SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK2_A_T44A3002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)


(Saccharomyces
cerevisiae)
PF01088
(Peptidase_C12)
4 GLN A 119
LEU A 116
LEU A  96
TYR A  93
None
0.72A 1hk2A-1cmxA:
undetectable
1hk2A-1cmxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN


(Homo sapiens)
PF07565
(Band_3_cyto)
4 ASN P 133
LEU P 136
LEU P 158
SER P 127
None
1.03A 1hk2A-1hynP:
0.2
1hk2A-1hynP:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikp EXOTOXIN A

(Pseudomonas
aeruginosa)
PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target)
4 ASN A 100
LEU A  99
LEU A 199
SER A 173
None
1.02A 1hk2A-1ikpA:
undetectable
1hk2A-1ikpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kz7 GUANINE NUCLEOTIDE
EXCHANGE FACTOR DBS


(Mus musculus)
PF00169
(PH)
PF00621
(RhoGEF)
4 LEU A 831
LEU A 825
TYR A 821
SER A 894
None
1.25A 1hk2A-1kz7A:
undetectable
1hk2A-1kz7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes)
PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8)
4 GLN A  95
LEU A 119
LEU A 103
LEU A 110
None
1.05A 1hk2A-1m9sA:
undetectable
1hk2A-1m9sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)


(Klebsiella
pneumoniae)
PF00148
(Oxidored_nitro)
PF11844
(DUF3364)
4 ASN B 441
LEU B 469
LEU B 462
LEU B 423
None
1.22A 1hk2A-1qh1B:
undetectable
1hk2A-1qh1B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)


(Homo sapiens)
PF00753
(Lactamase_B)
PF16123
(HAGH_C)
4 TYR A 221
LYS A 196
LEU A 136
SER A 213
None
1.11A 1hk2A-1qh5A:
0.0
1hk2A-1qh5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjq POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 1


(Homo sapiens)
no annotation 4 GLN A  54
LEU A  24
LEU A  94
SER A  89
None
1.24A 1hk2A-1sjqA:
undetectable
1hk2A-1sjqA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
4 LEU A 481
LEU A 522
TYR A 699
LYS A 703
None
1.25A 1hk2A-1t6pA:
0.9
1hk2A-1t6pA:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
6 GLN A 390
LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
None
0.58A 1hk2A-1tf0A:
48.4
1hk2A-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
6 LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
None
0.37A 1hk2A-1tf0A:
48.4
1hk2A-1tf0A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT


(Rhodococcus
jostii)
PF00866
(Ring_hydroxyl_B)
4 GLN B  23
LEU B  22
LEU B 155
SER B 131
None
1.11A 1hk2A-1uliB:
undetectable
1hk2A-1uliB:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgm 378AA LONG
HYPOTHETICAL CITRATE
SYNTHASE


(Sulfurisphaera
tokodaii)
PF00285
(Citrate_synt)
4 LEU A  19
LEU A  48
TYR A  45
SER A 338
None
1.24A 1hk2A-1vgmA:
0.1
1hk2A-1vgmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG


(Thermus
thermophilus)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II)
4 LEU A 305
LEU A 325
LEU A 356
SER A 318
None
1.18A 1hk2A-1wdtA:
undetectable
1hk2A-1wdtA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 GLN B  22
LEU B  21
LEU B 154
SER B 130
None
1.11A 1hk2A-1wqlB:
undetectable
1hk2A-1wqlB:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyr RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 6


(Homo sapiens)
PF00307
(CH)
4 ASN A 111
LEU A 107
LEU A  52
SER A  17
None
1.05A 1hk2A-1wyrA:
undetectable
1hk2A-1wyrA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6g GUANYLATE KINASE

(Plasmodium
falciparum)
PF00625
(Guanylate_kin)
4 LEU A 168
LEU A 186
TYR A 190
LEU A  99
None
1.17A 1hk2A-1z6gA:
undetectable
1hk2A-1z6gA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbp HYPOTHETICAL PROTEIN
VPA1032


(Vibrio
parahaemolyticus)
PF07024
(ImpE)
4 GLN A  86
ASN A 108
LEU A 109
LEU A 167
None
1.06A 1hk2A-1zbpA:
undetectable
1hk2A-1zbpA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb6 TRANSCOBALAMIN II

(Bos taurus)
PF01122
(Cobalamin_bind)
4 LEU A  27
LEU A  58
TYR A  62
LEU A 363
None
None
None
B12  A   0 (-3.7A)
1.22A 1hk2A-2bb6A:
undetectable
1hk2A-2bb6A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkl PROLYL ENDOPEPTIDASE

(Myxococcus
xanthus)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
4 LEU A 549
TYR A 422
LEU A 483
SER A 424
None
1.05A 1hk2A-2bklA:
undetectable
1hk2A-2bklA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chp METALLOREGULATION
DNA-BINDING STRESS
PROTEIN


(Bacillus
subtilis)
PF00210
(Ferritin)
4 GLN A 102
LEU A 148
LEU A  46
SER A  96
None
1.25A 1hk2A-2chpA:
undetectable
1hk2A-2chpA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu2 PUTATIVE
MANNOSE-1-PHOSPHATE
GUANYLYL TRANSFERASE


(Thermus
thermophilus)
PF00483
(NTP_transferase)
4 LEU A 205
LEU A 228
TYR A 225
LEU A 215
None
1.13A 1hk2A-2cu2A:
undetectable
1hk2A-2cu2A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Escherichia
coli)
PF00698
(Acyl_transf_1)
4 GLN A  63
LEU A  67
LEU A  44
TYR A  42
SO4  A1001 (-3.9A)
None
None
None
1.16A 1hk2A-2g2oA:
1.4
1hk2A-2g2oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I


(Homo sapiens)
PF00270
(DEAD)
4 ASN A  38
LEU A  39
LEU A  64
LYS A  69
None
None
None
MLY  A  68 ( 3.2A)
1.11A 1hk2A-2g9nA:
undetectable
1hk2A-2g9nA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'


(Homo sapiens)
PF03095
(PTPA)
4 LEU A  81
TYR A 188
LEU A 163
SER A 142
None
1.23A 1hk2A-2ixmA:
2.4
1hk2A-2ixmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixm SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
REGULATORY SUBUNIT
B'


(Homo sapiens)
PF03095
(PTPA)
4 LEU A 119
LEU A  81
TYR A 188
LEU A 163
None
1.22A 1hk2A-2ixmA:
2.4
1hk2A-2ixmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum)
PF00753
(Lactamase_B)
PF16123
(HAGH_C)
4 ASN A 264
LEU A 265
TYR A 242
SER A 255
None
1.25A 1hk2A-2p18A:
undetectable
1hk2A-2p18A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 GLN A 739
LEU A 748
LEU A 765
LEU A 862
None
0.77A 1hk2A-2pffA:
2.3
1hk2A-2pffA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1


(Homo sapiens)
PF00151
(Lipase)
PF01477
(PLAT)
4 GLN A  84
ASN A 119
LEU A  70
LEU A 154
None
1.17A 1hk2A-2pplA:
undetectable
1hk2A-2pplA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN


(Shewanella
denitrificans)
PF11528
(DUF3224)
4 LEU A  46
TYR A  42
LEU A  85
SER A  50
None
1.04A 1hk2A-2q03A:
undetectable
1hk2A-2q03A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhd CYTOCHROME C551
PEROXIDASE


(Pseudomonas
aeruginosa)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
4 GLN A 185
LEU A 206
LEU A 174
SER A 168
None
0.99A 1hk2A-2vhdA:
undetectable
1hk2A-2vhdA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA


(Comamonas
testosteroni)
PF00866
(Ring_hydroxyl_B)
4 GLN B  22
LEU B  21
LEU B 154
SER B 130
None
1.16A 1hk2A-3gzyB:
undetectable
1hk2A-3gzyB:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Vibrio cholerae)
PF00698
(Acyl_transf_1)
4 GLN A  68
LEU A  72
LEU A  49
TYR A  47
CL  A 331 ( 4.2A)
None
None
CXS  A 325 (-4.2A)
1.16A 1hk2A-3hjvA:
undetectable
1hk2A-3hjvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE


(Geobacter
sulfurreducens)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
4 GLN A 207
LEU A 228
LEU A 196
SER A 190
None
1.04A 1hk2A-3hq9A:
undetectable
1hk2A-3hq9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE


(Colwellia
psychrerythraea)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLN A 210
ASN A 208
LEU A 209
LEU A 317
None
None
None
FAD  A 490 (-4.2A)
0.99A 1hk2A-3ic9A:
3.7
1hk2A-3ic9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwo PUTATIVE
BACTERIOFERRITIN


(Campylobacter
jejuni)
PF00210
(Ferritin)
4 ASN A 128
LEU A 102
TYR A  99
SER A 135
None
1.26A 1hk2A-3kwoA:
undetectable
1hk2A-3kwoA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF00202
(Aminotran_3)
4 GLN A 263
ASN A 262
LEU A 215
SER A 269
None
1.16A 1hk2A-3nx3A:
2.2
1hk2A-3nx3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS0355


(Streptococcus
agalactiae)
PF03816
(LytR_cpsA_psr)
4 GLN A 226
LEU A  63
LEU A 125
SER A  82
None
1.10A 1hk2A-3okzA:
undetectable
1hk2A-3okzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pju CYCLIC DIMERIC GMP
BINDING PROTEIN


(Pseudomonas
fluorescens)
PF00563
(EAL)
4 GLN A 536
ASN A 499
LEU A 500
LEU A 448
None
C2E  A2256 (-3.2A)
None
C2E  A2256 (-3.8A)
1.18A 1hk2A-3pjuA:
undetectable
1hk2A-3pjuA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC


(Escherichia
coli)
PF01266
(DAO)
PF05430
(Methyltransf_30)
4 ASN A 323
LEU A 322
TYR A 400
LEU A 372
None
1.07A 1hk2A-3ps9A:
undetectable
1hk2A-3ps9A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor)
PF01244
(Peptidase_M19)
4 LEU A  35
LEU A  23
LEU A  55
SER A 118
None
1.04A 1hk2A-3s2jA:
undetectable
1hk2A-3s2jA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA


(Pyrococcus
furiosus)
PF09376
(NurA)
4 LEU A 146
LEU A 280
TYR A 279
LEU A 133
None
1.23A 1hk2A-3talA:
undetectable
1hk2A-3talA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
4 ASN A 197
LEU A  96
TYR A 159
SER A 145
NAP  A 601 (-4.3A)
None
NAP  A 601 (-4.7A)
NAP  A 601 (-3.3A)
1.11A 1hk2A-3toxA:
undetectable
1hk2A-3toxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqe MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE


(Coxiella
burnetii)
PF00698
(Acyl_transf_1)
4 GLN A  64
LEU A  68
LEU A  45
TYR A  43
GLY  A 314 ( 4.2A)
None
None
None
1.24A 1hk2A-3tqeA:
undetectable
1hk2A-3tqeA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B


(Homo sapiens)
PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN)
4 GLN A 315
LEU A 171
TYR A 174
LEU A 296
None
0.92A 1hk2A-3tw8A:
2.6
1hk2A-3tw8A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII


(Pseudoxanthomonas
mexicana)
PF10459
(Peptidase_S46)
4 GLN A  33
LEU A  34
LEU A  56
SER A 578
None
1.04A 1hk2A-3wonA:
undetectable
1hk2A-3wonA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC


(Homo sapiens)
PF00155
(Aminotran_1_2)
4 GLN A 204
LEU A 177
TYR A 158
LEU A 188
None
0.85A 1hk2A-3wzfA:
undetectable
1hk2A-3wzfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqs E3 UBIQUITIN-PROTEIN
LIGASE FANCL


(Homo sapiens)
PF09765
(WD-3)
4 GLN A 189
LEU A 152
LEU A 121
SER A 182
None
0.87A 1hk2A-3zqsA:
undetectable
1hk2A-3zqsA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
4 GLN A 593
ASN A 727
LEU A 460
LEU A 612
None
1.20A 1hk2A-4cakA:
undetectable
1hk2A-4cakA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
4 GLN A 741
LEU A 749
LEU A1056
LEU A1100
None
1.26A 1hk2A-4ddwA:
undetectable
1hk2A-4ddwA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E


(Burkholderia
thailandensis)
PF01370
(Epimerase)
4 GLN A 190
ASN A 189
LEU A 326
SER A 182
None
1.24A 1hk2A-4ej0A:
undetectable
1hk2A-4ej0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5


(Saccharomyces
cerevisiae)
PF10483
(Elong_Iki1)
4 LEU B 158
LEU B  26
LYS B 209
LEU B 121
None
0.84A 1hk2A-4ejsB:
undetectable
1hk2A-4ejsB:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
4 GLN A 471
ASN A 199
LEU A 196
LEU A 223
None
1.25A 1hk2A-4gv1A:
undetectable
1hk2A-4gv1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxz SUPPRESSION OF
COPPER SENSITIVITY
PROTEIN


(Salmonella
enterica)
PF01323
(DSBA)
4 GLN A 146
ASN A 144
LEU A 147
LEU A  90
None
1.15A 1hk2A-4gxzA:
undetectable
1hk2A-4gxzA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0a UNCHARACTERIZED
PROTEIN


(Staphylococcus
aureus)
PF00188
(CAP)
PF14504
(CAP_assoc_N)
4 GLN A 295
ASN A 296
LEU A 340
LEU A 307
None
1.17A 1hk2A-4h0aA:
undetectable
1hk2A-4h0aA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb9 SIMILARITIES WITH
PROBABLE
MONOOXYGENASE


(Photorhabdus
laumondii)
PF01494
(FAD_binding_3)
4 LEU A 304
LEU A 172
TYR A 171
SER A 309
None
EDO  A 502 ( 4.0A)
EDO  A 509 (-4.0A)
None
1.16A 1hk2A-4hb9A:
undetectable
1hk2A-4hb9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isd GLUTATHIONE
S-TRANSFERASE


(Burkholderia
glumae)
PF13417
(GST_N_3)
PF14834
(GST_C_4)
4 LEU A 146
LEU A 175
TYR A 192
LEU A 105
None
0.92A 1hk2A-4isdA:
2.1
1hk2A-4isdA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7b LYTB

(Plasmodium
falciparum)
PF02401
(LYTB)
4 GLN A 253
LEU A 281
TYR A 288
LEU A 215
None
0.91A 1hk2A-4n7bA:
undetectable
1hk2A-4n7bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA


(Yersinia pestis)
PF00496
(SBP_bac_5)
4 ASN A 293
LEU A 290
LEU A 393
TYR A 397
None
0.88A 1hk2A-4oflA:
undetectable
1hk2A-4oflA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA


(Yersinia pestis)
PF00496
(SBP_bac_5)
4 GLN A 288
LEU A 290
LEU A 393
TYR A 397
None
0.98A 1hk2A-4oflA:
undetectable
1hk2A-4oflA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae)
PF07201
(HrpJ)
4 GLN A 271
LEU A 220
LEU A 206
LEU A 196
None
0.89A 1hk2A-4p3zA:
2.3
1hk2A-4p3zA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
4 ASN A 391
LEU A 407
TYR A 411
LEU A 453
NPS  A 601 (-4.3A)
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.7A)
1.02A 1hk2A-4po0A:
48.8
1hk2A-4po0A:
74.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 GLN A 390
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
0.68A 1hk2A-4po0A:
48.8
1hk2A-4po0A:
74.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
0.62A 1hk2A-4po0A:
48.8
1hk2A-4po0A:
74.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4j ABC TRANSPORTER

(Thermotoga
maritima)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 GLN A 122
LEU A 126
LEU A   4
LEU A  92
None
1.09A 1hk2A-4q4jA:
undetectable
1hk2A-4q4jA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2


(Erythrobacter
litoralis)
PF07568
(HisKA_2)
PF13581
(HATPase_c_2)
4 GLN A 335
LEU A 276
LEU A 205
TYR A 204
None
1.19A 1hk2A-4r39A:
undetectable
1hk2A-4r39A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli)
PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C)
4 GLN A 199
LEU A 200
LYS A 319
LEU A 129
None
1.02A 1hk2A-4xjxA:
undetectable
1hk2A-4xjxA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Homo sapiens)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
4 GLN A 357
LEU A 353
TYR A 326
LEU A 280
None
1.25A 1hk2A-4xwhA:
2.7
1hk2A-4xwhA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001)
PF01425
(Amidase)
4 LEU A 309
LEU A 435
TYR A 434
LEU A 377
None
1.19A 1hk2A-4yjiA:
undetectable
1hk2A-4yjiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxw C-DOMAIN TYPE II
PEPTIDE SYNTHETASE


(Streptomyces
globisporus)
PF00668
(Condensation)
4 LEU A 133
LEU A  78
LEU A  24
SER A  18
None
1.13A 1hk2A-4zxwA:
undetectable
1hk2A-4zxwA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeu BIPHENYL DIOXYGENASE
SUBUNIT BETA


(Paraburkholderia
xenovorans)
PF00866
(Ring_hydroxyl_B)
4 GLN B  24
LEU B  23
LEU B 156
SER B 132
None
1.10A 1hk2A-5aeuB:
undetectable
1hk2A-5aeuB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4p REPEBODY

(synthetic
construct)
PF11921
(DUF3439)
PF12354
(Internalin_N)
PF13855
(LRR_8)
4 GLN A  60
LEU A  84
LEU A  68
LEU A  75
SO4  A 302 ( 4.9A)
None
None
None
1.12A 1hk2A-5b4pA:
undetectable
1hk2A-5b4pA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE


(Thymus vulgaris)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 LEU A 562
LEU A 482
TYR A 478
SER A 416
LEU  A 562 ( 0.6A)
LEU  A 482 ( 0.5A)
TYR  A 478 ( 1.3A)
SER  A 416 ( 0.0A)
1.20A 1hk2A-5c05A:
2.2
1hk2A-5c05A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 ASN A 390
LEU A 393
LEU A 406
TYR A 410
SER A 488
None
1.12A 1hk2A-5dqfA:
49.1
1hk2A-5dqfA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
4 LEU A 393
LEU A 406
LEU A 452
SER A 488
None
0.79A 1hk2A-5dqfA:
49.1
1hk2A-5dqfA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
5 LEU A 393
LEU A 406
TYR A 410
LYS A 413
SER A 488
None
0.55A 1hk2A-5dqfA:
49.1
1hk2A-5dqfA:
76.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis)
PF01425
(Amidase)
4 GLN A 384
LEU A 283
LEU A 480
SER A 451
None
1.16A 1hk2A-5ewqA:
undetectable
1hk2A-5ewqA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
4 ASN A 391
LEU A 407
TYR A 411
LEU A 453
None
1.05A 1hk2A-5ghkA:
46.8
1hk2A-5ghkA:
79.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
5 LEU A 394
LEU A 407
TYR A 411
LEU A 453
SER A 489
None
0.44A 1hk2A-5ghkA:
46.8
1hk2A-5ghkA:
79.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
5 LEU A 394
LEU A 407
TYR A 411
LYS A 414
SER A 489
None
0.60A 1hk2A-5ghkA:
46.8
1hk2A-5ghkA:
79.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
4 LEU A 224
LEU A 197
LEU A 167
SER A 190
None
1.17A 1hk2A-5gr8A:
undetectable
1hk2A-5gr8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzh ENDO-BETA-1,2-GLUCAN
ASE


(Chitinophaga
pinensis)
PF10091
(Glycoamylase)
4 LEU A 433
LEU A 213
TYR A 274
LEU A 255
None
1.24A 1hk2A-5gzhA:
undetectable
1hk2A-5gzhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus)
no annotation 4 LEU C 282
LEU C 193
TYR C 189
LEU C 225
None
1.13A 1hk2A-5hr4C:
undetectable
1hk2A-5hr4C:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5io8 VIRG-LIKE PROTEIN

(Salmonella
enterica)
no annotation 4 GLN A  20
LEU A  22
LEU A  95
TYR A  91
None
1.12A 1hk2A-5io8A:
3.3
1hk2A-5io8A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0w SEC71
SEC72


(Chaetomium
thermophilum)
PF09802
(Sec66)
no annotation
4 GLN A  32
LEU B  44
LEU B  12
LEU B  28
None
1.16A 1hk2A-5l0wA:
undetectable
1hk2A-5l0wA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens)
PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
4 GLN A 153
LEU A 130
LEU A 138
LEU A 183
None
1.08A 1hk2A-5lfnA:
undetectable
1hk2A-5lfnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens)
PF04598
(Gasdermin)
4 LEU A 447
LEU A 469
LEU A 388
SER A 382
None
1.05A 1hk2A-5nh1A:
undetectable
1hk2A-5nh1A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE


(Campylobacter
lari)
no annotation 4 LEU A 673
LEU A 661
LEU A 612
SER A 669
None
1.13A 1hk2A-5oglA:
3.1
1hk2A-5oglA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
4 GLN T1005
ASN T1002
LEU T1001
SER T1009
None
1.19A 1hk2A-5ojsT:
undetectable
1hk2A-5ojsT:
9.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 6 LEU A 393
LEU A 406
TYR A 410
LYS A 413
LEU A 452
SER A 488
None
0.45A 1hk2A-5oriA:
48.4
1hk2A-5oriA:
74.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY


(Thermococcus
kodakarensis)
no annotation 4 TYR A 346
LYS A 394
LEU A 318
SER A 379
None
1.26A 1hk2A-5ot1A:
undetectable
1hk2A-5ot1A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5trw PYRIDOXAL KINASE
PDXY


(Paraburkholderia
xenovorans)
PF08543
(Phos_pyr_kin)
4 GLN A  89
TYR A 109
LEU A 131
SER A  81
None
1.18A 1hk2A-5trwA:
undetectable
1hk2A-5trwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE


(Culex
quinquefasciatus)
PF00135
(COesterase)
4 LEU A 449
LEU A 468
TYR A 465
LEU A  24
None
1.17A 1hk2A-5w1uA:
2.6
1hk2A-5w1uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
no annotation 4 ASN A 131
LEU A 135
LEU A 121
LEU A  94
None
1.24A 1hk2A-5wy4A:
undetectable
1hk2A-5wy4A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus)
PF05505
(Ebola_NP)
4 LEU A 230
LEU A 282
TYR A 279
SER A 245
None
1.25A 1hk2A-5xsqA:
undetectable
1hk2A-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 5 ASN A 391
LEU A 394
LEU A 407
LEU A 453
SER A 489
None
1.10A 1hk2A-5yxeA:
46.1
1hk2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 6 LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
None
0.53A 1hk2A-5yxeA:
46.1
1hk2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anz UNCHARACTERIZED
PROTEIN


(Neisseria
gonorrhoeae)
no annotation 4 ASN A  90
LEU A  91
LEU A  74
TYR A  67
None
0.96A 1hk2A-6anzA:
undetectable
1hk2A-6anzA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOMAL
RNA-PROCESSING
PROTEIN 15
RIBOSOME BIOGENESIS
PROTEIN SSF1


(Saccharomyces
cerevisiae)
no annotation 4 GLN w 205
LEU w 202
LEU v 140
SER v 185
None
1.19A 1hk2A-6c0fw:
undetectable
1hk2A-6c0fw:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
1


(Eremothecium
gossypii)
no annotation 4 GLN A 106
LEU A 107
TYR A 126
LEU A 114
None
1.20A 1hk2A-6dexA:
undetectable
1hk2A-6dexA:
9.52