SIMILAR PATTERNS OF AMINO ACIDS FOR 1HMY_A_SAMA328_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ahi | 7ALPHA-HYDROXYSTEROIDDEHYDROGENASE (Escherichiacoli) |
PF13561(adh_short_C2) | 4 | ASP A 68ILE A 69THR A 70LEU A 117 | NAI A 302 (-3.6A)NAI A 302 (-3.8A)NAI A 302 ( 4.0A)None | 0.83A | 1hmyA-1ahiA:2.2 | 1hmyA-1ahiA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1boo | PROTEIN (N-4CYTOSINE-SPECIFICMETHYLTRANSFERASEPVU II) (Proteusvulgaris) |
PF01555(N6_N4_Mtase) | 4 | PHE A 273GLU A 294ASP A 34PRO A 55 | SAH A 401 (-4.6A)SAH A 401 (-2.9A)SAH A 401 (-4.0A)SAH A 401 (-3.9A) | 0.74A | 1hmyA-1booA:5.7 | 1hmyA-1booA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cpt | CYTOCHROME P450-TERP (Pseudomonas sp.) |
PF00067(p450) | 4 | ASP A 359ILE A 360THR A 361LEU A 292 | None | 0.90A | 1hmyA-1cptA:undetectable | 1hmyA-1cptA:21.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dct | PROTEIN(MODIFICATIONMETHYLASE HAEIII) (Haemophilusinfluenzae) |
PF00145(DNA_methylase) | 6 | PHE A 7GLU A 29ASP A 50ILE A 51PRO A 70LEU A 90 | None | 0.76A | 1hmyA-1dctA:27.1 | 1hmyA-1dctA:33.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ile | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1)PF08264(Anticodon_1) | 4 | PHE A 209ILE A 226THR A 228PRO A 292 | None | 0.86A | 1hmyA-1ileA:undetectable | 1hmyA-1ileA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jc6 | VENOM BASIC PROTEASEINHIBITORS IX ANDVIIIB (Bungarusfasciatus) |
PF00014(Kunitz_BPTI) | 4 | PHE A 23ASP A 51ILE A 50PRO A 21 | None | 0.85A | 1hmyA-1jc6A:undetectable | 1hmyA-1jc6A:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcx | DIHYDROPYRIMIDINASERELATED PROTEIN-1 (Mus musculus) |
PF01979(Amidohydro_1) | 4 | GLU A 232ILE A 264PRO A 278LEU A 326 | None | 0.78A | 1hmyA-1kcxA:undetectable | 1hmyA-1kcxA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nyl | GLUTAMINYL-TRNASYNTHETASE (Escherichiacoli) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C) | 4 | PHE A 213ILE A 217PRO A 209LEU A 106 | None | 0.87A | 1hmyA-1nylA:undetectable | 1hmyA-1nylA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oqp | CALTRACTIN (Chlamydomonasreinhardtii) |
PF13499(EF-hand_7) | 4 | PHE A 107ASP A 122ILE A 118THR A 119 | None | 0.94A | 1hmyA-1oqpA:undetectable | 1hmyA-1oqpA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1osn | THYMIDINE KINASE (Humanalphaherpesvirus3) |
PF00693(Herpes_TK) | 4 | GLU A 164ILE A 213THR A 212LEU A 209 | None | 0.94A | 1hmyA-1osnA:undetectable | 1hmyA-1osnA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6e | TYPEIII-SECRETEDPROTEIN EFFECTOR:INVASION-ASSOCIATEDPROTEIN (Salmonellaenterica) |
PF07487(SopE_GEF) | 5 | PHE A 213ILE A 114THR A 110PRO A 211LEU A 212 | None | 1.43A | 1hmyA-1r6eA:undetectable | 1hmyA-1r6eA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t3q | QUINOLINE2-OXIDOREDUCTASELARGE SUBUNIT (Pseudomonasputida) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2) | 4 | PHE B 442ILE B 645THR B 658LEU B 456 | None | 0.86A | 1hmyA-1t3qB:undetectable | 1hmyA-1t3qB:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ue0 | ISOLEUCYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00133(tRNA-synt_1) | 4 | PHE A 209THR A 228PRO A 292LEU A 234 | None | 0.82A | 1hmyA-1ue0A:undetectable | 1hmyA-1ue0A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1usy | ATPPHOSPHORIBOSYLTRANSFERASE (Thermotogamaritima) |
PF01634(HisG) | 4 | ILE E 81THR E 83PRO E 7LEU E 11 | None | 0.84A | 1hmyA-1usyE:undetectable | 1hmyA-1usyE:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v2d | GLUTAMINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 4 | PHE A 275GLU A 273PRO A 40LEU A 224 | None | 0.92A | 1hmyA-1v2dA:3.6 | 1hmyA-1v2dA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wch | PROTEIN TYROSINEPHOSPHATASE,NON-RECEPTOR TYPE 13 (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | PHE A2459ILE A2421PRO A2382LEU A2388 | None | 0.94A | 1hmyA-1wchA:undetectable | 1hmyA-1wchA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x0l | HOMOISOCITRATEDEHYDROGENASE (Thermusthermophilus) |
PF00180(Iso_dh) | 4 | PHE A 34GLU A 36ILE A 5LEU A 25 | None | 0.95A | 1hmyA-1x0lA:2.2 | 1hmyA-1x0lA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xru | 4-DEOXY-L-THREO-5-HEXOSULOSE-URONATEKETOL-ISOMERASE (Escherichiacoli) |
PF04962(KduI) | 4 | PHE A 126ILE A 89THR A 90PRO A 52 | None | 0.90A | 1hmyA-1xruA:undetectable | 1hmyA-1xruA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a81 | CARB (Pectobacteriumcarotovorum) |
PF00378(ECH_1) | 4 | PHE A 110GLU A 131ILE A 157LEU A 164 | NoneBCN A 501 (-3.5A)NoneNone | 0.92A | 1hmyA-2a81A:undetectable | 1hmyA-2a81A:23.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eey | MOLYBDOPTERINBIOSYNTHESIS (Geobacilluskaustophilus) |
PF01967(MoaC) | 4 | ASP A 17ILE A 18THR A 19PRO A 78 | None | 0.93A | 1hmyA-2eeyA:undetectable | 1hmyA-2eeyA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2et6 | (3R)-HYDROXYACYL-COADEHYDROGENASE (Candidatropicalis) |
PF00106(adh_short) | 4 | GLU A 538ILE A 494THR A 453LEU A 475 | None | 0.94A | 1hmyA-2et6A:4.7 | 1hmyA-2et6A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ftw | DIHYDROPYRIMIDINEAMIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF01979(Amidohydro_1) | 4 | GLU A 225ILE A 257PRO A 271LEU A 319 | None | 0.86A | 1hmyA-2ftwA:undetectable | 1hmyA-2ftwA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdn | ELONGATION FACTOREF-TU (Escherichiacoli) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 4 | ASP B 369ILE B 298PRO B 213LEU B 211 | None | 0.90A | 1hmyA-2hdnB:undetectable | 1hmyA-2hdnB:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnh | DNA POLYMERASE IIIALPHA SUBUNIT (Escherichiacoli) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 4 | ILE A 522THR A 523PRO A 537LEU A 528 | None | 0.84A | 1hmyA-2hnhA:undetectable | 1hmyA-2hnhA:16.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2i9k | MODIFICATIONMETHYLASE HHAI (Haemophilushaemolyticus) |
PF00145(DNA_methylase) | 8 | PHE A 18GLU A 40TRP A 41ASP A 60ILE A 61THR A 62PRO A 80LEU A 100 | SAH A 328 (-4.9A)SAH A 328 (-2.8A)SAH A 328 (-3.4A)SAH A 328 (-3.6A)SAH A 328 (-4.3A)SAH A 328 ( 4.3A)SAH A 328 (-4.0A)SAH A 328 ( 4.9A) | 0.52A | 1hmyA-2i9kA:43.3 | 1hmyA-2i9kA:99.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ooq | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE T (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | PHE A1157ILE A1119PRO A1078LEU A1084 | None | 0.94A | 1hmyA-2ooqA:undetectable | 1hmyA-2ooqA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozv | HYPOTHETICAL PROTEINATU0636 (Agrobacteriumfabrum) |
PF05175(MTS) | 4 | GLU A 75ASP A 106THR A 108PRO A 132 | None | 0.80A | 1hmyA-2ozvA:8.8 | 1hmyA-2ozvA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pq6 | UDP-GLUCURONOSYL/UDP-GLUCOSYLTRANSFERASE (Medicagotruncatula) |
PF00201(UDPGT) | 4 | PHE A 37ILE A 474PRO A 9LEU A 479 | None | 0.86A | 1hmyA-2pq6A:3.4 | 1hmyA-2pq6A:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q2r | GLUCOKINASE 1,PUTATIVE (Trypanosomacruzi) |
PF02685(Glucokinase) | 4 | PHE A 104ASP A 61ILE A 62THR A 63 | None | 0.62A | 1hmyA-2q2rA:undetectable | 1hmyA-2q2rA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qep | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE N2 (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | PHE A 997ILE A 958PRO A 917LEU A 923 | None | 0.73A | 1hmyA-2qepA:undetectable | 1hmyA-2qepA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qr4 | PEPTIDASE M3B,OLIGOENDOPEPTIDASE F (Enterococcusfaecium) |
PF01432(Peptidase_M3)PF08439(Peptidase_M3_N) | 4 | PHE A 30ILE A 75THR A 72LEU A 102 | None | 0.90A | 1hmyA-2qr4A:undetectable | 1hmyA-2qr4A:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w92 | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D (Streptococcuspneumoniae) |
PF03644(Glyco_hydro_85) | 4 | PHE A 493ILE A 514PRO A 473LEU A 470 | None | 0.94A | 1hmyA-2w92A:undetectable | 1hmyA-2w92A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0q | ALCALIGINBIOSYNTHESIS PROTEIN (Bordetellabronchiseptica) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | PHE A 289GLU A 155ASP A 150PRO A 382LEU A 383 | None | 1.37A | 1hmyA-2x0qA:undetectable | 1hmyA-2x0qA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxe | PROTEIN-L-ISOASPARTATEO-METHYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF01135(PCMT) | 4 | GLU A 109ASP A 136THR A 138LEU A 207 | None | 0.92A | 1hmyA-2yxeA:5.1 | 1hmyA-2yxeA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zie | PUTATIVEMODIFICATIONMETHYLASE (Thermusthermophilus) |
PF01555(N6_N4_Mtase) | 4 | PHE A 243GLU A 264ASP A 28PRO A 49 | None | 0.83A | 1hmyA-2zieA:4.9 | 1hmyA-2zieA:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | PHE A1148GLU A1171ASP A1193PRO A1227LEU A1250 | SAM A 1 (-4.9A)SAM A 1 (-2.6A)SAM A 1 (-3.6A)NoneSAM A 1 (-4.6A) | 1.42A | 1hmyA-3av6A:16.7 | 1hmyA-3av6A:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3av6 | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Mus musculus) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC)PF12047(DNMT1-RFD) | 5 | PHE A1148GLU A1171ASP A1193PRO A1228LEU A1250 | SAM A 1 (-4.9A)SAM A 1 (-2.6A)SAM A 1 (-3.6A)SAM A 1 ( 4.2A)SAM A 1 (-4.6A) | 0.63A | 1hmyA-3av6A:16.7 | 1hmyA-3av6A:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bac | DNA LIGASE (Haemophilusinfluenzae) |
PF01653(DNA_ligase_aden) | 4 | GLU A 300ILE A 98PRO A 106LEU A 109 | None | 0.87A | 1hmyA-3bacA:undetectable | 1hmyA-3bacA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cc8 | PUTATIVEMETHYLTRANSFERASE (Bacillus cereus) |
PF13489(Methyltransf_23) | 4 | GLU A 60ASP A 80ILE A 81LEU A 105 | None | 0.91A | 1hmyA-3cc8A:6.9 | 1hmyA-3cc8A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cyg | UNCHARACTERIZEDPROTEIN (Fervidobacteriumnodosum) |
PF11738(DUF3298)PF13739(DUF4163) | 5 | PHE A 227ASP A 194ILE A 191PRO A 225LEU A 217 | None | 1.28A | 1hmyA-3cygA:undetectable | 1hmyA-3cygA:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dc8 | DIHYDROPYRIMIDINASE (Sinorhizobiummeliloti) |
PF01979(Amidohydro_1) | 4 | GLU A 214ILE A 246PRO A 260LEU A 307 | None | 0.77A | 1hmyA-3dc8A:undetectable | 1hmyA-3dc8A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh1 | TRNA-SPECIFICADENOSINE DEAMINASE2 (Homo sapiens) |
PF14437(MafB19-deam) | 4 | PHE A 95ILE A 77PRO A 91LEU A 81 | None | 0.76A | 1hmyA-3dh1A:undetectable | 1hmyA-3dh1A:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqz | RESPONSE REGULATOR (Colwelliapsychrerythraea) |
PF00072(Response_reg) | 4 | GLU A 112ILE A 21THR A 20LEU A 17 | GLU A 112 ( 0.6A)ILE A 21 ( 0.7A)THR A 20 ( 0.8A)LEU A 17 ( 0.5A) | 0.79A | 1hmyA-3eqzA:5.7 | 1hmyA-3eqzA:15.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fay | RASGTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 (Homo sapiens) |
PF00616(RasGAP) | 4 | GLU A1326ASP A1322ILE A1324LEU A 978 | None | 0.78A | 1hmyA-3fayA:undetectable | 1hmyA-3fayA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0q | A/G-SPECIFIC ADENINEGLYCOSYLASE (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD)PF14815(NUDIX_4) | 4 | PHE A 58ASP A 63ILE A 62PRO A 29 | None | 0.84A | 1hmyA-3g0qA:undetectable | 1hmyA-3g0qA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7u | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Escherichiacoli) |
PF00145(DNA_methylase) | 4 | PHE A 7GLU A 29ASP A 51PRO A 78 | None | 0.87A | 1hmyA-3g7uA:25.2 | 1hmyA-3g7uA:29.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7u | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Escherichiacoli) |
PF00145(DNA_methylase) | 4 | PHE A 7GLU A 29PRO A 78LEU A 97 | None | 0.57A | 1hmyA-3g7uA:25.2 | 1hmyA-3g7uA:29.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxk | GOOSE-TYPE LYSOZYME1 (Gadus morhua) |
PF01464(SLT) | 4 | ASP A 7ILE A 8THR A 9PRO A 63 | None | 0.89A | 1hmyA-3gxkA:undetectable | 1hmyA-3gxkA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvd | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 4 | GLU A 535ASP A 546ILE A 547THR A 548 | None | 0.92A | 1hmyA-3hvdA:undetectable | 1hmyA-3hvdA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hxs | THIOREDOXIN (Bacteroidesfragilis) |
PF00085(Thioredoxin) | 4 | PHE A 111ASP A 57ILE A 109LEU A 130 | None | 0.94A | 1hmyA-3hxsA:undetectable | 1hmyA-3hxsA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i0p | MALATE DEHYDROGENASE (Entamoebahistolytica) |
PF02615(Ldh_2) | 4 | PHE A 55ASP A 61ILE A 60LEU A 355 | None | 0.95A | 1hmyA-3i0pA:undetectable | 1hmyA-3i0pA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l93 | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Yersinia pestis) |
PF01467(CTP_transf_like) | 4 | ASP A 141ILE A 142THR A 143LEU A 155 | None | 0.90A | 1hmyA-3l93A:3.5 | 1hmyA-3l93A:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ldu | PUTATIVE METHYLASE (Clostridioidesdifficile) |
PF01170(UPF0020)PF02926(THUMP) | 4 | ASP A 289THR A 291PRO A 307LEU A 321 | GTP A 383 ( 3.8A)GTP A 383 ( 4.3A)GTP A 383 (-3.7A)None | 0.89A | 1hmyA-3lduA:6.6 | 1hmyA-3lduA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lms | CARBOXYPEPTIDASE B2 (Homo sapiens) |
PF00246(Peptidase_M14) | 4 | ILE A 25THR A 26PRO A 109LEU A 50 | None | 0.70A | 1hmyA-3lmsA:undetectable | 1hmyA-3lmsA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwf | PUTATIVETRANSCRIPTIONALREGULATOR (Listeriainnocua) |
PF02082(Rrf2) | 4 | ILE A 13THR A 14PRO A 48LEU A 49 | NoneNoneSO4 A 148 ( 4.5A)None | 0.90A | 1hmyA-3lwfA:undetectable | 1hmyA-3lwfA:17.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lx6 | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Shigellaflexneri) |
PF00145(DNA_methylase) | 6 | PHE A 93GLU A 115ASP A 140ILE A 141PRO A 176LEU A 205 | None | 0.67A | 1hmyA-3lx6A:30.3 | 1hmyA-3lx6A:33.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3me5 | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Shigellaflexneri) |
PF00145(DNA_methylase) | 5 | PHE A 93GLU A 115ILE A 141PRO A 176LEU A 205 | None | 0.56A | 1hmyA-3me5A:27.8 | 1hmyA-3me5A:30.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmp | ELONGATION FACTOR TU2, ELONGATION FACTORTS (Escherichiacoli) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 4 | ASP A1369ILE A1298PRO A1213LEU A1211 | None | 0.89A | 1hmyA-3mmpA:undetectable | 1hmyA-3mmpA:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oo3 | OXY PROTEIN (Actinoplanesteichomyceticus) |
PF00067(p450) | 4 | ASP A 314ILE A 315THR A 316LEU A 251 | None | 0.69A | 1hmyA-3oo3A:undetectable | 1hmyA-3oo3A:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgb | PUTATIVEUNCHARACTERIZEDPROTEIN (Aspergillusnidulans) |
PF01179(Cu_amine_oxid)PF09248(DUF1965) | 4 | PHE A 310ILE A 222THR A 223LEU A 278 | None | 0.95A | 1hmyA-3pgbA:undetectable | 1hmyA-3pgbA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pn1 | DNA LIGASE (Haemophilusinfluenzae) |
PF01653(DNA_ligase_aden) | 4 | GLU A 300ILE A 98PRO A 106LEU A 109 | None | 0.89A | 1hmyA-3pn1A:undetectable | 1hmyA-3pn1A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psh | PROTEIN HI_1472 (Haemophilusinfluenzae) |
PF01497(Peripla_BP_2) | 5 | GLU A 305ILE A 52THR A 49PRO A 302LEU A 135 | None | 1.45A | 1hmyA-3pshA:undetectable | 1hmyA-3pshA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pta | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF00145(DNA_methylase)PF01426(BAH)PF02008(zf-CXXC) | 5 | PHE A1145GLU A1168ASP A1190PRO A1225LEU A1247 | SAH A1601 (-4.4A)SAH A1601 (-3.0A)SAH A1601 ( 4.7A)SAH A1601 (-4.2A)SAH A1601 (-3.7A) | 0.55A | 1hmyA-3ptaA:26.1 | 1hmyA-3ptaA:16.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9t | CHOLINEDEHYDROGENASE ANDRELATEDFLAVOPROTEINS (Aspergillusoryzae) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLU A 367ASP A 369PRO A 384LEU A 458 | None | 0.92A | 1hmyA-3q9tA:undetectable | 1hmyA-3q9tA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qb5 | TRANSLIN-ASSOCIATEDPROTEIN X (Homo sapiens) |
PF01997(Translin) | 4 | GLU K 89ASP K 82ILE K 77THR K 78 | None | 0.87A | 1hmyA-3qb5K:undetectable | 1hmyA-3qb5K:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qrx | CENTRIN (Chlamydomonasreinhardtii) |
PF13499(EF-hand_7) | 4 | PHE A 107ASP A 122ILE A 118THR A 119 | None CA A 172 (-2.1A)None CA A 172 ( 4.2A) | 0.88A | 1hmyA-3qrxA:undetectable | 1hmyA-3qrxA:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg1 | CD180 MOLECULE (Bos taurus) |
PF00560(LRR_1)PF13855(LRR_8) | 4 | PHE A 170ILE A 143PRO A 171LEU A 148 | None | 0.91A | 1hmyA-3rg1A:undetectable | 1hmyA-3rg1A:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slg | PBGP3 PROTEIN (Burkholderiapseudomallei) |
PF01370(Epimerase) | 4 | ASP A 56ILE A 57THR A 58LEU A 96 | None | 0.68A | 1hmyA-3slgA:4.6 | 1hmyA-3slgA:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3svt | SHORT-CHAIN TYPEDEHYDROGENASE/REDUCTASE (Mycobacteriumulcerans) |
PF13561(adh_short_C2) | 4 | ASP A 67ILE A 68THR A 69LEU A 118 | None | 0.72A | 1hmyA-3svtA:7.0 | 1hmyA-3svtA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tex | PROTECTIVE ANTIGEN (Bacillusanthracis) |
PF03495(Binary_toxB)PF07691(PA14)PF17475(Binary_toxB_2)PF17476(Binary_toxB_3) | 4 | GLU A 535ASP A 546ILE A 547THR A 548 | None | 0.80A | 1hmyA-3texA:undetectable | 1hmyA-3texA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tm5 | CRYSTAL STRUCTURE OFTRM14 (Pyrococcusfuriosus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | GLU A 248ASP A 276THR A 278PRO A 295LEU A 309 | SFG A 401 (-2.6A)SFG A 401 (-3.4A)SFG A 401 ( 4.1A)SFG A 401 ( 4.4A)None | 1.03A | 1hmyA-3tm5A:9.2 | 1hmyA-3tm5A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 4 | PHE A 192ASP A 243PRO A 262LEU A 276 | None | 0.87A | 1hmyA-3tmaA:9.2 | 1hmyA-3tmaA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3toy | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Bradyrhizobiumsp. ORS 278) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ILE A 6THR A 41PRO A 80LEU A 78 | None | 0.89A | 1hmyA-3toyA:undetectable | 1hmyA-3toyA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucx | SHORT CHAINDEHYDROGENASE (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 4 | ASP A 64ILE A 65THR A 66LEU A 115 | None | 0.73A | 1hmyA-3ucxA:6.4 | 1hmyA-3ucxA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugg | SUCROSE:(SUCROSE/FRUCTAN)6-FRUCTOSYLTRANSFERASE (Pachysandraterminalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | PHE A 448ASP A 279ILE A 500THR A 501 | None | 0.87A | 1hmyA-3uggA:undetectable | 1hmyA-3uggA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vf1 | 11R-LIPOXYGENASE (Gersemiafruticosa) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | PHE A 176GLU A 179PRO A 167LEU A 415 | None | 0.65A | 1hmyA-3vf1A:undetectable | 1hmyA-3vf1A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vnd | TRYPTOPHAN SYNTHASEALPHA CHAIN (Shewanellafrigidimarina) |
PF00290(Trp_syntA) | 4 | GLU A 32ASP A 28ILE A 37LEU A 252 | None | 0.95A | 1hmyA-3vndA:undetectable | 1hmyA-3vndA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsj | 2-AMINO-5-CHLOROPHENOL 1,6-DIOXYGENASEBETA SUBUNIT (Comamonastestosteroni) |
PF02900(LigB) | 5 | PHE B 90ASP B 128ILE B 132THR B 131PRO B 15 | NoneNoneNoneNone2XP B 402 (-4.4A) | 1.39A | 1hmyA-3vsjB:undetectable | 1hmyA-3vsjB:22.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vti | HYDROGENASEMATURATION FACTOR (Caldanaerobactersubterraneus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | PHE C 118GLU C 115ILE C 157LEU C 79 | None | 0.89A | 1hmyA-3vtiC:undetectable | 1hmyA-3vtiC:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5o | BIFUNCTIONAL PROTEINFOLD (Pseudomonasaeruginosa) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 4 | PHE A 63ILE A 19PRO A 34LEU A 276 | None | 0.85A | 1hmyA-4a5oA:undetectable | 1hmyA-4a5oA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4avy | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF13561(adh_short_C2) | 4 | ASP A 61ILE A 62THR A 63LEU A 105 | None | 0.83A | 1hmyA-4avyA:7.8 | 1hmyA-4avyA:24.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cg1 | CUTINASE (Thermobifidafusca) |
PF12740(Chlorophyllase2) | 4 | GLU A 98ASP A 91ILE A 87THR A 88 | None | 0.84A | 1hmyA-4cg1A:4.5 | 1hmyA-4cg1A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cns | DIHYDROPYRIMIDINASE-LIKE 3 (Homo sapiens) |
PF01979(Amidohydro_1) | 4 | GLU A 232ILE A 264PRO A 278LEU A 326 | None | 0.82A | 1hmyA-4cnsA:undetectable | 1hmyA-4cnsA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnt | DIHYDROPYRIMIDINASE-LIKE 3 (Homo sapiens) |
PF01979(Amidohydro_1) | 4 | GLU A 232ILE A 264PRO A 278LEU A 326 | None | 0.81A | 1hmyA-4cntA:undetectable | 1hmyA-4cntA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkj | CYTOSINE-SPECIFICMETHYLTRANSFERASE (Mycoplasmapenetrans) |
PF00145(DNA_methylase) | 7 | PHE A 17GLU A 45TRP A 46ASP A 113ILE A 114PRO A 134LEU A 157 | SAH A 501 (-4.8A)SAH A 501 (-3.0A)SAH A 501 (-4.0A)SAH A 501 (-3.7A)SAH A 501 (-4.3A)SAH A 501 ( 4.4A)SAH A 501 (-4.8A) | 0.59A | 1hmyA-4dkjA:29.5 | 1hmyA-4dkjA:27.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h59 | IRON-COMPOUND ABCTRANSPORTER, IRONCOMPOUND-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF01497(Peripla_BP_2) | 5 | GLU A 250ILE A 224THR A 212PRO A 243LEU A 210 | None | 1.49A | 1hmyA-4h59A:undetectable | 1hmyA-4h59A:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hz4 | GLUTATHIONE-S-TRANSFERASE (Actinobacilluspleuropneumoniae) |
PF00043(GST_C)PF02798(GST_N) | 4 | PHE A 137ILE A 181THR A 182LEU A 170 | None | 0.81A | 1hmyA-4hz4A:undetectable | 1hmyA-4hz4A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iyp | IMMUNOGLOBULIN-BINDING PROTEIN 1 (Homo sapiens) |
PF04177(TAP42) | 4 | PHE A 124ILE A 201PRO A 127LEU A 113 | None | 0.74A | 1hmyA-4iypA:undetectable | 1hmyA-4iypA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j6c | CYTOCHROME P450MONOOXYGENASE (Nocardiafarcinica) |
PF00067(p450) | 4 | ASP A 338ILE A 339THR A 340LEU A 269 | None | 0.87A | 1hmyA-4j6cA:undetectable | 1hmyA-4j6cA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4krt | AUTOLYTIC LYSOZYME (Clostridiumphage phiSM101) |
PF01183(Glyco_hydro_25)PF08239(SH3_3) | 4 | TRP A 313ASP A 312ILE A 324THR A 325 | NoneNoneNoneACT A 405 ( 4.7A) | 0.81A | 1hmyA-4krtA:undetectable | 1hmyA-4krtA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgv | GLUCOSE-6-PHOSPHATE1-DEHYDROGENASE (Mycobacteriumavium) |
PF00479(G6PD_N)PF02781(G6PD_C) | 4 | ASP A 89THR A 91PRO A 116LEU A 119 | None | 0.61A | 1hmyA-4lgvA:5.9 | 1hmyA-4lgvA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lrq | PHOSPHOTYROSINEPROTEIN PHOSPHATASE (Vibrio cholerae) |
PF01451(LMWPc) | 4 | PHE A 77ILE A 72THR A 40LEU A 94 | None | 0.93A | 1hmyA-4lrqA:3.7 | 1hmyA-4lrqA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4me3 | DNA REPLICATIONLICENSING FACTOR MCMRELATED PROTEIN (Thermoplasmaacidophilum) |
PF17207(MCM_OB) | 4 | GLU A 71ILE A 94PRO A 63LEU A 117 | None | 0.95A | 1hmyA-4me3A:undetectable | 1hmyA-4me3A:24.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n49 | CAP-SPECIFIC MRNA(NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1 (Homo sapiens) |
PF01728(FtsJ) | 4 | ASP A 335ILE A 336THR A 337LEU A 383 | SAM A 601 (-3.6A)SAM A 601 (-4.1A)SAM A 601 ( 3.9A)SAM A 601 (-4.6A) | 0.57A | 1hmyA-4n49A:6.3 | 1hmyA-4n49A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n5c | CARGO-TRANSPORTPROTEIN YPP1 (Saccharomycescerevisiae) |
no annotation | 4 | PHE A 401ASP A 360ILE A 362LEU A 29 | None | 0.92A | 1hmyA-4n5cA:undetectable | 1hmyA-4n5cA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ne4 | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN(PROLINE/GLYCINE/BETAINE) (Agrobacteriumfabrum) |
PF04069(OpuAC) | 4 | PHE A 249ILE A 24PRO A 226LEU A 21 | None | 0.95A | 1hmyA-4ne4A:undetectable | 1hmyA-4ne4A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nwb | MRNA TURNOVERPROTEIN 4 (Chaetomiumthermophilum) |
PF00466(Ribosomal_L10) | 4 | PHE A 116ASP A 111ILE A 112LEU A 60 | None | 0.91A | 1hmyA-4nwbA:undetectable | 1hmyA-4nwbA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o7z | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Pyrococcushorikoshii) |
PF01259(SAICAR_synt) | 4 | ILE A 231THR A 232PRO A 194LEU A 52 | None | 0.75A | 1hmyA-4o7zA:undetectable | 1hmyA-4o7zA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4olq | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Hyphomonasneptunium) |
PF00378(ECH_1) | 4 | ILE A 162THR A 159PRO A 135LEU A 163 | None | 0.84A | 1hmyA-4olqA:undetectable | 1hmyA-4olqA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4onq | DNAMETHYLTRANSFERASE (Nicotianatabacum) |
PF00145(DNA_methylase) | 5 | PHE A 488GLU A 512ASP A 539PRO A 566LEU A 588 | SFG A 700 (-4.5A)SFG A 700 (-2.1A)SFG A 700 ( 4.4A)NoneSFG A 700 (-4.9A) | 1.32A | 1hmyA-4onqA:6.8 | 1hmyA-4onqA:20.21 |