SIMILAR PATTERNS OF AMINO ACIDS FOR 1H8S_A_AICA1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bvl HULYS11

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		7 TYR B  36
GLN B  89
PHE B  98
ASN A  35
VAL A  37
ALA A  96
TRP A 106
 None
 0.67A 1h8sA-1bvlB:
21.3		 1h8sA-1bvlB:
59.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dvf FV E5.2

(Mus musculus) 		PF07686
(V-set) 		7 TYR C  36
GLN C  89
PHE C  98
ASN D  35
VAL D  37
ALA D  93
TRP D 103
 None
 0.61A 1h8sA-1dvfC:
21.5		 1h8sA-1dvfC:
60.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i3g ANTIBODY FV FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		11 TYR L  44
GLN L 107
TYR L 135
LEU L 137
PHE L 139
TRP H  40
ASN H  42
VAL H  44
ASN H  57
ALA H 107
TRP H 139
 None
MPD  L 500 (-3.1A)
None
None
None
None
MPD  L 500 (-3.8A)
None
None
MPD  L 500 ( 3.9A)
MPD  L 500 (-4.5A)
 0.33A 1h8sA-1i3gL:
23.3		 1h8sA-1i3gL:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j05 ANTI-CEA MAB T84.66,
HEAVY CHAIN
ANTI-CEA MAB T84.66,
LIGHT CHAIN

(Mus musculus) 		no annotation 6 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.48A 1h8sA-1j05L:
21.4		 1h8sA-1j05L:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jhl IGG1-KAPPA D11.15 FV
(HEAVY CHAIN)
IGG1-KAPPA D11.15 FV
(LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		8 TYR L  36
GLN L  89
TYR L  94
PHE L  98
TRP H  33
ASN H  35
VAL H  37
ASN H  50
 None
 0.48A 1h8sA-1jhlL:
21.3		 1h8sA-1jhlL:
54.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kcv PC282 IMMUNOGLOBULIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
LEU L  96
PHE L  98
ASN H  36
ALA H  97
TRP H 106
 None
 0.73A 1h8sA-1kcvL:
22.6		 1h8sA-1kcvL:
43.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kyo HEAVY CHAIN (VH) OF
FV-FRAGMENT
LIGHT CHAIN (VL) OF
FV-FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		6 TYR K  36
GLN K  89
PHE K  98
ASN J  36
ALA J  97
TRP J 112
 None
 0.89A 1h8sA-1kyoK:
20.2		 1h8sA-1kyoK:
58.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lk3 9D7 HEAVY CHAIN
9D7 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  35
GLN L  88
LEU L  95
PHE L  97
VAL H  37
TRP H 109
 None
 0.75A 1h8sA-1lk3L:
21.6		 1h8sA-1lk3L:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mj8 IMMUNOGLOBULIN
MS6-126

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TRP H  33
ASN H  35
VAL H  37
ASN H  50
ALA H  93
TRP H 103
 PO4  H 805 (-4.7A)
PO4  H 805 ( 3.1A)
None
PO4  H 805 (-4.1A)
GOL  H 701 ( 4.2A)
None
 0.34A 1h8sA-1mj8H:
14.7		 1h8sA-1mj8H:
44.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qfw ANTIBODY (ANTI ALPHA
SUBUNIT) (HEAVY
CHAIN)
ANTIBODY (ANTI ALPHA
SUBUNIT) (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		8 TYR L  40
GLN L  93
TYR L 100
PHE L 104
TRP H  33
VAL H  37
ALA H  97
TRP H 107
 None
 0.88A 1h8sA-1qfwL:
17.8		 1h8sA-1qfwL:
54.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rvf FAB 17-IA

(Mus musculus) 		PF07686
(V-set) 		8 GLN L  89
TYR L  94
PHE L  98
TRP H  33
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.88A 1h8sA-1rvfL:
17.9		 1h8sA-1rvfL:
33.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uyw FAB ANTIBODY HEAVY
CHAIN
FAB ANTIBODY LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
TYR L  94
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.52A 1h8sA-1uywL:
22.7		 1h8sA-1uywL:
45.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wt5 ANTI EGFR ANTIBODY
FV REGION

(Homo sapiens) 		PF07686
(V-set) 		7 TYR C  41
PHE C 103
TRP A  33
VAL A  37
ASN A  50
ALA A  97
TRP A 108
 None
 0.70A 1h8sA-1wt5C:
20.7		 1h8sA-1wt5C:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
LEU L  96
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.53A 1h8sA-1xgyL:
19.8		 1h8sA-1xgyL:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zan FAB AD11 HEAVY CHAIN
FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.68A 1h8sA-1zanL:
22.0		 1h8sA-1zanL:
39.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zan FAB AD11 HEAVY CHAIN
FAB AD11 LIGHT CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
TYR L  94
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.89A 1h8sA-1zanL:
22.0		 1h8sA-1zanL:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		6 TYR L  36
LEU L  96
PHE L  98
VAL H  37
ALA H  97
TRP H 106
 None
 0.78A 1h8sA-2d7tL:
21.9		 1h8sA-2d7tL:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		6 TYR L  36
TYR L  94
LEU L  96
PHE L  98
VAL H  37
TRP H 106
 None
 0.90A 1h8sA-2d7tL:
21.9		 1h8sA-2d7tL:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e27 ANTI-CIGUATOXIN
ANTIBODY, HEAVY
CHAIN
ANTI-CIGUATOXIN
ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		6 TYR L  36
PHE L  98
TRP H  33
VAL H  37
ALA H  93
TRP H 103
 None
None
AB0  H6001 (-3.7A)
None
None
None
 0.80A 1h8sA-2e27L:
20.6		 1h8sA-2e27L:
26.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
TYR L  94
PHE L  98
ALA H  98
TRP H 122
 None
 0.65A 1h8sA-2f5aL:
22.5		 1h8sA-2f5aL:
39.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ghw ANTI-SARS SCFV
ANTIBODY, 80R

(Homo sapiens) 		PF07686
(V-set) 		6 TYR B 168
GLN B 221
PHE B 230
VAL B  37
ALA B  97
TRP B 107
 None
 0.64A 1h8sA-2ghwB:
22.1		 1h8sA-2ghwB:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2x7l FAB HEAVY CHAIN
FAB LIGHT CHAIN

(unidentified) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR B  36
PHE B 101
TRP A  33
ASN A  35
VAL A  37
ALA A  95
TRP A 107
 None
 0.69A 1h8sA-2x7lB:
20.2		 1h8sA-2x7lB:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ab0 ANTIBODY SCFV
FRAGMENT, HEAVY
CHAIN
ANTIBODY SCFV
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		6 TYR C  36
GLN C  89
PHE C  98
VAL B  37
ALA B  96
TRP B 106
 None
 0.76A 1h8sA-3ab0C:
19.8		 1h8sA-3ab0C:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cvh 25-D1.16 HEAVY CHAIN
25-D1.16 LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  35
GLN L  88
LEU L  95
PHE L  97
VAL H  36
ALA H  96
TRP H 110
 None
 0.70A 1h8sA-3cvhL:
22.1		 1h8sA-3cvhL:
41.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3esu ANTIBODY 14B7* LIGHT
CHAIN AND ANTIBODY
14B7* HEAVY CHAIN
LINKED WITH A
SYNTHETIC (GGGGS)4
LINKER

(Mus musculus) 		PF07686
(V-set) 		8 TYR F  36
GLN F  89
PHE F  98
TRP F1033
ASN F1035
VAL F1037
ALA F1093
TRP F1103
 None
 0.67A 1h8sA-3esuF:
32.1		 1h8sA-3esuF:
70.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		6 TYR C  42
GLN C  95
PHE C 104
ASN C 169
VAL C 171
TRP C 244
 None
 0.70A 1h8sA-3h3bC:
31.8		 1h8sA-3h3bC:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h3b ANTI-ERBB2 ANTIBODY
CHA21

(Mus musculus) 		PF07686
(V-set) 		6 TYR C  42
GLN C  95
TYR C 100
ASN C 169
VAL C 171
TRP C 244
 None
 0.71A 1h8sA-3h3bC:
31.8		 1h8sA-3h3bC:
65.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iy0 FAB 14, HEAVY DOMAIN
FAB 14, LIGHT DOMAIN

(Mus musculus) 		PF07686
(V-set) 		7 TYR L  36
GLN L  89
PHE L  98
ASN H  35
VAL H  37
ALA H  97
TRP H 110
 None
 0.68A 1h8sA-3iy0L:
22.4		 1h8sA-3iy0L:
72.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3iy5 ANTIBODY FRAGMENT
IGG2A (HEAVY CHAIN)
ANTIBODY FRAGMENT
IGG2A (LIGHT CHAIN)

(Mus musculus) 		PF07686
(V-set) 		6 TYR A  37
GLN A  90
TYR A  95
PHE A  99
VAL B 145
TRP B 219
 None
 0.81A 1h8sA-3iy5A:
20.0		 1h8sA-3iy5A:
54.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3j8v H16.14J HEAVY CHAIN
H16.14J LIGHT CHAIN

(Mus musculus) 		no annotation 8 TYR L  36
GLN L  89
LEU L  96
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.66A 1h8sA-3j8vL:
22.2		 1h8sA-3j8vL:
49.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juy 3B3 SINGLE CHAIN
VARIANT HIV-1
ANTIBODY

(Homo sapiens) 		no annotation 6 TYR B 179
GLN B 232
PHE B 241
VAL B  37
ALA B  97
TRP B 117
 None
 0.61A 1h8sA-3juyB:
23.0		 1h8sA-3juyB:
29.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mj8 STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
HEAVY CHAIN
STIMULATORY HAMSTER
ANTIBODY HL4E10 FAB
LIGHT CHAIN

(Cricetulus
migratorius) 		no annotation 6 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.65A 1h8sA-3mj8L:
17.4		 1h8sA-3mj8L:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ntc FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
TYR L  94
PHE L  98
TRP H  33
TRP H 103
 None
None
EDO  H 220 (-4.9A)
None
EDO  H 220 ( 3.9A)
None
 0.75A 1h8sA-3ntcL:
21.3		 1h8sA-3ntcL:
41.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qpx FAB C2507 HEAVY
CHAIN
FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
PHE L  97
TRP H  33
ASN H  35
ALA H  97
TRP H 109
 None
None
None
SO4  H 230 (-4.1A)
None
None
None
 0.69A 1h8sA-3qpxL:
21.9		 1h8sA-3qpxL:
40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ux9 SCFV ANTIBODY

(Homo sapiens) 		PF07686
(V-set) 		6 TYR B  39
GLN B  92
PHE B 103
VAL B 171
ALA B 231
TRP B 243
 None
 0.74A 1h8sA-3ux9B:
27.3		 1h8sA-3ux9B:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4buh CLONE M0418 SCFV

(Homo sapiens) 		PF07686
(V-set) 		6 TYR A 178
PHE A 242
TRP A  33
VAL A  37
ALA A  97
TRP A 116
 None
 0.53A 1h8sA-4buhA:
22.6		 1h8sA-4buhA:
33.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4d3c SFN68 FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
PHE L  99
VAL H  37
ALA H  97
TRP H 106
 None
 0.84A 1h8sA-4d3cL:
20.7		 1h8sA-4d3cL:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 6 TYR D  36
GLN D  89
TYR D  94
PHE D  98
VAL D 168
TRP D 243
 None
 0.74A 1h8sA-4f9lD:
30.2		 1h8sA-4f9lD:
69.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ffy DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (HEAVY
CHAIN)
DENV1-E111 SINGLE
CHAIN VARIABLE
FRAGMENT (LIGHT
CHAIN)

(Mus musculus) 		PF07686
(V-set) 		7 TYR L  36
GLN L  89
PHE L  98
TRP H  33
VAL H  37
ALA H  97
TRP H 108
 None
 0.78A 1h8sA-4ffyL:
21.1		 1h8sA-4ffyL:
60.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hjj ANTI-IL12 ANTI-IL18
DFAB HEAVY CHAIN
ANTI-IL12 ANTI-IL18
DFAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L 149
GLN L 202
PHE L 212
TRP H 158
VAL H 162
ALA H 222
TRP H 236
 None
 0.67A 1h8sA-4hjjL:
22.6		 1h8sA-4hjjL:
36.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ht1 CHIMERIC ANTIBODY
FAB

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
TYR H 103
PHE L 102
VAL H  37
ALA H  97
TRP H 110
 None
 1.27A 1h8sA-4ht1L:
20.2		 1h8sA-4ht1L:
37.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB
LIGHT CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.66A 1h8sA-4i3rL:
19.0		 1h8sA-4i3rL:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.84A 1h8sA-4idjL:
21.6		 1h8sA-4idjL:
40.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens) 		no annotation 6 TYR L  35
GLN L  88
PHE L  99
VAL H  37
ALA H  97
TRP H 119
 None
 0.69A 1h8sA-4imlL:
16.6		 1h8sA-4imlL:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j8r HEAVY CHAIN OF POM2
FAB
LIGHT CHAIN OF POM2
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR A  35
GLN A  88
PHE A  96
VAL B  37
ALA B  93
TRP B 103
 None
 0.58A 1h8sA-4j8rA:
21.3		 1h8sA-4j8rA:
53.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
ANTI-HCV E2 FAB
HC84-1 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR B  35
GLN B  88
PHE B  97
VAL A  37
ALA A  97
TRP A 109
 None
 0.63A 1h8sA-4jznB:
18.2		 1h8sA-4jznB:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k2u ANTIBODY HEAVY CHAIN
ANTIBODY LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.62A 1h8sA-4k2uL:
15.7		 1h8sA-4k2uL:
37.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4llv 4E10 FV HEAVY CHAIN
4E10 FV LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		6 TYR B  36
GLN B  89
PHE B  98
VAL A  37
ALA A  93
TRP A 103
 None
 0.60A 1h8sA-4llvB:
21.6		 1h8sA-4llvB:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ncc FAB FRAGMENT HEAVY
FAB FRAGMENT LIGHT

(Mus musculus) 		no annotation 6 GLN L  88
TYR L  93
PHE L  97
VAL H  37
ALA H  97
TRP H 109
 None
 0.81A 1h8sA-4nccL:
20.9		 1h8sA-4nccL:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4pp1 HEAVY CHAIN OF FAB
FRAGMENT OF MAB 5H8
LIGHT CHAIN OF FAB
FRAGMENT OF MAB 5H8

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR C  36
GLN C  89
PHE C  97
ASN D  35
VAL D  37
ALA D  96
TRP D 110
 None
 0.78A 1h8sA-4pp1C:
21.4		 1h8sA-4pp1C:
38.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r96 LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET H
CHAIN
LLAMA GLAMA FAB 48A2
AGAINST HUMAN CMET L
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR A  42
GLN A  95
PHE A 104
VAL B  37
ALA B  97
TRP B 109
 None
 0.61A 1h8sA-4r96A:
21.2		 1h8sA-4r96A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 6 TYR L  36
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.65A 1h8sA-4rzcL:
18.6		 1h8sA-4rzcL:
29.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xny HEAVY CHAIN OF
ANTIBODY VRC08C
LIGHT CHAIN OF
ANTIBODY VRC08C

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
PHE L  98
ASN H  35
VAL H  37
TRP H 103
 None
 0.82A 1h8sA-4xnyL:
20.0		 1h8sA-4xnyL:
36.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
ANTIBODY HC26AM
LIGHT CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		6 TYR A  35
GLN A  88
PHE A  97
VAL B  62
ALA B 122
TRP B 134
 None
 0.61A 1h8sA-4z0xA:
17.8		 1h8sA-4z0xA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ztp HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53
LIGHT CHAIN OF FAB
FRAGMENT OF RABBIT
MONOCLONAL ANTIBODY
R53

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
GLN L  89
PHE L  98
VAL H  36
ALA H  92
TRP H 102
 None
 0.72A 1h8sA-4ztpL:
20.4		 1h8sA-4ztpL:
36.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5awn HEAVY CHAIN OF
3BC176 FAB
LIGHT CHAIN OF
3BC176 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  36
LEU L  96
PHE L  98
VAL H  37
ALA H  93
TRP H 103
 None
 0.77A 1h8sA-5awnL:
17.6		 1h8sA-5awnL:
34.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b3n ANTI-H4K20ME1_SCFV

(Mus musculus) 		PF07686
(V-set) 		7 TYR A 178
GLN A 231
LEU A 238
PHE A 240
VAL A  39
ALA A  99
TRP A 113
 None
 0.69A 1h8sA-5b3nA:
21.8		 1h8sA-5b3nA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8c PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)

(Homo sapiens) 		PF07686
(V-set) 		7 TYR A  40
GLN A  93
LEU A 100
PHE A 102
VAL B  37
ALA B  97
TRP B 110
 None
 0.54A 1h8sA-5b8cA:
22.0		 1h8sA-5b8cA:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c0n FAB CA33 HEAVY CHAIN
FAB CA33 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 6 TYR L  36
GLN L  89
PHE L 103
VAL H  36
ALA H  93
TRP H 110
 None
 0.74A 1h8sA-5c0nL:
20.7		 1h8sA-5c0nL:
36.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cma ANTIBODY CH8H9 FAB
HEAVY CHAIN
ANTIBODY CH8H9 FAB
LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		8 TYR A  36
GLN A  89
LEU A  96
PHE A  98
ASN B  35
VAL B  37
ALA B  97
TRP B 108
 None
 0.69A 1h8sA-5cmaA:
21.6		 1h8sA-5cmaA:
39.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dhx ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
LIGHT CHAIN,ANTI-REV
ANTIBODY FAB
SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN

(Oryctolagus
cuniculus) 		PF07686
(V-set) 		7 TYR B  36
PHE B 101
TRP B 143
ASN B 145
VAL B 147
ALA B 205
TRP B 217
 None
 0.70A 1h8sA-5dhxB:
28.4		 1h8sA-5dhxB:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR B  35
GLN B  88
PHE B  97
VAL A  37
ALA A  97
TRP A 109
 None
 0.66A 1h8sA-5esaB:
17.8		 1h8sA-5esaB:
33.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		8 GLN C 133
TYR C 138
LEU C 140
PHE C 142
TRP C 202
ASN C 204
VAL C 206
ALA C 266
 None
 0.73A 1h8sA-5f3jC:
28.5		 1h8sA-5f3jC:
58.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f3j ANTIBODY 2D10 SINGLE
CHAIN VARIABLE
FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		8 TYR C 138
LEU C 140
PHE C 142
TRP C 202
ASN C 204
VAL C 206
ALA C 266
TRP C 279
 None
 0.82A 1h8sA-5f3jC:
28.5		 1h8sA-5f3jC:
58.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f72 SINGLE CHAIN FV FROM
A FAB

(Homo sapiens) 		no annotation 6 TYR T 177
GLN T 230
PHE T 239
VAL T  37
ALA T  97
TRP T 111
 None
 0.74A 1h8sA-5f72T:
21.8		 1h8sA-5f72T:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fgc ANTI-HCV E2 FAB
HC33.8 HEAVY CHAIN
ANTI-HCV E2 FAB
HC33.8 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR B  35
GLN B  88
PHE B  98
VAL E  37
ALA E  97
TRP E 117
 None
 0.80A 1h8sA-5fgcB:
17.7		 1h8sA-5fgcB:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  40
GLN L  93
PHE L 102
ASN H 159
VAL H 161
ALA H 220
TRP H 232
 None
 0.59A 1h8sA-5fhxL:
21.5		 1h8sA-5fhxL:
35.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		6 TYR H 170
GLN H 223
PHE H 232
ASN L  36
ALA L  97
TRP L 106
 TYR  H 170 ( 1.3A)
GLN  H 223 ( 0.6A)
PHE  H 232 ( 1.3A)
ASN  L  36 ( 0.6A)
ALA  L  97 ( 0.0A)
TRP  L 106 ( 0.5A)
 0.74A 1h8sA-5gruH:
21.4		 1h8sA-5gruH:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		6 TYR L 157
GLN L 210
PHE L 219
VAL H  37
ALA H  97
TRP H 119
 TYR  L 157 ( 1.3A)
GLN  L 210 ( 0.6A)
PHE  L 219 ( 1.3A)
VAL  H  37 ( 0.6A)
ALA  H  97 ( 0.0A)
TRP  H 119 ( 0.5A)
 0.72A 1h8sA-5gruL:
13.9		 1h8sA-5gruL:
26.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs2 ANTI-MBP
ANTI-REPEBODY

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		6 TYR D 162
GLN D 215
PHE D 224
VAL H  37
ALA H  97
TRP H 117
 None
 0.67A 1h8sA-5gs2D:
21.4		 1h8sA-5gs2D:
39.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs2 ANTI-MBP
ANTI-REPEBODY

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		6 TYR H 168
TYR H 226
PHE H 230
VAL D  37
ALA D  97
TRP D 111
 None
 0.39A 1h8sA-5gs2H:
13.2		 1h8sA-5gs2H:
76.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j13 ANTI-TSLP
FAB-FRAGMENT, HEAVY
CHAIN
ANTI-TSLP
FAB-FRAGMENT, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR B  38
GLN B  91
PHE B 102
VAL C  40
ALA C 100
TRP C 115
 None
 0.63A 1h8sA-5j13B:
18.0		 1h8sA-5j13B:
29.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jyl SCFV TSP7

(Mus musculus) 		PF07686
(V-set) 		6 TYR B 174
GLN B 227
PHE B 236
VAL B  37
ALA B  97
TRP B 109
 None
 0.59A 1h8sA-5jylB:
22.9		 1h8sA-5jylB:
33.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jym ANTIBODY SCFV TSP11

(Mus musculus) 		PF07686
(V-set) 		10 TYR B 178
GLN B 231
TYR B 236
PHE B 240
TRP B  33
ASN B  35
VAL B  37
ASN B  50
ALA B  97
TRP B 112
 None
 0.63A 1h8sA-5jymB:
12.8		 1h8sA-5jymB:
40.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kve ZV-48 ANTIBODY SCFV
HEAVY CHAIN
ZV-48 ANTIBODY SCFV
LIGHT CHAIN

(Mus musculus) 		PF07686
(V-set) 		8 TYR L  36
GLN L  89
TYR L  94
PHE L  98
TRP H  33
VAL H  37
ALA H  93
TRP H 103
 None
 0.85A 1h8sA-5kveL:
20.9		 1h8sA-5kveL:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		6 TYR H 175
GLN H 228
PHE H 237
VAL H  37
ALA H  97
TRP H 108
 None
 0.57A 1h8sA-5lx9H:
22.9		 1h8sA-5lx9H:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5m63 H CHAIN OF FAB
NVS-1-19-5
L CHAIN OF FAB
NVS-1-19-5

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  60
TYR H  78
PHE L 125
VAL H  55
ALA H 115
TRP H 134
 None
 0.90A 1h8sA-5m63L:
20.3		 1h8sA-5m63L:
32.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR L  40
GLN L  93
PHE L 102
VAL H  37
ALA H  99
TRP H 111
 None
 0.69A 1h8sA-5nbiL:
22.1		 1h8sA-5nbiL:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
HEAVY-CHAIN
ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN

(Homo sapiens) 		no annotation 6 TYR L  38
PHE L 102
ASN H  35
VAL H  37
ALA H  97
TRP H 105
 None
 0.56A 1h8sA-5ngvL:
17.9		 1h8sA-5ngvL:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5npi SINGLE CHAIN
VARIABLE FRAGMENT OF
THE NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07686
(V-set) 		6 GLN A 229
LEU A 236
PHE A 238
VAL A  37
ALA A  97
TRP A 110
 None
 0.64A 1h8sA-5npiA:
22.4		 1h8sA-5npiA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07686
(V-set) 		6 TYR L  36
GLN L  89
TYR L  94
LEU L  96
PHE L  98
TRP H 103
 None
 0.53A 1h8sA-5tr1L:
20.9		 1h8sA-5tr1L:
85.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3p DH511.4 FAB HEAVY
CHAIN
DH511.4 FAB LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		7 TYR L  36
GLN L  89
LEU L  96
PHE L  98
TRP H  33
VAL H  37
TRP H 103
 None
 0.96A 1h8sA-5u3pL:
15.7		 1h8sA-5u3pL:
38.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		7 TYR E 201
GLN E 254
PHE E 264
ASN E  54
VAL E  56
ALA E 116
TRP E 133
 None
 0.76A 1h8sA-5u68E:
21.5		 1h8sA-5u68E:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA
VL-SARAH(S37C)
CHIMERA,VL-SARAH(S37
C) CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		7 TYR B  36
GLN B  89
LEU B  96
PHE B  98
VAL A  37
ALA A  93
TRP A 103
 None
 0.79A 1h8sA-5xcuB:
20.1		 1h8sA-5xcuB:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xcx VH(S112C)-SARAH
CHIMERA
VL-SARAH(S37C)
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		6 TYR B  36
GLN B  89
LEU B  96
PHE B  98
VAL A  37
TRP A 103
 None
 0.61A 1h8sA-5xcxB:
21.1		 1h8sA-5xcxB:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xj3 IPILIMUMAB-VH
IPILIMUMAB-VL

(Homo sapiens) 		no annotation 6 TYR B  37
GLN B  90
PHE B  99
VAL A  37
ALA A  97
TRP A 108
 None
 0.59A 1h8sA-5xj3B:
21.3		 1h8sA-5xj3B:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yax SCFV1 ANTIBODY

(Homo sapiens) 		no annotation 6 TYR A1042
GLN A1105
PHE A1118
ASN A  40
ALA A 105
TRP A 118
 None
 0.61A 1h8sA-5yaxA:
21.6		 1h8sA-5yaxA:
32.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5yd5 SCFV 4B08

(Mus musculus) 		no annotation 6 TYR A 239
PHE A 243
TRP A  35
VAL A  39
ALA A  99
TRP A 109
 None
 0.68A 1h8sA-5yd5A:
22.0		 1h8sA-5yd5A:
47.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq7 POM6 FAB HEAVY CHAIN
POM6 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 7 TYR L  40
GLN L  93
LEU L 100
PHE L 102
VAL H  36
ALA H  96
TRP H 105
 None
 0.99A 1h8sA-6aq7L:
21.6		 1h8sA-6aq7L:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c08 ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN

(Mus musculus) 		no annotation 6 TYR B  39
PHE B 101
ASN A  35
VAL A  37
ALA A  97
TRP A 109
 None
 0.55A 1h8sA-6c08B:
21.1		 1h8sA-6c08B:
32.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk

() 		no annotation 6 TYR A  36
GLN A  89
PHE A  98
VAL B  37
ALA B  93
TRP B 103
 None
 0.71A 1h8sA-6cjkA:
20.6		 1h8sA-6cjkA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehv SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 6 TYR X 171
GLN X 224
PHE X 234
VAL X  38
ALA X  98
TRP X 109
 None
 0.62A 1h8sA-6ehvX:
21.8		 1h8sA-6ehvX:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY

(Homo sapiens) 		no annotation 8 TYR B 172
GLN B 225
TYR B 230
LEU B 232
PHE B 234
VAL B  37
ALA B  97
TRP B 111
 None
 0.63A 1h8sA-6ehxB:
21.9		 1h8sA-6ehxB:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ehy SCFV ANTIBODY
FRAGMENT

(Homo sapiens) 		no annotation 8 TYR A 174
GLN A 227
TYR A 232
LEU A 234
PHE A 236
VAL A  37
ALA A  97
TRP A 111
 None
 0.64A 1h8sA-6ehyA:
22.5		 1h8sA-6ehyA:
30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejg SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 7 TYR C  78
PHE C 140
TRP C 202
ASN C 204
VAL C 206
ALA C 266
TRP C 279
 None
 0.66A 1h8sA-6ejgC:
31.3		 1h8sA-6ejgC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek2 SINGLE CHAIN FV
FRAGMENT

(Mus musculus) 		no annotation 6 TYR H 374
GLN H 427
PHE H 436
VAL H 206
ALA H 266
TRP H 279
 None
 0.80A 1h8sA-6ek2H:
21.8		 1h8sA-6ek2H:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eqc SCFV OF 9C12
ANTIBODY

(Mus musculus) 		no annotation 6 TYR D  43
LEU D 103
PHE D 105
VAL D 167
ALA D 226
TRP D 237
 None
 0.67A 1h8sA-6eqcD:
28.9		 1h8sA-6eqcD:
68.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6g8r SHORT-CHAIN VARIABLE
FRAGMENT

(Homo sapiens) 		no annotation 6 TYR A 170
GLN A 223
PHE A 231
VAL A  37
ALA A  97
TRP A 109
 None
 0.68A 1h8sA-6g8rA:
21.1		 1h8sA-6g8rA:
30.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)
IGG1-LAMBDA HIL FAB
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		6 TYR A  35
GLN A  88
PHE A  97
VAL B  37
ALA B  97
TRP B 111
 None
 0.82A 1h8sA-8fabA:
17.8		 1h8sA-8fabA:
32.44