SIMILAR PATTERNS OF AMINO ACIDS FOR 1H4O_H_BEZH1162

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4o PEROXIREDOXIN 5

(Homo sapiens)
PF08534
(Redoxin)
9 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
THR A 147
BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
0.25A 1h4oH-1h4oA:
34.8
1h4oH-1h4oA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae)
PF00462
(Glutaredoxin)
PF08534
(Redoxin)
7 PRO A  42
THR A  46
PRO A  47
CYH A  49
LEU A 118
PHE A 120
ARG A 126
None
0.84A 1h4oH-1nm3A:
24.3
1h4oH-1nm3A:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE


(Streptococcus
pneumoniae)
PF08534
(Redoxin)
5 PRO A  51
THR A  55
CYH A  58
LEU A   5
ARG A 127
None
1.10A 1h4oH-1psqA:
19.4
1h4oH-1psqA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
5 THR A  30
PRO A  31
GLY A  32
CYH A  33
LEU A  63
None
0.97A 1h4oH-1qd1A:
0.1
1h4oH-1qd1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE


(Pyrococcus
abyssi)
PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g)
5 PRO A  11
PRO A  16
GLY A  15
PHE A  82
THR A  49
None
1.39A 1h4oH-1rqgA:
0.0
1h4oH-1rqgA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE


(Saccharomyces
cerevisiae)
PF01218
(Coprogen_oxidas)
5 THR A 283
PRO A 284
GLY A 285
LEU A  78
ARG A  46
None
1.25A 1h4oH-1tklA:
0.5
1h4oH-1tklA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa)
PF08534
(Redoxin)
5 PRO A  44
THR A  48
PRO A  49
CYH A  51
ARG A 129
None
SO4  A1248 ( 4.6A)
SO4  A1248 (-3.6A)
None
None
0.16A 1h4oH-1tp9A:
26.8
1h4oH-1tp9A:
43.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa)
PF08534
(Redoxin)
5 THR A  48
PRO A  49
CYH A  51
LEU A 118
ARG A 129
SO4  A1248 ( 4.6A)
SO4  A1248 (-3.6A)
None
None
None
0.58A 1h4oH-1tp9A:
26.8
1h4oH-1tp9A:
43.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
5 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
None
0.60A 1h4oH-2a4vA:
20.1
1h4oH-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs8 XAA-PRO DIPEPTIDASE

(Alteromonas
macleodii)
PF01979
(Amidohydro_1)
5 PRO A 135
THR A 102
GLY A 106
PHE A  72
THR A 109
None
1.33A 1h4oH-2qs8A:
0.0
1h4oH-2qs8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
5 THR A1122
PRO A1123
GLY A1512
PHE A1517
THR A1232
None
1.32A 1h4oH-2vz9A:
undetectable
1h4oH-2vz9A:
6.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina)
PF08534
(Redoxin)
5 THR A  71
PRO A  72
GLY A  73
LEU A 141
ARG A 152
None
0.57A 1h4oH-2wfcA:
31.3
1h4oH-2wfcA:
64.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE


(Aquifex
aeolicus)
PF08534
(Redoxin)
6 PRO A  54
THR A  58
PRO A  59
CYH A  61
LEU A 126
ARG A 132
None
0.91A 1h4oH-2yzhA:
19.0
1h4oH-2yzhA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE


(Aquifex
aeolicus)
PF08534
(Redoxin)
5 THR A  58
PRO A  59
CYH A  61
ARG A 132
THR A 153
None
0.74A 1h4oH-2yzhA:
19.0
1h4oH-2yzhA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 PRO A 450
THR A 447
GLY A 465
LEU A 212
ARG A 492
None
1.48A 1h4oH-3a24A:
undetectable
1h4oH-3a24A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN


(Aeropyrum
pernix)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
None
0.51A 1h4oH-3a5wA:
16.4
1h4oH-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt3 GLYOXALASE-RELATED
ENZYME, ARAC TYPE


(Lachnoclostridium
phytofermentans)
no annotation 5 THR A 252
GLY A 255
CYH A 256
PHE A 158
THR A 148
None
1.09A 1h4oH-3bt3A:
undetectable
1h4oH-3bt3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE


(Escherichia
coli)
PF00425
(Chorismate_bind)
5 PRO A  20
THR A  22
PRO A  23
GLY A  24
ARG A  26
None
1.28A 1h4oH-3bzmA:
undetectable
1h4oH-3bzmA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG


(Sulfolobus
solfataricus)
PF00578
(AhpC-TSA)
5 PRO A  38
THR A  42
PRO A  43
GLY A  44
ARG A 112
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.7A)
0.37A 1h4oH-3drnA:
19.5
1h4oH-3drnA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III


(Ruegeria
pomeroyi)
PF00202
(Aminotran_3)
5 PRO A 229
THR A 270
GLY A 266
CYH A 265
THR A 276
None
1.35A 1h4oH-3hmuA:
undetectable
1h4oH-3hmuA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivr PUTATIVE
LONG-CHAIN-FATTY-ACI
D COA LIGASE


(Rhodopseudomonas
palustris)
PF00501
(AMP-binding)
5 THR A 215
GLY A 310
LEU A 281
PHE A 256
THR A 302
None
None
GOL  A 512 (-4.7A)
None
GOL  A 512 (-4.7A)
1.42A 1h4oH-3ivrA:
undetectable
1h4oH-3ivrA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xylella
fastidiosa)
PF00578
(AhpC-TSA)
5 PRO A  40
THR A  44
PRO A  45
GLY A  46
ARG A 122
None
0.45A 1h4oH-3ixrA:
19.0
1h4oH-3ixrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxa CONTACTIN 4

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
5 PRO A 208
PRO A 146
GLY A 145
LEU A 206
ARG A 129
None
1.45A 1h4oH-3jxaA:
undetectable
1h4oH-3jxaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988


(Thermus
thermophilus)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
5 PRO A 186
PRO A 121
GLY A 122
LEU A 346
PHE A 345
None
1.35A 1h4oH-3oepA:
undetectable
1h4oH-3oepA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE


(Staphylococcus
aureus)
PF08534
(Redoxin)
5 PRO A  53
THR A  57
CYH A  60
LEU A 123
ARG A 128
None
0.86A 1h4oH-3p7xA:
18.7
1h4oH-3p7xA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  40
THR A  44
PRO A  45
CYH A  47
ARG A 129
GOL  A 223 (-4.3A)
GOL  A 223 ( 4.3A)
GOL  A 223 (-3.6A)
GOL  A 223 (-4.4A)
GOL  A 223 (-4.1A)
0.55A 1h4oH-3tb2A:
17.6
1h4oH-3tb2A:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
5 PRO A  42
THR A  46
PRO A  47
CYH A  49
ARG A 127
None
0.18A 1h4oH-3umaA:
27.5
1h4oH-3umaA:
37.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis)
PF08534
(Redoxin)
5 PRO A  54
THR A  58
CYH A  61
LEU A 127
ARG A 133
None
0.92A 1h4oH-3zreA:
18.2
1h4oH-3zreA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f82 THIOREDOXIN
REDUCTASE


(Burkholderia
cenocepacia)
PF08534
(Redoxin)
5 PRO A  48
THR A  52
PRO A  53
CYH A  55
ARG A 133
None
0.13A 1h4oH-4f82A:
27.8
1h4oH-4f82A:
42.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f82 THIOREDOXIN
REDUCTASE


(Burkholderia
cenocepacia)
PF08534
(Redoxin)
5 THR A  52
PRO A  53
CYH A  55
LEU A 122
ARG A 133
None
0.66A 1h4oH-4f82A:
27.8
1h4oH-4f82A:
42.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE


(Aspergillus
nidulans)
PF16363
(GDP_Man_Dehyd)
5 THR A 153
PRO A 152
GLY A 151
LEU A 320
ARG A 137
None
1.33A 1h4oH-4lisA:
undetectable
1h4oH-4lisA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120)
no annotation 5 PRO A 480
PRO A 538
GLY A 506
PHE A 493
THR A 503
None
1.42A 1h4oH-4oj5A:
undetectable
1h4oH-4oj5A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4piv FATTY ACID SYNTHASE

(Homo sapiens)
PF08242
(Methyltransf_12)
PF08659
(KR)
5 THR A1120
PRO A1121
GLY A1512
PHE A1517
THR A1230
None
1.33A 1h4oH-4pivA:
undetectable
1h4oH-4pivA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN


(Burkholderia
ambifaria)
PF00578
(AhpC-TSA)
6 PRO A  37
THR A  41
PRO A  42
GLY A  43
CYH A  44
ARG A 119
None
0.33A 1h4oH-5enuA:
19.0
1h4oH-5enuA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
6 PRO A  45
THR A  49
PRO A  50
GLY A  51
CYH A  52
ARG A 124
None
0.89A 1h4oH-5epfA:
20.9
1h4oH-5epfA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xanthomonas
campestris)
PF00578
(AhpC-TSA)
6 PRO A  41
THR A  45
PRO A  46
GLY A  47
CYH A  48
ARG A 123
None
0.66A 1h4oH-5ipgA:
18.2
1h4oH-5ipgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae)
no annotation 5 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
None
1.48A 1h4oH-5jtaA:
undetectable
1h4oH-5jtaA:
13.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus)
PF08534
(Redoxin)
5 PRO A  41
THR A  45
PRO A  46
PHE A 117
ARG A 124
None
0.87A 1h4oH-5k1gA:
28.1
1h4oH-5k1gA:
43.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E


(Pyrococcus
furiosus)
no annotation 5 THR A 119
PRO A 120
GLY A 121
LEU A 112
THR A 124
None
1.30A 1h4oH-6cfwA:
undetectable
1h4oH-6cfwA:
undetectable