SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK1_A_T44A3004_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 PHE A 117
LEU A  32
VAL A 125
MET A 124
 None
 0.96A 1hk1A-1ad3A:
0.0		 1hk1A-1ad3A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0r THERMOSOME

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLU B 245
LEU B 244
VAL B 278
MET B 277
 None
 0.84A 1hk1A-1e0rB:
0.0		 1hk1A-1e0rB:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 GLU A1034
LEU A1035
VAL A1019
MET A1020
 None
 1.04A 1hk1A-1eg7A:
0.6		 1hk1A-1eg7A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2r HYPOTHETICAL
ISOCHORISMATASE
FAMILY PROTEIN YECD

(Escherichia
coli) 		PF00857
(Isochorismatase) 		4 PHE A 158
GLU A 124
LEU A 123
VAL A  23
 None
 0.98A 1hk1A-1j2rA:
0.0		 1hk1A-1j2rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		4 PHE A  79
GLU A  46
LEU A  22
VAL A  30
 None
DHS  A 301 (-2.6A)
None
None
 1.07A 1hk1A-1l9wA:
0.0		 1hk1A-1l9wA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PHE A 137
GLU A 142
LEU A 144
VAL A 119
 None
 1.06A 1hk1A-1rcqA:
0.0		 1hk1A-1rcqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		4 GLU A  61
LEU A  62
VAL A  94
MET A  93
 None
 0.96A 1hk1A-1rfvA:
4.2		 1hk1A-1rfvA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		4 PHE A 860
GLU A 973
LEU A 974
VAL A 900
 None
 0.99A 1hk1A-1werA:
0.0		 1hk1A-1werA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4m FAR UPSTREAM ELEMENT
BINDING PROTEIN 1

(Mus musculus) 		PF00013
(KH_1) 		4 GLU A  42
LEU A  40
VAL A  80
MET A  79
 None
 1.05A 1hk1A-1x4mA:
1.3		 1hk1A-1x4mA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1

(Rattus
norvegicus) 		PF01661
(Macro) 		4 PHE A 142
GLU A 108
LEU A 110
VAL A  78
 None
 0.90A 1hk1A-1yd9A:
undetectable		 1hk1A-1yd9A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ypz T-CELL RECEPTOR
GAMMA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE F 192
GLU F 155
LEU F 154
VAL F 164
 None
 1.07A 1hk1A-1ypzF:
undetectable		 1hk1A-1ypzF:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		4 PHE A 319
GLU A 285
LEU A 287
VAL A 255
 None
 0.96A 1hk1A-1zr5A:
undetectable		 1hk1A-1zr5A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 215
PHE A 240
GLU A 210
LEU A 208
 None
 0.99A 1hk1A-2avtA:
undetectable		 1hk1A-2avtA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A 215
PHE A 240
GLU A 210
LEU A 208
 None
 0.92A 1hk1A-2awaA:
undetectable		 1hk1A-2awaA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 PHE A 267
LEU A 307
VAL A 294
MET A 291
 None
 0.97A 1hk1A-2b8nA:
undetectable		 1hk1A-2b8nA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		4 PHE A   5
GLU A 295
LEU A 296
VAL A 271
 None
 1.04A 1hk1A-2cbnA:
undetectable		 1hk1A-2cbnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfa HYPOTHETICAL UPF0271
PROTEIN TTHB195

(Thermus
thermophilus) 		PF03746
(LamB_YcsF) 		4 GLU A 167
LEU A 220
VAL A 200
MET A 199
 None
 1.00A 1hk1A-2dfaA:
undetectable		 1hk1A-2dfaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		4 GLU A 128
LEU A 129
VAL A 173
MET A 174
 None
 1.04A 1hk1A-2ioyA:
undetectable		 1hk1A-2ioyA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lna AFG3-LIKE PROTEIN 2

(Homo sapiens) 		PF06480
(FtsH_ext) 		4 PHE A  70
GLU A  75
LEU A  77
VAL A  24
 None
 1.02A 1hk1A-2lnaA:
undetectable		 1hk1A-2lnaA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzj GTP-BINDING PROTEIN
REM 1

(Homo sapiens) 		PF00071
(Ras) 		4 PHE A 100
GLU A 237
LEU A 235
VAL A 158
 None
 0.95A 1hk1A-2nzjA:
undetectable		 1hk1A-2nzjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		4 PHE B 298
PHE B 264
LEU B 254
VAL B 295
 None
 1.01A 1hk1A-2odrB:
undetectable		 1hk1A-2odrB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odt INOSITOL-TETRAKISPHO
SPHATE 1-KINASE

(Homo sapiens) 		PF05770
(Ins134_P3_kin) 		4 GLU X 146
LEU X 145
VAL X 187
MET X 131
 None
 1.08A 1hk1A-2odtX:
undetectable		 1hk1A-2odtX:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onf HYPOTHETICAL PROTEIN
TA0195

(Thermoplasma
acidophilum) 		PF02566
(OsmC) 		4 PHE A  46
PHE A  90
GLU A  43
VAL A  76
 None
 1.02A 1hk1A-2onfA:
2.4		 1hk1A-2onfA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4o HYPOTHETICAL PROTEIN

(Nostoc
punctiforme) 		no annotation 4 PHE A 261
GLU A 296
LEU A 295
VAL A 234
 None
 0.91A 1hk1A-2p4oA:
undetectable		 1hk1A-2p4oA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0o PROBABLE
TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Sinorhizobium
fredii) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 PHE A  30
LEU A  14
VAL A 157
MET A 156
 None
 0.84A 1hk1A-2q0oA:
undetectable		 1hk1A-2q0oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7m 5-FORMAMINOIMIDAZOLE
-4-CARBOXAMIDE-1-(BE
TA)-D-RIBOFURANOSYL
5'-MONOPHOSPHATE
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 PHE A 294
GLU A 221
LEU A 222
VAL A 271
 None
 1.01A 1hk1A-2r7mA:
undetectable		 1hk1A-2r7mA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 PHE A 267
GLU A 195
LEU A 196
VAL A 245
 None
 1.05A 1hk1A-2r87A:
undetectable		 1hk1A-2r87A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 PHE A 156
GLU A 136
LEU A 172
VAL A 116
 None
 0.98A 1hk1A-2vfvA:
undetectable		 1hk1A-2vfvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 PHE A 706
GLU A 709
LEU A 713
VAL A 692
 None
 1.02A 1hk1A-3apoA:
undetectable		 1hk1A-3apoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLU A 127
LEU A 125
VAL A  58
MET A  61
 None
 1.02A 1hk1A-3c8eA:
2.9		 1hk1A-3c8eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		4 GLU A 109
LEU A 110
VAL A 207
MET A 206
 None
 1.02A 1hk1A-3f41A:
3.1		 1hk1A-3f41A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhx PYRIDOXAL KINASE

(Homo sapiens) 		PF08543
(Phos_pyr_kin) 		4 GLU A  61
LEU A  62
VAL A  94
MET A  93
 SO4  A 320 (-2.8A)
None
None
SO4  A 316 (-4.8A)
 0.75A 1hk1A-3fhxA:
4.0		 1hk1A-3fhxA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1c THE TRPR LIKE
PROTEIN FROM
EUBACTERIUM ELIGENS
ATCC 27750

([Eubacterium]
eligens) 		PF01371
(Trp_repressor) 		5 PHE A  46
PHE A  90
GLU A  54
LEU A  52
VAL A  75
 None
 1.46A 1hk1A-3g1cA:
undetectable		 1hk1A-3g1cA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf8 PUTATIVE
POLYSACCHARIDE
BINDING PROTEINS
(DUF1812)

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		4 GLU A  61
LEU A  62
VAL A  39
MET A  89
 None
 1.08A 1hk1A-3gf8A:
undetectable		 1hk1A-3gf8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 GLU A1199
LEU A1200
VAL A1215
MET A1212
 None
 1.03A 1hk1A-3h0gA:
undetectable		 1hk1A-3h0gA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l MITOCHONDRIAL
UBIQUINOL-CYTOCHROME
-C REDUCTASE COMPLEX
CORE PROTEIN I

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 GLU A 393
LEU A 392
VAL A 366
MET A 365
 None
 0.90A 1hk1A-3h1lA:
undetectable		 1hk1A-3h1lA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE A   2
GLU A  92
LEU A  97
VAL A  68
 None
 0.90A 1hk1A-3hi8A:
undetectable		 1hk1A-3hi8A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5q NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		no annotation 4 PHE B1416
PHE B1391
GLU B1447
LEU B1451
 None
 1.00A 1hk1A-3i5qB:
3.7		 1hk1A-3i5qB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		4 GLU A 254
LEU A 253
VAL A 287
MET A 286
 None
 0.90A 1hk1A-3j1cA:
undetectable		 1hk1A-3j1cA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S2,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S23,
MITOCHONDRIAL

(Bos taurus) 		PF00318
(Ribosomal_S2) 		5 PHE B  62
PHE B 126
GLU B  54
LEU B  56
VAL b  34
 None
 1.46A 1hk1A-3jd5B:
2.7		 1hk1A-3jd5B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lx6 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PHE A  87
GLU A 451
LEU A 450
MET A 220
 None
 1.05A 1hk1A-3lx6A:
undetectable		 1hk1A-3lx6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Shigella
flexneri) 		PF00145
(DNA_methylase) 		4 PHE A  87
GLU A 451
LEU A 450
MET A 220
 None
 0.98A 1hk1A-3me5A:
undetectable		 1hk1A-3me5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		4 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
None
FMN  A 313 ( 4.9A)
None
 1.07A 1hk1A-3mhuA:
undetectable		 1hk1A-3mhuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 PHE A   8
LEU A 133
VAL A  16
MET A  15
 None
 0.91A 1hk1A-3oh8A:
undetectable		 1hk1A-3oh8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe5 UNCHARACTERIZED
PROTEIN

([Clostridium]
leptum) 		PF03816
(LytR_cpsA_psr) 		4 PHE A 199
PHE A 267
LEU A 206
VAL A 275
 None
 1.05A 1hk1A-3pe5A:
undetectable		 1hk1A-3pe5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5e ATLASTIN-1

(Homo sapiens) 		PF02263
(GBP) 		4 PHE A 293
PHE A  82
LEU A 286
VAL A 100
 None
GDP  A3850 (-4.2A)
None
None
 0.78A 1hk1A-3q5eA:
4.0		 1hk1A-3q5eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc2 SUGAR
3-KETOREDUCTASE

(Actinomadura
kijaniata) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 155
GLU A 245
LEU A 253
VAL A 140
 None
 1.07A 1hk1A-3rc2A:
undetectable		 1hk1A-3rc2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 PHE A 117
LEU A  32
VAL A 125
MET A 124
 None
 1.01A 1hk1A-3szbA:
undetectable		 1hk1A-3szbA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3l TABLYSIN 15

(Tabanus yao) 		PF00188
(CAP) 		4 PHE C 188
GLU C 155
LEU C 156
VAL C  50
 None
None
None
PLM  C 233 ( 4.1A)
 1.06A 1hk1A-3u3lC:
undetectable		 1hk1A-3u3lC:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wso F-BOX ONLY PROTEIN
44

(Homo sapiens) 		PF04300
(FBA)
PF12937
(F-box-like) 		4 PHE A 126
GLU A 107
LEU A 109
VAL A 122
 None
 1.04A 1hk1A-3wsoA:
undetectable		 1hk1A-3wsoA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc1 AFTRAX

(Archaeoglobus
fulgidus) 		PF01997
(Translin) 		4 GLU A 118
LEU A 119
VAL A 141
MET A 142
 None
 1.05A 1hk1A-3zc1A:
2.9		 1hk1A-3zc1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 PHE A 318
GLU A 174
LEU A 172
VAL A 197
 None
 0.94A 1hk1A-4a27A:
undetectable		 1hk1A-4a27A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac3 BIFUNCTIONAL PROTEIN
GLMU

(Streptococcus
pneumoniae) 		PF00132
(Hexapep)
PF00483
(NTP_transferase)
PF14602
(Hexapep_2) 		4 GLU A 182
LEU A 184
VAL A  82
MET A  83
 None
 0.86A 1hk1A-4ac3A:
undetectable		 1hk1A-4ac3A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 GLU A 180
LEU A 179
VAL A 267
MET A 268
 None
 1.05A 1hk1A-4bfrA:
undetectable		 1hk1A-4bfrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		4 PHE B 370
PHE B 455
LEU B 425
VAL B 427
 None
 1.01A 1hk1A-4cakB:
undetectable		 1hk1A-4cakB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 PHE A 141
PHE A 374
GLU A 175
VAL A 342
 None
 1.05A 1hk1A-4ehjA:
undetectable		 1hk1A-4ehjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fj4 UNCHARACTERIZED
PROTEIN

(Halobacterium
salinarum) 		PF07920
(DUF1684) 		4 PHE A 117
PHE A 151
LEU A  91
VAL A 136
 None
 1.05A 1hk1A-4fj4A:
undetectable		 1hk1A-4fj4A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 4 PHE A  39
GLU A  37
LEU A 235
VAL A  77
 None
 1.08A 1hk1A-4fq7A:
undetectable		 1hk1A-4fq7A:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		4 PHE A 140
PHE A  67
LEU A  58
MET A 164
 None
 0.90A 1hk1A-4gxtA:
undetectable		 1hk1A-4gxtA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 PHE M 122
PHE M 201
LEU M 115
VAL M 163
 None
 1.06A 1hk1A-4heaM:
1.8		 1hk1A-4heaM:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k08 METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER

(Anaeromyxobacter
dehalogenans) 		PF17200
(sCache_2) 		4 GLU A  82
LEU A  81
VAL A 105
MET A 106
 None
 0.97A 1hk1A-4k08A:
undetectable		 1hk1A-4k08A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzw GLUTATHIONE
S-TRANSFERASE

(Streptococcus
sanguinis) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 GLU A 124
LEU A 122
VAL A  55
MET A  58
 None
 1.05A 1hk1A-4mzwA:
2.6		 1hk1A-4mzwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 PHE A  59
GLU A  93
LEU A  97
MET A  66
 None
 0.90A 1hk1A-4n4pA:
undetectable		 1hk1A-4n4pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nax GLUTATHIONE
S-TRANSFERASE,
N-TERMINAL DOMAIN
PROTEIN

(Pseudomonas
putida) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 GLU A  99
LEU A  97
VAL A  34
MET A  37
 None
 1.01A 1hk1A-4naxA:
3.1		 1hk1A-4naxA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 286
GLU A 288
LEU A 112
VAL A 267
 None
 0.92A 1hk1A-4rcnA:
undetectable		 1hk1A-4rcnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wij SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 PHE A 394
PHE A 436
LEU A 387
VAL A 375
 None
 1.04A 1hk1A-4wijA:
undetectable		 1hk1A-4wijA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wik SPLICING FACTOR,
PROLINE- AND
GLUTAMINE-RICH

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 PHE A 394
PHE A 436
LEU A 387
VAL A 375
 None
 1.03A 1hk1A-4wikA:
undetectable		 1hk1A-4wikA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzh DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
braziliensis) 		PF01180
(DHO_dh) 		4 GLU A 278
LEU A 275
VAL A  22
MET A  23
 None
 0.97A 1hk1A-4wzhA:
undetectable		 1hk1A-4wzhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 PHE A  75
PHE A  64
GLU A  55
LEU A  54
 None
 0.94A 1hk1A-4zq8A:
undetectable		 1hk1A-4zq8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a62 PUTATIVE ALPHA/BETA
HYDROLASE FOLD
PROTEIN

(Candidatus
Nitrososphaera
gargensis) 		PF00561
(Abhydrolase_1) 		4 PHE A 265
GLU A 239
LEU A 240
VAL A 217
 None
 0.96A 1hk1A-5a62A:
undetectable		 1hk1A-5a62A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bpt MGC81278 PROTEIN

(Xenopus laevis) 		PF12894
(ANAPC4_WD40)
PF12896
(ANAPC4) 		4 PHE A 121
GLU A 240
LEU A 238
VAL A 111
 None
 0.86A 1hk1A-5bptA:
2.6		 1hk1A-5bptA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUCLEOPORIN NUP62
NUP54

(Xenopus laevis) 		PF05064
(Nsp1_C)
PF13874
(Nup54) 		4 GLU A 388
LEU A 389
VAL C 407
MET C 404
 None
 1.06A 1hk1A-5c3lA:
undetectable		 1hk1A-5c3lA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 PHE A  52
GLU A  78
LEU A  77
VAL A 121
 None
 1.01A 1hk1A-5cwdA:
undetectable		 1hk1A-5cwdA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxl TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Aspergillus
fumigatus) 		PF02358
(Trehalose_PPase) 		4 GLU A 131
LEU A 137
VAL A 114
MET A 115
 None
 0.82A 1hk1A-5dxlA:
2.7		 1hk1A-5dxlA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 PHE A 228
GLU A 269
LEU A 270
VAL A 352
 None
 1.06A 1hk1A-5e26A:
undetectable		 1hk1A-5e26A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis) 		PF00067
(p450) 		4 PHE A 112
LEU A 153
VAL A 229
MET A 230
 None
None
HEM  A 401 ( 4.3A)
None
 0.66A 1hk1A-5ex8A:
3.1		 1hk1A-5ex8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqh ANTI-CRISPR PROTEIN
3

(Pseudomonas
phage JBD5) 		no annotation 4 GLU B  16
LEU B  47
VAL B 102
MET B 103
 None
 1.01A 1hk1A-5gqhB:
2.3		 1hk1A-5gqhB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		4 PHE A 112
LEU A 153
VAL A 229
MET A 230
 None
None
HEM  A 401 ( 3.7A)
None
 0.91A 1hk1A-5hh3A:
undetectable		 1hk1A-5hh3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 PHE A 802
LEU A 841
VAL A 814
MET A 813
 None
 0.57A 1hk1A-5hzrA:
undetectable		 1hk1A-5hzrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		4 GLU A 302
LEU A 303
VAL A 436
MET A 435
 None
 1.08A 1hk1A-5jijA:
undetectable		 1hk1A-5jijA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kem BDBV91 VARIABLE FAB
DOMAIN LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 PHE C  62
GLU C  81
LEU C  78
VAL C  19
 None
 1.07A 1hk1A-5kemC:
undetectable		 1hk1A-5kemC:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kut MITOCHONDRIAL RHO
GTPASE 2

(Homo sapiens) 		no annotation 4 PHE A 567
PHE A 432
LEU A 520
VAL A 552
 None
 0.90A 1hk1A-5kutA:
undetectable		 1hk1A-5kutA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lso SPLICING FACTOR 45

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLU A 323
LEU A 322
VAL A 313
MET A 312
 None
 1.00A 1hk1A-5lsoA:
undetectable		 1hk1A-5lsoA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 PHE A 115
LEU A 170
VAL A 111
MET A 184
 None
 1.04A 1hk1A-5mifA:
undetectable		 1hk1A-5mifA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 4 PHE A 295
PHE A 529
LEU A 498
VAL A 270
 None
 1.05A 1hk1A-5odoA:
undetectable		 1hk1A-5odoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 PHE A 790
GLU A 669
LEU A 670
VAL A 714
 None
 1.01A 1hk1A-5te1A:
2.8		 1hk1A-5te1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tet ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 PHE B 790
GLU B 669
LEU B 670
VAL B 714
 None
 0.92A 1hk1A-5tetB:
undetectable		 1hk1A-5tetB:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES

(Drosophila
melanogaster) 		no annotation 4 PHE A1259
PHE A1277
LEU A1300
VAL A1312
 None
 1.00A 1hk1A-5vjcA:
undetectable		 1hk1A-5vjcA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x88 CUTINASE

(Malbranchea
cinnamomea) 		no annotation 4 PHE A  56
GLU A 195
LEU A 194
VAL A 107
 None
 1.03A 1hk1A-5x88A:
undetectable		 1hk1A-5x88A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpv AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 4 GLU A  63
LEU A  62
VAL A  33
MET A  34
 None
 1.01A 1hk1A-5xpvA:
undetectable		 1hk1A-5xpvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpw AMPHIOXUS IGVJ-C2

(Branchiostoma
floridae) 		no annotation 4 GLU A  63
LEU A  62
VAL A  33
MET A  34
 None
 1.08A 1hk1A-5xpwA:
undetectable		 1hk1A-5xpwA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN SA

(Trichomonas
vaginalis) 		PF00318
(Ribosomal_S2) 		4 PHE A 101
GLU A 134
VAL A  72
MET A 120
 None
A  21131 ( 3.1A)
None
None
 1.06A 1hk1A-5xyiA:
undetectable		 1hk1A-5xyiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P
KLLA0F20922P

(Kluyveromyces
lactis) 		no annotation 4 GLU A 523
LEU B 217
VAL A 186
MET A 187
 None
 0.90A 1hk1A-5y5aA:
undetectable		 1hk1A-5y5aA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yx3 CHALCONE-FLAVONONE
ISOMERASE FAMILY
PROTEIN

(Deschampsia
antarctica) 		no annotation 4 PHE A  79
GLU A 187
LEU A 186
VAL A  49
 None
 1.02A 1hk1A-5yx3A:
undetectable		 1hk1A-5yx3A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 4 GLU A 531
LEU A 532
VAL A 547
MET A 548
 None
 0.71A 1hk1A-5yxeA:
46.4		 1hk1A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9g ATLASTIN-1

(Homo sapiens) 		no annotation 4 PHE B 293
PHE B  82
LEU B 286
VAL B 100
 None
GDP  B 401 (-4.3A)
None
None
 0.61A 1hk1A-6b9gB:
undetectable		 1hk1A-6b9gB:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0m HEMAGGLUTININ-NEURAM
INIDASE

(Human
respirovirus 3) 		no annotation 4 PHE A 311
GLU A 341
LEU A 340
VAL A 378
 None
 0.94A 1hk1A-6c0mA:
undetectable		 1hk1A-6c0mA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 4 PHE A 214
PHE A 185
VAL A 142
MET A 141
 None
 1.04A 1hk1A-6c5cA:
undetectable		 1hk1A-6c5cA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
1

(Eremothecium
gossypii) 		no annotation 4 PHE A  74
GLU A  47
LEU A  50
VAL A  26
 None
 1.08A 1hk1A-6dexA:
undetectable		 1hk1A-6dexA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 GLU A  64
LEU A  63
VAL A 127
MET A 126
 None
 0.97A 1hk1A-6em0A:
undetectable		 1hk1A-6em0A:
8.91