SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK1_A_T44A3003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		4 ILE A 307
LYS A 256
ALA A 250
VAL A 298
 COA  A3000 (-4.4A)
COA  A3000 (-2.8A)
None
None
 0.93A 1hk1A-1aj8A:
1.6		 1hk1A-1aj8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chk CHITOSANASE

(Streptomyces
sp. N174) 		PF01374
(Glyco_hydro_46) 		4 LYS A  10
LYS A  11
ALA A  14
VAL A 127
 None
 0.68A 1hk1A-1chkA:
0.0		 1hk1A-1chkA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 HIS A  57
ILE A  54
ALA A 287
VAL A 167
 None
NAP  A 386 (-3.6A)
None
NAP  A 386 (-4.7A)
 1.04A 1hk1A-1civA:
undetectable		 1hk1A-1civA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		4 HIS A  51
ILE A  49
ALA A 300
VAL A  47
 None
 0.96A 1hk1A-1e19A:
0.6		 1hk1A-1e19A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN

(Homo sapiens) 		PF09034
(TRADD_N) 		4 HIS A  65
ILE A  64
ALA A  31
VAL A  41
 None
 0.99A 1hk1A-1f2hA:
undetectable		 1hk1A-1f2hA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpj GLUTAMYL-TRNA
REDUCTASE

(Methanopyrus
kandleri) 		PF00745
(GlutR_dimer)
PF01488
(Shikimate_DH)
PF05201
(GlutR_N) 		4 HIS A  70
ILE A  69
ALA A  62
VAL A  53
 None
 0.85A 1hk1A-1gpjA:
2.4		 1hk1A-1gpjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		4 LYS A 322
LYS A 321
ALA A 320
VAL A 190
 None
 1.04A 1hk1A-1iokA:
2.1		 1hk1A-1iokA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 ILE A  72
LYS A 113
ALA A 112
VAL A  42
 None
 0.93A 1hk1A-1iwpA:
0.0		 1hk1A-1iwpA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 HIS A 460
ILE A 363
ALA A 303
VAL A 344
 None
 1.05A 1hk1A-1kq0A:
0.0		 1hk1A-1kq0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 HIS A 233
ILE A 232
ALA A 194
VAL A 187
 MRD  A 503 (-4.0A)
None
None
None
 0.94A 1hk1A-1lamA:
undetectable		 1hk1A-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 HIS A 233
ILE A 232
ALA A 283
VAL A 187
 MRD  A 503 (-4.0A)
None
None
None
 0.99A 1hk1A-1lamA:
undetectable		 1hk1A-1lamA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		4 ILE B 119
LYS B  85
ALA B  87
VAL B 134
 None
 0.96A 1hk1A-1mioB:
undetectable		 1hk1A-1mioB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnt OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 HIS A 250
LYS A  75
ALA A 254
VAL A 310
 FE  A 333 ( 3.5A)
None
None
None
 1.02A 1hk1A-1nntA:
undetectable		 1hk1A-1nntA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ILE A 154
LYS A 446
ALA A 357
VAL A 394
 None
 0.94A 1hk1A-1ot5A:
undetectable		 1hk1A-1ot5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7h CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF01472
(PUA)
PF09183
(DUF1947) 		4 HIS A  82
ILE A  83
ALA A 137
VAL A 109
 ZN  A 201 (-3.9A)
None
None
None
 0.99A 1hk1A-1q7hA:
undetectable		 1hk1A-1q7hA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkq HYPOTHETICAL PROTEIN
YIDA

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		4 ILE A   4
LYS A 267
ALA A 264
VAL A 234
 None
 1.01A 1hk1A-1rkqA:
undetectable		 1hk1A-1rkqA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryo SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 HIS A 249
LYS A  78
ALA A 253
VAL A 305
 FE  A 329 ( 3.3A)
None
None
None
 1.01A 1hk1A-1ryoA:
undetectable		 1hk1A-1ryoA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ILE A 281
LYS A 267
ALA A 271
VAL A 334
 None
 0.93A 1hk1A-1suvA:
2.7		 1hk1A-1suvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		4 HIS A 164
ILE A 130
ALA A  98
VAL A 117
 None
 1.04A 1hk1A-1t35A:
undetectable		 1hk1A-1t35A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 HIS A  40
ILE A  41
LYS A 117
VAL A  15
 None
 1.04A 1hk1A-1uarA:
undetectable		 1hk1A-1uarA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		4 HIS A  40
ILE A 126
ALA A  20
VAL A  75
 None
 1.03A 1hk1A-1vgjA:
undetectable		 1hk1A-1vgjA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we7 SF3A1 PROTEIN

(Mus musculus) 		PF00240
(ubiquitin) 		4 HIS A  66
ILE A  65
ALA A 105
VAL A  30
 None
 1.04A 1hk1A-1we7A:
undetectable		 1hk1A-1we7A:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtz RIBOSE-5-PHOSPHATE
ISOMERASE

(Saccharomyces
cerevisiae) 		PF06026
(Rib_5-P_isom_A) 		4 HIS A 152
ILE A 215
ALA A 183
VAL A 161
 None
 0.98A 1hk1A-1xtzA:
undetectable		 1hk1A-1xtzA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 HIS A 510
LYS A 524
LYS A 525
ALA A 528
 None
 0.93A 1hk1A-1ysxA:
13.8		 1hk1A-1ysxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		5 ILE A 114
LYS A 273
LYS A 270
ALA A 271
VAL A 165
 None
 1.44A 1hk1A-1zbtA:
3.2		 1hk1A-1zbtA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zos 5'-METHYLTHIOADENOSI
NE /
S-ADENOSYLHOMOCYSTEI
NE NUCLEOSIDASE

(Streptococcus
pneumoniae) 		PF01048
(PNP_UDP_1) 		4 HIS A 164
ILE A 161
ALA A  81
VAL A 171
 None
 0.90A 1hk1A-1zosA:
undetectable		 1hk1A-1zosA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 HIS A 460
ILE A 363
ALA A 303
VAL A 344
 None
 1.02A 1hk1A-2aduA:
undetectable		 1hk1A-2aduA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		4 HIS A 376
ILE A 377
ALA A 431
VAL A 447
 None
 0.92A 1hk1A-2bvtA:
undetectable		 1hk1A-2bvtA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		4 HIS A 115
ILE A  51
ALA A  47
VAL A   7
 None
None
None
CL  A1143 ( 4.1A)
 0.80A 1hk1A-2cdpA:
undetectable		 1hk1A-2cdpA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 HIS A 250
LYS A  75
ALA A 254
VAL A 310
 AL  A 687 ( 3.3A)
None
None
None
 1.04A 1hk1A-2d3iA:
undetectable		 1hk1A-2d3iA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		4 ILE A 241
LYS A 276
ALA A 278
VAL A 174
 None
 0.95A 1hk1A-2eguA:
undetectable		 1hk1A-2eguA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		4 ILE A 168
LYS A 130
ALA A 214
VAL A 208
 None
 1.00A 1hk1A-2eo5A:
undetectable		 1hk1A-2eo5A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 HIS A 318
ILE A 317
ALA A 136
VAL A 269
 None
 1.01A 1hk1A-2gz3A:
undetectable		 1hk1A-2gz3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 HIS A 202
ILE A 201
ALA A 445
VAL A 450
 None
 1.04A 1hk1A-2h88A:
2.0		 1hk1A-2h88A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		4 ILE A 220
LYS A 252
ALA A 279
VAL A 305
 None
NA  A3001 ( 2.3A)
None
None
 1.02A 1hk1A-2hb6A:
undetectable		 1hk1A-2hb6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixb ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Elizabethkingia
meningoseptica) 		PF01408
(GFO_IDH_MocA) 		4 ILE A 414
LYS A 278
ALA A 255
VAL A 283
 None
 1.01A 1hk1A-2ixbA:
undetectable		 1hk1A-2ixbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		4 ILE A 114
LYS A  47
ALA A  40
VAL A  66
 None
 0.99A 1hk1A-2jj4A:
undetectable		 1hk1A-2jj4A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jk0 L-ASPARAGINASE

(Pectobacterium
carotovorum) 		PF00710
(Asparaginase) 		4 ILE A 188
LYS A 140
ALA A 142
VAL A 155
 None
 0.98A 1hk1A-2jk0A:
undetectable		 1hk1A-2jk0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbz 15 PROTEIN
(BACTERIOPHAGE SPP1
COMPLETE NUCLEOTIDE
SEQUENCE)

(Bacillus phage
SPP1) 		PF05135
(Phage_connect_1) 		4 ILE A  84
LYS A  68
ALA A  67
VAL A  88
 None
 0.96A 1hk1A-2kbzA:
undetectable		 1hk1A-2kbzA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n00 INTERFERON-INDUCIBLE
PROTEIN AIM2

(Mus musculus) 		PF02758
(PYRIN) 		4 LYS A  84
LYS A  85
ALA A  88
VAL A  62
 None
 1.05A 1hk1A-2n00A:
undetectable		 1hk1A-2n00A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 HIS A 159
ILE A 165
ALA A  91
VAL A 179
 None
AXX  A 753 ( 4.3A)
AXX  A 753 (-3.5A)
AXX  A 753 ( 4.6A)
 0.97A 1hk1A-2pziA:
3.2		 1hk1A-2pziA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 HIS A  70
ILE A  71
ALA A 309
VAL A  80
 None
 0.91A 1hk1A-2vosA:
3.5		 1hk1A-2vosA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		4 HIS A  97
ILE A  69
ALA A  54
VAL A  67
 None
ACT  A1344 ( 4.6A)
None
GOL  A1349 (-4.4A)
 0.98A 1hk1A-2waaA:
undetectable		 1hk1A-2waaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjv REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 HIS A 535
ILE A 534
ALA A 526
VAL A 519
 None
 1.00A 1hk1A-2wjvA:
2.0		 1hk1A-2wjvA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		4 HIS A 318
ILE A 319
ALA A 351
VAL A 221
 GDD  A 400 ( 4.9A)
None
None
None
 1.02A 1hk1A-2wvlA:
2.6		 1hk1A-2wvlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyr COBALT-ACTIVATED
PEPTIDASE TET1

(Pyrococcus
horikoshii) 		PF05343
(Peptidase_M42) 		4 ILE A  31
LYS A 185
ALA A 183
VAL A  47
 None
 1.01A 1hk1A-2wyrA:
undetectable		 1hk1A-2wyrA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 HIS A 398
ILE A 399
ALA A 390
VAL A 423
 None
 0.99A 1hk1A-2x3lA:
undetectable		 1hk1A-2x3lA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yu1 JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 1A

(Homo sapiens) 		PF02373
(JmjC) 		4 HIS A 284
ILE A 234
ALA A  51
VAL A 262
 FE2  A 600 ( 3.4A)
None
None
None
 1.05A 1hk1A-2yu1A:
undetectable		 1hk1A-2yu1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt)
no annotation 		4 ILE B  87
LYS B 105
ALA B 108
VAL A  69
 None
 1.00A 1hk1A-3aqcB:
undetectable		 1hk1A-3aqcB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 HIS A 114
ILE A 111
ALA A 150
VAL A 123
 None
 0.94A 1hk1A-3bfnA:
undetectable		 1hk1A-3bfnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ILE A  98
LYS A  12
ALA A  87
VAL A  72
 None
 1.04A 1hk1A-3bitA:
undetectable		 1hk1A-3bitA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1o EUGENOL SYNTHASE

(Clarkia breweri) 		PF05368
(NmrA) 		4 HIS A  92
ILE A  93
ALA A 100
VAL A  78
 None
 1.02A 1hk1A-3c1oA:
undetectable		 1hk1A-3c1oA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2

(Burkholderia
pseudomallei) 		PF00464
(SHMT) 		4 HIS A 226
LYS A 254
ALA A 258
VAL A 244
 None
 1.05A 1hk1A-3ecdA:
undetectable		 1hk1A-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewe NUCLEOPORIN NUP85

(Saccharomyces
cerevisiae) 		PF07575
(Nucleopor_Nup85) 		4 HIS B 403
ILE B 402
LYS B 427
ALA B 426
 None
 0.93A 1hk1A-3eweB:
3.1		 1hk1A-3eweB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 HIS A 269
ILE A 270
ALA A 230
VAL A 272
 None
 1.03A 1hk1A-3g1uA:
undetectable		 1hk1A-3g1uA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		4 HIS A 281
ILE A 280
ALA A 274
VAL A 337
 None
 0.90A 1hk1A-3g77A:
undetectable		 1hk1A-3g77A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 HIS A 257
ILE A 248
ALA A 261
VAL A  43
 None
 1.01A 1hk1A-3ljpA:
undetectable		 1hk1A-3ljpA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 HIS A  56
ILE A  55
ALA A 132
VAL A 254
 None
 0.93A 1hk1A-3nfbA:
undetectable		 1hk1A-3nfbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 582
LYS A 314
ALA A 317
VAL A 531
 None
1PE  A 602 (-2.8A)
None
None
 0.99A 1hk1A-3owaA:
1.0		 1hk1A-3owaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		4 HIS A  54
LYS A  82
ALA A  85
VAL A  75
 None
 0.91A 1hk1A-3p8aA:
undetectable		 1hk1A-3p8aA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdk PHOSPHOGLUCOSAMINE
MUTASE

(Bacillus
anthracis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 HIS A 175
ILE A 176
ALA A 248
VAL A 349
 None
 0.97A 1hk1A-3pdkA:
undetectable		 1hk1A-3pdkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 HIS A 203
ILE A 202
ALA A 250
VAL A 257
 None
 1.05A 1hk1A-3pxxA:
undetectable		 1hk1A-3pxxA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1i SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
marinum) 		PF13561
(adh_short_C2) 		4 ILE A  55
LYS A  25
ALA A  19
VAL A  38
 None
 0.98A 1hk1A-3r1iA:
undetectable		 1hk1A-3r1iA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rku OXIDOREDUCTASE
YMR226C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 ILE A 167
LYS A 172
ALA A 174
VAL A 123
 None
NAP  A 268 (-3.1A)
None
None
 0.88A 1hk1A-3rkuA:
undetectable		 1hk1A-3rkuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 HIS A  92
ILE A  91
ALA A  62
VAL A 161
 None
 1.06A 1hk1A-3tg9A:
undetectable		 1hk1A-3tg9A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		4 HIS A  90
ILE A  89
ALA A 153
VAL A 101
 None
 0.98A 1hk1A-3tr2A:
undetectable		 1hk1A-3tr2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ct7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12842
(DUF3819) 		4 HIS A1373
ILE A1374
ALA A1496
VAL A1393
 None
 1.00A 1hk1A-4ct7A:
undetectable		 1hk1A-4ct7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 HIS A 274
ILE A 194
LYS A 240
ALA A 243
 HIS  A 274 (-1.0A)
ILE  A 194 ( 0.7A)
LYS  A 240 ( 0.0A)
ALA  A 243 ( 0.0A)
 0.98A 1hk1A-4dlkA:
undetectable		 1hk1A-4dlkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9q 4-CARBOXYMUCONOLACTO
NE DECARBOXYLASE

(Sinorhizobium
meliloti) 		PF02627
(CMD) 		4 HIS A 201
ILE A 186
ALA A  61
VAL A 218
 None
 1.04A 1hk1A-4g9qA:
undetectable		 1hk1A-4g9qA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 HIS A  78
ILE A  77
ALA A 123
VAL A 137
 DMA  A 402 (-3.9A)
None
None
None
 0.90A 1hk1A-4gp1A:
2.2		 1hk1A-4gp1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ily CHITOSANASE

(Streptomyces
sp. SirexAA-E) 		PF01374
(Glyco_hydro_46) 		4 LYS A  62
LYS A  63
ALA A  66
VAL A 179
 None
 0.68A 1hk1A-4ilyA:
undetectable		 1hk1A-4ilyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		4 ILE A 211
LYS A 219
ALA A 223
VAL A 228
 MG  A 304 ( 3.7A)
None
None
None
 0.96A 1hk1A-4jejA:
undetectable		 1hk1A-4jejA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 HIS A 338
ILE A 341
ALA A 290
VAL A 334
 None
 0.98A 1hk1A-4kf7A:
1.0		 1hk1A-4kf7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 HIS A 313
ILE A 331
LYS A 337
VAL A 288
 None
 0.99A 1hk1A-4lcbA:
2.6		 1hk1A-4lcbA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4x ARYL HYDROCARBON
RECEPTOR

(Mus musculus) 		PF00989
(PAS) 		4 HIS A 161
ILE A 160
ALA A 263
VAL A 156
 None
 1.02A 1hk1A-4m4xA:
undetectable		 1hk1A-4m4xA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 HIS A 694
ILE A 693
ALA A 739
VAL A 707
 None
 0.99A 1hk1A-4oj5A:
undetectable		 1hk1A-4oj5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		4 ILE A  51
LYS A  20
ALA A  14
VAL A  33
 None
 0.83A 1hk1A-4rzhA:
undetectable		 1hk1A-4rzhA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 HIS A 198
ILE A 197
ALA A 277
VAL A 260
 None
 1.04A 1hk1A-4wkyA:
undetectable		 1hk1A-4wkyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xut ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		4 HIS A 235
ILE A 236
ALA A 176
VAL A 224
 None
 0.95A 1hk1A-4xutA:
undetectable		 1hk1A-4xutA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybn FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN

(Mycolicibacterium
smegmatis) 		PF12900
(Pyridox_ox_2) 		4 HIS A  63
ILE A  62
ALA A  73
VAL A  38
 HEM  A 304 ( 3.6A)
None
None
None
 1.06A 1hk1A-4ybnA:
undetectable		 1hk1A-4ybnA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 HIS A 637
ILE A 629
ALA A 625
VAL A 173
 None
 1.02A 1hk1A-5az4A:
undetectable		 1hk1A-5az4A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bk6 PUTATIVE AMIDASE

(Rhizobium
leguminosarum) 		no annotation 4 HIS A 142
ILE A 140
ALA A  31
VAL A 156
 None
 0.87A 1hk1A-5bk6A:
undetectable		 1hk1A-5bk6A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4g PHOSPHATIDYLINOSITOL
4-KINASE BETA

(Homo sapiens) 		PF00454
(PI3_PI4_kinase) 		4 HIS E 672
ILE E 671
ALA E 666
VAL E 598
 None
None
None
BQR  E 803 (-3.8A)
 1.05A 1hk1A-5c4gE:
undetectable		 1hk1A-5c4gE:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		4 ILE A1444
LYS A1197
ALA A1196
VAL A1423
 None
 0.97A 1hk1A-5deuA:
undetectable		 1hk1A-5deuA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 ILE A 512
LYS A 523
ALA A 527
VAL A 554
 None
 1.05A 1hk1A-5dqfA:
46.4		 1hk1A-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		4 HIS A 398
ILE A 399
LYS A 407
ALA A 410
 None
 0.95A 1hk1A-5fqeA:
0.9		 1hk1A-5fqeA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g56 CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase)
PF03422
(CBM_6) 		4 HIS A 169
ILE A 168
ALA A 155
VAL A 209
 None
 1.03A 1hk1A-5g56A:
undetectable		 1hk1A-5g56A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		4 HIS A  25
ILE A  78
ALA A  47
VAL A  80
 None
 0.91A 1hk1A-5ghsA:
undetectable		 1hk1A-5ghsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 ILE A 155
LYS A 160
ALA A 162
VAL A 110
 None
NAD  A 301 (-2.9A)
None
None
 0.87A 1hk1A-5ig2A:
undetectable		 1hk1A-5ig2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw7 RIBOSOME BIOGENESIS
PROTEIN
TSR1,RIBOSOME
BIOGENESIS PROTEIN
TSR1

(Saccharomyces
cerevisiae) 		PF04950
(RIBIOP_C)
PF08142
(AARP2CN) 		4 ILE A 148
LYS A 153
ALA A 155
VAL A  89
 None
 0.90A 1hk1A-5iw7A:
undetectable		 1hk1A-5iw7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdo HAPTOGLOBIN-HAEMOGLO
BIN RECEPTOR

(Trypanosoma
congolense) 		PF16731
(GARP) 		4 ILE B  56
LYS B  59
ALA B  63
VAL B 101
 None
 1.02A 1hk1A-5jdoB:
3.7		 1hk1A-5jdoB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy5 THIOREDOXIN

(Cryptococcus
neoformans) 		PF00085
(Thioredoxin) 		4 ILE A  84
LYS A 101
ALA A 104
VAL A  20
 None
 1.00A 1hk1A-5jy5A:
undetectable		 1hk1A-5jy5A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 26S PROTEASE
REGULATORY SUBUNIT 4

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 ILE d 351
LYS d 237
ALA d 240
VAL d 222
 None
 0.84A 1hk1A-5m32d:
undetectable		 1hk1A-5m32d:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		4 HIS A 738
ILE A 739
ALA A 677
VAL A 670
 None
 0.99A 1hk1A-5mswA:
3.1		 1hk1A-5mswA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00478
(IMPDH) 		4 ILE A 344
LYS A 352
ALA A 356
VAL A 361
 None
 1.01A 1hk1A-5uuwA:
undetectable		 1hk1A-5uuwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		4 HIS A  38
ILE A  37
ALA A  96
VAL A 115
 None
 1.03A 1hk1A-5x6sA:
undetectable		 1hk1A-5x6sA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bi4 DTDP-GLUCOSE
4,6-DEHYDRATASE

(Bacillus
anthracis) 		no annotation 4 ILE A 267
LYS A 203
ALA A 198
VAL A 253
 None
 1.02A 1hk1A-6bi4A:
undetectable		 1hk1A-6bi4A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 4 HIS A 663
ILE A 666
LYS A 673
ALA A 680
 None
 1.01A 1hk1A-6d14A:
undetectable		 1hk1A-6d14A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 4 HIS D 121
ILE D 137
ALA D 113
VAL D 104
 None
 0.89A 1hk1A-6e29D:
undetectable		 1hk1A-6e29D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 4 HIS D 121
ILE D 137
ALA D 125
VAL D 104
 None
 1.01A 1hk1A-6e29D:
undetectable		 1hk1A-6e29D:
undetectable