SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK4_A_T44A1008

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		5 ASP A  86
ALA A  90
GLU A 419
ASN A 341
VAL A 347
 None
 1.42A 1hk4A-1de6A:
0.0		 1hk4A-1de6A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LYS A 190
ALA A 191
GLU A 425
ASN A 429
LYS A 432
 None
 0.92A 1hk4A-1tf0A:
37.9		 1hk4A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgy ENOLASE FROM THE
ENVIRONMENTAL GENOME
SHOTGUN SEQUENCING
OF THE SARGASSO SEA

(-) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 267
LYS A 239
GLU A 250
ASN A 271
VAL A 246
 None
None
MG  A 701 (-2.4A)
None
None
 1.47A 1hk4A-2qgyA:
0.1		 1hk4A-2qgyA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 5 ASP Q  38
ALA Q  42
LYS Q  46
GLU Q  71
VAL Q  58
 None
 1.47A 1hk4A-3ksdQ:
0.0		 1hk4A-3ksdQ:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 ASP B1110
ALA B1108
GLU B1067
ASN B1065
VAL B1063
 None
 1.25A 1hk4A-5gjeB:
undetectable		 1hk4A-5gjeB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11

(Saccharomyces
cerevisiae) 		PF13656
(RNA_pol_L_2) 		5 ASP K  82
ALA K  86
GLU K  79
ASN K  29
VAL K  56
 None
 1.48A 1hk4A-5ip7K:
2.1		 1hk4A-5ip7K:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 5 ASP A 453
LYS A 456
ALA A 457
GLU A 329
VAL A 449
 None
 1.49A 1hk4A-6b5iA:
0.0		 1hk4A-6b5iA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1
RNAP2

(Escherichia
virus N4) 		no annotation 5 ASP B 353
GLU A 266
ASN B 349
TYR B   9
VAL B  72
 None
 1.32A 1hk4A-6c2jB:
1.5		 1hk4A-6c2jB:
9.09