SIMILAR PATTERNS OF AMINO ACIDS FOR 1HBP_A_RTLA184

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		5 ALA A 217
VAL A 127
MET A 218
TYR A 215
LEU A 165
 None
 1.31A 1hbpA-1aq0A:
0.0		 1hbpA-1aq0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		5 PHE A  87
ALA A  78
ALA A  68
VAL A  28
LEU A  74
 None
 1.35A 1hbpA-1ce7A:
0.0		 1hbpA-1ce7A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxy D-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Lactobacillus
casei) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 292
PHE A 195
ALA A 219
VAL A 290
MET A 243
 None
 1.23A 1hbpA-1dxyA:
0.0		 1hbpA-1dxyA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		5 LEU A 142
ALA A 125
VAL A  80
MET A 122
HIS A 105
 None
 1.29A 1hbpA-1dy6A:
0.0		 1hbpA-1dy6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e25 EXTENDED-SPECTRUM
BETA-LACTAMASE PER-1

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 ALA A 106
VAL A  97
TYR A 125
LEU A 122
GLN A 121
 None
 1.30A 1hbpA-1e25A:
undetectable		 1hbpA-1e25A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 LEU B  98
ALA B  90
MET B   8
MET B  23
LEU B  29
 None
 1.19A 1hbpA-1ep2B:
0.0		 1hbpA-1ep2B:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		5 PHE A  89
ALA A  80
ALA A  70
VAL A  29
LEU A  76
 None
 1.27A 1hbpA-1hwnA:
undetectable		 1hbpA-1hwnA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A 279
ALA A 293
ALA A 295
VAL A 281
MET A 296
 None
 1.24A 1hbpA-1i7oA:
0.0		 1hbpA-1i7oA:
16.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		6 ALA A  57
VAL A  61
MET A  73
LEU A  97
GLN A  98
HIS A 117
 RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.6A)
 1.32A 1hbpA-1iiuA:
32.2		 1hbpA-1iiuA:
79.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1iiu PLASMA
RETINOL-BINDING
PROTEIN

(Gallus gallus) 		PF00061
(Lipocalin) 		11 LEU A  35
PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
 RTL  A 176 (-4.5A)
RTL  A 176 ( 4.8A)
RTL  A 176 ( 3.8A)
RTL  A 176 ( 3.8A)
None
RTL  A 176 ( 4.0A)
RTL  A 176 (-3.4A)
RTL  A 176 ( 4.0A)
RTL  A 176 (-4.0A)
RTL  A 176 (-3.8A)
RTL  A 176 ( 4.7A)
 0.37A 1hbpA-1iiuA:
32.2		 1hbpA-1iiuA:
79.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1

(Homo sapiens) 		PF00005
(ABC_tran) 		5 LEU A 673
ALA A 548
VAL A 681
LEU A 653
GLN A 649
 None
 1.06A 1hbpA-1jj7A:
undetectable		 1hbpA-1jj7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 PHE A  35
ALA A  68
VAL A 229
LEU A 219
GLN A 217
 None
 1.33A 1hbpA-1khdA:
undetectable		 1hbpA-1khdA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2f KAIA

(Synechococcus
elongatus) 		no annotation 5 ALA A 123
ALA A 121
TYR A 116
LEU A 114
GLN A 113
 None
 1.26A 1hbpA-1m2fA:
undetectable		 1hbpA-1m2fA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj8 TALIN 1

(Mus musculus) 		PF09141
(Talin_middle) 		5 LEU A 495
ALA A 505
VAL A 577
LEU A 623
GLN A 627
 None
 1.35A 1hbpA-1sj8A:
undetectable		 1hbpA-1sj8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thm THERMITASE

(Thermoactinomyces
vulgaris) 		PF00082
(Peptidase_S8) 		5 LEU A 143
ALA A 182
ALA A 180
VAL A 147
LEU A 132
 None
None
NA  A 303 ( 4.1A)
None
None
 1.36A 1hbpA-1thmA:
undetectable		 1hbpA-1thmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 PHE A 114
ALA A 121
TYR A  37
LEU A 194
GLN A 195
 None
None
YSA  A3001 (-4.7A)
None
YSA  A3001 (-4.4A)
 1.23A 1hbpA-1vbmA:
undetectable		 1hbpA-1vbmA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wra TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/CHOLINE
BINDING PROTEIN E
(CBPE)

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A 273
PHE A 105
ALA A  55
VAL A 275
MET A 184
 None
 1.07A 1hbpA-1wraA:
undetectable		 1hbpA-1wraA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 LEU A 235
PHE A 228
ALA A 248
ALA A 251
LEU A 120
 None
 1.36A 1hbpA-1wytA:
undetectable		 1hbpA-1wytA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 LEU A 361
ALA A  20
ALA A  17
VAL A 363
LEU A  11
 None
None
None
None
EDO  A 501 (-3.7A)
 1.26A 1hbpA-1x3lA:
undetectable		 1hbpA-1x3lA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		5 ALA A 282
ALA A 278
VAL A 259
MET A 277
LEU A 247
 None
 1.32A 1hbpA-1x9jA:
undetectable		 1hbpA-1x9jA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 136
ALA A 139
VAL A 147
LEU A  51
GLN A  50
 None
 1.23A 1hbpA-1ysjA:
undetectable		 1hbpA-1ysjA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 LEU A  59
ALA A 202
ALA A 387
TYR A 395
LEU A 399
 None
 1.30A 1hbpA-1z6rA:
undetectable		 1hbpA-1z6rA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A  90
ALA A 154
VAL A 116
LEU A 172
HIS A 279
 None
 1.36A 1hbpA-2bi0A:
0.3		 1hbpA-2bi0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		5 LEU A 248
PHE A  80
ALA A  30
VAL A 250
MET A 159
 None
 1.11A 1hbpA-2bibA:
undetectable		 1hbpA-2bibA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		5 LEU A 118
PHE A 319
VAL A  98
MET A 172
LEU A 205
 None
 1.37A 1hbpA-2c6xA:
undetectable		 1hbpA-2c6xA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvz INOSITOL
MONOPHOSPHATASE 2

(Homo sapiens) 		PF00459
(Inositol_P) 		5 LEU A 227
ALA A 168
ALA A 221
VAL A 261
LEU A 211
 None
 1.27A 1hbpA-2fvzA:
1.3		 1hbpA-2fvzA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		5 PHE A  87
ALA A  86
ALA A  83
LEU A  10
GLN A   9
 None
 1.19A 1hbpA-2hujA:
undetectable		 1hbpA-2hujA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owy RECOMBINATION-ASSOCI
ATED PROTEIN RDGC

(Pseudomonas
aeruginosa) 		PF04381
(RdgC) 		5 LEU A 223
ALA A 185
VAL A 229
LEU A 214
GLN A 220
 None
 1.35A 1hbpA-2owyA:
0.8		 1hbpA-2owyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2w CITRATE SYNTHASE

(Thermotoga
maritima) 		PF00285
(Citrate_synt) 		5 ALA A  75
ALA A  77
VAL A  93
TYR A  82
LEU A  84
 None
 1.29A 1hbpA-2p2wA:
undetectable		 1hbpA-2p2wA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 LEU A 112
ALA A 190
ALA A 121
MET A 120
LEU A 244
 None
None
None
ACY  A 500 ( 4.4A)
None
 1.33A 1hbpA-2qc3A:
undetectable		 1hbpA-2qc3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrp AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		5 LEU B  59
ALA B  45
ALA B  48
VAL B 118
LEU B  54
 None
 1.37A 1hbpA-2vrpB:
undetectable		 1hbpA-2vrpB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzw PROBABLE HISTIDINE
KINASE RESPONSE
REGULATOR

(Mycobacterium
tuberculosis) 		PF13185
(GAF_2) 		5 LEU A 203
ALA A 189
ALA A 191
VAL A  86
LEU A  66
 None
 1.28A 1hbpA-2vzwA:
undetectable		 1hbpA-2vzwA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  35
PHE A  45
ALA A  55
ALA A  57
MET A  88
TYR A  90
 OLA  A1179 (-4.8A)
OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
 1.35A 1hbpA-2wq9A:
31.3		 1hbpA-2wq9A:
93.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wq9 RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		10 PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  73
MET A  88
TYR A  90
LEU A  97
GLN A  98
HIS A 104
 OLA  A1179 (-4.6A)
OLA  A1179 (-3.5A)
OLA  A1179 ( 3.7A)
None
OLA  A1179 ( 4.9A)
OLA  A1179 ( 3.8A)
OLA  A1179 (-3.7A)
None
None
OLA  A1179 (-4.5A)
 0.59A 1hbpA-2wq9A:
31.3		 1hbpA-2wq9A:
93.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ych COMPETENCE PROTEIN
PILM

(Thermus
thermophilus) 		PF11104
(PilM_2) 		5 LEU A 208
ALA A 365
VAL A 195
TYR A 179
LEU A 181
 None
 1.36A 1hbpA-2ychA:
undetectable		 1hbpA-2ychA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 LEU A 760
ALA A1048
ALA A1004
VAL A 765
GLN A 744
 None
 1.23A 1hbpA-2yocA:
undetectable		 1hbpA-2yocA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 256
ALA A 312
ALA A 172
VAL A 164
LEU A 251
 None
 1.35A 1hbpA-2z7rA:
undetectable		 1hbpA-2z7rA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 PHE A 412
ALA A 170
ALA A 174
LEU A 158
GLN A 157
 None
 1.28A 1hbpA-3bmaA:
undetectable		 1hbpA-3bmaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bx4 AGGRETIN BETA CHAIN

(Calloselasma
rhodostoma) 		PF00059
(Lectin_C) 		5 LEU B  59
ALA B  45
ALA B  48
VAL B 118
LEU B  54
 None
 1.35A 1hbpA-3bx4B:
undetectable		 1hbpA-3bx4B:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejb BIOTIN BIOSYNTHESIS
CYTOCHROME P450-LIKE
ENZYME

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU B 251
ALA B 139
ALA B 135
VAL B 391
LEU B 361
 None
 0.99A 1hbpA-3ejbB:
undetectable		 1hbpA-3ejbB:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fh3 PUTATIVE ECF-TYPE
SIGMA FACTOR
NEGATIVE EFFECTOR

(Bacillus
anthracis) 		PF12207
(DUF3600) 		5 LEU A  89
PHE A 147
MET A 154
TYR A 114
GLN A  90
 None
 1.25A 1hbpA-3fh3A:
undetectable		 1hbpA-3fh3A:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  35
PHE A  45
ALA A  55
ALA A  57
MET A  73
GLN A  98
 2T1  A 184 (-4.0A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.0A)
 1.15A 1hbpA-3fmzA:
30.5		 1hbpA-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
PHE A  45
ALA A  55
ALA A  57
MET A  88
TYR A  90
GLN A  98
HIS A 104
 2T1  A 184 (-4.0A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.0A)
2T1  A 184 (-3.7A)
 0.87A 1hbpA-3fmzA:
30.5		 1hbpA-3fmzA:
92.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		8 LEU A  35
PHE A  45
ALA A  55
ALA A  57
VAL A  61
MET A  88
TYR A  90
HIS A 104
 2T1  A 184 (-4.0A)
None
2T1  A 184 ( 4.3A)
2T1  A 184 (-3.6A)
None
2T1  A 184 (-3.1A)
2T1  A 184 (-3.8A)
2T1  A 184 (-3.7A)
 0.72A 1hbpA-3fmzA:
30.5		 1hbpA-3fmzA:
92.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvh MALATE DEHYDROGENASE

(Brucella
abortus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
NAD  A 400 ( 4.7A)
None
None
None
 1.26A 1hbpA-3gvhA:
undetectable		 1hbpA-3gvhA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		5 LEU A 164
ALA A 178
MET A 247
GLN A 168
HIS A  86
 None
 1.27A 1hbpA-3gzjA:
undetectable		 1hbpA-3gzjA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		5 PHE A  74
ALA A 133
VAL A 412
LEU A 161
HIS A 344
 None
 1.34A 1hbpA-3hd6A:
undetectable		 1hbpA-3hd6A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 112
ALA A  66
ALA A  70
VAL A  79
LEU A  40
 None
 1.02A 1hbpA-3i6tA:
undetectable		 1hbpA-3i6tA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9w SENSOR PROTEIN TORS

(Escherichia
coli) 		no annotation 5 LEU A 144
VAL A 249
TYR A 189
LEU A 196
GLN A 148
 None
 1.31A 1hbpA-3i9wA:
undetectable		 1hbpA-3i9wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		5 LEU A  42
PHE A  77
ALA A  74
VAL A  31
GLN A  15
 None
 1.35A 1hbpA-3ic5A:
undetectable		 1hbpA-3ic5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 322
PHE A 226
ALA A 227
VAL A 239
LEU A 247
 None
 1.07A 1hbpA-3il4A:
undetectable		 1hbpA-3il4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		5 LEU A 224
ALA A  43
ALA A  41
VAL A 226
LEU A 260
 None
 1.14A 1hbpA-3iomA:
undetectable		 1hbpA-3iomA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mew SAGA-ASSOCIATED
FACTOR 29 HOMOLOG

(Homo sapiens) 		PF07039
(DUF1325) 		5 LEU A 130
ALA A 247
ALA A 236
TYR A 260
GLN A 281
 None
 1.36A 1hbpA-3mewA:
undetectable		 1hbpA-3mewA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkb HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA

(Isurus
oxyrinchus;
Isurus
oxyrinchus) 		PF00042
(Globin)
PF00042
(Globin) 		5 LEU A 127
PHE B 117
ALA A  28
VAL A  66
LEU A  17
 None
 1.35A 1hbpA-3mkbA:
undetectable		 1hbpA-3mkbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		5 LEU A 486
ALA A 405
ALA A 481
VAL A 460
LEU A 412
 None
 1.21A 1hbpA-3mplA:
undetectable		 1hbpA-3mplA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no2 UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		no annotation 5 ALA A 234
VAL A  27
LEU A 264
GLN A 263
HIS A 252
 None
None
None
None
CIT  A   2 (-3.8A)
 1.14A 1hbpA-3no2A:
undetectable		 1hbpA-3no2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohw PHYCOBILISOME LCM
CORE-MEMBRANE LINKER
POLYPEPTIDE

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU B 814
ALA B 833
ALA B 837
MET B 838
LEU B 809
 None
 1.32A 1hbpA-3ohwB:
undetectable		 1hbpA-3ohwB:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os6 ISOCHORISMATE
SYNTHASE DHBC

(Bacillus
anthracis) 		PF00425
(Chorismate_bind) 		5 LEU A  58
ALA A 298
ALA A 296
VAL A  71
GLN A  55
 None
 1.27A 1hbpA-3os6A:
undetectable		 1hbpA-3os6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		5 LEU A 360
ALA A 373
ALA A 371
VAL A 121
LEU A 147
 HEM  A 501 (-4.3A)
None
None
None
None
 1.28A 1hbpA-3p3lA:
undetectable		 1hbpA-3p3lA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 ALA B 243
ALA B 368
MET B 248
TYR B 252
LEU B 375
 None
 1.35A 1hbpA-3p8cB:
undetectable		 1hbpA-3p8cB:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 LEU A  79
ALA A 427
ALA A 437
VAL A 219
LEU A  73
 None
None
FDA  A 483 (-3.3A)
None
None
 1.27A 1hbpA-3rhaA:
undetectable		 1hbpA-3rhaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 126
ALA A 138
ALA A 134
VAL A 314
GLN A 127
 SO4  A 320 (-3.9A)
None
None
None
None
 1.30A 1hbpA-3tqhA:
undetectable		 1hbpA-3tqhA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 LEU A 324
ALA A  15
ALA A  11
LEU A 331
GLN A  41
 None
 1.32A 1hbpA-3upyA:
undetectable		 1hbpA-3upyA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v75 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Streptomyces
avermitilis) 		PF00215
(OMPdecase) 		5 LEU A  20
ALA A  88
ALA A  86
VAL A  22
LEU A  54
 None
 1.24A 1hbpA-3v75A:
undetectable		 1hbpA-3v75A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		5 LEU A 381
ALA A 346
ALA A 343
VAL A 385
LEU A  54
 None
 1.04A 1hbpA-3v7pA:
undetectable		 1hbpA-3v7pA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A  77
ALA A 429
ALA A 439
VAL A 217
LEU A  71
 None
None
FAD  A 600 (-3.5A)
None
None
 1.14A 1hbpA-3zyxA:
undetectable		 1hbpA-3zyxA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ALA A 398
VAL A 376
TYR A 428
LEU A 409
GLN A 413
 None
 1.29A 1hbpA-4bx9A:
undetectable		 1hbpA-4bx9A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce4 MRPL15

(Sus scrofa) 		PF00828
(Ribosomal_L27A) 		5 LEU P 118
ALA P 166
ALA P 163
VAL P 138
LEU P  96
 None
 1.27A 1hbpA-4ce4P:
undetectable		 1hbpA-4ce4P:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ege DIPEPTIDASE PEPE

(Mycobacterium
ulcerans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A  75
ALA A 101
ALA A 103
VAL A  85
LEU A  55
 None
 1.25A 1hbpA-4egeA:
undetectable		 1hbpA-4egeA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		5 LEU A 581
ALA A 381
VAL A 461
TYR A 316
LEU A 330
 None
 1.30A 1hbpA-4fgmA:
undetectable		 1hbpA-4fgmA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 701 ( 4.6A)
None
 1.26A 1hbpA-4fxsA:
undetectable		 1hbpA-4fxsA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia) 		PF00933
(Glyco_hydro_3) 		5 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
 None
 1.00A 1hbpA-4g6cA:
undetectable		 1hbpA-4g6cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk9 AGGLUTININ (BOA)

(Burkholderia
oklahomensis) 		no annotation 5 LEU A 244
ALA A 141
ALA A 169
VAL A 177
MET A  30
 None
 1.18A 1hbpA-4gk9A:
3.2		 1hbpA-4gk9A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		5 LEU A 192
PHE A  91
ALA A  86
VAL A 101
LEU A 165
 None
 1.15A 1hbpA-4gysA:
undetectable		 1hbpA-4gysA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8a UREIDOGLYCOLATE
DEHYDROGENASE

(Escherichia
coli) 		PF02615
(Ldh_2) 		5 PHE A  67
ALA A  89
ALA A  85
VAL A  49
LEU A  33
 None
 1.31A 1hbpA-4h8aA:
undetectable		 1hbpA-4h8aA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 190
ALA A 265
ALA A 263
VAL A 239
LEU A 356
 None
 1.36A 1hbpA-4hjhA:
undetectable		 1hbpA-4hjhA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqe CARBOXYVINYL-CARBOXY
PHOSPHONATE
PHOSPHORYLMUTASE

(Bacillus
anthracis) 		PF13714
(PEP_mutase) 		5 LEU A  14
PHE A  97
ALA A  75
VAL A  82
GLN A  11
 None
 1.20A 1hbpA-4iqeA:
undetectable		 1hbpA-4iqeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix2 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH) 		5 PHE A 461
ALA A 354
ALA A 352
VAL A 362
GLN A 436
 None
None
None
IMP  A 501 (-4.4A)
None
 1.18A 1hbpA-4ix2A:
undetectable		 1hbpA-4ix2A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 PHE A 314
ALA A 341
ALA A 339
VAL A  93
LEU A  95
 None
 1.33A 1hbpA-4j1sA:
undetectable		 1hbpA-4j1sA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		5 LEU A  31
PHE A 169
ALA A 275
VAL A 123
LEU A 151
 None
None
None
FAD  A 601 (-4.3A)
None
 1.20A 1hbpA-4k2xA:
undetectable		 1hbpA-4k2xA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 LEU A 208
ALA A 152
ALA A 150
VAL A 130
LEU A 189
 None
None
None
None
ACT  A 302 ( 4.9A)
 1.34A 1hbpA-4ohnA:
undetectable		 1hbpA-4ohnA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 561
ALA A 570
ALA A 574
VAL A 750
GLN A 756
 None
None
GLC  A1010 (-3.5A)
None
None
 1.33A 1hbpA-4okdA:
undetectable		 1hbpA-4okdA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 LEU A 252
ALA A  88
VAL A 260
MET A  85
LEU A  30
 None
 1.35A 1hbpA-4pf6A:
undetectable		 1hbpA-4pf6A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 ALA A 314
ALA A 301
VAL A  56
LEU A 307
GLN A 310
 None
 1.30A 1hbpA-4pwvA:
undetectable		 1hbpA-4pwvA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 LEU A 505
ALA A 184
ALA A 418
MET A 419
LEU A 490
 None
 1.27A 1hbpA-4pxqA:
undetectable		 1hbpA-4pxqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 PHE A  61
ALA A 291
VAL A  16
LEU A 242
HIS A 284
 None
 1.04A 1hbpA-4rtbA:
undetectable		 1hbpA-4rtbA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 LEU A 168
PHE A 193
ALA A 195
VAL A 212
GLN A 165
 None
 1.31A 1hbpA-4wy9A:
undetectable		 1hbpA-4wy9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		5 LEU A  37
ALA A 433
ALA A 435
LEU A 402
GLN A 400
 None
 1.06A 1hbpA-4zm4A:
undetectable		 1hbpA-4zm4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 LEU A1084
ALA A 668
ALA A 672
VAL A1099
GLN A1116
 None
 1.29A 1hbpA-5a0zA:
undetectable		 1hbpA-5a0zA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e38 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Mycobacterium
tuberculosis) 		PF14681
(UPRTase) 		5 LEU A  32
ALA A 190
ALA A 133
VAL A 158
LEU A 196
 None
 1.36A 1hbpA-5e38A:
undetectable		 1hbpA-5e38A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		5 LEU A 281
ALA A 293
ALA A 291
MET A 288
LEU A 284
 None
 1.34A 1hbpA-5e9hA:
undetectable		 1hbpA-5e9hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 5 LEU A 135
ALA A 242
ALA A 246
MET A 247
LEU A 185
 None
 1.16A 1hbpA-5hssA:
undetectable		 1hbpA-5hssA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 PHE A 416
ALA A 268
ALA A 266
VAL A 409
LEU A 293
 None
 1.25A 1hbpA-5i67A:
undetectable		 1hbpA-5i67A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liy ALDO-KETO REDUCTASE
FAMILY 1 MEMBER B10

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 ALA X 136
ALA X 141
VAL X 159
LEU X 170
GLN X 166
 None
 1.20A 1hbpA-5liyX:
undetectable		 1hbpA-5liyX:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		5 LEU A 480
PHE A 660
ALA A 562
ALA A 558
HIS A 510
 None
 1.13A 1hbpA-5nnpA:
undetectable		 1hbpA-5nnpA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		5 LEU A 306
ALA A 284
ALA A 280
VAL A 272
GLN A 303
 None
None
None
None
IOD  A 501 ( 4.4A)
 1.25A 1hbpA-5t12A:
undetectable		 1hbpA-5t12A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2o J30 CCH

(Thermobacillus
composti) 		no annotation 5 LEU A 285
ALA A 366
ALA A 362
TYR A 331
GLN A 282
 None
 1.32A 1hbpA-5u2oA:
undetectable		 1hbpA-5u2oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulv MALATE DEHYDROGENASE

(Methylobacterium
extorquens) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 136
ALA A 145
TYR A 270
LEU A 130
GLN A 131
 None
 1.29A 1hbpA-5ulvA:
undetectable		 1hbpA-5ulvA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwz ALDEHYDE
DECARBONYLASE

(Gloeobacter
violaceus) 		no annotation 5 LEU A 156
ALA A 172
VAL A 109
MET A 224
LEU A 211
 None
 1.29A 1hbpA-5uwzA:
undetectable		 1hbpA-5uwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 LEU A  30
PHE A 165
ALA A 263
VAL A 122
LEU A 147
 None
None
None
FAD  A 501 (-4.0A)
None
 1.25A 1hbpA-6c7sA:
undetectable		 1hbpA-6c7sA:
undetectable