0.77A 1hmyA-3dc8A:
undetectable
1hmyA-3dc8A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh1 TRNA-SPECIFIC
ADENOSINE DEAMINASE
2


(Homo sapiens)
PF14437
(MafB19-deam)
4 PHE A  95
ILE A  77
PRO A  91
LEU A  81
None
0.76A 1hmyA-3dh1A:
undetectable
1hmyA-3dh1A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqz RESPONSE REGULATOR

(Colwellia
psychrerythraea)
PF00072
(Response_reg)
4 GLU A 112
ILE A  21
THR A  20
LEU A  17
GLU  A 112 ( 0.6A)
ILE  A  21 ( 0.7A)
THR  A  20 ( 0.8A)
LEU  A  17 ( 0.5A)
0.79A 1hmyA-3eqzA:
5.7
1hmyA-3eqzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fay RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1


(Homo sapiens)
PF00616
(RasGAP)
4 GLU A1326
ASP A1322
ILE A1324
LEU A 978
None
0.78A 1hmyA-3fayA:
undetectable
1hmyA-3fayA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE


(Geobacillus
stearothermophilus)
PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4)
4 PHE A  58
ASP A  63
ILE A  62
PRO A  29
None
0.84A 1hmyA-3g0qA:
undetectable
1hmyA-3g0qA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Escherichia
coli)
PF00145
(DNA_methylase)
4 PHE A   7
GLU A  29
ASP A  51
PRO A  78
None
0.87A 1hmyA-3g7uA:
25.2
1hmyA-3g7uA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Escherichia
coli)
PF00145
(DNA_methylase)
4 PHE A   7
GLU A  29
PRO A  78
LEU A  97
None
0.57A 1hmyA-3g7uA:
25.2
1hmyA-3g7uA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1


(Gadus morhua)
PF01464
(SLT)
4 ASP A   7
ILE A   8
THR A   9
PRO A  63
None
0.89A 1hmyA-3gxkA:
undetectable
1hmyA-3gxkA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
4 GLU A 535
ASP A 546
ILE A 547
THR A 548
None
0.92A 1hmyA-3hvdA:
undetectable
1hmyA-3hvdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxs THIOREDOXIN

(Bacteroides
fragilis)
PF00085
(Thioredoxin)
4 PHE A 111
ASP A  57
ILE A 109
LEU A 130
None
0.94A 1hmyA-3hxsA:
undetectable
1hmyA-3hxsA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica)
PF02615
(Ldh_2)
4 PHE A  55
ASP A  61
ILE A  60
LEU A 355
None
0.95A 1hmyA-3i0pA:
undetectable
1hmyA-3i0pA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l93 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Yersinia pestis)
PF01467
(CTP_transf_like)
4 ASP A 141
ILE A 142
THR A 143
LEU A 155
None
0.90A 1hmyA-3l93A:
3.5
1hmyA-3l93A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldu PUTATIVE METHYLASE

(Clostridioides
difficile)
PF01170
(UPF0020)
PF02926
(THUMP)
4 ASP A 289
THR A 291
PRO A 307
LEU A 321
GTP  A 383 ( 3.8A)
GTP  A 383 ( 4.3A)
GTP  A 383 (-3.7A)
None
0.89A 1hmyA-3lduA:
6.6
1hmyA-3lduA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
4 ILE A  25
THR A  26
PRO A 109
LEU A  50
None
0.70A 1hmyA-3lmsA:
undetectable
1hmyA-3lmsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwf PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Listeria
innocua)
PF02082
(Rrf2)
4 ILE A  13
THR A  14
PRO A  48
LEU A  49
None
None
SO4  A 148 ( 4.5A)
None
0.90A 1hmyA-3lwfA:
undetectable
1hmyA-3lwfA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Shigella
flexneri)
PF00145
(DNA_methylase)
6 PHE A  93
GLU A 115
ASP A 140
ILE A 141
PRO A 176
LEU A 205
None
0.67A 1hmyA-3lx6A:
30.3
1hmyA-3lx6A:
33.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Shigella
flexneri)
PF00145
(DNA_methylase)
5 PHE A  93
GLU A 115
ILE A 141
PRO A 176
LEU A 205
None
0.56A 1hmyA-3me5A:
27.8
1hmyA-3me5A:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 ASP A1369
ILE A1298
PRO A1213
LEU A1211
None
0.89A 1hmyA-3mmpA:
undetectable
1hmyA-3mmpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus)
PF00067
(p450)
4 ASP A 314
ILE A 315
THR A 316
LEU A 251
None
0.69A 1hmyA-3oo3A:
undetectable
1hmyA-3oo3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgb PUTATIVE
UNCHARACTERIZED
PROTEIN


(Aspergillus
nidulans)
PF01179
(Cu_amine_oxid)
PF09248
(DUF1965)
4 PHE A 310
ILE A 222
THR A 223
LEU A 278
None
0.95A 1hmyA-3pgbA:
undetectable
1hmyA-3pgbA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae)
PF01653
(DNA_ligase_aden)
4 GLU A 300
ILE A  98
PRO A 106
LEU A 109
None
0.89A 1hmyA-3pn1A:
undetectable
1hmyA-3pn1A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae)
PF01497
(Peripla_BP_2)
5 GLU A 305
ILE A  52
THR A  49
PRO A 302
LEU A 135
None
1.45A 1hmyA-3pshA:
undetectable
1hmyA-3pshA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
5 PHE A1145
GLU A1168
ASP A1190
PRO A1225
LEU A1247
SAH  A1601 (-4.4A)
SAH  A1601 (-3.0A)
SAH  A1601 ( 4.7A)
SAH  A1601 (-4.2A)
SAH  A1601 (-3.7A)
0.55A 1hmyA-3ptaA:
26.1
1hmyA-3ptaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9t CHOLINE
DEHYDROGENASE AND
RELATED
FLAVOPROTEINS


(Aspergillus
oryzae)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLU A 367
ASP A 369
PRO A 384
LEU A 458
None
0.92A 1hmyA-3q9tA:
undetectable
1hmyA-3q9tA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb5 TRANSLIN-ASSOCIATED
PROTEIN X


(Homo sapiens)
PF01997
(Translin)
4 GLU K  89
ASP K  82
ILE K  77
THR K  78
None
0.87A 1hmyA-3qb5K:
undetectable
1hmyA-3qb5K:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qrx CENTRIN

(Chlamydomonas
reinhardtii)
PF13499
(EF-hand_7)
4 PHE A 107
ASP A 122
ILE A 118
THR A 119
None
CA  A 172 (-2.1A)
None
CA  A 172 ( 4.2A)
0.88A 1hmyA-3qrxA:
undetectable
1hmyA-3qrxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus)
PF00560
(LRR_1)
PF13855
(LRR_8)
4 PHE A 170
ILE A 143
PRO A 171
LEU A 148
None
0.91A 1hmyA-3rg1A:
undetectable
1hmyA-3rg1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei)
PF01370
(Epimerase)
4 ASP A  56
ILE A  57
THR A  58
LEU A  96
None
0.68A 1hmyA-3slgA:
4.6
1hmyA-3slgA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE


(Mycobacterium
ulcerans)
PF13561
(adh_short_C2)
4 ASP A  67
ILE A  68
THR A  69
LEU A 118
None
0.72A 1hmyA-3svtA:
7.0
1hmyA-3svtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis)
PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3)
4 GLU A 535
ASP A 546
ILE A 547
THR A 548
None
0.80A 1hmyA-3texA:
undetectable
1hmyA-3texA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm5 CRYSTAL STRUCTURE OF
TRM14


(Pyrococcus
furiosus)
PF01170
(UPF0020)
PF02926
(THUMP)
5 GLU A 248
ASP A 276
THR A 278
PRO A 295
LEU A 309
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
SFG  A 401 ( 4.1A)
SFG  A 401 ( 4.4A)
None
1.03A 1hmyA-3tm5A:
9.2
1hmyA-3tm5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus)
PF01170
(UPF0020)
PF02926
(THUMP)
4 PHE A 192
ASP A 243
PRO A 262
LEU A 276
None
0.87A 1hmyA-3tmaA:
9.2
1hmyA-3tmaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Bradyrhizobium
sp. ORS 278)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ILE A   6
THR A  41
PRO A  80
LEU A  78
None
0.89A 1hmyA-3toyA:
undetectable
1hmyA-3toyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE


(Mycolicibacterium
smegmatis)
PF13561
(adh_short_C2)
4 ASP A  64
ILE A  65
THR A  66
LEU A 115
None
0.73A 1hmyA-3ucxA:
6.4
1hmyA-3ucxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugg SUCROSE:(SUCROSE/FRU
CTAN)
6-FRUCTOSYLTRANSFERA
SE


(Pachysandra
terminalis)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
4 PHE A 448
ASP A 279
ILE A 500
THR A 501
None
0.87A 1hmyA-3uggA:
undetectable
1hmyA-3uggA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 PHE A 176
GLU A 179
PRO A 167
LEU A 415
None
0.65A 1hmyA-3vf1A:
undetectable
1hmyA-3vf1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnd TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Shewanella
frigidimarina)
PF00290
(Trp_syntA)
4 GLU A  32
ASP A  28
ILE A  37
LEU A 252
None
0.95A 1hmyA-3vndA:
undetectable
1hmyA-3vndA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT


(Comamonas
testosteroni)
PF02900
(LigB)
5 PHE B  90
ASP B 128
ILE B 132
THR B 131
PRO B  15
None
None
None
None
2XP  B 402 (-4.4A)
1.39A 1hmyA-3vsjB:
undetectable
1hmyA-3vsjB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR


(Caldanaerobacter
subterraneus)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 PHE C 118
GLU C 115
ILE C 157
LEU C  79
None
0.89A 1hmyA-3vtiC:
undetectable
1hmyA-3vtiC:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5o BIFUNCTIONAL PROTEIN
FOLD


(Pseudomonas
aeruginosa)
PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C)
4 PHE A  63
ILE A  19
PRO A  34
LEU A 276
None
0.85A 1hmyA-4a5oA:
undetectable
1hmyA-4a5oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avy PROBABLE SHORT-CHAIN
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF13561
(adh_short_C2)
4 ASP A  61
ILE A  62
THR A  63
LEU A 105
None
0.83A 1hmyA-4avyA:
7.8
1hmyA-4avyA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg1 CUTINASE

(Thermobifida
fusca)
PF12740
(Chlorophyllase2)
4 GLU A  98
ASP A  91
ILE A  87
THR A  88
None
0.84A 1hmyA-4cg1A:
4.5
1hmyA-4cg1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3


(Homo sapiens)
PF01979
(Amidohydro_1)
4 GLU A 232
ILE A 264
PRO A 278
LEU A 326
None
0.82A 1hmyA-4cnsA:
undetectable
1hmyA-4cnsA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3


(Homo sapiens)
PF01979
(Amidohydro_1)
4 GLU A 232
ILE A 264
PRO A 278
LEU A 326
None
0.81A 1hmyA-4cntA:
undetectable
1hmyA-4cntA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Mycoplasma
penetrans)
PF00145
(DNA_methylase)
7 PHE A  17
GLU A  45
TRP A  46
ASP A 113
ILE A 114
PRO A 134
LEU A 157
SAH  A 501 (-4.8A)
SAH  A 501 (-3.0A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
0.59A 1hmyA-4dkjA:
29.5
1hmyA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h59 IRON-COMPOUND ABC
TRANSPORTER, IRON
COMPOUND-BINDING
PROTEIN


(Streptococcus
pneumoniae)
PF01497
(Peripla_BP_2)
5 GLU A 250
ILE A 224
THR A 212
PRO A 243
LEU A 210
None
1.49A 1hmyA-4h59A:
undetectable
1hmyA-4h59A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz4 GLUTATHIONE-S-TRANSF
ERASE


(Actinobacillus
pleuropneumoniae)
PF00043
(GST_C)
PF02798
(GST_N)
4 PHE A 137
ILE A 181
THR A 182
LEU A 170
None
0.81A 1hmyA-4hz4A:
undetectable
1hmyA-4hz4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1


(Homo sapiens)
PF04177
(TAP42)
4 PHE A 124
ILE A 201
PRO A 127
LEU A 113
None
0.74A 1hmyA-4iypA:
undetectable
1hmyA-4iypA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE


(Nocardia
farcinica)
PF00067
(p450)
4 ASP A 338
ILE A 339
THR A 340
LEU A 269
None
0.87A 1hmyA-4j6cA:
undetectable
1hmyA-4j6cA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101)
PF01183
(Glyco_hydro_25)
PF08239
(SH3_3)
4 TRP A 313
ASP A 312
ILE A 324
THR A 325
None
None
None
ACT  A 405 ( 4.7A)
0.81A 1hmyA-4krtA:
undetectable
1hmyA-4krtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE


(Mycobacterium
avium)
PF00479
(G6PD_N)
PF02781
(G6PD_C)
4 ASP A  89
THR A  91
PRO A 116
LEU A 119
None
0.61A 1hmyA-4lgvA:
5.9
1hmyA-4lgvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrq PHOSPHOTYROSINE
PROTEIN PHOSPHATASE


(Vibrio cholerae)
PF01451
(LMWPc)
4 PHE A  77
ILE A  72
THR A  40
LEU A  94
None
0.93A 1hmyA-4lrqA:
3.7
1hmyA-4lrqA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me3 DNA REPLICATION
LICENSING FACTOR MCM
RELATED PROTEIN


(Thermoplasma
acidophilum)
PF17207
(MCM_OB)
4 GLU A  71
ILE A  94
PRO A  63
LEU A 117
None
0.95A 1hmyA-4me3A:
undetectable
1hmyA-4me3A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1


(Homo sapiens)
PF01728
(FtsJ)
4 ASP A 335
ILE A 336
THR A 337
LEU A 383
SAM  A 601 (-3.6A)
SAM  A 601 (-4.1A)
SAM  A 601 ( 3.9A)
SAM  A 601 (-4.6A)
0.57A 1hmyA-4n49A:
6.3
1hmyA-4n49A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1


(Saccharomyces
cerevisiae)
no annotation 4 PHE A 401
ASP A 360
ILE A 362
LEU A  29
None
0.92A 1hmyA-4n5cA:
undetectable
1hmyA-4n5cA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ne4 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(PROLINE/GLYCINE/BET
AINE)


(Agrobacterium
fabrum)
PF04069
(OpuAC)
4 PHE A 249
ILE A  24
PRO A 226
LEU A  21
None
0.95A 1hmyA-4ne4A:
undetectable
1hmyA-4ne4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwb MRNA TURNOVER
PROTEIN 4


(Chaetomium
thermophilum)
PF00466
(Ribosomal_L10)
4 PHE A 116
ASP A 111
ILE A 112
LEU A  60
None
0.91A 1hmyA-4nwbA:
undetectable
1hmyA-4nwbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE


(Pyrococcus
horikoshii)
PF01259
(SAICAR_synt)
4 ILE A 231
THR A 232
PRO A 194
LEU A  52
None
0.75A 1hmyA-4o7zA:
undetectable
1hmyA-4o7zA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Hyphomonas
neptunium)
PF00378
(ECH_1)
4 ILE A 162
THR A 159
PRO A 135
LEU A 163
None
0.84A 1hmyA-4olqA:
undetectable
1hmyA-4olqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onq DNA
METHYLTRANSFERASE


(Nicotiana
tabacum)
PF00145
(DNA_methylase)
5 PHE A 488
GLU A 512
ASP A 539
PRO A 566
LEU A 588
SFG  A 700 (-4.5A)
SFG  A 700 (-2.1A)
SFG  A 700 ( 4.4A)
None
SFG  A 700 (-4.9A)
1.32A 1hmyA-4onqA:
6.8
1hmyA-4onqA:
20.21