SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK3_A_T44A3004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 PHE A 117
LEU A  32
VAL A 125
MET A 124
 None
 0.95A 1hk3A-1ad3A:
0.0		 1hk3A-1ad3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5t GUANINE NUCLEOTIDE
DISSOCIATION
INHIBITOR

(Bos taurus) 		PF00996
(GDI) 		4 GLU A  95
LEU A  92
VAL A  88
LEU A 234
 None
 0.94A 1hk3A-1d5tA:
undetectable		 1hk3A-1d5tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0r THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.88A 1hk3A-1e0rB:
undetectable		 1hk3A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2r HYPOTHETICAL
ISOCHORISMATASE
FAMILY PROTEIN YECD

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 PHE A 158
GLU A 124
LEU A 123
VAL A  23
 None
 0.96A 1hk3A-1j2rA:
undetectable		 1hk3A-1j2rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mky PROBABLE GTP-BINDING
PROTEIN ENGA

(Thermotoga
maritima) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 PHE A 414
LEU A 382
VAL A 401
LEU A 369
 None
 0.97A 1hk3A-1mkyA:
undetectable		 1hk3A-1mkyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu9 STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		4 GLU C 187
LEU C 188
VAL C 171
LEU C 231
 None
 1.02A 1hk3A-1nu9C:
2.0		 1hk3A-1nu9C:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR

(Homo sapiens) 		PF02089
(Palm_thioest) 		4 GLU A 298
LEU A 301
VAL A  39
LEU A  56
 None
 0.96A 1hk3A-1pjaA:
undetectable		 1hk3A-1pjaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr7 PHENYLALANINE-REGULA
TED
3-DEOXY-D-ARABINO-HE
PTULOSONATE-7-PHOSPH
ATE SYNTHASE

(Escherichia
coli) 		PF00793
(DAHP_synth_1) 		4 GLU A  86
LEU A  54
VAL A 299
LEU A 337
 None
 1.00A 1hk3A-1qr7A:
0.3		 1hk3A-1qr7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		4 LEU A 177
VAL A 149
MET A 150
LEU A 138
 None
 0.73A 1hk3A-1rk2A:
undetectable		 1hk3A-1rk2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0m ENDO-1,4-BETA-XYLANA
SE A

(Streptomyces
lividans) 		PF00331
(Glyco_hydro_10) 		4 GLU A 236
LEU A 237
VAL A 250
LEU A 222
 XDN  A1303 (-2.8A)
None
None
None
 1.02A 1hk3A-1v0mA:
0.0		 1hk3A-1v0mA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE

(Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin) 		4 GLU A 236
LEU A 237
VAL A 250
LEU A 222
 XYP  A 452 (-2.7A)
None
None
None
 1.01A 1hk3A-1v6uA:
undetectable		 1hk3A-1v6uA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6y ENDO-1,4-BETA-D-XYLA
NASE AND
ENDO-1,4-BETA-XYLANA
SE B

(Cellulomonas
fimi;
Streptomyces
olivaceoviridis) 		PF00331
(Glyco_hydro_10) 		4 GLU A 235
LEU A 236
VAL A 259
LEU A 221
 None
 1.01A 1hk3A-1v6yA:
undetectable		 1hk3A-1v6yA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLU A 260
LEU A 175
VAL A 212
LEU A 265
 None
 0.90A 1hk3A-1vz8A:
undetectable		 1hk3A-1vz8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		4 GLU A 230
LEU A 229
VAL A 257
LEU A 299
 None
 1.03A 1hk3A-1wlsA:
undetectable		 1hk3A-1wlsA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 GLU A 108
LEU A 109
VAL A 117
LEU A  96
 SO4  A4770 ( 3.7A)
None
None
None
 1.03A 1hk3A-1zccA:
undetectable		 1hk3A-1zccA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		4 PHE A 319
GLU A 285
LEU A 287
VAL A 255
 None
 0.97A 1hk3A-1zr5A:
undetectable		 1hk3A-1zr5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1d STAPHYLOCOAGULASE

(Staphylococcus
aureus) 		PF08764
(Coagulase) 		4 GLU D 187
LEU D 188
VAL D 171
LEU D 231
 None
 1.00A 1hk3A-2a1dD:
2.1		 1hk3A-2a1dD:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 PHE A 267
LEU A 307
VAL A 294
MET A 291
 None
 1.02A 1hk3A-2b8nA:
undetectable		 1hk3A-2b8nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		4 GLU A 112
LEU A 111
VAL A 136
LEU A 125
 None
 0.65A 1hk3A-2gu0A:
undetectable		 1hk3A-2gu0A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 LEU A   7
VAL A 245
MET A 246
LEU A 254
 None
 0.97A 1hk3A-2j5tA:
undetectable		 1hk3A-2j5tA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 GLU A 309
LEU A 308
VAL A 286
LEU A 275
 None
 1.00A 1hk3A-2jakA:
undetectable		 1hk3A-2jakA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 GLU A 402
LEU A 403
VAL A 392
LEU A 483
 None
 0.94A 1hk3A-2jisA:
undetectable		 1hk3A-2jisA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		4 GLU A 343
LEU A 344
VAL A 304
LEU A 333
 None
 0.89A 1hk3A-2knhA:
undetectable		 1hk3A-2knhA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		4 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.92A 1hk3A-2nzjA:
undetectable		 1hk3A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 PHE B 298
PHE B 264
LEU B 254
VAL B 295
 None
 1.01A 1hk3A-2odrB:
undetectable		 1hk3A-2odrB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onf HYPOTHETICAL PROTEIN
TA0195

(Thermoplasma
acidophilum) 		PF02566
(OsmC) 		4 PHE A  46
PHE A  90
GLU A  43
VAL A  76
 None
 0.99A 1hk3A-2onfA:
2.5		 1hk3A-2onfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5
REGULATOR OF
G-PROTEIN SIGNALING
9

(Mus musculus) 		PF00400
(WD40)
PF00610
(DEP)
PF00615
(RGS)
PF00631
(G-gamma) 		4 GLU A 333
LEU A 335
VAL A 343
LEU B 188
 None
 1.01A 1hk3A-2pbiA:
1.4		 1hk3A-2pbiA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.84A 1hk3A-2q0oA:
undetectable		 1hk3A-2q0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv CARBON CATABOLITE
DEREPRESSING PROTEIN
KINASE

(Saccharomyces
cerevisiae) 		PF16579
(AdenylateSensor) 		4 LEU A 572
VAL A 518
MET A 519
LEU A 626
 None
 0.96A 1hk3A-2qlvA:
undetectable		 1hk3A-2qlvA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 LEU A 635
VAL A 607
MET A 608
LEU A 562
 None
 0.96A 1hk3A-2qnaA:
2.5		 1hk3A-2qnaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 0.96A 1hk3A-2r7mA:
undetectable		 1hk3A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf4 DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA4

(Saccharomyces
cerevisiae) 		PF03876
(SHS2_Rpb7-N)
PF08203
(RNA_polI_A14) 		4 LEU B  89
VAL A  70
MET A  71
LEU A 122
 None
 0.82A 1hk3A-2rf4B:
2.6		 1hk3A-2rf4B:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 366
VAL A 506
MET A 509
LEU A 354
 LEU  A 366 ( 0.6A)
VAL  A 506 ( 0.6A)
MET  A 509 ( 0.0A)
LEU  A 354 ( 0.6A)
 0.98A 1hk3A-2vbfA:
undetectable		 1hk3A-2vbfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN

(Bombyx mori) 		PF06585
(JHBP) 		4 GLU A  26
LEU A  25
VAL A 204
LEU A  43
 None
 0.64A 1hk3A-3a1zA:
undetectable		 1hk3A-3a1zA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		4 PHE A  82
LEU A  50
VAL A  33
LEU A 100
 None
 0.94A 1hk3A-3d4uA:
undetectable		 1hk3A-3d4uA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 GLU A  57
LEU A  56
VAL A  52
LEU A 104
 None
 0.92A 1hk3A-3d7rA:
undetectable		 1hk3A-3d7rA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk3A-3fhxA:
3.8		 1hk3A-3fhxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.94A 1hk3A-3h1lA:
undetectable		 1hk3A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		4 GLU C  64
LEU C  62
VAL C 147
LEU C 129
 None
 1.03A 1hk3A-3kwvC:
undetectable		 1hk3A-3kwvC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2p DNA LIGASE 3

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 GLU A 178
LEU A 176
VAL A 290
LEU A 218
 None
 0.84A 1hk3A-3l2pA:
undetectable		 1hk3A-3l2pA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		4 GLU A 236
LEU A 234
VAL A 182
LEU A 176
 None
None
UNL  A 292 ( 4.6A)
UNL  A 292 ( 4.7A)
 0.90A 1hk3A-3louA:
undetectable		 1hk3A-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m66 MTERF
DOMAIN-CONTAINING
PROTEIN 1,
MITOCHONDRIAL

(Homo sapiens) 		PF02536
(mTERF) 		4 PHE A 264
LEU A 287
VAL A 280
LEU A 269
 None
 1.04A 1hk3A-3m66A:
undetectable		 1hk3A-3m66A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PHE A  87
GLU A 451
LEU A 450
MET A 220
 None
 1.00A 1hk3A-3me5A:
undetectable		 1hk3A-3me5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 GLU A 256
VAL A 338
MET A 339
LEU A 239
 GLU  A 256 ( 0.6A)
VAL  A 338 ( 0.6A)
MET  A 339 ( 0.0A)
LEU  A 239 ( 0.6A)
 0.83A 1hk3A-3o96A:
1.6		 1hk3A-3o96A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 PHE A   8
LEU A 133
VAL A  16
MET A  15
 None
 0.92A 1hk3A-3oh8A:
undetectable		 1hk3A-3oh8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		4 PHE A 194
LEU A 161
VAL A 144
LEU A 212
 None
 0.94A 1hk3A-3oslA:
undetectable		 1hk3A-3oslA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 GLU A  41
LEU A  64
VAL A 111
LEU A  31
 None
EDO  A 701 (-3.7A)
None
None
 0.99A 1hk3A-3ovaA:
undetectable		 1hk3A-3ovaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 GLU A 971
LEU A 973
VAL A 935
LEU A 963
 None
 0.95A 1hk3A-3psfA:
2.3		 1hk3A-3psfA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsg NAD-BINDING
PHOSPHOGLUCONATE
DEHYDROGENASE-LIKE
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		4 GLU A 185
LEU A 184
VAL A 220
LEU A 200
 None
 0.96A 1hk3A-3qsgA:
undetectable		 1hk3A-3qsgA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3l TABLYSIN 15

(Tabanus yao) 		PF00188
(CAP) 		4 PHE C 188
GLU C 155
LEU C 156
VAL C  50
 None
None
None
PLM  C 233 ( 4.1A)
 1.04A 1hk3A-3u3lC:
undetectable		 1hk3A-3u3lC:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 GLU A 327
LEU A 280
VAL A 376
LEU A 275
 None
 0.95A 1hk3A-3ut3A:
undetectable		 1hk3A-3ut3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 LEU A 115
VAL A 202
MET A 201
LEU A 135
 None
 1.01A 1hk3A-3wwxA:
undetectable		 1hk3A-3wwxA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 GLU A 180
LEU A 179
VAL A 267
MET A 268
 None
 1.01A 1hk3A-4bfrA:
1.2		 1hk3A-4bfrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkx HISTONE DEACETYLASE
1

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 LEU B 171
VAL B 248
MET B 249
LEU B 373
 None
 0.98A 1hk3A-4bkxB:
undetectable		 1hk3A-4bkxB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 PHE B 370
PHE B 455
LEU B 425
VAL B 427
 None
 0.94A 1hk3A-4cakB:
undetectable		 1hk3A-4cakB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj4 UNCHARACTERIZED
PROTEIN

(Halobacterium
salinarum) 		PF07920
(DUF1684) 		4 PHE A 117
PHE A 151
LEU A  91
VAL A 136
 None
 1.02A 1hk3A-4fj4A:
undetectable		 1hk3A-4fj4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Thermobifida
fusca) 		PF09485
(CRISPR_Cse2) 		4 PHE A 192
GLU A 114
LEU A 112
LEU A 129
 None
EDO  A 301 (-4.7A)
None
None
 0.97A 1hk3A-4h79A:
undetectable		 1hk3A-4h79A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0x ESAT-6-LIKE PROTEIN
MAB_3112
ESAT-6-LIKE PROTEIN
MAB_3113

(Mycobacteroides
abscessus) 		PF06013
(WXG100) 		4 GLU B  71
LEU B  72
VAL B  30
LEU A  62
 None
 0.83A 1hk3A-4i0xB:
2.6		 1hk3A-4i0xB:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgp SPORULATION KINASE D

(Bacillus
subtilis) 		PF02743
(dCache_1) 		4 GLU A 121
LEU A 122
VAL A 115
LEU A  93
 None
 1.01A 1hk3A-4jgpA:
undetectable		 1hk3A-4jgpA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldm MATRIX PROTEIN VP40

(Zaire
ebolavirus) 		PF07447
(VP40) 		4 GLU A  76
LEU A 181
MET A 116
LEU A 149
 None
 1.02A 1hk3A-4ldmA:
undetectable		 1hk3A-4ldmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 PHE A 859
LEU A 820
VAL A 827
LEU A 841
 None
 0.88A 1hk3A-4n1aA:
undetectable		 1hk3A-4n1aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p42 EXTENDED
SYNAPTOTAGMIN-2

(Homo sapiens) 		PF00168
(C2)
PF17047
(SMP_LBD) 		4 GLU A 553
LEU A 520
VAL A 576
LEU A 514
 None
 0.86A 1hk3A-4p42A:
undetectable		 1hk3A-4p42A:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 GLU A 153
LEU A 154
VAL A 142
LEU A 190
 None
 0.86A 1hk3A-4po0A:
45.4		 1hk3A-4po0A:
74.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		4 GLU A 531
LEU A 532
VAL A 547
LEU A 575
 None
 0.86A 1hk3A-4po0A:
45.4		 1hk3A-4po0A:
74.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 286
GLU A 288
LEU A 112
VAL A 267
 None
 0.88A 1hk3A-4rcnA:
undetectable		 1hk3A-4rcnA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s37 PHAGE BASEPLATE
PROTEIN

(Pseudomonas
aeruginosa) 		PF04717
(Phage_base_V) 		4 PHE A  79
GLU A  63
LEU A  83
LEU A  68
 None
 0.84A 1hk3A-4s37A:
undetectable		 1hk3A-4s37A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzh DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
braziliensis) 		PF01180
(DHO_dh) 		4 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
 1.01A 1hk3A-4wzhA:
undetectable		 1hk3A-4wzhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		4 GLU A 734
VAL A 745
MET A 746
LEU A 714
 None
 1.00A 1hk3A-4xmvA:
undetectable		 1hk3A-4xmvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 GLU A  91
LEU A   2
VAL A  19
LEU A  37
 None
 0.92A 1hk3A-4zpqA:
undetectable		 1hk3A-4zpqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		4 PHE A 265
GLU A 239
LEU A 240
VAL A 217
 None
 0.96A 1hk3A-5a62A:
undetectable		 1hk3A-5a62A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b01 MOEN5

(Streptomyces
viridosporus) 		no annotation 4 GLU A 175
LEU A 150
VAL A  38
LEU A 238
 None
 0.92A 1hk3A-5b01A:
2.8		 1hk3A-5b01A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0l MOEN5,DNA-BINDING
PROTEIN 7D

(Streptomyces
viridosporus;
Sulfolobus
solfataricus) 		no annotation 4 GLU A 175
LEU A 150
VAL A  38
LEU A 238
 None
BNG  A 501 ( 4.0A)
None
None
 0.90A 1hk3A-5b0lA:
2.3		 1hk3A-5b0lA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5k IZUMO SPERM-EGG
FUSION PROTEIN 1

(Mus musculus) 		PF15005
(IZUMO)
PF16706
(Izumo-Ig) 		4 LEU A  41
VAL A  53
MET A  54
LEU A 112
 None
 0.90A 1hk3A-5b5kA:
1.4		 1hk3A-5b5kA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 GLU C  88
LEU C  56
VAL C 301
LEU C 335
 None
 1.01A 1hk3A-5d04C:
undetectable		 1hk3A-5d04C:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 GLU A 152
LEU A 153
VAL A 141
LEU A 189
 None
 1.01A 1hk3A-5dqfA:
45.9		 1hk3A-5dqfA:
76.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 GLU A 452
LEU A 451
VAL A 370
LEU A  34
 None
 0.86A 1hk3A-5eawA:
undetectable		 1hk3A-5eawA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 PHE A 112
LEU A 153
VAL A 229
MET A 230
 None
None
HEM  A 401 ( 4.3A)
None
 0.67A 1hk3A-5ex8A:
2.7		 1hk3A-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 6

(Homo sapiens) 		PF07571
(TAF6_C) 		4 PHE J 344
LEU J 336
VAL J 286
LEU J 297
 None
 0.98A 1hk3A-5furJ:
undetectable		 1hk3A-5furJ:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 PHE A 802
LEU A 841
VAL A 814
MET A 813
 None
 0.56A 1hk3A-5hzrA:
undetectable		 1hk3A-5hzrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA

(Homo sapiens) 		PF08332
(CaMKII_AD) 		4 PHE A 399
LEU A 357
MET A 372
LEU A 392
 None
 0.88A 1hk3A-5ig3A:
undetectable		 1hk3A-5ig3A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		4 GLU A 567
VAL A 573
MET A 574
LEU A 526
 None
 0.67A 1hk3A-5jhqA:
undetectable		 1hk3A-5jhqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 441
VAL A 310
MET A 307
LEU A 463
 None
 0.87A 1hk3A-5ko1A:
undetectable		 1hk3A-5ko1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1x HMPV F1 SUBUNIT
HMPV F2 SUBUNIT

(Human
metapneumovirus) 		PF00523
(Fusion_gly) 		4 GLU A  51
LEU A  50
VAL B 203
LEU A  81
 None
 0.97A 1hk3A-5l1xA:
undetectable		 1hk3A-5l1xA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 PHE A  82
PHE A 287
VAL A  39
LEU A  78
 None
 1.03A 1hk3A-5l3sA:
4.2		 1hk3A-5l3sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 GLU B 406
LEU B 407
VAL B 450
LEU B 443
 None
 0.98A 1hk3A-5l3xB:
undetectable		 1hk3A-5l3xB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0k BETA-XYLANASE

(Cellulomonas
flavigena) 		no annotation 4 GLU A 233
LEU A 234
VAL A 249
LEU A 219
 None
 0.98A 1hk3A-5m0kA:
undetectable		 1hk3A-5m0kA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m9n TUDOR
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00567
(TUDOR) 		4 GLU A 506
LEU A 608
VAL A 662
LEU A 625
 None
 1.00A 1hk3A-5m9nA:
undetectable		 1hk3A-5m9nA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn7 URACIL-DNA
GLYCOSYLASE

(Human
gammaherpesvirus
8) 		no annotation 4 GLU A  54
LEU A  55
VAL A  61
LEU A  68
 None
 0.95A 1hk3A-5nn7A:
undetectable		 1hk3A-5nn7A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 4 GLU A 170
LEU A 171
VAL A 212
LEU A 162
 None
 0.92A 1hk3A-5nuxA:
undetectable		 1hk3A-5nuxA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 790
GLU B 669
LEU B 670
VAL B 714
 None
 0.98A 1hk3A-5tetB:
undetectable		 1hk3A-5tetB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 PHE A  61
LEU A 296
VAL A  46
LEU A  56
 None
 1.00A 1hk3A-5uhuA:
2.5		 1hk3A-5uhuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis) 		no annotation 4 GLU A 686
LEU A 685
VAL A 720
LEU A 692
 None
 0.96A 1hk3A-5ve8A:
2.1		 1hk3A-5ve8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES

(Drosophila
melanogaster) 		no annotation 4 PHE A1259
PHE A1277
LEU A1300
VAL A1312
 None
 1.00A 1hk3A-5vjcA:
2.6		 1hk3A-5vjcA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wml -

(-) 		no annotation 4 PHE A 288
GLU A 255
LEU A 253
LEU A 236
 None
 0.98A 1hk3A-5wmlA:
undetectable		 1hk3A-5wmlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P
KLLA0F20922P

(Kluyveromyces
lactis) 		no annotation 4 GLU A 523
LEU B 217
VAL A 186
MET A 187
 None
 0.87A 1hk3A-5y5aA:
undetectable		 1hk3A-5y5aA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx3 CHALCONE-FLAVONONE
ISOMERASE FAMILY
PROTEIN

(Deschampsia
antarctica) 		no annotation 4 PHE A  79
GLU A 187
LEU A 186
VAL A  49
 None
 0.99A 1hk3A-5yx3A:
undetectable		 1hk3A-5yx3A:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 GLU A 531
LEU A 532
VAL A 547
MET A 548
LEU A 575
 None
 0.85A 1hk3A-5yxeA:
46.2		 1hk3A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9g ATLASTIN-1

(Homo sapiens) 		no annotation 4 PHE B 293
PHE B  82
LEU B 286
VAL B 100
 None
GDP  B 401 (-4.3A)
None
None
 0.57A 1hk3A-6b9gB:
undetectable		 1hk3A-6b9gB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 4 PHE A 311
GLU A 341
LEU A 340
VAL A 378
 None
 0.95A 1hk3A-6c0mA:
undetectable		 1hk3A-6c0mA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf6 TANKYRASE-1

(Mus musculus) 		no annotation 4 GLU A 560
VAL A 566
MET A 567
LEU A 519
 None
 0.75A 1hk3A-6cf6A:
undetectable		 1hk3A-6cf6A:
9.79