SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK3_A_T44A3003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 LYS A  28
ALA A  27
MET A 143
 None
 1.04A 1hk3A-1a1sA:
undetectable		 1hk3A-1a1sA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 LYS A 294
ALA A 297
MET A 370
 None
 1.06A 1hk3A-1bs0A:
0.0		 1hk3A-1bs0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwu RIBOSOMAL PROTEIN L1

(Methanothermococcus
thermolithotrophicus) 		PF00687
(Ribosomal_L1) 		3 LYS A  65
ALA A  64
MET A 111
 None
 1.05A 1hk3A-1dwuA:
undetectable		 1hk3A-1dwuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f68 HISTONE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00439
(Bromodomain) 		3 LYS A 745
ALA A 750
MET A 754
 None
 0.97A 1hk3A-1f68A:
undetectable		 1hk3A-1f68A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 LYS A 156
ALA A 153
MET A  45
 None
 1.07A 1hk3A-1fnoA:
0.6		 1hk3A-1fnoA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg2 CLATHRIN ASSEMBLY
PROTEIN SHORT FORM

(Rattus
norvegicus) 		PF07651
(ANTH) 		3 LYS A 134
ALA A 135
MET A  86
 None
 1.06A 1hk3A-1hg2A:
undetectable		 1hk3A-1hg2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ivh ISOVALERYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LYS A 181
ALA A 180
MET A 147
 None
 1.04A 1hk3A-1ivhA:
undetectable		 1hk3A-1ivhA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 LYS A 127
ALA A 130
MET A 111
 None
 0.90A 1hk3A-1ji6A:
0.9		 1hk3A-1ji6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7x CITRATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00285
(Citrate_synt) 		3 LYS A 119
ALA A 120
MET A 202
 None
 1.05A 1hk3A-1o7xA:
2.2		 1hk3A-1o7xA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		3 LYS A 406
ALA A 409
MET A 293
 None
 1.07A 1hk3A-1ofeA:
undetectable		 1hk3A-1ofeA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		3 LYS A  82
ALA A  86
MET A 117
 None
 0.93A 1hk3A-1r5jA:
undetectable		 1hk3A-1r5jA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		3 LYS A 401
ALA A 400
MET A 163
 None
 1.01A 1hk3A-1sjpA:
undetectable		 1hk3A-1sjpA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		3 LYS A 525
ALA A 528
MET A 548
 None
 0.99A 1hk3A-1tf0A:
48.1		 1hk3A-1tf0A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to0 HYPOTHETICAL UPF0247
PROTEIN YYDA

(Bacillus
subtilis) 		PF02590
(SPOUT_MTase) 		3 LYS A 124
ALA A  75
MET A 118
 None
 0.92A 1hk3A-1to0A:
undetectable		 1hk3A-1to0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vr4 HYPOTHETICAL PROTEIN
APC22750

(Bacillus cereus) 		PF01906
(YbjQ_1) 		3 LYS A  66
ALA A  69
MET A   1
 None
 0.87A 1hk3A-1vr4A:
undetectable		 1hk3A-1vr4A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		3 LYS A1134
ALA A1137
MET A1126
 None
 0.93A 1hk3A-1w1wA:
undetectable		 1hk3A-1w1wA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9d ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 LYS A 416
ALA A 420
MET A 363
 None
 0.85A 1hk3A-1x9dA:
2.0		 1hk3A-1x9dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		3 LYS A  93
ALA A  90
MET A  63
 None
 1.01A 1hk3A-1y7iA:
undetectable		 1hk3A-1y7iA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap9 ACETYLGLUTAMATE
KINASE

(Mycobacterium
tuberculosis) 		PF00696
(AA_kinase) 		3 LYS A 253
ALA A 256
MET A 213
 None
 1.07A 1hk3A-2ap9A:
undetectable		 1hk3A-2ap9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btm PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Geobacillus
stearothermophilus) 		PF00121
(TIM) 		3 LYS A 111
ALA A 114
MET A  65
 None
 0.96A 1hk3A-2btmA:
undetectable		 1hk3A-2btmA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LYS A 178
ALA A 177
MET A 144
 None
 1.05A 1hk3A-2ebaA:
undetectable		 1hk3A-2ebaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		3 LYS A 277
ALA A 278
MET A  17
 None
 1.05A 1hk3A-2i2xA:
0.9		 1hk3A-2i2xA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if4 ATFKBP42

(Arabidopsis
thaliana) 		PF00254
(FKBP_C)
PF13181
(TPR_8) 		3 LYS A 229
ALA A 225
MET A 214
 None
 1.07A 1hk3A-2if4A:
undetectable		 1hk3A-2if4A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		3 LYS A  88
ALA A  91
MET A 124
 None
 0.75A 1hk3A-2pjdA:
undetectable		 1hk3A-2pjdA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Sphingomonas
elodea) 		PF00483
(NTP_transferase) 		3 LYS A  63
ALA A  65
MET A  31
 None
 0.92A 1hk3A-2ux8A:
undetectable		 1hk3A-2ux8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 LYS F 446
ALA F 445
MET F 459
 None
 0.94A 1hk3A-2v2fF:
undetectable		 1hk3A-2v2fF:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		3 LYS A 128
ALA A 143
MET A 119
 None
 0.97A 1hk3A-2xhgA:
undetectable		 1hk3A-2xhgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajx 3-HEXULOSE-6-PHOSPHA
TE SYNTHASE

(Mycobacterium
gastri) 		PF00215
(OMPdecase) 		3 LYS A1116
ALA A1120
MET A1133
 None
 1.05A 1hk3A-3ajxA:
undetectable		 1hk3A-3ajxA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 LYS A 184
ALA A 183
MET A 150
 None
 1.05A 1hk3A-3d6bA:
undetectable		 1hk3A-3d6bA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dz1 DIHYDRODIPICOLINATE
SYNTHASE

(Rhodopseudomonas
palustris) 		PF00701
(DHDPS) 		3 LYS A   2
ALA A 102
MET A  97
 None
 1.05A 1hk3A-3dz1A:
undetectable		 1hk3A-3dz1A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eya PYRUVATE
DEHYDROGENASE
[CYTOCHROME]

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 LYS A  11
ALA A  10
MET A  39
 None
 0.91A 1hk3A-3eyaA:
undetectable		 1hk3A-3eyaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsn RA14 TCR ALPHA CHAIN
(TRAV24, TRAJ49)

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 LYS A  57
ALA A  64
MET A  50
 None
 1.03A 1hk3A-3gsnA:
undetectable		 1hk3A-3gsnA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 LYS A  69
ALA A   6
MET A   1
 None
 1.01A 1hk3A-3hoaA:
undetectable		 1hk3A-3hoaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz7 UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF01206
(TusA) 		3 LYS A  19
ALA A  18
MET A  48
 None
 0.95A 1hk3A-3hz7A:
undetectable		 1hk3A-3hz7A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		3 LYS A 206
ALA A 209
MET A 147
 None
 0.72A 1hk3A-3icoA:
undetectable		 1hk3A-3icoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		3 LYS B 335
ALA B 323
MET B 251
 None
 1.06A 1hk3A-3j9oB:
undetectable		 1hk3A-3j9oB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 LYS A 101
ALA A 104
MET A 415
 ADP  A 873 (-3.2A)
None
None
 1.01A 1hk3A-3juxA:
3.2		 1hk3A-3juxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 LYS A 485
ALA A 488
MET A 303
 None
 0.61A 1hk3A-3kt4A:
undetectable		 1hk3A-3kt4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2y PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  66
ALA A  65
MET A 187
 None
 0.97A 1hk3A-3o2yA:
undetectable		 1hk3A-3o2yA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		3 LYS A 205
ALA A 208
MET A 146
 None
 0.76A 1hk3A-3oc6A:
undetectable		 1hk3A-3oc6A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of3 PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE 1

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		3 LYS A 209
ALA A 210
MET A 147
 None
 1.07A 1hk3A-3of3A:
undetectable		 1hk3A-3of3A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		3 LYS A 181
ALA A 180
MET A 341
 None
 0.92A 1hk3A-3p24A:
undetectable		 1hk3A-3p24A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q7z BETA-LACTAMASE
REGULATORY PROTEIN
BLAR1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase) 		3 LYS A 392
ALA A 396
MET A 434
 BOU  A 584 ( 3.9A)
None
None
 1.05A 1hk3A-3q7zA:
undetectable		 1hk3A-3q7zA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkb UNCHARACTERIZED
PROTEIN

(Pediococcus
pentosaceus) 		no annotation 3 LYS A  49
ALA A  52
MET A   1
 None
 0.91A 1hk3A-3qkbA:
undetectable		 1hk3A-3qkbA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 3 LYS M 265
ALA M 268
MET M 345
 None
 1.02A 1hk3A-3rkoM:
3.0		 1hk3A-3rkoM:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		3 LYS A 201
ALA A 204
MET A 140
 None
 1.06A 1hk3A-3ro8A:
undetectable		 1hk3A-3ro8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		3 LYS A 550
ALA A 553
MET A 641
 None
 0.82A 1hk3A-3t6aA:
undetectable		 1hk3A-3t6aA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgn ADC OPERON REPRESSOR
ADCR

(Streptococcus
pneumoniae) 		PF01047
(MarR) 		3 LYS A   6
ALA A   5
MET A   1
 None
 0.99A 1hk3A-3tgnA:
undetectable		 1hk3A-3tgnA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		3 LYS A 207
ALA A 210
MET A 148
 None
 0.74A 1hk3A-3tx2A:
undetectable		 1hk3A-3tx2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 LYS A 397
ALA A 396
MET A 365
 None
 0.94A 1hk3A-3ue3A:
undetectable		 1hk3A-3ue3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvt D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Actinomadura
sp. R39) 		PF02113
(Peptidase_S13) 		3 LYS A  52
ALA A  56
MET A 295
 B07  A 500 (-3.4A)
None
None
 0.98A 1hk3A-3zvtA:
undetectable		 1hk3A-3zvtA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 LYS A 392
ALA A 401
MET A 433
 None
 0.73A 1hk3A-4bh6A:
undetectable		 1hk3A-4bh6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezb UNCHARACTERIZED
CONSERVED PROTEIN

(Sinorhizobium
meliloti) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		3 LYS A 180
ALA A 257
MET A 237
 None
 1.03A 1hk3A-4ezbA:
2.3		 1hk3A-4ezbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 LYS A 332
ALA A 335
MET A 323
 None
 0.92A 1hk3A-4gqoA:
undetectable		 1hk3A-4gqoA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l83 UBE2I2 PROTEIN

(Brugia malayi) 		PF00179
(UQ_con) 		3 LYS A  60
ALA A  45
MET A 165
 None
 0.95A 1hk3A-4l83A:
undetectable		 1hk3A-4l83A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		3 LYS A 201
ALA A 200
MET A 150
 None
None
22J  A 301 ( 3.8A)
 1.06A 1hk3A-4lxiA:
undetectable		 1hk3A-4lxiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng4 PHOSPHOGLYCERATE
KINASE

(Coxiella
burnetii) 		PF00162
(PGK) 		3 LYS A  49
ALA A  50
MET A   9
 None
 1.05A 1hk3A-4ng4A:
undetectable		 1hk3A-4ng4A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4orx PROSTAGLANDIN-H2
D-ISOMERASE

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  66
ALA A  65
MET A 187
 None
 0.87A 1hk3A-4orxA:
undetectable		 1hk3A-4orxA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 LYS A 415
ALA A 358
MET A 325
 None
 1.07A 1hk3A-4ptxA:
undetectable		 1hk3A-4ptxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		3 LYS A  71
ALA A 301
MET A 305
 None
 1.01A 1hk3A-4pwvA:
4.1		 1hk3A-4pwvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj1 ANTIGEN MTB48,
MYCOBACTERIAL
PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 3 LYS A  52
ALA A  51
MET A 122
 None
 0.93A 1hk3A-4wj1A:
undetectable		 1hk3A-4wj1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 LYS A 398
ALA A 410
MET A 416
 None
 1.03A 1hk3A-4wv3A:
undetectable		 1hk3A-4wv3A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		3 LYS A 164
ALA A 163
MET A  24
 None
 1.06A 1hk3A-4x3fA:
undetectable		 1hk3A-4x3fA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y8f TRIOSEPHOSPHATE
ISOMERASE

(Clostridium
perfringens) 		PF00121
(TIM) 		3 LYS A 114
ALA A 117
MET A  68
 None
 0.95A 1hk3A-4y8fA:
undetectable		 1hk3A-4y8fA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		3 LYS A 324
ALA A 327
MET A 381
 None
 0.66A 1hk3A-4ye5A:
undetectable		 1hk3A-4ye5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 LYS R 316
ALA R 325
MET R 357
 None
 0.77A 1hk3A-5a31R:
undetectable		 1hk3A-5a31R:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 LYS A 325
ALA A 328
MET A 705
 None
 1.06A 1hk3A-5a3fA:
undetectable		 1hk3A-5a3fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmo HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Neisseria
meningitidis) 		PF01648
(ACPS) 		3 LYS A  51
ALA A  54
MET A 110
 None
 1.03A 1hk3A-5cmoA:
undetectable		 1hk3A-5cmoA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		3 LYS A 241
ALA A 244
MET A 259
 None
 0.73A 1hk3A-5d01A:
undetectable		 1hk3A-5d01A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE

(Chromohalobacter
salexigens) 		PF00120
(Gln-synt_C) 		3 LYS A 373
ALA A 370
MET A 413
 None
 0.93A 1hk3A-5dm3A:
undetectable		 1hk3A-5dm3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2v GTP
PYROPHOSPHOKINASE
YJBM

(Bacillus
subtilis) 		no annotation 3 LYS V  56
ALA V  57
MET V  70
 APC  V 301 (-2.8A)
None
None
 0.99A 1hk3A-5f2vV:
2.4		 1hk3A-5f2vV:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fip GH5 CELLULASE

(unidentified) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 LYS A 173
ALA A 176
MET A 224
 EDO  A1390 (-3.3A)
None
None
 1.03A 1hk3A-5fipA:
undetectable		 1hk3A-5fipA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		3 LYS A 392
ALA A 387
MET A 327
 None
 1.00A 1hk3A-5gooA:
undetectable		 1hk3A-5gooA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0m HNH ENDONUCLEASE

(Geobacillus
virus E2) 		PF01844
(HNH) 		3 LYS A  71
ALA A  67
MET A 107
 None
 1.05A 1hk3A-5h0mA:
undetectable		 1hk3A-5h0mA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hnm D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Enterococcus
faecalis) 		PF02557
(VanY) 		3 LYS A 173
ALA A 176
MET A 155
 None
 0.83A 1hk3A-5hnmA:
undetectable		 1hk3A-5hnmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE

(synthetic
construct) 		PF00497
(SBP_bac_3) 		3 LYS A  99
ALA A 100
MET A  75
 None
 1.02A 1hk3A-5josA:
undetectable		 1hk3A-5josA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Rhinovirus C) 		PF00073
(Rhv) 		3 LYS A 104
ALA A 100
MET B 228
 None
 1.00A 1hk3A-5k0uA:
undetectable		 1hk3A-5k0uA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5m RNA DEPENDENT RNA
POLYMERASE

(Dengue virus) 		PF00972
(Flavi_NS5) 		3 LYS A 375
ALA A 378
MET A 552
 None
 1.07A 1hk3A-5k5mA:
2.4		 1hk3A-5k5mA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6u PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A 174
ALA A 165
MET A  92
 None
 0.60A 1hk3A-5k6uA:
undetectable		 1hk3A-5k6uA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6w PROTEIN SIDEKICK-1

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A 174
ALA A 165
MET A  92
 None
 0.69A 1hk3A-5k6wA:
undetectable		 1hk3A-5k6wA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A 174
ALA A 165
MET A  92
 None
 0.67A 1hk3A-5k6zA:
undetectable		 1hk3A-5k6zA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A 174
ALA A 165
MET A  92
 None
 0.84A 1hk3A-5k70A:
undetectable		 1hk3A-5k70A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E

(Homo sapiens) 		PF01532
(Glyco_hydro_47) 		3 LYS A 416
ALA A 420
MET A 363
 None
 0.86A 1hk3A-5kijA:
undetectable		 1hk3A-5kijA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 3 LYS A 739
ALA A 744
MET A 748
 None
 0.97A 1hk3A-5ml0A:
2.1		 1hk3A-5ml0A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA

(Nostoc sp. PCC
7120) 		no annotation 3 LYS A 260
ALA A 265
MET A 252
 None
 0.97A 1hk3A-5n3uA:
undetectable		 1hk3A-5n3uA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA

(Haemophilus
influenzae) 		PF04348
(LppC) 		3 LYS A 448
ALA A 445
MET A 481
 None
 0.94A 1hk3A-5vatA:
2.5		 1hk3A-5vatA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 3 LYS A 137
ALA A 141
MET A 196
 None
 0.98A 1hk3A-5vfzA:
2.3		 1hk3A-5vfzA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		3 LYS A  32
ALA A  35
MET A  22
 None
 0.95A 1hk3A-5wwtA:
undetectable		 1hk3A-5wwtA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1n VANILLATE/3-O-METHYL
GALLATE
O-DEMETHYLASE

(Sphingobium sp.
SYK-6) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		3 LYS A 225
ALA A 226
MET A 199
 None
 1.07A 1hk3A-5x1nA:
undetectable		 1hk3A-5x1nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xz3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN

(Apis mellifera) 		no annotation 3 LYS A  22
ALA A  21
MET A  62
 None
 1.07A 1hk3A-5xz3A:
undetectable		 1hk3A-5xz3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		3 LYS A 513
ALA A 516
MET A 582
 None
 0.62A 1hk3A-5y7oA:
undetectable		 1hk3A-5y7oA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 3 LYS A 525
ALA A 528
MET A 548
 None
 0.92A 1hk3A-5yxeA:
46.2		 1hk3A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 3 LYS A 459
ALA A 463
MET A 358
 None
 1.00A 1hk3A-6c93A:
undetectable		 1hk3A-6c93A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czp OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Vibrio
vulnificus) 		no annotation 3 LYS A  26
ALA A  29
MET A 157
 None
 0.76A 1hk3A-6czpA:
4.4		 1hk3A-6czpA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 3 LYS K 807
ALA K 811
MET K 758
 None
 1.07A 1hk3A-6d6qK:
undetectable		 1hk3A-6d6qK:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2

(Sulfobacillus) 		no annotation 3 LYS B 123
ALA B 122
MET B 152
 None
 1.00A 1hk3A-6eqnB:
undetectable		 1hk3A-6eqnB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exc ICMP (DOTM)

(Legionella
pneumophila) 		no annotation 3 LYS A 177
ALA A 193
MET A 375
 None
 0.86A 1hk3A-6excA:
2.0		 1hk3A-6excA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Sus scrofa) 		no annotation 3 LYS E 115
ALA E 114
MET E 110
 None
 0.96A 1hk3A-6exvE:
undetectable		 1hk3A-6exvE:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 3 LYS C 170
ALA C 169
MET C 136
 None
 1.04A 1hk3A-6fahC:
undetectable		 1hk3A-6fahC:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 3 LYS A 144
ALA A 145
MET A 110
 None
 1.06A 1hk3A-6fcxA:
undetectable		 1hk3A-6fcxA:
9.90