SIMILAR PATTERNS OF AMINO ACIDS FOR 1HK1_A_T44A3002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 GLN A 390
ASN A 391
LEU A 394
LEU A 407
LEU A 453
SER A 489
 None
 1.05A 1hk1A-1tf0A:
48.8		 1hk1A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 GLN A 390
LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
 None
 0.45A 1hk1A-1tf0A:
48.8		 1hk1A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcx UROPORPHYRINOGEN III
SYNTHASE

(Thermus
thermophilus) 		PF02602
(HEM4) 		5 GLN A 137
LEU A 138
LEU A 146
ARG A  97
LEU A  62
 None
None
None
GOL  A1001 (-3.6A)
None
 1.47A 1hk1A-1wcxA:
0.0		 1hk1A-1wcxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		5 GLN A  43
LEU A  39
LEU A  67
ARG A  70
LEU A   9
 None
 1.22A 1hk1A-3eq2A:
0.0		 1hk1A-3eq2A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 ASN A 391
LEU A 394
LEU A 407
TYR A 411
LEU A 453
SER A 489
 NPS  A 601 (-4.3A)
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 1.07A 1hk1A-4po0A:
46.1		 1hk1A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 GLN A 390
LEU A 394
LEU A 407
TYR A 411
LEU A 453
SER A 489
 None
None
NPS  A 601 ( 4.9A)
NPS  A 601 (-4.3A)
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.57A 1hk1A-4po0A:
46.1		 1hk1A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 GLN A 390
LEU A 394
TYR A 411
LYS A 414
LEU A 453
SER A 489
 None
None
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
NPS  A 601 (-4.7A)
NPS  A 601 (-3.1A)
 0.81A 1hk1A-4po0A:
46.1		 1hk1A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LEU A 430
ARG A 410
TYR A 411
LYS A 414
SER A 489
 NPS  A 601 ( 4.0A)
NPS  A 601 (-4.5A)
NPS  A 601 (-4.3A)
NPS  A 601 (-2.7A)
NPS  A 601 (-3.1A)
 1.39A 1hk1A-4po0A:
46.1		 1hk1A-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 ASN A 390
LEU A 393
LEU A 406
TYR A 410
LEU A 452
SER A 488
 None
 1.14A 1hk1A-5dqfA:
46.4		 1hk1A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 LEU A 393
LEU A 406
TYR A 410
LYS A 413
LEU A 452
SER A 488
 None
 0.70A 1hk1A-5dqfA:
46.4		 1hk1A-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ASN A 391
LEU A 394
LEU A 407
TYR A 411
LEU A 453
SER A 489
 None
 1.04A 1hk1A-5ghkA:
45.9		 1hk1A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
 None
 0.66A 1hk1A-5ghkA:
45.9		 1hk1A-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nh1 GASDERMIN-D

(Homo sapiens) 		PF04598
(Gasdermin) 		5 LEU A 447
LEU A 469
ARG A 465
LEU A 388
SER A 382
 None
 1.21A 1hk1A-5nh1A:
0.1		 1hk1A-5nh1A:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 ASN A 390
LEU A 393
LEU A 406
TYR A 410
LEU A 452
SER A 488
 None
 1.06A 1hk1A-5oriA:
45.3		 1hk1A-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 393
LEU A 406
TYR A 410
LYS A 413
LEU A 452
SER A 488
 None
 0.48A 1hk1A-5oriA:
45.3		 1hk1A-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 LEU A 429
ARG A 409
TYR A 410
LYS A 413
SER A 488
 None
 1.26A 1hk1A-5oriA:
45.3		 1hk1A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 ASN A 391
LEU A 394
LEU A 407
TYR A 411
LEU A 453
SER A 489
 None
 1.02A 1hk1A-5yxeA:
46.4		 1hk1A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 LEU A 394
LEU A 407
TYR A 411
LYS A 414
LEU A 453
SER A 489
 None
 0.56A 1hk1A-5yxeA:
46.4		 1hk1A-5yxeA:
11.11