SIMILAR PATTERNS OF AMINO ACIDS FOR 1H4O_G_BEZG1162

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4o PEROXIREDOXIN 5

(Homo sapiens)
PF08534
(Redoxin)
8 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
LEU A 116
PHE A 120
ARG A 127
BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
None
BEZ  A1162 (-3.7A)
0.07A 1h4oG-1h4oA:
35.6
1h4oG-1h4oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
4 PRO B  43
THR A  35
PRO A  36
GLY A  37
None
0.76A 1h4oG-1hr7B:
undetectable
1h4oG-1hr7B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8r PROTEIN KINASE BYR2

(Schizosaccharomyces
pombe)
PF14847
(Ras_bdg_2)
4 THR B  94
GLY B  89
LEU B 143
PHE B  75
None
0.72A 1h4oG-1k8rB:
undetectable
1h4oG-1k8rB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miu BREAST CANCER TYPE 2
SUSCEPTIBILITY
PROTEIN


(Mus musculus)
PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical)
4 THR A2528
PRO A2529
GLY A2530
LEU A2575
None
0.60A 1h4oG-1miuA:
undetectable
1h4oG-1miuA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus)
PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical)
4 THR A2528
PRO A2529
GLY A2530
LEU A2575
None
0.72A 1h4oG-1mjeA:
undetectable
1h4oG-1mjeA:
13.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae)
PF00462
(Glutaredoxin)
PF08534
(Redoxin)
7 PRO A  42
THR A  46
PRO A  47
CYH A  49
LEU A 118
PHE A 120
ARG A 126
None
0.79A 1h4oG-1nm3A:
24.1
1h4oG-1nm3A:
32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1


(Mycobacterium
tuberculosis)
PF12849
(PBP_like_2)
4 THR A 218
PRO A 219
GLY A 220
CYH A 221
None
0.68A 1h4oG-1pc3A:
undetectable
1h4oG-1pc3A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE


(Streptococcus
pneumoniae)
PF08534
(Redoxin)
5 PRO A  51
THR A  55
CYH A  58
LEU A   5
ARG A 127
None
1.05A 1h4oG-1psqA:
19.3
1h4oG-1psqA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
4 THR A  30
PRO A  31
GLY A  32
CYH A  33
None
0.37A 1h4oG-1qd1A:
undetectable
1h4oG-1qd1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  44
THR A  48
CYH A  51
ARG A 127
None
0.53A 1h4oG-1qmvA:
18.4
1h4oG-1qmvA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 106
PRO A 107
GLY A 108
LEU A  87
None
0.56A 1h4oG-1r9jA:
undetectable
1h4oG-1r9jA:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa)
PF08534
(Redoxin)
5 PRO A  44
THR A  48
PRO A  49
CYH A  51
ARG A 129
None
SO4  A1248 ( 4.6A)
SO4  A1248 (-3.6A)
None
None
0.17A 1h4oG-1tp9A:
26.7
1h4oG-1tp9A:
43.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa)
PF08534
(Redoxin)
5 THR A  48
PRO A  49
CYH A  51
LEU A 118
ARG A 129
SO4  A1248 ( 4.6A)
SO4  A1248 (-3.6A)
None
None
None
0.60A 1h4oG-1tp9A:
26.7
1h4oG-1tp9A:
43.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE


(Aeropyrum
pernix)
PF00793
(DAHP_synth_1)
4 THR A 259
PRO A 260
GLY A 261
ARG A 265
None
0.82A 1h4oG-1vs1A:
undetectable
1h4oG-1vs1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B)
PF00680
(RdRP_1)
4 THR A  19
PRO A  20
LEU A  58
PHE A 274
None
0.81A 1h4oG-1xr5A:
undetectable
1h4oG-1xr5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A)
PF00680
(RdRP_1)
4 THR A  19
PRO A  20
LEU A  58
PHE A 274
None
0.75A 1h4oG-1xr6A:
undetectable
1h4oG-1xr6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y25 PROBABLE THIOL
PEROXIDASE


(Mycobacterium
tuberculosis)
PF08534
(Redoxin)
4 PRO A  53
THR A  57
PRO A  58
ARG A 130
None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.1A)
0.49A 1h4oG-1y25A:
19.0
1h4oG-1y25A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd)
5 THR A 160
PRO A 159
GLY A 158
LEU A 318
ARG A 144
None
None
None
UPG  A 704 (-3.9A)
None
1.27A 1h4oG-1z45A:
undetectable
1h4oG-1z45A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z60 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX P44 SUBUNIT


(Homo sapiens)
PF07975
(C1_4)
4 PRO A 383
GLY A 384
CYH A 385
PHE A 331
None
ZN  A   2 ( 4.6A)
ZN  A   2 (-2.3A)
None
0.66A 1h4oG-1z60A:
undetectable
1h4oG-1z60A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE


(Bos taurus)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  40
THR A  44
CYH A  47
ARG A 123
None
0.66A 1h4oG-1zyeA:
19.0
1h4oG-1zyeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
5 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
None
0.62A 1h4oG-2a4vA:
20.0
1h4oG-2a4vA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx4 BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Aeropyrum
pernix)
PF00578
(AhpC-TSA)
4 PRO A  42
PRO A  47
CYH A  49
ARG A 122
None
0.36A 1h4oG-2cx4A:
21.0
1h4oG-2cx4A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 110
PRO A 111
GLY A 112
LEU A  91
None
0.46A 1h4oG-2e6kA:
undetectable
1h4oG-2e6kA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9h PTS SYSTEM, IIA
COMPONENT


(Enterococcus
faecalis)
PF03829
(PTSIIA_gutA)
4 PRO A 111
THR A  63
GLY A  61
LEU A 105
None
0.74A 1h4oG-2f9hA:
undetectable
1h4oG-2f9hA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A


(Pseudomonas
putida)
PF00724
(Oxidored_FMN)
4 THR A  67
PRO A  68
GLY A  69
CYH A  70
None
SO4  A1506 ( 4.7A)
None
None
0.82A 1h4oG-2h8xA:
undetectable
1h4oG-2h8xA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE


(Fowl
aviadenovirus A)
PF16812
(AdHead_fibreRBD)
4 THR A 781
PRO A 782
LEU A 755
PHE A 757
None
0.75A 1h4oG-2iunA:
undetectable
1h4oG-2iunA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jx1 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A  14
PRO A  15
GLY A  16
CYH A  17
None
0.74A 1h4oG-2jx1A:
undetectable
1h4oG-2jx1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
4 PRO A 198
THR A 215
PRO A 216
GLY A 217
None
0.72A 1h4oG-2kbeA:
undetectable
1h4oG-2kbeA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lex PROBABLE WRKY
TRANSCRIPTION FACTOR
4


(Arabidopsis
thaliana)
PF03106
(WRKY)
4 THR A 436
PRO A 437
GLY A 438
CYH A 439
ZN  A 500 (-3.5A)
None
None
ZN  A 500 (-2.5A)
0.66A 1h4oG-2lexA:
undetectable
1h4oG-2lexA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf8 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A 804
PRO A 805
GLY A 806
CYH A 807
ZN  A 901 (-4.0A)
None
None
ZN  A 901 (-1.9A)
0.82A 1h4oG-2mf8A:
undetectable
1h4oG-2mf8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf8 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A 848
PRO A 849
GLY A 850
CYH A 851
ZN  A 902 (-3.2A)
None
None
ZN  A 902 (-2.3A)
0.83A 1h4oG-2mf8A:
undetectable
1h4oG-2mf8A:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pwj MITOCHONDRIAL
PEROXIREDOXIN


(Pisum sativum)
PF08534
(Redoxin)
4 PRO A  52
THR A  56
CYH A  59
ARG A 137
None
0.51A 1h4oG-2pwjA:
26.3
1h4oG-2pwjA:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens)
PF00004
(AAA)
4 PRO A 480
PRO A 351
GLY A 352
CYH A 353
None
ADP  A 700 (-4.8A)
ADP  A 700 (-3.6A)
None
0.85A 1h4oG-2qz4A:
undetectable
1h4oG-2qz4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  38
THR A  42
PRO A  43
ARG A 128
BEZ  A1222 ( 4.6A)
BEZ  A1222 (-3.6A)
BEZ  A1222 (-3.2A)
BEZ  A1222 (-3.3A)
0.48A 1h4oG-2v41A:
18.4
1h4oG-2v41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE


(Digitalis
lanata)
PF01370
(Epimerase)
4 THR A  51
PRO A  52
GLY A  53
LEU A  42
None
0.51A 1h4oG-2v6gA:
2.1
1h4oG-2v6gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Homo sapiens)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
4 PRO A 650
PRO A 687
GLY A 688
ARG A 638
None
0.74A 1h4oG-2vxoA:
undetectable
1h4oG-2vxoA:
17.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina)
PF08534
(Redoxin)
4 PRO A  67
THR A  71
GLY A  73
ARG A 152
None
0.60A 1h4oG-2wfcA:
31.6
1h4oG-2wfcA:
64.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina)
PF08534
(Redoxin)
5 THR A  71
PRO A  72
GLY A  73
LEU A 141
ARG A 152
None
0.56A 1h4oG-2wfcA:
31.6
1h4oG-2wfcA:
64.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE


(Aquifex
aeolicus)
PF08534
(Redoxin)
6 PRO A  54
THR A  58
PRO A  59
CYH A  61
LEU A 126
ARG A 132
None
0.92A 1h4oG-2yzhA:
19.0
1h4oG-2yzhA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 PRO A 450
THR A 447
GLY A 465
LEU A 212
ARG A 492
None
1.47A 1h4oG-3a24A:
undetectable
1h4oG-3a24A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN


(Aeropyrum
pernix)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
None
0.49A 1h4oG-3a5wA:
16.3
1h4oG-3a5wA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis)
PF00294
(PfkB)
4 PRO A 143
GLY A 142
LEU A 179
PHE A 174
AMP  A 501 (-4.6A)
None
None
None
0.84A 1h4oG-3b1rA:
undetectable
1h4oG-3b1rA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans)
PF12697
(Abhydrolase_6)
4 PRO A 228
PRO A 252
GLY A 253
ARG A 283
None
0.85A 1h4oG-3bwxA:
undetectable
1h4oG-3bwxA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Mus musculus)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 648
PRO A 520
GLY A 521
CYH A 522
None
ADP  A 900 ( 4.9A)
ADP  A 900 (-3.4A)
None
0.82A 1h4oG-3cf0A:
undetectable
1h4oG-3cf0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF01301
(Glyco_hydro_35)
4 PRO A  55
GLY A 578
CYH A 579
PHE A 305
None
0.85A 1h4oG-3d3aA:
undetectable
1h4oG-3d3aA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 PRO A 218
THR A 221
PRO A 222
GLY A 223
None
0.83A 1h4oG-3ddlA:
undetectable
1h4oG-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG


(Sulfolobus
solfataricus)
PF00578
(AhpC-TSA)
5 PRO A  38
THR A  42
PRO A  43
GLY A  44
ARG A 112
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.7A)
0.39A 1h4oG-3drnA:
19.4
1h4oG-3drnA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609


(Methanocaldococcus
jannaschii)
PF13520
(AA_permease_2)
4 THR C 408
GLY C 411
LEU C 333
PHE C 334
None
0.76A 1h4oG-3gi8C:
undetectable
1h4oG-3gi8C:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE


(Streptomyces
antibioticus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 THR A 450
GLY A 452
PHE A 546
ARG A 496
None
0.82A 1h4oG-3gyrA:
undetectable
1h4oG-3gyrA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2y GTPASE FAMILY
PROTEIN


(Bacillus
anthracis)
PF01926
(MMR_HSR1)
4 THR A 218
PRO A 219
GLY A 220
LEU A  63
None
0.82A 1h4oG-3h2yA:
undetectable
1h4oG-3h2yA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE


(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
4 THR A 351
PRO A 352
GLY A 353
ARG A 357
None
0.75A 1h4oG-3h4iA:
2.7
1h4oG-3h4iA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xylella
fastidiosa)
PF00578
(AhpC-TSA)
5 PRO A  40
THR A  44
PRO A  45
GLY A  46
ARG A 122
None
0.43A 1h4oG-3ixrA:
18.9
1h4oG-3ixrA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxa CONTACTIN 4

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
5 PRO A 208
PRO A 146
GLY A 145
LEU A 206
ARG A 129
None
1.48A 1h4oG-3jxaA:
undetectable
1h4oG-3jxaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw7 LACCASE B

(Trametes sp.
AH28-2)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PRO A   4
GLY A   3
LEU A  68
PHE A  97
None
0.86A 1h4oG-3kw7A:
undetectable
1h4oG-3kw7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 GLY A 213
CYH A 212
LEU A 260
PHE A 261
None
0.77A 1h4oG-3mn3A:
undetectable
1h4oG-3mn3A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083


(Pyrococcus
furiosus)
PF01593
(Amino_oxidase)
4 PRO A 181
PRO A  83
GLY A  85
LEU A 183
None
0.84A 1h4oG-3nrnA:
undetectable
1h4oG-3nrnA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988


(Thermus
thermophilus)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
5 PRO A 186
PRO A 121
GLY A 122
LEU A 346
PHE A 345
None
1.30A 1h4oG-3oepA:
undetectable
1h4oG-3oepA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE


(Staphylococcus
aureus)
PF08534
(Redoxin)
5 PRO A  53
THR A  57
CYH A  60
LEU A 123
ARG A 128
None
0.92A 1h4oG-3p7xA:
18.7
1h4oG-3p7xA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpm PEROXIREDOXIN

(Larimichthys
crocea)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A 106
THR A 110
CYH A 113
ARG A 189
None
0.57A 1h4oG-3qpmA:
16.6
1h4oG-3qpmA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens)
PF08337
(Plexin_cytopl)
4 PRO X1584
PRO X1578
GLY X1579
LEU X1640
None
0.83A 1h4oG-3su8X:
undetectable
1h4oG-3su8X:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  40
THR A  44
PRO A  45
CYH A  47
ARG A 129
GOL  A 223 (-4.3A)
GOL  A 223 ( 4.3A)
GOL  A 223 (-3.6A)
GOL  A 223 (-4.4A)
GOL  A 223 (-4.1A)
0.56A 1h4oG-3tb2A:
17.6
1h4oG-3tb2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  80
THR A  84
CYH A  87
ARG A 163
None
0.57A 1h4oG-3tkrA:
18.6
1h4oG-3tkrA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk1 TRANSKETOLASE

(Burkholderia
thailandensis)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 THR A 126
PRO A 127
GLY A 128
LEU A 107
None
0.49A 1h4oG-3uk1A:
undetectable
1h4oG-3uk1A:
15.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
5 PRO A  42
THR A  46
PRO A  47
CYH A  49
ARG A 127
None
0.16A 1h4oG-3umaA:
27.6
1h4oG-3umaA:
37.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up4 OTEMO

(Pseudomonas
putida)
PF00743
(FMO-like)
4 THR A 222
PRO A 223
LEU A 305
PHE A 333
None
0.84A 1h4oG-3up4A:
undetectable
1h4oG-3up4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxi DYP

(Bjerkandera
adusta)
PF04261
(Dyp_perox)
4 PRO A 187
GLY A 188
LEU A 281
ARG A 315
None
ASC  A 502 (-4.6A)
None
HEM  A 501 ( 3.9A)
0.84A 1h4oG-3vxiA:
undetectable
1h4oG-3vxiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 THR A 113
PRO A 114
GLY A 115
LEU A 152
None
0.78A 1h4oG-3zl8A:
undetectable
1h4oG-3zl8A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis)
PF08534
(Redoxin)
4 PRO A  54
THR A  58
CYH A  61
ARG A 133
None
0.44A 1h4oG-3zreA:
18.1
1h4oG-3zreA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af2 THIOL PEROXIDASE

(Escherichia
coli)
PF08534
(Redoxin)
4 PRO A  54
THR A  58
LEU A 127
ARG A 133
None
0.83A 1h4oG-4af2A:
18.7
1h4oG-4af2A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1q HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9


(Mus musculus)
PF00856
(SET)
4 PRO A 244
GLY A 245
LEU A 271
PHE A 273
None
0.80A 1h4oG-4c1qA:
undetectable
1h4oG-4c1qA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE


(Streptomyces
coelicolor)
PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
4 THR A 291
PRO A 292
GLY A 293
LEU A 175
None
0.73A 1h4oG-4c7gA:
undetectable
1h4oG-4c7gA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 PRO A 101
THR A 109
GLY A 107
CYH A 108
LEU A  74
None
1.39A 1h4oG-4c7vA:
undetectable
1h4oG-4c7vA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL


(Homo sapiens)
PF00753
(Lactamase_B)
4 THR A 136
PRO A 137
GLY A 138
CYH A 139
None
0.78A 1h4oG-4chlA:
undetectable
1h4oG-4chlA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN


(Metallosphaera
sedula)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 270
PRO A 140
GLY A 141
CYH A 142
None
None
ADP  A1367 (-3.2A)
None
0.80A 1h4oG-4d82A:
undetectable
1h4oG-4d82A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE


(Thermotoga
maritima)
PF00578
(AhpC-TSA)
PF00881
(Nitroreductase)
4 PRO A  33
THR A  37
GLY A  39
ARG A 103
None
SO4  A 402 (-3.4A)
SO4  A 402 (-3.3A)
SO4  A 402 (-3.5A)
0.40A 1h4oG-4eo3A:
17.8
1h4oG-4eo3A:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f82 THIOREDOXIN
REDUCTASE


(Burkholderia
cenocepacia)
PF08534
(Redoxin)
5 PRO A  48
THR A  52
PRO A  53
CYH A  55
ARG A 133
None
0.18A 1h4oG-4f82A:
27.4
1h4oG-4f82A:
42.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f82 THIOREDOXIN
REDUCTASE


(Burkholderia
cenocepacia)
PF08534
(Redoxin)
5 THR A  52
PRO A  53
CYH A  55
LEU A 122
ARG A 133
None
0.68A 1h4oG-4f82A:
27.4
1h4oG-4f82A:
42.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria)
PF00962
(A_deaminase)
4 PRO A   9
THR A   4
PRO A   5
GLY A   6
None
0.80A 1h4oG-4gxwA:
undetectable
1h4oG-4gxwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1f TRYPAREDOXIN
PEROXIDASE


(Leishmania
major)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  45
THR A  49
CYH A  52
ARG A 128
None
PGE  A 201 ( 4.1A)
None
None
0.51A 1h4oG-4k1fA:
17.3
1h4oG-4k1fA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 273
PRO A 143
GLY A 144
CYH A 145
None
None
CL  A 401 ( 4.4A)
None
0.72A 1h4oG-4lgmA:
undetectable
1h4oG-4lgmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE


(Trypanosoma
cruzi)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  45
THR A  49
CYH A  52
ARG A 128
None
0.49A 1h4oG-4llrA:
17.3
1h4oG-4llrA:
27.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 PRO A3312
GLY A3337
CYH A3339
LEU A3329
PHE A3268
None
1.46A 1h4oG-4tktA:
undetectable
1h4oG-4tktA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmk PROTEIN (THYMIDYLATE
KINASE)


(Escherichia
coli)
PF02223
(Thymidylate_kin)
4 PRO A 133
GLY A  98
LEU A 128
PHE A 131
None
0.81A 1h4oG-4tmkA:
undetectable
1h4oG-4tmkA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT


(Desulfovibrio
vulgaris)
PF00374
(NiFeSe_Hases)
4 THR L 293
GLY L 291
LEU L 392
PHE L 296
None
None
MPD  L 604 ( 4.4A)
None
0.76A 1h4oG-4u9iL:
undetectable
1h4oG-4u9iL:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c04 PUTATIVE
PEROXIREDOXIN MT2298


(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
4 PRO A  38
THR A  42
CYH A  45
ARG A 116
None
0.50A 1h4oG-5c04A:
19.4
1h4oG-5c04A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Homo sapiens)
PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C)
4 PRO A 238
LEU A 222
PHE A 230
ARG A 365
None
0.84A 1h4oG-5c1bA:
undetectable
1h4oG-5c1bA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF00752
(XPG_N)
PF00867
(XPG_I)
4 PRO A 206
GLY A 207
CYH A 208
LEU A 244
None
0.70A 1h4oG-5co8A:
undetectable
1h4oG-5co8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5coa IRIDOID SYNTHASE

(Catharanthus
roseus)
no annotation 4 THR A  54
PRO A  55
GLY A  56
LEU A  45
None
0.55A 1h4oG-5coaA:
2.2
1h4oG-5coaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 PRO A 198
THR A 215
PRO A 216
GLY A 217
U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
0.57A 1h4oG-5elxA:
undetectable
1h4oG-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN


(Burkholderia
ambifaria)
PF00578
(AhpC-TSA)
6 PRO A  37
THR A  41
PRO A  42
GLY A  43
CYH A  44
ARG A 119
None
0.34A 1h4oG-5enuA:
18.9
1h4oG-5enuA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
6 PRO A  45
THR A  49
PRO A  50
GLY A  51
CYH A  52
ARG A 124
None
0.90A 1h4oG-5epfA:
20.8
1h4oG-5epfA:
28.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE


(Pyrococcus
horikoshii)
PF00004
(AAA)
4 PRO A 277
PRO A 149
GLY A 150
CYH A 151
None
ACT  A 402 ( 3.6A)
ADP  A 401 (-3.1A)
None
0.80A 1h4oG-5eqtA:
undetectable
1h4oG-5eqtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xanthomonas
campestris)
PF00578
(AhpC-TSA)
6 PRO A  41
THR A  45
PRO A  46
GLY A  47
CYH A  48
ARG A 123
None
0.68A 1h4oG-5ipgA:
18.0
1h4oG-5ipgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL


(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  40
THR A  44
CYH A  47
ARG A 123
None
0.53A 1h4oG-5jcgA:
17.5
1h4oG-5jcgA:
27.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jg7 FUR REGULATED
SALMONELLA IRON
TRANSPORTER


(Salmonella
enterica)
PF01297
(ZnuA)
4 THR A  69
PRO A  70
GLY A  71
ARG A  75
None
0.86A 1h4oG-5jg7A:
undetectable
1h4oG-5jg7A:
21.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus)
PF08534
(Redoxin)
5 PRO A  41
THR A  45
PRO A  46
PHE A 117
ARG A 124
None
0.94A 1h4oG-5k1gA:
27.9
1h4oG-5k1gA:
43.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE


(Mycobacterium
tuberculosis)
PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB)
4 PRO A 440
PRO A 295
GLY A 296
CYH A 297
None
ADP  A 701 (-4.9A)
ADP  A 701 (-3.3A)
None
0.83A 1h4oG-5kwaA:
undetectable
1h4oG-5kwaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride)
no annotation 4 PRO A 382
THR A 389
PRO A 390
GLY A 391
None
None
GOL  A 609 ( 4.8A)
GOL  A 609 (-4.0A)
0.83A 1h4oG-5o5dA:
undetectable
1h4oG-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3d PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE


(Streptomyces
wedmorensis)
PF01467
(CTP_transf_like)
4 PRO A  17
THR A 124
PRO A 125
GLY A 126
None
7XL  A 201 (-4.4A)
None
None
0.66A 1h4oG-5x3dA:
undetectable
1h4oG-5x3dA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii)
no annotation 4 PRO A  39
THR A  43
PRO A  44
ARG A 121
OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 2.3A)
0.42A 1h4oG-5xbqA:
18.1
1h4oG-5xbqA:
undetectable