SIMILAR PATTERNS OF AMINO ACIDS FOR 1H7X_A_URFA1033_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE


(Escherichia
coli)
PF00266
(Aminotran_5)
4 ASN A 199
ILE A 338
SER A 296
ASN A 151
LLP  A 198 ( 4.3A)
None
None
None
1.25A 1h7xA-1bjnA:
undetectable
1h7xA-1bjnA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE


(Fusarium
oxysporum)
PF00067
(p450)
4 ASN A 176
ASN A 241
SER A 150
ASN A 171
None
1.17A 1h7xA-1f26A:
undetectable
1h7xA-1f26A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Escherichia
coli)
PF01180
(DHO_dh)
4 ASN A 111
ASN A 172
ASN A 246
THR A 247
ORO  A1338 ( 2.9A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
ORO  A1338 ( 2.6A)
0.16A 1h7xA-1f76A:
29.5
1h7xA-1f76A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
4 ASN A 464
ILE A 194
ASN A 201
THR A 789
None
1.06A 1h7xA-1g8kA:
undetectable
1h7xA-1g8kA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE


(Sus scrofa)
PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21)
6 ASN A 609
ILE A 613
ASN A 668
SER A 670
ASN A 736
THR A 737
FMN  A1030 (-3.7A)
None
FMN  A1030 (-4.0A)
None
FMN  A1030 (-3.6A)
FMN  A1030 ( 4.4A)
0.20A 1h7xA-1h7wA:
59.2
1h7xA-1h7wA:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0v PROTEIN-TYROSINE
PHOSPHATASE YOPH


(Yersinia
pseudotuberculosis)
PF09013
(YopH_N)
4 ILE A  44
SER A  51
ASN A  34
THR A  24
None
1.09A 1h7xA-1m0vA:
undetectable
1h7xA-1m0vA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE


(Homo sapiens)
PF00579
(tRNA-synt_1b)
4 ILE A 254
ASN A 250
ASN A 291
THR A 301
None
1.27A 1h7xA-1o5tA:
undetectable
1h7xA-1o5tA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz2 CONSERVED
HYPOTHETICAL PROTEIN
BA4783


(Bacillus
anthracis)
PF04203
(Sortase)
4 ASN A 102
ILE A 192
ASN A 134
ASN A 126
None
1.23A 1h7xA-1rz2A:
undetectable
1h7xA-1rz2A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq1 CHORISMATE SYNTHASE

(Campylobacter
jejuni)
PF01264
(Chorismate_synt)
4 ILE A 287
ASN A 271
SER A 273
ASN A 282
None
0.95A 1h7xA-1sq1A:
undetectable
1h7xA-1sq1A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE


(Rattus rattus)
PF01180
(DHO_dh)
4 ASN A 145
ASN A 212
ASN A 284
THR A 285
ORO  A1399 ( 3.0A)
FMN  A1398 ( 3.0A)
ORO  A1399 ( 3.2A)
ORO  A1399 (-2.7A)
0.66A 1h7xA-1uuoA:
31.0
1h7xA-1uuoA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvf SERINE PROTEINASE
INHIBITOR KAZAL TYPE
5


(Homo sapiens)
PF00050
(Kazal_1)
4 ILE A  52
SER A   2
ASN A  43
THR A  48
None
1.17A 1h7xA-1uvfA:
undetectable
1h7xA-1uvfA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w7c LYSYL OXIDASE

(Komagataella
pastoris)
PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF09248
(DUF1965)
4 ILE A 502
SER A 526
ASN A 391
THR A 394
TPQ  A 478 ( 4.8A)
None
None
None
1.03A 1h7xA-1w7cA:
undetectable
1h7xA-1w7cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE


(Entamoeba
histolytica)
PF05770
(Ins134_P3_kin)
4 ASN X 235
ILE X 229
ASN X 175
THR X 193
None
0.97A 1h7xA-1z2oX:
undetectable
1h7xA-1z2oX:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae)
PF03097
(BRO1)
4 ILE A 124
ASN A  67
ASN A  55
THR A  13
None
1.27A 1h7xA-1zb1A:
undetectable
1h7xA-1zb1A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R


(Homo sapiens)
PF00102
(Y_phosphatase)
4 ILE A 452
ASN A 450
SER A 430
ASN A 427
None
1.27A 1h7xA-2a8bA:
undetectable
1h7xA-2a8bA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5


(Homo sapiens)
PF00102
(Y_phosphatase)
4 ILE A 335
ASN A 333
SER A 313
ASN A 310
None
1.26A 1h7xA-2bv5A:
undetectable
1h7xA-2bv5A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccm CALEXCITIN

(Doryteuthis
pealeii)
no annotation 4 ASN A 183
ILE A  14
SER A   7
ASN A 176
None
1.21A 1h7xA-2ccmA:
undetectable
1h7xA-2ccmA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE


(Halothiobacillus
neapolitanus)
PF08936
(CsoSCA)
4 ASN A  59
ILE A 185
ASN A 375
THR A  54
None
1.19A 1h7xA-2fgyA:
undetectable
1h7xA-2fgyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 ASN A 503
ILE A 429
ASN A 436
THR A 442
None
1.27A 1h7xA-2iujA:
undetectable
1h7xA-2iujA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k24 PUTATIVE
UNCHARACTERIZED
PROTEIN TA0956


(Thermoplasma
acidophilum)
PF11513
(TA0956)
4 ASN A  71
SER A  10
ASN A   8
THR A  18
None
1.12A 1h7xA-2k24A:
undetectable
1h7xA-2k24A:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4e O-GLCNACASE NAGJ

(Clostridium
perfringens)
PF00963
(Cohesin)
4 ASN A  71
ILE A  95
ASN A 138
THR A 137
None
1.06A 1h7xA-2o4eA:
undetectable
1h7xA-2o4eA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqz SORTASE B

(Bacillus
anthracis)
PF04203
(Sortase)
4 ASN A 102
ILE A 192
ASN A 134
ASN A 126
CS4  A 233 ( 4.1A)
None
None
None
1.21A 1h7xA-2oqzA:
undetectable
1h7xA-2oqzA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C


(Listeria
monocytogenes)
PF00388
(PI-PLC-X)
4 ILE A 143
SER A 176
ASN A 178
THR A 180
None
1.06A 1h7xA-2plcA:
undetectable
1h7xA-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C


(Listeria
monocytogenes)
PF00388
(PI-PLC-X)
4 ILE A 289
ASN A 292
SER A  40
THR A 265
None
1.26A 1h7xA-2plcA:
undetectable
1h7xA-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qg7 ETHANOLAMINE KINASE
PV091845


(Plasmodium
vivax)
PF01633
(Choline_kinase)
4 ASN A 122
ILE A 350
ASN A 301
SER A 300
SO4  A 600 (-3.5A)
None
None
None
0.94A 1h7xA-2qg7A:
undetectable
1h7xA-2qg7A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
4 ASN A 739
ILE A 694
SER A  99
THR A 309
None
1.09A 1h7xA-2wyhA:
undetectable
1h7xA-2wyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7q POSSIBLE THIAMINE
BIOSYNTHESIS ENZYME


(Candida
albicans)
PF09084
(NMT1)
4 ASN A  52
ILE A  46
ASN A  72
ASN A  74
CA  A1308 (-3.3A)
None
None
None
1.25A 1h7xA-2x7qA:
undetectable
1h7xA-2x7qA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
4 ASN A 465
ILE A 158
SER A 226
THR A 469
None
TOE  A1492 (-4.4A)
None
None
1.24A 1h7xA-2xdrA:
undetectable
1h7xA-2xdrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1


(Plasmodium
falciparum)
PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS)
4 ASN A 160
ILE A  86
ASN A 148
THR A 151
None
1.07A 1h7xA-2yk0A:
undetectable
1h7xA-2yk0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Plasmodium
vivax)
PF01233
(NMT)
PF02799
(NMT_C)
4 ILE A  52
ASN A  55
ASN A 187
THR A 183
None
None
NHW  A1000 (-4.3A)
NHW  A1000 (-3.7A)
1.24A 1h7xA-2yneA:
undetectable
1h7xA-2yneA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER


(Escherichia
coli)
PF03797
(Autotransporter)
4 ASN A1093
ILE A1203
SER A1223
ASN A1207
None
1.22A 1h7xA-3aehA:
undetectable
1h7xA-3aehA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfg CLASS A
BETA-LACTAMASE SED1


(Citrobacter
sedlakii)
PF13354
(Beta-lactamase2)
4 ASN A 136
ASN A 170
ASN A 104
THR A 103
None
MER  A 301 (-2.6A)
MER  A 301 ( 4.1A)
None
1.25A 1h7xA-3bfgA:
undetectable
1h7xA-3bfgA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN


(Bacillus
anthracis)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 ASN A 383
ILE A  55
ASN A  52
SER A 255
None
1.25A 1h7xA-3cqfA:
undetectable
1h7xA-3cqfA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3


(Saccharomyces
cerevisiae)
PF03571
(Peptidase_M49)
4 ILE A 235
SER A 299
ASN A 211
THR A 212
None
1.25A 1h7xA-3cskA:
undetectable
1h7xA-3cskA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7k 3-METHYLITACONATE
ISOMERASE


(Eubacterium
barkeri)
PF04303
(PrpF)
4 ASN A 203
ILE A  99
ASN A 126
THR A 129
None
1.21A 1h7xA-3g7kA:
undetectable
1h7xA-3g7kA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g85 TRANSCRIPTIONAL
REGULATOR (LACI
FAMILY)


(Clostridium
acetobutylicum)
PF13377
(Peripla_BP_3)
4 ASN A 280
ILE A 277
ASN A 249
ASN A 224
None
1.15A 1h7xA-3g85A:
undetectable
1h7xA-3g85A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL


(Plasmodium
falciparum)
PF01180
(DHO_dh)
4 ASN A 274
ASN A 342
ASN A 458
THR A 459
ORO  A1003 ( 3.1A)
ORO  A1003 ( 3.5A)
ORO  A1003 ( 3.0A)
ORO  A1003 (-2.6A)
0.41A 1h7xA-3i6rA:
8.3
1h7xA-3i6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0b PREDICTED
N6-ADENINE-SPECIFIC
DNA METHYLASE


(Listeria
monocytogenes)
PF01170
(UPF0020)
PF02926
(THUMP)
4 ILE A  45
ASN A  49
SER A 156
THR A   9
None
None
None
GOL  A 701 (-2.6A)
1.00A 1h7xA-3k0bA:
3.8
1h7xA-3k0bA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4f SPERMIDINE SYNTHASE

(Escherichia
coli)
PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N)
4 ILE A 163
SER A 205
ASN A 192
THR A 232
None
1.15A 1h7xA-3o4fA:
3.5
1h7xA-3o4fA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix DIHYDROOROTATE
OXIDASE
PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE


(Streptococcus
mutans)
PF01180
(DHO_dh)
4 ASN A  69
ASN A 128
SER A 130
ASN A 194
FMN  A 400 (-3.6A)
FMN  A 400 (-3.3A)
None
FMN  A 400 (-3.4A)
0.96A 1h7xA-3oixA:
16.3
1h7xA-3oixA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus)
PF00008
(EGF)
PF02210
(Laminin_G_2)
4 ASN A 440
ILE A 656
SER A 510
THR A 429
None
1.05A 1h7xA-3qcwA:
undetectable
1h7xA-3qcwA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
4 ASN A 179
ILE A  62
ASN A 211
THR A 169
None
None
SO4  A 260 (-3.3A)
SO4  A 262 (-3.8A)
1.26A 1h7xA-3r4cA:
2.7
1h7xA-3r4cA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj9 ALCOHOL
DEHYDROGENASE


(Scaptodrosophila
lebanonensis)
PF00106
(adh_short)
4 ILE A  94
ASN A 107
SER A 154
THR A 140
None
1.26A 1h7xA-3rj9A:
4.7
1h7xA-3rj9A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N


(Escherichia
coli)
no annotation 4 ASN N 121
ILE N   9
SER N  51
THR N  77
None
1.18A 1h7xA-3rkoN:
undetectable
1h7xA-3rkoN:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER


(Haemophilus
influenzae)
PF02395
(Peptidase_S6)
PF03212
(Pertactin)
4 ASN A  99
ILE A  93
SER A  80
ASN A  82
None
1.22A 1h7xA-3syjA:
undetectable
1h7xA-3syjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE


(Brucella
abortus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
4 ASN A 165
ILE A 344
SER A 346
ASN A 294
None
None
None
NA  A 410 (-3.4A)
0.98A 1h7xA-3u0fA:
undetectable
1h7xA-3u0fA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxf FIMBRIAL SUBUNIT
TYPE 1


(Actinomyces
oris)
no annotation 4 ILE A 324
ASN A 326
SER A 328
THR A 148
None
1.13A 1h7xA-3uxfA:
undetectable
1h7xA-3uxfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
4 ILE A 438
ASN A 441
SER A 436
THR A 466
None
1.16A 1h7xA-3v5rA:
undetectable
1h7xA-3v5rA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis)
PF00232
(Glyco_hydro_1)
4 ILE A 400
ASN A 335
ASN A 192
THR A 145
None
SA0  A 507 ( 4.9A)
SA0  A 507 (-3.4A)
None
1.24A 1h7xA-3vilA:
6.4
1h7xA-3vilA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis)
PF00232
(Glyco_hydro_1)
4 ILE A 400
ASN A 335
SER A 251
ASN A 192
None
SA0  A 507 ( 4.9A)
None
SA0  A 507 (-3.4A)
1.24A 1h7xA-3vilA:
6.4
1h7xA-3vilA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N)
4 ILE A 286
ASN A 270
ASN A 522
THR A 519
None
GOL  A1010 ( 4.0A)
GOL  A1010 (-3.0A)
None
1.17A 1h7xA-3welA:
7.3
1h7xA-3welA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11


(Homo sapiens)
PF00225
(Kinesin)
4 ASN A 190
ILE A 319
ASN A 262
ASN A  98
None
1.00A 1h7xA-3zcwA:
undetectable
1h7xA-3zcwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga)
PF00704
(Glyco_hydro_18)
4 ASN A  23
ILE A 168
ASN A 169
SER A  96
None
0.90A 1h7xA-4a5qA:
10.8
1h7xA-4a5qA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akx EXOU

(Pseudomonas
aeruginosa)
PF01734
(Patatin)
4 ASN B 360
ASN B 371
SER B 106
ASN B 369
None
1.16A 1h7xA-4akxB:
2.3
1h7xA-4akxB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE


(Streptococcus
pneumoniae)
PF00728
(Glyco_hydro_20)
4 ASN A 225
SER A 437
ASN A 356
THR A 291
LOG  A1614 ( 4.2A)
None
None
None
1.24A 1h7xA-4az7A:
5.1
1h7xA-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4v OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Escherichia
coli)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
4 ASN A 606
ASN A 506
SER A 508
THR A 567
None
1.04A 1h7xA-4c4vA:
undetectable
1h7xA-4c4vA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
4 ASN A 516
ILE A 401
ASN A 405
SER A 456
None
1.15A 1h7xA-4fysA:
undetectable
1h7xA-4fysA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE


(Thermococcus
kodakarensis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
4 ILE A 281
SER A 165
ASN A 172
THR A 174
None
PO4  A 601 (-4.6A)
None
None
1.00A 1h7xA-4ga4A:
3.3
1h7xA-4ga4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE


(Thermococcus
kodakarensis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
4 ILE A 281
SER A 165
ASN A 172
THR A 174
None
SO4  A 602 ( 4.4A)
None
None
1.00A 1h7xA-4ga6A:
4.3
1h7xA-4ga6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi7 GI20122

(Drosophila
mojavensis)
PF00043
(GST_C)
PF13417
(GST_N_3)
4 ILE A  65
ASN A  64
ASN A  50
THR A  54
None
None
None
GSH  A 301 (-4.2A)
1.16A 1h7xA-4hi7A:
2.2
1h7xA-4hi7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2


(Pseudomonas
phage phi12)
no annotation 4 ASN A 246
ASN A 544
ASN A 200
THR A 192
None
1.24A 1h7xA-4iegA:
undetectable
1h7xA-4iegA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8z SPECKLE-TYPE POZ
PROTEIN


(Homo sapiens)
PF00651
(BTB)
4 ILE A 305
ASN A 301
SER A 298
THR A 335
None
1.26A 1h7xA-4j8zA:
undetectable
1h7xA-4j8zA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE


(Thermotoga
maritima)
PF02568
(ThiI)
PF02926
(THUMP)
4 ILE A 360
SER A 302
ASN A 299
THR A 296
None
1.06A 1h7xA-4kr9A:
2.6
1h7xA-4kr9A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
4 ASN A 135
ILE A 162
ASN A 187
THR A 184
None
1.03A 1h7xA-4nsxA:
undetectable
1h7xA-4nsxA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN


(Streptococcus
pyogenes)
PF16569
(GramPos_pilinBB)
4 ILE A  97
ASN A  98
ASN A 318
THR A 132
None
1.17A 1h7xA-4p0dA:
undetectable
1h7xA-4p0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167)
PF00232
(Glyco_hydro_1)
4 ASN A 171
ILE A 289
ASN A 253
ASN A 174
None
1.14A 1h7xA-4r27A:
7.8
1h7xA-4r27A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Verminephrobacter
eiseniae)
PF13407
(Peripla_BP_4)
4 ASN A 171
ASN A 280
SER A 138
ASN A 140
TLZ  A 401 (-3.0A)
TLZ  A 401 (-3.7A)
None
None
1.27A 1h7xA-4ry9A:
4.2
1h7xA-4ry9A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trg SIDC

(Legionella
pneumophila)
no annotation 4 ILE A 150
ASN A 458
SER A 154
ASN A 156
None
1.11A 1h7xA-4trgA:
undetectable
1h7xA-4trgA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 ASN A2543
ILE A2372
SER A2374
THR A2499
None
1.17A 1h7xA-4tvcA:
3.2
1h7xA-4tvcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Sulfolobus
solfataricus)
PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N)
4 ILE A  85
SER A 284
ASN A 269
THR A 268
None
1.15A 1h7xA-4twbA:
2.5
1h7xA-4twbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5a SPOROZOITE MICRONEME
PROTEIN ESSENTIAL
FOR CELL TRAVERSAL


(Plasmodium
berghei)
no annotation 4 ASN A 119
ILE A 124
ASN A 125
SER A 126
None
1.16A 1h7xA-4u5aA:
undetectable
1h7xA-4u5aA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
4 ILE A  47
ASN A 384
SER A  42
THR A 390
None
1.20A 1h7xA-4wzbA:
undetectable
1h7xA-4wzbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xk1 PHOSPHOSERINE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00266
(Aminotran_5)
4 ASN A 198
ILE A 337
SER A 295
ASN A 151
LLP  A 197 ( 4.2A)
None
None
None
1.20A 1h7xA-4xk1A:
undetectable
1h7xA-4xk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xq6 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Mycobacterium
tuberculosis)
PF01180
(DHO_dh)
4 ASN A 115
ASN A 176
ASN A 241
THR A 242
FMN  A 401 ( 3.5A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.6A)
CL  A 403 (-3.1A)
0.75A 1h7xA-4xq6A:
32.4
1h7xA-4xq6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 ASN A 299
SER A 224
ASN A 169
THR A 121
None
1.12A 1h7xA-4zfmA:
10.7
1h7xA-4zfmA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N)
4 ILE A 847
SER A 851
ASN A 854
THR A 865
None
1.13A 1h7xA-4zktA:
undetectable
1h7xA-4zktA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zud CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND TYPE-1
ANGIOTENSIN II
RECEPTOR


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
4 ASN A  46
ILE A 245
SER A 115
ASN A 111
None
1.09A 1h7xA-4zudA:
undetectable
1h7xA-4zudA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxk SIALIDASE A

(Streptococcus
pneumoniae)
PF02973
(Sialidase)
4 ILE A 269
ASN A 169
SER A 172
THR A 278
None
1.25A 1h7xA-4zxkA:
undetectable
1h7xA-4zxkA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
ALPHA SUBUNIT


(Sulfurisphaera
tokodaii)
PF01558
(POR)
PF01855
(POR_N)
PF17147
(PFOR_II)
4 ASN A  37
ILE A 602
ASN A 572
SER A 522
None
1.20A 1h7xA-5b47A:
2.1
1h7xA-5b47A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmv RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C


(Homo sapiens)
PF00041
(fn3)
PF12567
(CD45)
4 ASN A 468
ILE A 462
ASN A 434
THR A 421
NAG  A1578 (-1.9A)
None
NAG  A1578 (-4.3A)
NAG  A1578 (-3.0A)
1.23A 1h7xA-5fmvA:
undetectable
1h7xA-5fmvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens)
PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC)
4 ASN B 119
ILE B 111
SER B  92
ASN B 187
None
1.18A 1h7xA-5fwwB:
undetectable
1h7xA-5fwwB:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpd STEROL REGULATORY
ELEMENT-BINDING
PROTEIN 1


(Schizosaccharomyces
pombe)
PF09427
(DUF2014)
4 ILE A 785
ASN A 786
SER A 788
THR A 827
None
0.98A 1h7xA-5gpdA:
undetectable
1h7xA-5gpdA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 ASN A 397
ILE A  68
ASN A  65
SER A 269
None
1.16A 1h7xA-5imtA:
undetectable
1h7xA-5imtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
4 ASN A 397
ILE A  68
ASN A  65
SER A 269
None
1.21A 1h7xA-5imwA:
undetectable
1h7xA-5imwA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE


(Bacillus cereus)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
4 ILE A 179
ASN A 175
SER A 122
THR A  96
EPE  A 402 (-4.8A)
None
EPE  A 402 (-3.4A)
NAD  A 401 (-4.0A)
1.26A 1h7xA-5je8A:
undetectable
1h7xA-5je8A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE


(Campylobacter
jejuni)
PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE)
4 ASN A 779
ASN A  23
ASN A  27
THR A  30
None
1.05A 1h7xA-5jxlA:
undetectable
1h7xA-5jxlA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38


(Enterococcus
faecalis)
PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid)
4 ASN A 733
ILE A 689
SER A  99
THR A 308
None
1.14A 1h7xA-5kbpA:
1.7
1h7xA-5kbpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klf CARBOHYDRATE BINDING
MODULE E1


(uncultured
bacterium)
no annotation 4 ILE A  42
ASN A  63
SER A  50
THR A  46
None
1.16A 1h7xA-5klfA:
undetectable
1h7xA-5klfA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE


(Lactococcus
lactis)
PF01180
(DHO_dh)
4 ASN A 132
SER A 134
ASN A 197
THR A 198
FMN  A 401 (-3.3A)
None
FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
0.84A 1h7xA-5kswA:
36.1
1h7xA-5kswA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL


(Homo sapiens)
PF01180
(DHO_dh)
4 ASN A 145
ASN A 212
ASN A 284
THR A 285
ORO  A 402 ( 3.1A)
ORO  A 402 ( 3.2A)
ORO  A 402 ( 2.9A)
ORO  A 402 ( 2.8A)
0.34A 1h7xA-5mvdA:
30.3
1h7xA-5mvdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X


(Streptococcus
thermophilus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA)
4 ILE A 684
SER A 677
ASN A 710
THR A 707
None
1.13A 1h7xA-5u47A:
undetectable
1h7xA-5u47A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
4 ASN A 378
ILE A 407
ASN A 203
THR A 200
CIT  A 503 ( 3.3A)
None
None
CIT  A 503 (-3.6A)
1.22A 1h7xA-5uldA:
undetectable
1h7xA-5uldA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR


(Synechocystis
sp. PCC 6803)
no annotation 4 ASN A 225
ASN A 164
SER A 148
THR A 201
None
PGA  A 401 (-3.1A)
PGA  A 401 (-3.5A)
PGA  A 401 (-3.6A)
1.14A 1h7xA-5y2wA:
undetectable
1h7xA-5y2wA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8s DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)


(Helicobacter
pylori)
no annotation 4 ASN A 116
ASN A 178
ASN A 243
THR A 244
FMN  A 401 (-3.6A)
FMN  A 401 (-2.9A)
FMN  A 401 (-3.6A)
FMN  A 401 ( 4.8A)
0.53A 1h7xA-6b8sA:
30.4
1h7xA-6b8sA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci9 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Mycolicibacterium
smegmatis)
no annotation 4 ILE A  94
ASN A 115
SER A 160
THR A 145
None
None
None
F3V  A 302 (-3.9A)
1.19A 1h7xA-6ci9A:
5.4
1h7xA-6ci9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp0 -

(-)
no annotation 4 ILE A 345
SER A 438
ASN A  43
THR A  44
None
1.19A 1h7xA-6cp0A:
undetectable
1h7xA-6cp0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czx PHOSPHOSERINE
AMINOTRANSFERASE 1,
CHLOROPLASTIC


(Arabidopsis
thaliana)
no annotation 4 ASN A 266
ILE A 406
SER A 364
ASN A 219
LLP  A 265 ( 4.9A)
None
None
None
1.25A 1h7xA-6czxA:
undetectable
1h7xA-6czxA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dde MU-TYPE OPIOID
RECEPTOR


(Mus musculus)
no annotation 4 ASN R 191
ILE R 186
ASN R 183
THR R 160
None
1.17A 1h7xA-6ddeR:
undetectable
1h7xA-6ddeR:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni)
no annotation 4 ASN A 106
ILE A  37
SER A  86
THR A 111
None
1.06A 1h7xA-6ejjA:
2.2
1h7xA-6ejjA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B


(Homo sapiens)
no annotation 4 ASN A 509
ILE A 500
SER A 505
ASN A 601
90V  A 804 ( 4.6A)
DMS  A 805 (-4.9A)
None
90V  A 804 (-3.8A)
1.05A 1h7xA-6ek6A:
undetectable
1h7xA-6ek6A:
6.26