SIMILAR PATTERNS OF AMINO ACIDS FOR 1HA2_A_SWFA3001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 PHE A 198
ALA A 197
LEU A  23
ARG A  26
LEU A 161
 None
 1.04A 1ha2A-1ao0A:
undetectable		 1ha2A-1ao0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		5 LEU A 207
LEU A 178
LEU A 170
SER A 192
ALA A 190
 None
 1.08A 1ha2A-1e0tA:
0.0		 1ha2A-1e0tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ALA B 815
LEU B 595
LEU B 811
ILE B 882
ALA B 885
 None
 1.04A 1ha2A-1ej6B:
2.8		 1ha2A-1ej6B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 ALA A  76
LEU A 330
LEU A  54
ILE A  64
ALA A  69
 None
 1.06A 1ha2A-1exbA:
undetectable		 1ha2A-1exbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A  22
LEU A  21
SER A  63
ILE A  66
ALA A  67
 None
None
GDN  A 203 (-2.6A)
None
None
 0.93A 1ha2A-1gsqA:
undetectable		 1ha2A-1gsqA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mor GLUCOSAMINE
6-PHOSPHATE SYNTHASE

(Escherichia
coli) 		PF01380
(SIS) 		5 ALA A 285
LEU A 289
LEU A 281
LEU A 389
ILE A 344
 None
 0.98A 1ha2A-1morA:
undetectable		 1ha2A-1morA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf1 PROTEIN
(NEUROFIBROMIN)

(Homo sapiens) 		PF00616
(RasGAP) 		5 PHE A1247
LEU A1239
LEU A1490
ILE A1497
ALA A1226
 None
 1.07A 1ha2A-1nf1A:
undetectable		 1ha2A-1nf1A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spg HEMOGLOBIN

(Leiostomus
xanthurus) 		PF00042
(Globin) 		5 ALA A 137
LEU A 138
LEU A 134
ILE A  64
ALA A  67
 None
HEM  A 144 ( 4.9A)
None
CMO  A 145 ( 4.0A)
HEM  A 144 (-3.4A)
 0.98A 1ha2A-1spgA:
undetectable		 1ha2A-1spgA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6k PHENAZINE
BIOSYNTHESIS PROTEIN
PHZF

(Pseudomonas
fluorescens) 		PF02567
(PhzC-PhzF) 		6 ALA A  58
LEU A  94
LEU A  92
LEU A 105
ILE A  81
ALA A  82
 None
 1.41A 1ha2A-1t6kA:
undetectable		 1ha2A-1t6kA:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 ALA A 215
LEU A 219
ARG A 222
LEU A 238
HIS A 242
LEU A 260
SER A 287
ILE A 290
ALA A 291
 None
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.72A 1ha2A-1tf0A:
38.8		 1ha2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 PHE A 211
ALA A 215
LEU A 219
LEU A 238
HIS A 242
LEU A 260
SER A 287
ILE A 290
ALA A 291
 None
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.60A 1ha2A-1tf0A:
38.8		 1ha2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 PHE A 211
TRP A 214
ALA A 215
LEU A 219
HIS A 242
LEU A 260
SER A 287
ILE A 290
ALA A 291
 None
None
None
None
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.69A 1ha2A-1tf0A:
38.8		 1ha2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 PHE A 211
TRP A 214
ALA A 215
LEU A 219
ILE A 264
 None
 1.04A 1ha2A-1tf0A:
38.8		 1ha2A-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		9 TRP A 214
ALA A 215
LEU A 219
ARG A 222
HIS A 242
LEU A 260
SER A 287
ILE A 290
ALA A 291
 None
None
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.79A 1ha2A-1tf0A:
38.8		 1ha2A-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		5 ALA A1189
LEU A1003
LEU A1008
LEU A 983
SER A1134
 None
 0.96A 1ha2A-1vprA:
undetectable		 1ha2A-1vprA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		5 LEU A 361
ARG A 252
LEU A 370
SER A 224
ILE A 225
 None
 1.05A 1ha2A-1wcgA:
undetectable		 1ha2A-1wcgA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwx E74-LIKE FACTOR 5
ESE-2B

(Homo sapiens) 		PF00178
(Ets) 		5 ALA A  68
LEU A  11
LEU A  69
SER A  44
ALA A  48
 None
 1.07A 1ha2A-1wwxA:
undetectable		 1ha2A-1wwxA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		6 ALA A 228
LEU A 222
LEU A 199
HIS A 198
ILE A 173
ALA A 174
 None
 1.28A 1ha2A-2a9jA:
undetectable		 1ha2A-2a9jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		5 ALA A 124
LEU A 125
ARG A  97
LEU A  80
ALA A  94
 ACO  A1313 ( 3.8A)
None
None
ACO  A1313 (-4.2A)
None
 1.04A 1ha2A-2c27A:
undetectable		 1ha2A-2c27A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.04A 1ha2A-2g37A:
undetectable		 1ha2A-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 TRP A 166
ALA A 163
LEU A  96
LEU A 188
ALA A 182
 None
 0.86A 1ha2A-2hytA:
3.8		 1ha2A-2hytA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 ALA A 285
LEU A 289
LEU A 281
LEU A 389
ILE A 344
 None
 0.90A 1ha2A-2j6hA:
2.7		 1ha2A-2j6hA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqg TALIN-1

(Mus musculus) 		no annotation 6 ALA A 920
LEU A 917
LEU A1034
LEU A 994
SER A 992
ALA A 989
 None
 1.45A 1ha2A-2lqgA:
undetectable		 1ha2A-2lqgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml8 FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 210
LEU A 151
LEU A 206
LEU A 175
ILE A 186
 None
 1.02A 1ha2A-2ml8A:
undetectable		 1ha2A-2ml8A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00531
(Death) 		5 ALA H 856
LEU H 857
LEU H 853
LEU H 787
ALA H 796
 None
 1.00A 1ha2A-2of5H:
undetectable		 1ha2A-2of5H:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		5 ALA A 180
LEU A 181
SER A 106
ILE A 107
ALA A 108
 None
 1.06A 1ha2A-2p91A:
undetectable		 1ha2A-2p91A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		5 LEU A  53
LEU A  26
LEU A  18
ILE A  48
ALA A  45
 None
 1.08A 1ha2A-2qbuA:
undetectable		 1ha2A-2qbuA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 LEU A 318
LEU A  81
LEU A  66
SER A  68
ALA A  71
 None
 1.05A 1ha2A-2r9yA:
undetectable		 1ha2A-2r9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 284
LEU A 199
LEU A 203
SER A 206
ALA A 261
 None
 1.06A 1ha2A-2yxzA:
undetectable		 1ha2A-2yxzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.02A 1ha2A-3draB:
undetectable		 1ha2A-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ALA A 122
LEU A  60
LEU A 134
LEU A 109
SER A 113
 None
 1.01A 1ha2A-3eixA:
undetectable		 1ha2A-3eixA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epj TRNA
ISOPENTENYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01715
(IPPT) 		5 LEU A 315
LEU A 204
LEU A  34
ILE A 332
ALA A 333
 None
 1.07A 1ha2A-3epjA:
undetectable		 1ha2A-3epjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		5 ALA A 267
LEU A 268
LEU A 264
ILE A 199
ALA A 178
 None
 1.07A 1ha2A-3jzdA:
undetectable		 1ha2A-3jzdA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 PHE A  75
LEU A 149
LEU A  42
LEU A 224
ILE A 176
 None
 0.93A 1ha2A-3l84A:
undetectable		 1ha2A-3l84A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 ALA A  51
LEU A 172
LEU A  68
ILE A 179
ALA A 178
 None
 1.02A 1ha2A-3la2A:
undetectable		 1ha2A-3la2A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la2 GLOBAL NITROGEN
REGULATOR

(Nostoc sp. PCC
7120) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		5 PHE A 160
LEU A 174
LEU A 156
ILE A 183
ALA A 182
 None
 1.03A 1ha2A-3la2A:
undetectable		 1ha2A-3la2A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		5 LEU A 216
LEU A 193
LEU A 189
ILE A 167
ALA A 168
 None
 1.02A 1ha2A-3lntA:
undetectable		 1ha2A-3lntA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ALA A 121
LEU A  59
LEU A 133
LEU A 108
SER A 112
 None
 1.04A 1ha2A-3mwgA:
undetectable		 1ha2A-3mwgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2h BACTERIOFERRITIN

(Pseudomonas
aeruginosa) 		PF00210
(Ferritin) 		5 ALA A  99
LEU A 100
LEU A  14
LEU A  58
ILE A 118
 None
 1.04A 1ha2A-3r2hA:
undetectable		 1ha2A-3r2hA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 ALA A   2
LEU A 393
LEU A   4
LEU A 104
ALA A 386
 None
 1.05A 1ha2A-3rscA:
undetectable		 1ha2A-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqk PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Francisella
tularensis) 		PF00793
(DAHP_synth_1) 		5 PHE A 158
ALA A 159
LEU A 184
ILE A 167
ALA A 166
 None
 1.04A 1ha2A-3tqkA:
undetectable		 1ha2A-3tqkA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		5 ALA A  29
LEU A  25
LEU A  70
SER A 299
ALA A 301
 None
 1.07A 1ha2A-3u1hA:
undetectable		 1ha2A-3u1hA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		5 ALA A  55
LEU A 209
LEU A  95
SER A 163
ALA A  92
 None
 0.99A 1ha2A-3ufkA:
undetectable		 1ha2A-3ufkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 PHE A 405
ALA A 232
SER A 287
ILE A 290
ALA A 291
 None
 0.89A 1ha2A-3wajA:
2.9		 1ha2A-3wajA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 ALA A 556
LEU A 540
LEU A 461
SER A 525
ILE A 526
 None
 1.04A 1ha2A-4acqA:
2.7		 1ha2A-4acqA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B)
PF01267
(F-actin_cap_A) 		5 LEU B  16
LEU B  12
LEU B  28
ILE A  10
ALA A  11
 None
 1.04A 1ha2A-4akrB:
undetectable		 1ha2A-4akrB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 PHE A 523
LEU A 227
LEU A 229
LEU A 550
ALA A 176
 None
 1.05A 1ha2A-4bx9A:
3.3		 1ha2A-4bx9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		5 ALA A 173
LEU A 199
LEU A 177
LEU A  96
ALA A  83
 None
 0.94A 1ha2A-4ecgA:
undetectable		 1ha2A-4ecgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		5 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 1.06A 1ha2A-4ernA:
undetectable		 1ha2A-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		6 ALA A 213
LEU A 210
LEU A 215
LEU A 217
ILE A 260
ALA A 226
 None
 1.17A 1ha2A-4fmcA:
undetectable		 1ha2A-4fmcA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmf EXOENZYME T
PROBABLE CHAPERONE

(Pseudomonas
aeruginosa) 		PF05932
(CesT)
no annotation 		5 ALA A  59
LEU B  16
LEU B  30
LEU B  39
ILE B   9
 None
 1.01A 1ha2A-4jmfA:
undetectable		 1ha2A-4jmfA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jot ENOYL-COA HYDRATASE,
PUTATIVE

(Deinococcus
radiodurans) 		PF00378
(ECH_1) 		5 ALA A 126
LEU A 158
LEU A 122
ILE A 177
ALA A 182
 None
 0.99A 1ha2A-4jotA:
2.5		 1ha2A-4jotA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		5 PHE A 223
ALA A  84
SER A  38
ILE A  41
ALA A  42
 None
 1.01A 1ha2A-4k8lA:
undetectable		 1ha2A-4k8lA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 PHE A 530
ALA A 526
LEU A 522
ILE A1014
ALA A 517
 None
 1.03A 1ha2A-4kf7A:
undetectable		 1ha2A-4kf7A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		5 PHE A 125
ALA A 110
LEU A 123
ILE A 258
ALA A 192
 None
 0.99A 1ha2A-4kujA:
undetectable		 1ha2A-4kujA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
 None
 0.90A 1ha2A-4mbgB:
undetectable		 1ha2A-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 TRP A 245
ALA A   4
LEU A  91
ILE A  37
ALA A  36
 SO4  A 407 (-4.6A)
None
None
None
None
 1.04A 1ha2A-4nq3A:
undetectable		 1ha2A-4nq3A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 PHE A  61
ALA A  62
LEU A  27
LEU A 116
LEU A  91
 None
 0.93A 1ha2A-4olqA:
2.0		 1ha2A-4olqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A  49
LEU A  28
LEU A 142
ILE A 139
ALA A 137
 None
 0.96A 1ha2A-4p0vA:
undetectable		 1ha2A-4p0vA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 ALA A 304
LEU A 511
LEU A 280
ILE A 298
ALA A 299
 None
 0.81A 1ha2A-4pfwA:
undetectable		 1ha2A-4pfwA:
19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		8 TRP A 214
ALA A 215
LEU A 219
ARG A 222
LEU A 238
HIS A 242
LEU A 260
ILE A 290
 None
 0.58A 1ha2A-4po0A:
42.2		 1ha2A-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiq D-XYLOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF00083
(Sugar_tr) 		5 PHE A 363
ALA A 372
LEU A 373
ILE A 313
ALA A 314
 None
 0.90A 1ha2A-4qiqA:
undetectable		 1ha2A-4qiqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiq D-XYLOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF00083
(Sugar_tr) 		5 PHE A 363
LEU A 373
SER A 310
ILE A 313
ALA A 314
 None
 0.94A 1ha2A-4qiqA:
undetectable		 1ha2A-4qiqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		5 ALA A 521
LEU A 549
LEU A 517
LEU A 535
ILE A 174
 None
 0.99A 1ha2A-4r3uA:
undetectable		 1ha2A-4r3uA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 ALA O 630
LEU O 634
LEU O 601
LEU A1787
ALA A1792
 None
 0.90A 1ha2A-5a31O:
2.9		 1ha2A-5a31O:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c17 MERB2

(Bacillus
megaterium) 		PF03243
(MerB) 		5 ALA A 115
LEU A  93
ARG A  96
LEU A 113
ILE A  33
 None
 1.06A 1ha2A-5c17A:
undetectable		 1ha2A-5c17A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		5 LEU A 242
LEU A 250
LEU A 228
SER A 230
ALA A 233
 None
 0.98A 1ha2A-5c6gA:
2.5		 1ha2A-5c6gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		6 LEU A 167
LEU A 154
LEU A 137
SER A 135
ILE A 100
ALA A 131
 None
 1.24A 1ha2A-5c9eA:
3.1		 1ha2A-5c9eA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 ALA A 414
LEU A 415
LEU A 411
LEU A 229
ILE A 308
 None
 1.04A 1ha2A-5cjuA:
undetectable		 1ha2A-5cjuA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 ALA A  95
LEU A  96
LEU A  92
LEU A 210
ALA A 143
 None
 1.04A 1ha2A-5ck7A:
undetectable		 1ha2A-5ck7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN

(Mycolicibacterium
smegmatis) 		PF05108
(T7SS_ESX1_EccB) 		5 ALA A 458
LEU A 106
LEU A 431
ILE A 422
ALA A 423
 None
 0.98A 1ha2A-5cyuA:
undetectable		 1ha2A-5cyuA:
19.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 TRP A 213
LEU A 218
LEU A 237
HIS A 241
LEU A 259
SER A 286
ILE A 289
ALA A 290
 None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 ( 4.5A)
PG4  A 602 (-3.9A)
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
 0.62A 1ha2A-5dqfA:
43.1		 1ha2A-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		5 ALA B  38
LEU B 186
LEU B  35
ILE B 170
ALA B 167
 None
 1.04A 1ha2A-5exeB:
undetectable		 1ha2A-5exeB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa9 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Treponema
denticola) 		PF01625
(PMSR)
PF01641
(SelR) 		5 ALA A 243
LEU A 244
LEU A 219
LEU A 291
ALA A 266
 None
 0.91A 1ha2A-5fa9A:
undetectable		 1ha2A-5fa9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 1.06A 1ha2A-5fmf1:
undetectable		 1ha2A-5fmf1:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		6 PHE A 376
ALA A 308
LEU A 312
ARG A 315
LEU A 388
LEU A 345
 None
 1.47A 1ha2A-5ft6A:
undetectable		 1ha2A-5ft6A:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		7 PHE A 211
TRP A 214
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ALA A 291
 None
 0.93A 1ha2A-5ghkA:
39.7		 1ha2A-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 PHE A 211
TRP A 214
LEU A 219
LEU A 238
HIS A 242
LEU A 260
SER A 287
ALA A 291
 None
 0.68A 1ha2A-5ghkA:
39.7		 1ha2A-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 PHE A 143
LEU A 176
LEU A 164
SER A 160
ILE A 183
 None
 0.99A 1ha2A-5gs0A:
undetectable		 1ha2A-5gs0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 TRP B1317
ALA B1318
LEU B1322
LEU B1423
ALA B1368
 None
 1.02A 1ha2A-5hb4B:
undetectable		 1ha2A-5hb4B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		5 ALA A 119
LEU A 120
LEU A 135
HIS A  93
SER A 128
 61G  A 403 (-4.8A)
None
61G  A 403 ( 4.5A)
PIS  A 402 (-4.1A)
None
 1.07A 1ha2A-5hc8A:
undetectable		 1ha2A-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 ALA B 407
LEU B 403
LEU B 337
LEU B 826
ALA B 777
 None
 0.92A 1ha2A-5khnB:
3.2		 1ha2A-5khnB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 ALA B 822
LEU B 337
LEU B 826
ILE B 776
ALA B 777
 None
 1.02A 1ha2A-5khnB:
3.2		 1ha2A-5khnB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17

(Homo sapiens) 		PF00293
(NUDIX) 		5 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.00A 1ha2A-5lf8A:
undetectable		 1ha2A-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		5 ALA A 258
LEU A 255
LEU A 193
ILE A 211
ALA A 207
 None
None
EDO  A 605 ( 4.0A)
None
None
 1.07A 1ha2A-5m77A:
undetectable		 1ha2A-5m77A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgy FAD:PROTEIN FMN
TRANSFERASE

(Pseudomonas
stutzeri) 		no annotation 5 ALA H 215
LEU H 245
LEU H 213
ILE H 229
ALA H 228
 None
 1.06A 1ha2A-5mgyH:
undetectable		 1ha2A-5mgyH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		5 ALA A 196
LEU A 197
LEU A 185
LEU A 319
ILE A 403
 None
 1.03A 1ha2A-5mwlA:
undetectable		 1ha2A-5mwlA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 LEU A 218
LEU A 237
HIS A 241
LEU A 259
SER A 286
ILE A 289
ALA A 290
 None
 0.83A 1ha2A-5oriA:
41.6		 1ha2A-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		5 ALA A 219
LEU A 217
LEU A 200
LEU A 188
ILE A  19
 None
 1.05A 1ha2A-5te1A:
undetectable		 1ha2A-5te1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A  18
LEU A 112
LEU A 306
LEU A  48
ILE A  46
 None
 1.06A 1ha2A-5tulA:
undetectable		 1ha2A-5tulA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ALA A 380
LEU A 381
LEU A 377
LEU A 366
ALA A 207
 None
 0.89A 1ha2A-5tw7A:
undetectable		 1ha2A-5tw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj1 DNA TOPOISOMERASE 1

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 698
LEU A 693
LEU A 666
SER A 643
ILE A 644
 None
 1.07A 1ha2A-5uj1A:
undetectable		 1ha2A-5uj1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		5 PHE A 270
TRP A 273
ALA A 274
LEU A 278
ILE A 337
 None
 0.78A 1ha2A-5uljA:
undetectable		 1ha2A-5uljA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vve PHOSPHOGLYCERATE
MUTASE

(Naegleria
fowleri) 		PF00300
(His_Phos_1) 		5 LEU A 217
LEU A 194
LEU A 190
ILE A 168
ALA A 169
 None
 1.05A 1ha2A-5vveA:
undetectable		 1ha2A-5vveA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk1 MAJOR CAPSID PROTEIN

(Pseudoalteromonas
phage TW1) 		no annotation 5 LEU A 229
LEU A 210
LEU A 214
SER A 248
ILE A 247
 None
 0.97A 1ha2A-5wk1A:
undetectable		 1ha2A-5wk1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 PHE A 626
ALA A 630
LEU A 634
ILE A 562
ALA A 602
 None
 1.06A 1ha2A-5wvgA:
undetectable		 1ha2A-5wvgA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 PHE A 211
TRP A 214
LEU A 219
LEU A 238
HIS A 242
LEU A 260
SER A 287
ILE A 290
 None
 0.69A 1ha2A-5yxeA:
38.2		 1ha2A-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 6 PHE A 192
ALA A 188
LEU A 184
LEU A  70
ILE A 104
ALA A 156
 None
 1.39A 1ha2A-6c43A:
undetectable		 1ha2A-6c43A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 5 ALA B  33
LEU B  21
LEU D  52
SER D  50
ALA D  47
 None
 0.97A 1ha2A-6cfwB:
4.7		 1ha2A-6cfwB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgb IS607 FAMILY
TRANSPOSASE IS1535

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 134
LEU A 135
LEU A 131
LEU A 123
ILE A 106
 None
 1.01A 1ha2A-6dgbA:
undetectable		 1ha2A-6dgbA:
undetectable