SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK2_A_T44A3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpd L-ALA-D/L-GLU
EPIMERASE

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR X  51
LEU X 237
HIS X 229
ARG X  50
ALA X 207
 None
 1.43A 1hk2A-1jpdX:
0.0		 1hk2A-1jpdX:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 219
ARG A 218
LEU A 238
ARG A 257
ALA A 291
 None
CIT  A2001 (-4.0A)
DKA  A1003 (-4.3A)
DKA  A1003 (-4.1A)
CIT  A2001 ( 3.9A)
 1.50A 1hk2A-1tf0A:
48.4		 1hk2A-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 TYR A 150
LYS A 199
LEU A 219
ARG A 222
HIS A 242
 DKA  A1003 (-4.4A)
CIT  A2001 ( 2.7A)
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-3.7A)
 0.98A 1hk2A-1tf0A:
48.4		 1hk2A-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 TYR A 150
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 291
 DKA  A1003 (-4.4A)
CIT  A2001 ( 2.7A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
CIT  A2001 ( 3.9A)
 0.51A 1hk2A-1tf0A:
48.4		 1hk2A-1tf0A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo3 OXY PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		5 LEU A 342
ARG A 343
LEU A 267
HIS A 322
ALA A 335
 None
 1.50A 1hk2A-3oo3A:
1.1		 1hk2A-3oo3A:
21.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 TYR A 150
LEU A 219
LEU A 238
HIS A 242
ARG A 257
 None
 0.41A 1hk2A-4po0A:
48.8		 1hk2A-4po0A:
74.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 TYR A 149
LEU A 218
LEU A 237
HIS A 241
ARG A 256
ALA A 290
 PG4  A 602 (-4.9A)
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 (-3.4A)
 0.58A 1hk2A-5dqfA:
49.1		 1hk2A-5dqfA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 TYR A 149
LYS A 198
HIS A 241
ARG A 256
ALA A 290
 PG4  A 602 (-4.9A)
PG4  A 602 ( 4.3A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 (-3.4A)
 0.74A 1hk2A-5dqfA:
49.1		 1hk2A-5dqfA:
76.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 TYR A 150
LYS A 199
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ARG A 257
 None
 0.97A 1hk2A-5ghkA:
46.8		 1hk2A-5ghkA:
79.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 TYR A 150
LYS A 199
LEU A 219
LEU A 238
HIS A 242
ARG A 257
ALA A 291
 None
 0.68A 1hk2A-5ghkA:
46.8		 1hk2A-5ghkA:
79.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 TYR A 149
LEU A 218
LEU A 237
HIS A 241
ARG A 256
ALA A 290
 None
 0.62A 1hk2A-5oriA:
48.4		 1hk2A-5oriA:
74.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 TYR A 150
LEU A 219
LEU A 238
HIS A 242
ARG A 257
 None
 0.62A 1hk2A-5yxeA:
46.1		 1hk2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 TYR A 150
LYS A 199
LEU A 219
HIS A 242
ARG A 257
 None
 0.40A 1hk2A-5yxeA:
46.1		 1hk2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei1 ZINC FINGER WITH
UFM1-SPECIFIC
PEPTIDASE DOMAIN
PROTEIN

(Homo sapiens) 		no annotation 5 HIS A 488
LEU A 486
ARG A 493
LEU A 458
HIS A 455
 None
 1.45A 1hk2A-6ei1A:
0.4		 1hk2A-6ei1A:
8.73