SIMILAR PATTERNS OF AMINO ACIDS FOR 1GYX_A_BEZA1077

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gyj HYPOTHETICAL PROTEIN
YDCE

(Escherichia
coli) 		PF01361
(Tautomerase) 		5 CYH A   7
PHE A   8
ARG A  10
TRP A  51
TYR A  72
 None
 0.44A 1gyxA-1gyjA:
13.2
1gyxB-1gyjA:
13.3		 1gyxA-1gyjA:
100.00
1gyxB-1gyjA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 PHE A 124
TYR A 135
PRO A 127
SER A 128
 None
 1.47A 1gyxA-1iirA:
0.0
1gyxB-1iirA:
0.5		 1gyxA-1iirA:
13.30
1gyxB-1iirA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 4 PHE A 129
TYR A 170
PRO A 100
SER A 176
 None
 1.34A 1gyxA-1ollA:
0.0
1gyxB-1ollA:
undetectable		 1gyxA-1ollA:
17.44
1gyxB-1ollA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 PHE A 190
ARG A  48
PRO A 198
SER A 200
 None
 1.21A 1gyxA-2b3xA:
0.0
1gyxB-2b3xA:
0.0		 1gyxA-2b3xA:
9.25
1gyxB-2b3xA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 ARG A 314
TYR A 152
PRO A 143
SER A 142
 None
 1.47A 1gyxA-2e3jA:
0.3
1gyxB-2e3jA:
0.2		 1gyxA-2e3jA:
11.52
1gyxB-2e3jA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ARG B  78
TYR A 195
PRO B 273
SER A 209
 None
 1.31A 1gyxA-2f2aB:
0.0
1gyxB-2f2aB:
0.0		 1gyxA-2f2aB:
9.25
1gyxB-2f2aB:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 CYH A 140
TYR A 107
PRO A 137
SER A 109
 MO  A 810 ( 2.1A)
None
CYN  A 813 ( 4.6A)
None
 1.34A 1gyxA-2jirA:
0.0
1gyxB-2jirA:
0.0		 1gyxA-2jirA:
7.99
1gyxB-2jirA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ola O-SUCCINYLBENZOIC
ACID SYNTHETASE

(Staphylococcus
aureus) 		PF13378
(MR_MLE_C) 		4 PHE A  15
TYR A 275
PRO A  14
SER A  12
 None
 1.45A 1gyxA-2olaA:
0.0
1gyxB-2olaA:
0.0		 1gyxA-2olaA:
15.38
1gyxB-2olaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Candida
albicans) 		PF01704
(UDPGP) 		4 CYH A 306
PHE A 398
PRO A 399
SER A 400
 None
 1.33A 1gyxA-2yqhA:
0.8
1gyxB-2yqhA:
1.0		 1gyxA-2yqhA:
9.73
1gyxB-2yqhA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 CYH A  40
PHE A 115
PRO A  41
SER A  49
 None
 1.49A 1gyxA-3bxpA:
0.3
1gyxB-3bxpA:
0.3		 1gyxA-3bxpA:
13.72
1gyxB-3bxpA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k30 HISTAMINE
DEHYDROGENASE

(Pimelobacter
simplex) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 PHE A 568
ARG A 572
TYR A 181
SER A 266
 None
 1.36A 1gyxA-3k30A:
undetectable
1gyxB-3k30A:
undetectable		 1gyxA-3k30A:
7.29
1gyxB-3k30A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermus
thermophilus;
Thermus
thermophilus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 ARG F  78
TYR E 182
PRO F 268
SER E 196
 None
 1.47A 1gyxA-3kfuF:
undetectable
1gyxB-3kfuF:
undetectable		 1gyxA-3kfuF:
16.67
1gyxB-3kfuF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		4 CYH A  89
ARG A   8
PRO A  90
SER A 104
 None
 1.50A 1gyxA-3okxA:
undetectable
1gyxB-3okxA:
undetectable		 1gyxA-3okxA:
18.18
1gyxB-3okxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 PHE A 579
ARG A 526
TRP A 545
SER A 582
 None
 1.45A 1gyxA-4arxA:
undetectable
1gyxB-4arxA:
0.0		 1gyxA-4arxA:
9.49
1gyxB-4arxA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 CYH A 124
PHE A 127
ARG A 107
SER A 139
 None
None
EDO  A1287 (-4.0A)
None
 1.46A 1gyxA-4b4uA:
1.4
1gyxB-4b4uA:
1.0		 1gyxA-4b4uA:
14.19
1gyxB-4b4uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT B,
MITOCHONDRIAL

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01425
(Amidase)
PF02934
(GatB_N) 		4 ARG B 105
TYR A 171
PRO B 304
SER A 185
 None
 1.48A 1gyxA-4n0iB:
undetectable
1gyxB-4n0iB:
undetectable		 1gyxA-4n0iB:
13.35
1gyxB-4n0iB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		4 PHE A 190
ARG A 167
TYR A 234
SER A  88
 SIN  A 401 (-2.5A)
SIN  A 401 (-3.0A)
SIN  A 401 (-4.4A)
SIN  A 401 ( 3.5A)
 1.30A 1gyxA-4ovsA:
2.1
1gyxB-4ovsA:
2.0		 1gyxA-4ovsA:
14.16
1gyxB-4ovsA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 PHE A 100
TRP A  89
PRO A 101
SER A 103
 None
 1.39A 1gyxA-4tx8A:
undetectable
1gyxB-4tx8A:
undetectable		 1gyxA-4tx8A:
10.33
1gyxB-4tx8A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Homo sapiens) 		PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 PHE A 198
TRP A 649
TYR A 140
SER A 139
 None
XYL  A2015 ( 4.7A)
XYL  A2015 (-4.6A)
None
 1.21A 1gyxA-4xwhA:
undetectable
1gyxB-4xwhA:
undetectable		 1gyxA-4xwhA:
7.73
1gyxB-4xwhA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 PHE A 297
ARG A 301
PRO A 152
SER A 143
 None
 1.32A 1gyxA-6f8yA:
1.5
1gyxB-6f8yA:
1.4		 1gyxA-6f8yA:
undetectable
1gyxB-6f8yA:
undetectable