SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK2_A_T44A3004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)

(Pyrococcus
woesei) 		PF00382
(TFIIB) 		4 ALA B1133
GLU B1132
VAL B1154
MET B1155
 None
 0.88A 1hk2A-1aisB:
0.5		 1hk2A-1aisB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		4 ALA A1296
GLU A1295
LEU A1327
VAL A1175
 None
 0.93A 1hk2A-1c0iA:
0.0		 1hk2A-1c0iA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 PHE A 372
ALA A 305
LEU A 307
VAL A 327
 None
 0.95A 1hk2A-1e08A:
0.0		 1hk2A-1e08A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0r THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.88A 1hk2A-1e0rB:
0.0		 1hk2A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1h BOTULINUM NEUROTOXIN
TYPE A LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE A 162
ALA A 217
LEU A 220
VAL A  90
 None
 0.94A 1hk2A-1e1hA:
0.0		 1hk2A-1e1hA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT

(Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA A  23
LEU A  24
VAL A 158
MET A 157
 None
 0.83A 1hk2A-1e3dA:
undetectable		 1hk2A-1e3dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 PHE B 102
ALA B 129
LEU B 132
MET B 139
 None
 0.93A 1hk2A-1ep2B:
0.0		 1hk2A-1ep2B:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A  15
GLU A  18
LEU A  19
VAL A   3
 None
 0.94A 1hk2A-1f8wA:
0.0		 1hk2A-1f8wA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g67 THIAMIN PHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		5 ALA A 173
GLU A 172
LEU A 170
VAL A 137
MET A 134
 None
 1.49A 1hk2A-1g67A:
0.0		 1hk2A-1g67A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlm HEMOGLOBIN (CYANO
MET)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 PHE A 133
ALA A 127
GLU A 128
LEU A 129
 None
 0.94A 1hk2A-1hlmA:
0.0		 1hk2A-1hlmA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx6 MAJOR CAPSID PROTEIN

(Salmonella
virus PRD1) 		PF09018
(Phage_Capsid_P3) 		4 PHE A  55
ALA A 197
GLU A 195
VAL A  72
 None
 0.93A 1hk2A-1hx6A:
undetectable		 1hk2A-1hx6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iu9 ASPARTATE RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 ALA A 187
GLU A 183
LEU A 182
MET A 145
 None
 0.93A 1hk2A-1iu9A:
3.0		 1hk2A-1iu9A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PHE A 185
ALA A 130
GLU A 133
LEU A 131
MET A 111
 None
 1.47A 1hk2A-1ji6A:
2.1		 1hk2A-1ji6A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4l 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Magnaporthe
grisea) 		PF00926
(DHBP_synthase) 		4 ALA A 156
GLU A 159
LEU A 160
VAL A  28
 None
 0.92A 1hk2A-1k4lA:
undetectable		 1hk2A-1k4lA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khi HEX1

(Neurospora
crassa) 		PF01287
(eIF-5a) 		4 ALA A 144
LEU A 141
VAL A 154
MET A 168
 None
 0.89A 1hk2A-1khiA:
undetectable		 1hk2A-1khiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 ALA A  97
GLU A  96
LEU A  93
VAL A 165
 None
 0.93A 1hk2A-1nowA:
undetectable		 1hk2A-1nowA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		4 ALA A   6
GLU A   5
LEU A   8
VAL A  12
 None
 0.94A 1hk2A-1nznA:
2.7		 1hk2A-1nznA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 PHE C 304
GLU C 289
LEU C 290
VAL C 277
 None
 0.93A 1hk2A-1odtC:
undetectable		 1hk2A-1odtC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or5 ACYL CARRIER PROTEIN

(Streptomyces
roseofulvus) 		PF00550
(PP-binding) 		4 ALA A  41
GLU A  44
LEU A  43
VAL A  62
 None
 0.92A 1hk2A-1or5A:
undetectable		 1hk2A-1or5A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pku NUCLEOSIDE
DIPHOSPHATE KINASE I

(Oryza sativa) 		PF00334
(NDK) 		4 ALA A 139
GLU A 140
LEU A 138
VAL A  77
 None
 0.59A 1hk2A-1pkuA:
undetectable		 1hk2A-1pkuA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 ALA A 232
GLU A 233
LEU A 229
VAL A 110
 None
 0.72A 1hk2A-1q5dA:
1.8		 1hk2A-1q5dA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 PHE A 213
ALA A 156
GLU A 159
LEU A 155
 None
 0.90A 1hk2A-1qsaA:
undetectable		 1hk2A-1qsaA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 PHE A 593
ALA A 605
LEU A 608
VAL A 703
 None
 0.84A 1hk2A-1qvrA:
undetectable		 1hk2A-1qvrA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		4 GLU A  61
LEU A  62
VAL A  94
MET A  93
 None
 0.94A 1hk2A-1rfvA:
4.0		 1hk2A-1rfvA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqb TRANSCARBOXYLASE 5S
SUBUNIT

(Propionibacterium
freudenreichii) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 ALA A 324
GLU A 325
VAL A 363
MET A 364
 None
 0.64A 1hk2A-1rqbA:
undetectable		 1hk2A-1rqbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ALA A 249
GLU A 252
LEU A 253
MET A 341
 None
 0.81A 1hk2A-1u0mA:
undetectable		 1hk2A-1u0mA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 ALA A 119
GLU A  87
LEU A 121
VAL A 112
 None
 0.72A 1hk2A-1ub3A:
undetectable		 1hk2A-1ub3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 ALA A 449
GLU A 452
LEU A 453
MET A 432
 None
 0.48A 1hk2A-1ufaA:
undetectable		 1hk2A-1ufaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj4 RIBOSE 5-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF06026
(Rib_5-P_isom_A) 		4 ALA A  37
GLU A  40
LEU A  41
VAL A  26
 None
 0.71A 1hk2A-1uj4A:
undetectable		 1hk2A-1uj4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 118
GLU A 119
VAL A 195
MET A 181
 None
 0.92A 1hk2A-1v26A:
undetectable		 1hk2A-1v26A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 PHE A  12
ALA A 312
LEU A 309
VAL A 346
 None
 0.76A 1hk2A-1v72A:
undetectable		 1hk2A-1v72A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc9 NDX1

(Thermus
thermophilus) 		PF00293
(NUDIX) 		4 ALA A  43
GLU A  46
VAL A   9
MET A  81
 None
MG  A2001 (-2.6A)
None
None
 0.88A 1hk2A-1vc9A:
undetectable		 1hk2A-1vc9A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		4 PHE A 860
GLU A 973
LEU A 974
VAL A 900
 None
 0.91A 1hk2A-1werA:
undetectable		 1hk2A-1werA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4m FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		4 ALA A  44
LEU A  40
VAL A  80
MET A  79
 None
 0.90A 1hk2A-1x4mA:
undetectable		 1hk2A-1x4mA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yac YCAC GENE PRODUCT

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 PHE A  50
ALA A  42
LEU A  43
VAL A 136
 None
 0.94A 1hk2A-1yacA:
undetectable		 1hk2A-1yacA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		4 PHE A 142
GLU A 108
LEU A 110
VAL A  78
 None
 0.90A 1hk2A-1yd9A:
undetectable		 1hk2A-1yd9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE
ADENYLYLTRANSFERASE
SUBUNIT 2

(Pseudomonas
syringae) 		PF01507
(PAPS_reduct) 		4 ALA A  46
LEU A  43
VAL A  59
MET A  31
 None
 0.93A 1hk2A-1zunA:
undetectable		 1hk2A-1zunA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ALA A 123
GLU A 125
LEU A 126
MET A 154
 None
 0.93A 1hk2A-2be4A:
2.4		 1hk2A-2be4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ALA A 163
GLU A 160
LEU A 159
VAL A 175
 None
 0.89A 1hk2A-2cb1A:
undetectable		 1hk2A-2cb1A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		4 PHE A   5
GLU A 295
LEU A 296
VAL A 271
 None
 0.92A 1hk2A-2cbnA:
undetectable		 1hk2A-2cbnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 ALA A 360
LEU A 363
VAL A 345
MET A 299
 None
 0.92A 1hk2A-2csuA:
undetectable		 1hk2A-2csuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czo BUD EMERGENCE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		4 ALA A 331
LEU A 328
VAL A 393
MET A 392
 None
 0.91A 1hk2A-2czoA:
undetectable		 1hk2A-2czoA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 PHE A 287
ALA A 309
GLU A 312
VAL A 364
 None
None
None
FMT  A 402 (-3.7A)
 0.91A 1hk2A-2dbyA:
undetectable		 1hk2A-2dbyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		5 ALA A  46
GLU A 563
LEU A 564
VAL A 397
MET A  50
 None
 1.47A 1hk2A-2e0wA:
undetectable		 1hk2A-2e0wA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 PHE A 249
ALA A 306
LEU A 305
VAL A 303
 None
 0.93A 1hk2A-2f8lA:
undetectable		 1hk2A-2f8lA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ALA A 639
GLU A 419
LEU A 638
VAL A 587
 None
 0.80A 1hk2A-2hauA:
undetectable		 1hk2A-2hauA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi0 PUTATIVE
PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
delbrueckii) 		PF13419
(HAD_2) 		4 PHE A  38
ALA A  58
LEU A  59
VAL A  92
 None
 0.94A 1hk2A-2hi0A:
undetectable		 1hk2A-2hi0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		4 ALA A 172
GLU A 169
LEU A 168
VAL A 183
 None
 0.93A 1hk2A-2htmA:
undetectable		 1hk2A-2htmA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8l HYDROGENASE 3
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		4 ALA A  49
GLU A  52
LEU A  53
VAL A  35
 None
 0.81A 1hk2A-2i8lA:
undetectable		 1hk2A-2i8lA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE

(Streptomyces
diastaticus) 		PF06616
(BsuBI_PstI_RE) 		4 ALA A 249
LEU A 234
VAL A 186
MET A 185
 None
 0.89A 1hk2A-2ixsA:
undetectable		 1hk2A-2ixsA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k0m UNCHARACTERIZED
PROTEIN

(Rhodospirillum
rubrum) 		PF11523
(DUF3223) 		4 PHE A  23
ALA A  43
LEU A  45
VAL A  37
 None
 0.82A 1hk2A-2k0mA:
undetectable		 1hk2A-2k0mA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8j GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1

(Homo sapiens) 		PF02991
(Atg8) 		4 PHE A  79
ALA A  75
LEU A  76
VAL A  41
 None
 0.93A 1hk2A-2l8jA:
undetectable		 1hk2A-2l8jA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq0 MYOSIN-BINDING
PROTEIN C,
CARDIAC-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 ALA A 536
GLU A 537
LEU A 538
VAL A 471
 None
 0.87A 1hk2A-2mq0A:
undetectable		 1hk2A-2mq0A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		4 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.84A 1hk2A-2nzjA:
undetectable		 1hk2A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2t MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 PHE A 122
ALA A 195
LEU A 189
MET A 129
 None
 0.79A 1hk2A-2o2tA:
undetectable		 1hk2A-2o2tA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE

(Caenorhabditis
elegans) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ALA A 198
GLU A 201
LEU A 202
VAL A 132
 None
 0.73A 1hk2A-2o3jA:
undetectable		 1hk2A-2o3jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opv KHSRP PROTEIN

(Homo sapiens) 		PF00013
(KH_1) 		4 ALA A  47
LEU A  43
VAL A  83
MET A  82
 None
 0.87A 1hk2A-2opvA:
undetectable		 1hk2A-2opvA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 ALA A 137
GLU A 136
LEU A 138
VAL A 127
 None
 0.94A 1hk2A-2ozoA:
undetectable		 1hk2A-2ozoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 PHE A 261
GLU A 296
LEU A 295
VAL A 234
 None
 0.90A 1hk2A-2p4oA:
undetectable		 1hk2A-2p4oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4w TRANSCRIPTIONAL
REGULATORY PROTEIN
ARSR FAMILY

(Pyrococcus
furiosus) 		PF01022
(HTH_5) 		4 ALA A  44
GLU A  47
LEU A  46
VAL A  31
 None
 0.95A 1hk2A-2p4wA:
undetectable		 1hk2A-2p4wA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.86A 1hk2A-2q0oA:
undetectable		 1hk2A-2q0oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc7 ENDOPLASMIC
RETICULUM PROTEIN
ERP29

(Homo sapiens) 		PF07749
(ERp29)
PF07912
(ERp29_N) 		4 PHE A 118
PHE A  73
ALA A  38
VAL A  91
 None
 0.89A 1hk2A-2qc7A:
undetectable		 1hk2A-2qc7A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 PHE A 721
ALA A 639
LEU A 636
VAL A 724
 None
 0.81A 1hk2A-2qmaA:
undetectable		 1hk2A-2qmaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qni UNCHARACTERIZED
PROTEIN ATU0299

(Agrobacterium
fabrum) 		PF00300
(His_Phos_1) 		4 ALA A  84
GLU A  85
LEU A  83
VAL A 161
 None
 0.93A 1hk2A-2qniA:
undetectable		 1hk2A-2qniA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 0.91A 1hk2A-2r7mA:
undetectable		 1hk2A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		4 ALA A  99
GLU A  98
LEU A 102
VAL A  89
 None
 0.94A 1hk2A-2r94A:
undetectable		 1hk2A-2r94A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 ALA A 183
GLU A 184
LEU A 185
VAL A 187
 None
 0.90A 1hk2A-2uxyA:
undetectable		 1hk2A-2uxyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 ALA A 132
GLU A 133
LEU A 131
VAL A 129
 None
 0.86A 1hk2A-2wzsA:
undetectable		 1hk2A-2wzsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE

(Nocardia
farcinica) 		no annotation 4 ALA A 206
LEU A 202
VAL A 174
MET A 175
 None
 0.71A 1hk2A-2xecA:
undetectable		 1hk2A-2xecA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 130
GLU A 129
LEU A 128
VAL A  30
 None
 0.88A 1hk2A-2yquA:
2.7		 1hk2A-2yquA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  85
GLU A  84
LEU A  86
VAL A  75
 None
 0.91A 1hk2A-2zc8A:
undetectable		 1hk2A-2zc8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuf ARGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ALA A 576
GLU A 578
LEU A 579
VAL A 613
 None
G  B 922 ( 4.9A)
None
None
 0.82A 1hk2A-2zufA:
3.8		 1hk2A-2zufA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE B 158
ALA B 155
LEU B 153
VAL B 138
 None
 0.77A 1hk2A-3a79B:
undetectable		 1hk2A-3a79B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 PHE A 706
GLU A 709
LEU A 713
VAL A 692
 None
 0.95A 1hk2A-3apoA:
undetectable		 1hk2A-3apoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 ALA A 183
GLU A 184
LEU A 202
VAL A 247
 None
 0.89A 1hk2A-3auoA:
undetectable		 1hk2A-3auoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6l TCR 2W20 ALPHA CHAIN

(Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 PHE A  61
ALA A  85
LEU A 107
VAL A 109
 None
 0.95A 1hk2A-3c6lA:
undetectable		 1hk2A-3c6lA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ALA A 126
GLU A 127
LEU A 125
VAL A  58
MET A  61
 None
 1.25A 1hk2A-3c8eA:
2.7		 1hk2A-3c8eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 PHE A 560
ALA A 379
GLU A 380
LEU A 357
 None
 0.66A 1hk2A-3cmgA:
undetectable		 1hk2A-3cmgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 PHE A 243
ALA A 220
LEU A 217
VAL A 170
 None
 0.84A 1hk2A-3cswA:
undetectable		 1hk2A-3cswA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1l PUTATIVE NADP
OXIDOREDUCTASE
BF3122

(Bacteroides
fragilis) 		PF03807
(F420_oxidored)
PF10728
(DUF2520) 		4 ALA A  93
GLU A  92
LEU A  94
VAL A  96
 None
 0.89A 1hk2A-3d1lA:
2.3		 1hk2A-3d1lA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3del ARGININE BINDING
PROTEIN

(Chlamydia
trachomatis) 		PF00497
(SBP_bac_3) 		4 ALA B 201
LEU B 202
VAL B 177
MET B 178
 None
 0.70A 1hk2A-3delB:
undetectable		 1hk2A-3delB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do5 HOMOSERINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 PHE A   9
ALA A  55
LEU A  52
VAL A  36
 None
 0.86A 1hk2A-3do5A:
undetectable		 1hk2A-3do5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24) 		PF03807
(F420_oxidored) 		4 ALA A  72
GLU A  73
LEU A  74
VAL A  76
 None
 0.93A 1hk2A-3dttA:
undetectable		 1hk2A-3dttA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		4 ALA A 162
GLU A 163
LEU A 164
VAL A 123
 None
 0.94A 1hk2A-3dxxA:
undetectable		 1hk2A-3dxxA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk2A-3fhxA:
3.9		 1hk2A-3fhxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 313
ALA A 159
LEU A 155
MET A 247
 None
 0.95A 1hk2A-3fmeA:
undetectable		 1hk2A-3fmeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4) 		4 ALA A 189
GLU A 192
LEU A 193
VAL A 210
 None
 0.84A 1hk2A-3g0qA:
undetectable		 1hk2A-3g0qA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.95A 1hk2A-3h1lA:
undetectable		 1hk2A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A   2
GLU A  92
LEU A  97
VAL A  68
 None
 0.81A 1hk2A-3hi8A:
undetectable		 1hk2A-3hi8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 PHE A 239
ALA A 265
LEU A 262
VAL A 257
 None
 0.94A 1hk2A-3hjlA:
undetectable		 1hk2A-3hjlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvm AGMATINE DEIMINASE

(Helicobacter
pylori) 		PF04371
(PAD_porph) 		4 ALA A 219
GLU A 255
LEU A 254
VAL A 216
 None
 0.83A 1hk2A-3hvmA:
undetectable		 1hk2A-3hvmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 4 ALA A 229
LEU A 226
VAL A 207
MET A 206
 None
 0.94A 1hk2A-3i9wA:
undetectable		 1hk2A-3i9wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9y SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 4 ALA A 216
GLU A 158
LEU A 212
MET A 249
 None
 0.91A 1hk2A-3i9yA:
undetectable		 1hk2A-3i9yA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ico 6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacterium
tuberculosis) 		PF01182
(Glucosamine_iso) 		4 ALA A 162
GLU A 165
LEU A 164
VAL A 220
 None
 0.89A 1hk2A-3icoA:
undetectable		 1hk2A-3icoA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ALA A 397
GLU A 398
LEU A 394
VAL A 417
 None
 0.95A 1hk2A-3iv0A:
undetectable		 1hk2A-3iv0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 GLU A 254
LEU A 253
VAL A 287
MET A 286
 None
 0.90A 1hk2A-3j1cA:
1.4		 1hk2A-3j1cA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 PHE B 163
ALA B 218
LEU B 221
VAL B  91
 None
 0.93A 1hk2A-3k3qB:
undetectable		 1hk2A-3k3qB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k94 THIAMIN
PYROPHOSPHOKINASE

(Geobacillus
thermodenitrificans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 PHE A  66
ALA A  40
GLU A  39
LEU A  37
 None
 0.94A 1hk2A-3k94A:
undetectable		 1hk2A-3k94A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		4 PHE A 103
ALA A 134
LEU A 133
VAL A  63
 None
 0.92A 1hk2A-3lm6A:
undetectable		 1hk2A-3lm6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lrp ADP-RIBOSYLATION
FACTOR 1

(Plasmodium
falciparum) 		PF00025
(Arf) 		4 ALA A 103
GLU A 106
LEU A 107
VAL A 123
 None
 0.93A 1hk2A-3lrpA:
undetectable		 1hk2A-3lrpA:
14.16