SIMILAR PATTERNS OF AMINO ACIDS FOR 1H9Z_A_RWFA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		5 PHE A 198
ALA A 197
LEU A  23
ARG A  26
LEU A 161
 None
 1.06A 1h9zA-1ao0A:
undetectable		 1h9zA-1ao0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ALA B 815
LEU B 595
ARG B 592
LEU B 811
LEU B 886
 None
 1.15A 1h9zA-1ej6B:
2.6		 1h9zA-1ej6B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 ALA A 202
LEU A 206
LEU A 198
LEU A  54
ALA A  66
 None
 1.15A 1h9zA-1iugA:
undetectable		 1h9zA-1iugA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		5 ALA A 240
LEU A 241
LEU A 295
LEU A 419
ALA A 423
 None
 1.05A 1h9zA-1l5aA:
undetectable		 1h9zA-1l5aA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw1 CONSERVED
HYPOTHETICAL PROTEIN
YFFB

(Pseudomonas
aeruginosa) 		PF03960
(ArsC) 		5 ALA A  17
LEU A  21
LEU A  95
ARG A 100
ALA A 113
 None
None
None
IPA  A 300 (-3.4A)
None
 1.15A 1h9zA-1rw1A:
undetectable		 1h9zA-1rw1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1d APYRASE

(Homo sapiens) 		PF06079
(Apyrase) 		5 ALA A  38
LEU A 100
LEU A  59
LEU A  84
ALA A  41
 None
 1.17A 1h9zA-1s1dA:
undetectable		 1h9zA-1s1dA:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		10 PHE A 211
ALA A 215
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
None
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
CIT  A2001 ( 3.9A)
 0.74A 1h9zA-1tf0A:
38.2		 1h9zA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		10 PHE A 211
TRP A 214
ALA A 215
LEU A 219
ARG A 222
HIS A 242
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
None
None
None
CIT  A2001 ( 2.9A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
CIT  A2001 ( 3.9A)
 0.83A 1h9zA-1tf0A:
38.2		 1h9zA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		5 ALA A  94
LEU A  71
LEU A  73
LEU A 129
ALA A  40
 None
 1.12A 1h9zA-1v9sA:
undetectable		 1h9zA-1v9sA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ALA A 156
LEU A 160
LEU A 148
LEU A 140
ALA A 135
 None
 1.13A 1h9zA-1vf1A:
undetectable		 1h9zA-1vf1A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpr LUCIFERASE

(Lingulodinium
polyedra) 		PF10284
(Luciferase_3H)
PF10285
(Luciferase_cat) 		5 ALA A1189
LEU A1003
LEU A1008
LEU A 983
SER A1134
 None
 0.97A 1h9zA-1vprA:
undetectable		 1h9zA-1vprA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwx E74-LIKE FACTOR 5
ESE-2B

(Homo sapiens) 		PF00178
(Ets) 		5 ALA A  68
LEU A  11
LEU A  69
SER A  44
ALA A  48
 None
 1.11A 1h9zA-1wwxA:
undetectable		 1h9zA-1wwxA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c27 MYCOTHIOL SYNTHASE

(Mycobacterium
tuberculosis) 		PF00583
(Acetyltransf_1) 		5 ALA A 124
LEU A 125
ARG A  97
LEU A  80
ALA A  94
 ACO  A1313 ( 3.8A)
None
None
ACO  A1313 (-4.2A)
None
 1.02A 1h9zA-2c27A:
undetectable		 1h9zA-2c27A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 ALA A 248
LEU A 249
LEU A 245
LEU A 284
SER A 117
 None
 1.08A 1h9zA-2c2nA:
1.9		 1h9zA-2c2nA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0n PRECORRIN-2
C20-METHYLTRANSFERAS
E

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		5 ALA A  50
LEU A  12
LEU A  54
LEU A  59
ALA A 100
 None
 1.09A 1h9zA-2e0nA:
undetectable		 1h9zA-2e0nA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fd5 TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		5 ALA A 145
LEU A 149
LEU A 135
LEU A  70
ALA A  87
 None
 1.11A 1h9zA-2fd5A:
undetectable		 1h9zA-2fd5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.00A 1h9zA-2g37A:
undetectable		 1h9zA-2g37A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyt TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Pectobacterium
atrosepticum) 		PF00440
(TetR_N) 		5 TRP A 166
ALA A 163
LEU A  96
LEU A 188
ALA A 182
 None
 0.86A 1h9zA-2hytA:
3.2		 1h9zA-2hytA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 218
LEU A 221
LEU A 247
SER A 249
ALA A 253
 None
None
None
SO4  A 801 (-3.0A)
None
 1.14A 1h9zA-2i6uA:
undetectable		 1h9zA-2i6uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 ALA A 231
LEU A 101
LEU A 232
HIS A 229
LEU A 206
 None
 1.13A 1h9zA-2ja2A:
undetectable		 1h9zA-2ja2A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 240
LEU A 324
LEU A 290
LEU A 376
ALA A 309
 None
 1.14A 1h9zA-2jiiA:
undetectable		 1h9zA-2jiiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lqg TALIN-1

(Mus musculus) 		no annotation 6 ALA A 920
LEU A 917
LEU A1034
LEU A 994
SER A 992
ALA A 989
 None
 1.48A 1h9zA-2lqgA:
2.2		 1h9zA-2lqgA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00531
(Death) 		5 ALA H 856
LEU H 857
LEU H 853
LEU H 787
ALA H 796
 None
 1.01A 1h9zA-2of5H:
undetectable		 1h9zA-2of5H:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus) 		PF12796
(Ank_2) 		5 ALA A 180
LEU A 186
LEU A 177
LEU A 219
ALA A 225
 ALA  A 180 ( 0.0A)
LEU  A 186 ( 0.5A)
LEU  A 177 ( 0.6A)
LEU  A 219 ( 0.6A)
ALA  A 225 ( 0.0A)
 1.12A 1h9zA-2pnnA:
undetectable		 1h9zA-2pnnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8w AGR_C_1641P

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		5 ALA A 321
LEU A 276
LEU A 322
LEU A 296
ALA A 291
 None
 1.17A 1h9zA-2r8wA:
2.5		 1h9zA-2r8wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus) 		PF00079
(Serpin) 		5 LEU A 318
LEU A  81
LEU A  66
SER A  68
ALA A  71
 None
 1.07A 1h9zA-2r9yA:
undetectable		 1h9zA-2r9yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		5 ALA C 156
LEU C 157
LEU C 128
LEU C 125
ALA C  32
 None
 1.13A 1h9zA-2vpwC:
2.4		 1h9zA-2vpwC:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 ALA A 389
LEU A 390
LEU A 386
LEU A 369
ALA A 337
 None
 1.09A 1h9zA-2zyjA:
undetectable		 1h9zA-2zyjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ah5 THYMIDYLATE SYNTHASE
THYX

(Helicobacter
pylori) 		PF02511
(Thy1) 		5 ALA A 169
LEU A 112
LEU A 155
LEU A 152
SER A 176
 None
 1.01A 1h9zA-3ah5A:
2.6		 1h9zA-3ah5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT

(Candida
albicans) 		PF00432
(Prenyltrans) 		5 LEU B 367
LEU B   4
HIS B   9
LEU B 326
ALA B 353
 None
 1.03A 1h9zA-3draB:
undetectable		 1h9zA-3draB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 PHE C 195
ALA C 175
LEU C 161
LEU C 145
SER C 119
 None
 1.12A 1h9zA-3dwlC:
undetectable		 1h9zA-3dwlC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eix HTSA PROTEIN

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ALA A 122
LEU A  60
LEU A 134
LEU A 109
SER A 113
 None
 1.05A 1h9zA-3eixA:
undetectable		 1h9zA-3eixA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 178
LEU A 260
ARG A 255
LEU A 253
ALA A 248
 None
 1.10A 1h9zA-3enkA:
undetectable		 1h9zA-3enkA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3god CAS1

(Pseudomonas
aeruginosa) 		PF01867
(Cas_Cas1) 		5 ALA A 180
LEU A 177
ARG A 138
LEU A 186
LEU A 253
 None
 1.12A 1h9zA-3godA:
undetectable		 1h9zA-3godA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		5 LEU A  58
LEU A  81
LEU A  70
SER A 339
ALA A 341
 None
 1.10A 1h9zA-3h1wA:
undetectable		 1h9zA-3h1wA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hg7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Aeromonas
salmonicida) 		PF02826
(2-Hacid_dh_C) 		5 ALA A  65
LEU A  68
LEU A  62
LEU A  81
ALA A  53
 None
 1.15A 1h9zA-3hg7A:
undetectable		 1h9zA-3hg7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9x MUTT/NUDIX FAMILY
PROTEIN

(Listeria
innocua) 		PF00293
(NUDIX) 		5 PHE A 145
ALA A 150
LEU A 163
LEU A  48
ALA A 156
 None
 1.12A 1h9zA-3i9xA:
undetectable		 1h9zA-3i9xA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkl PROBABLE CHAPERONE
PROTEIN HSP33

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A 110
LEU A 142
LEU A 111
HIS A 108
LEU A 179
 None
 1.17A 1h9zA-3kklA:
undetectable		 1h9zA-3kklA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwg IRON-REGULATED ABC
TRANSPORTER
SIDEROPHORE-BINDING
PROTEIN SIRA

(Staphylococcus
aureus) 		PF01497
(Peripla_BP_2) 		5 ALA A 121
LEU A  59
LEU A 133
LEU A 108
SER A 112
 None
 1.08A 1h9zA-3mwgA:
undetectable		 1h9zA-3mwgA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		5 PHE A 321
ALA A 326
LEU A 330
ARG A 298
LEU A 295
 SO4  A 422 (-4.1A)
None
None
None
None
 1.05A 1h9zA-3n0lA:
2.1		 1h9zA-3n0lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 110
LEU A 134
ARG A 133
SER A 131
ALA A  17
 None
 1.11A 1h9zA-3nwrA:
undetectable		 1h9zA-3nwrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg6 E3 UBIQUITIN-PROTEIN
LIGASE DTX3L

(Homo sapiens) 		no annotation 5 ALA A 662
LEU A 664
HIS A 707
ARG A 729
SER A 725
 None
 1.14A 1h9zA-3pg6A:
undetectable		 1h9zA-3pg6A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 ALA A   2
LEU A 393
LEU A   4
LEU A 104
ALA A 386
 None
 1.08A 1h9zA-3rscA:
undetectable		 1h9zA-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		5 ALA A  99
LEU A 100
ARG A 391
LEU A 137
ALA A 109
 None
 0.98A 1h9zA-3t66A:
undetectable		 1h9zA-3t66A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		5 ALA A  29
LEU A  25
LEU A  70
SER A 299
ALA A 301
 None
 1.11A 1h9zA-3u1hA:
undetectable		 1h9zA-3u1hA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		5 ALA A  55
LEU A 209
LEU A  95
SER A 163
ALA A  92
 None
 1.05A 1h9zA-3ufkA:
undetectable		 1h9zA-3ufkA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT

(Thermus
aquaticus) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 PHE B 147
ALA B 152
LEU B 172
LEU B 192
ALA B 159
 None
 1.14A 1h9zA-3ufxB:
undetectable		 1h9zA-3ufxB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp8 ALLOPHANATE
HYDROLASE

(Pseudomonas sp.
ADP) 		PF01425
(Amidase) 		5 ALA A 125
LEU A  83
LEU A 122
LEU A 182
ALA A 238
 None
 1.12A 1h9zA-4cp8A:
undetectable		 1h9zA-4cp8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecg PUTATIVE
IRON-REGULATED
PROTEIN A

(Parabacteroides
distasonis) 		PF09375
(Peptidase_M75) 		5 ALA A 173
LEU A 199
LEU A 177
LEU A  96
ALA A  83
 None
 0.95A 1h9zA-4ecgA:
undetectable		 1h9zA-4ecgA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ern TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPB
SUBUNIT

(Homo sapiens) 		PF16203
(ERCC3_RAD25_C) 		5 LEU A 662
LEU A 547
HIS A 551
LEU A 693
ALA A 508
 None
 1.09A 1h9zA-4ernA:
undetectable		 1h9zA-4ernA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3v OXIDOREDUCTASE
DOMAIN PROTEIN

(Kribbella
flavida) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 194
LEU A 189
LEU A 215
SER A 376
ALA A 372
 None
 1.16A 1h9zA-4h3vA:
undetectable		 1h9zA-4h3vA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbq MUCOSAL ADDRESSIN
CELL ADHESION
MOLECULE 1

(Homo sapiens) 		PF09085
(Adhes-Ig_like) 		5 ALA A 139
LEU A 129
LEU A 103
SER A  99
ALA A 111
 None
 1.13A 1h9zA-4hbqA:
undetectable		 1h9zA-4hbqA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 PHE A 224
ALA A 259
LEU A 198
SER A 200
ALA A 252
 None
 1.14A 1h9zA-4hehA:
3.4		 1h9zA-4hehA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
 None
 0.94A 1h9zA-4mbgB:
undetectable		 1h9zA-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me2 UNCHARACTERIZED
PROTEIN

(Brachypodium
distachyon) 		no annotation 5 ALA A  52
LEU A  77
LEU A  56
SER A  99
ALA A 101
 None
 1.17A 1h9zA-4me2A:
undetectable		 1h9zA-4me2A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 ALA A 476
LEU A 477
HIS A 336
LEU A 649
ALA A 462
 None
 1.11A 1h9zA-4o5pA:
undetectable		 1h9zA-4o5pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		5 ALA A 113
LEU A 114
LEU A 110
LEU A 102
ALA A  82
 None
 1.17A 1h9zA-4oe1A:
undetectable		 1h9zA-4oe1A:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		8 TRP A 214
ALA A 215
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ARG A 257
LEU A 260
 None
 0.70A 1h9zA-4po0A:
41.4		 1h9zA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 ALA A 586
LEU A 587
LEU A 583
LEU A 610
ALA A 594
 None
 1.12A 1h9zA-4q2cA:
undetectable		 1h9zA-4q2cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 273
ALA A 261
LEU A 275
LEU A 311
ALA A 302
 None
 1.12A 1h9zA-4qdiA:
undetectable		 1h9zA-4qdiA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		5 LEU B 156
LEU B 378
LEU B  45
SER B 384
ALA B 375
 None
 1.17A 1h9zA-4tx2B:
undetectable		 1h9zA-4tx2B:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		5 ALA A 271
LEU A 278
ARG A 349
LEU A 411
SER A 435
 None
 1.14A 1h9zA-4u98A:
undetectable		 1h9zA-4u98A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 153
LEU A 126
HIS A 186
ARG A 161
ALA A 244
 None
None
NAI  A 345 ( 3.5A)
PO4  A 346 (-3.9A)
NAI  A 345 ( 2.8A)
 1.14A 1h9zA-4uupA:
undetectable		 1h9zA-4uupA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12859
(ANAPC1)
PF12862
(ANAPC5) 		5 ALA O 630
LEU O 634
LEU O 601
LEU A1787
ALA A1792
 None
 0.97A 1h9zA-5a31O:
2.1		 1h9zA-5a31O:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		5 ALA A  60
LEU A 106
ARG A  93
LEU A  91
ALA A  86
 None
 1.17A 1h9zA-5bp8A:
undetectable		 1h9zA-5bp8A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP

(Eremothecium
gossypii) 		PF10345
(Cohesin_load) 		5 LEU A 242
LEU A 250
LEU A 228
SER A 230
ALA A 233
 None
 1.01A 1h9zA-5c6gA:
3.0		 1h9zA-5c6gA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck7 ADP-DEPENDENT
GLUCOKINASE

(Mus musculus) 		PF04587
(ADP_PFK_GK) 		5 ALA A  95
LEU A  96
LEU A  92
LEU A 210
ALA A 143
 None
 1.05A 1h9zA-5ck7A:
undetectable		 1h9zA-5ck7A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5crl MERCURIC RESISTANCE
OPERON REGULATORY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00376
(MerR)
PF09278
(MerR-DNA-bind) 		5 PHE A  56
ALA A  60
LEU A  73
SER A  87
ALA A  89
 None
 1.15A 1h9zA-5crlA:
2.1		 1h9zA-5crlA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		5 ALA A 149
LEU A 147
LEU A 155
HIS A 176
ALA A 192
 None
 1.11A 1h9zA-5cykA:
undetectable		 1h9zA-5cykA:
21.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		8 TRP A 213
LEU A 218
LEU A 237
HIS A 241
ARG A 256
LEU A 259
SER A 286
ALA A 290
 None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 ( 4.5A)
PG4  A 602 (-3.9A)
PG4  A 602 (-3.4A)
 0.71A 1h9zA-5dqfA:
42.6		 1h9zA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa9 PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Treponema
denticola) 		PF01625
(PMSR)
PF01641
(SelR) 		5 ALA A 243
LEU A 244
LEU A 219
LEU A 291
ALA A 266
 None
 0.85A 1h9zA-5fa9A:
undetectable		 1h9zA-5fa9A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmf DNA REPAIR HELICASE
RAD25, SSL2

(Saccharomyces
cerevisiae) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		5 LEU 1 708
LEU 1 594
HIS 1 598
LEU 1 739
ALA 1 555
 None
 1.09A 1h9zA-5fmf1:
undetectable		 1h9zA-5fmf1:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 PHE A 211
TRP A 214
LEU A 219
ARG A 222
LEU A 238
HIS A 242
ARG A 257
ALA A 291
 None
 0.95A 1h9zA-5ghkA:
39.3		 1h9zA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 PHE A 211
TRP A 214
LEU A 219
LEU A 238
HIS A 242
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
 0.80A 1h9zA-5ghkA:
39.3		 1h9zA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 TRP B1317
ALA B1318
LEU B1322
LEU B1423
ALA B1368
 None
 1.00A 1h9zA-5hb4B:
undetectable		 1h9zA-5hb4B:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		5 ALA A 119
LEU A 120
LEU A 135
HIS A  93
SER A 128
 61G  A 403 (-4.8A)
None
61G  A 403 ( 4.5A)
PIS  A 402 (-4.1A)
None
 1.01A 1h9zA-5hc8A:
undetectable		 1h9zA-5hc8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		5 LEU A 286
HIS A 285
LEU A 282
SER A 279
ALA A 277
 None
 1.16A 1h9zA-5hh9A:
2.0		 1h9zA-5hh9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 PHE A   5
ARG A 433
LEU A 469
LEU A 379
ALA A 429
 None
 1.11A 1h9zA-5ikzA:
2.3		 1h9zA-5ikzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 ALA A 211
LEU A 212
LEU A 208
LEU A 234
ALA A 103
 None
None
None
HEM  A 401 ( 4.4A)
None
 1.11A 1h9zA-5it1A:
2.5		 1h9zA-5it1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdo HAPTOGLOBIN-HAEMOGLO
BIN RECEPTOR

(Trypanosoma
congolense) 		PF16731
(GARP) 		5 ALA B 147
LEU B 144
LEU B   9
LEU B 182
ALA B  16
 None
 1.10A 1h9zA-5jdoB:
2.8		 1h9zA-5jdoB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5khn RND TRANSPORTER

(Burkholderia
multivorans) 		no annotation 5 ALA B 407
LEU B 403
LEU B 337
LEU B 826
ALA B 777
 None
 0.90A 1h9zA-5khnB:
3.1		 1h9zA-5khnB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf8 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 17

(Homo sapiens) 		PF00293
(NUDIX) 		5 PHE A 284
LEU A 184
LEU A 163
LEU A  49
ALA A  59
 None
None
None
None
EMC  A 402 ( 4.1A)
 1.01A 1h9zA-5lf8A:
undetectable		 1h9zA-5lf8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfi LACTOCOCCIN-A
IMMUNITY PROTEIN

(Lactococcus
lactis) 		PF08951
(EntA_Immun) 		5 ALA A  38
LEU A  39
LEU A  35
LEU A  58
ALA A  50
 None
 1.03A 1h9zA-5lfiA:
3.1		 1h9zA-5lfiA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m42 PROLINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		5 ALA A 149
LEU A 150
LEU A 146
LEU A 100
ALA A 114
 None
 1.05A 1h9zA-5m42A:
undetectable		 1h9zA-5m42A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 5 ALA A 425
LEU A 435
LEU A 359
LEU A 338
SER A 350
 None
 1.13A 1h9zA-5mc5A:
undetectable		 1h9zA-5mc5A:
9.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 6 LEU A 218
ARG A 217
LEU A 237
ARG A 256
LEU A 259
ALA A 290
 None
 1.48A 1h9zA-5oriA:
41.0		 1h9zA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 7 LEU A 218
LEU A 237
HIS A 241
ARG A 256
LEU A 259
SER A 286
ALA A 290
 None
 0.89A 1h9zA-5oriA:
41.0		 1h9zA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Neisseria
gonorrhoeae) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 ALA A 380
LEU A 381
LEU A 377
LEU A 366
ALA A 207
 None
 0.85A 1h9zA-5tw7A:
undetectable		 1h9zA-5tw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u30 CRISPR-ASSOCIATED
ENDONUCLEASE C2C1

(Alicyclobacillus
acidoterrestris) 		no annotation 5 ALA A 980
LEU A 984
ARG A 987
LEU A 850
ALA A 896
 None
 1.17A 1h9zA-5u30A:
4.1		 1h9zA-5u30A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 ALA A 675
LEU A 648
LEU A 686
LEU A 708
ALA A 700
 None
 1.08A 1h9zA-5u89A:
undetectable		 1h9zA-5u89A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8j CYCLIC GMP-AMP
SYNTHASE

(Homo sapiens) 		PF03281
(Mab-21) 		5 ALA A 323
LEU A 322
LEU A 324
LEU A 262
ALA A 273
 None
 1.15A 1h9zA-5v8jA:
undetectable		 1h9zA-5v8jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlg REGULATORY PROTEIN
TETR

([Enterobacter]
lignolyticus) 		no annotation 5 ALA A  86
LEU A  87
LEU A  83
LEU A 190
ALA A 152
 None
 1.06A 1h9zA-5vlgA:
2.7		 1h9zA-5vlgA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w35 DNA PRIMASE

(Mycobacterium
tuberculosis) 		no annotation 5 ALA A 131
LEU A 132
ARG A 141
LEU A 223
ALA A 138
 None
 1.05A 1h9zA-5w35A:
undetectable		 1h9zA-5w35A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		5 ALA A 560
LEU A 563
LEU A 539
LEU A 512
ALA A 433
 None
 1.11A 1h9zA-5wu3A:
1.7		 1h9zA-5wu3A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 ALA A 532
LEU A 536
LEU A 529
LEU A 361
ALA A 398
 None
 1.13A 1h9zA-5x9wA:
undetectable		 1h9zA-5x9wA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 8 PHE A 211
TRP A 214
LEU A 219
LEU A 238
HIS A 242
ARG A 257
LEU A 260
SER A 287
 None
 0.74A 1h9zA-5yxeA:
38.0		 1h9zA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F

(Pyrococcus
furiosus) 		no annotation 5 ALA B  33
LEU B  21
LEU D  52
SER D  50
ALA D  47
 None
 0.99A 1h9zA-6cfwB:
4.2		 1h9zA-6cfwB:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co2 NUDT16-TUDOR-INTERAC
TING (NUDT16TI)

(Homo sapiens) 		no annotation 5 PHE A 111
ALA A 175
LEU A 176
LEU A 172
LEU A 160
 None
 1.15A 1h9zA-6co2A:
undetectable		 1h9zA-6co2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 PROBABLE INACTIVE
RECEPTOR KINASE
AT1G27190

(Arabidopsis
thaliana) 		no annotation 5 ALA B  85
LEU B 108
LEU B  38
LEU B  34
SER B  91
 None
 1.16A 1h9zA-6fg8B:
undetectable		 1h9zA-6fg8B:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 ALA A 135
LEU A  74
LEU A 136
LEU A  62
ALA A  68
 None
 1.15A 1h9zA-6fv5A:
undetectable		 1h9zA-6fv5A:
7.36