SIMILAR PATTERNS OF AMINO ACIDS FOR 1GX9_A_REAA1163

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 198
VAL A 200
ILE A 177
ILE A 180
MET A 221
 None
 1.38A 1gx9A-1brwA:
undetectable		 1gx9A-1brwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqw CU,ZN SUPEROXIDE
DISMUTASE

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 LEU A  27
VAL A  20
ILE A 147
VAL A  45
PHE A  43
 None
 1.28A 1gx9A-1eqwA:
0.2		 1gx9A-1eqwA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A 201
ILE A 303
GLU A 196
LYS A 274
ILE A 272
 None
None
None
SAM  A1699 (-4.4A)
None
 1.28A 1gx9A-1fpqA:
0.0		 1gx9A-1fpqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 177
VAL A 148
ILE A 432
VAL A 440
PHE A 166
 None
None
None
R03  A 800 ( 4.9A)
None
 1.06A 1gx9A-1h39A:
0.0		 1gx9A-1h39A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ILE A  61
GLU A  10
LYS A   3
VAL A 208
PHE A 212
 None
 1.38A 1gx9A-1kblA:
0.0		 1gx9A-1kblA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lth L-LACTATE
DEHYDROGENASE (T-
AND R- STATE
TETRAMER COMPLEX)

(Bifidobacterium
longum) 		no annotation 5 VAL T 127
GLU T 184
ILE T 240
VAL T  80
MET T 121
 None
None
NAD  T 321 ( 3.8A)
None
None
 1.20A 1gx9A-1lthT:
undetectable		 1gx9A-1lthT:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		5 ILE A 330
GLU A 341
ILE A 113
VAL A 367
PHE A 398
 None
 1.23A 1gx9A-1lwdA:
undetectable		 1gx9A-1lwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7t CHIMERA OF HUMAN AND
E. COLI THIOREDOXIN

(Escherichia
coli;
Homo sapiens) 		PF00085
(Thioredoxin) 		5 LEU A  79
VAL A  85
ILE A  71
VAL A  57
PHE A  11
 None
 1.39A 1gx9A-1m7tA:
undetectable		 1gx9A-1m7tA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc0 3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 2A

(Mus musculus) 		PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 513
VAL A 514
ILE A 458
VAL A 510
PHE A 426
 None
None
PCG  A 160 (-3.6A)
None
None
 1.19A 1gx9A-1mc0A:
0.0		 1gx9A-1mc0A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 LEU A  49
ILE A 301
ILE A 309
VAL A  58
GLN A  51
 None
 1.00A 1gx9A-1odoA:
undetectable		 1gx9A-1odoA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 ILE A 262
GLU A 321
LYS A 279
ILE A 266
PHE A 107
 None
 1.36A 1gx9A-1rqgA:
undetectable		 1gx9A-1rqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 LEU A 139
VAL A 136
ILE A  97
GLU A 132
VAL A  10
 None
 1.19A 1gx9A-1u2vA:
undetectable		 1gx9A-1u2vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr6 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		5 LEU A 337
VAL A 308
ILE A 322
PHE A 233
MET A 231
 None
 1.40A 1gx9A-1xr6A:
undetectable		 1gx9A-1xr6A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		5 LEU B 250
VAL B 253
ILE B 320
ILE B 325
MET B 313
 None
 1.32A 1gx9A-1xxiB:
undetectable		 1gx9A-1xxiB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxi DNA POLYMERASE III
SUBUNIT GAMMA

(Escherichia
coli) 		PF12169
(DNA_pol3_gamma3)
PF13177
(DNA_pol3_delta2) 		5 LEU B 288
VAL B 253
ILE B 320
ILE B 325
MET B 313
 None
 1.40A 1gx9A-1xxiB:
undetectable		 1gx9A-1xxiB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		5 LEU A 206
VAL A 205
ILE A  21
VAL A  29
PHE A 165
 None
 1.42A 1gx9A-2drhA:
undetectable		 1gx9A-2drhA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esf CARBONIC ANHYDRASE 2

(Escherichia
coli) 		PF00484
(Pro_CA) 		5 LEU A  78
VAL A  70
ILE A  93
ILE A 176
VAL A  85
 None
 1.41A 1gx9A-2esfA:
undetectable		 1gx9A-2esfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		5 LEU A 187
VAL A 186
ILE A 300
ILE A 299
GLN A 189
 None
 1.42A 1gx9A-2i05A:
undetectable		 1gx9A-2i05A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A  37
VAL A  16
GLU A  33
LYS A   1
PHE A  23
 None
 1.43A 1gx9A-2id5A:
undetectable		 1gx9A-2id5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ie8 PHOSPHOGLYCERATE
KINASE

(Thermus
caldophilus) 		PF00162
(PGK) 		5 LEU A 259
VAL A 257
ILE A 202
GLU A 251
VAL A 195
 None
 1.39A 1gx9A-2ie8A:
undetectable		 1gx9A-2ie8A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 308
LYS A 335
LYS A 339
ILE A 341
VAL A 301
 None
 1.43A 1gx9A-2j3zA:
undetectable		 1gx9A-2j3zA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrn THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Bacteroides sp.
4_3_47FAA) 		PF00578
(AhpC-TSA) 		5 VAL A 116
GLU A 119
LYS A  28
VAL A 101
PHE A  36
 None
 1.29A 1gx9A-2lrnA:
undetectable		 1gx9A-2lrnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltk MONO-CYSTEINE
GLUTAREDOXIN

(Trypanosoma
brucei) 		PF00462
(Glutaredoxin) 		5 VAL A 136
ILE A  82
VAL A  92
PHE A 149
GLN A 147
 None
 1.14A 1gx9A-2ltkA:
undetectable		 1gx9A-2ltkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mvg DECORIN-BINDING
PROTEIN B

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		5 VAL A 166
ILE A 130
LYS A 169
ILE A 131
VAL A 122
 None
 1.36A 1gx9A-2mvgA:
undetectable		 1gx9A-2mvgA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		5 LEU B  73
VAL B  71
ILE B  62
VAL B  56
PHE A 159
 None
 1.25A 1gx9A-2p1nB:
undetectable		 1gx9A-2p1nB:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU B 187
VAL B 189
ILE B 192
ILE B 158
VAL B 269
 None
 1.33A 1gx9A-2po2B:
undetectable		 1gx9A-2po2B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 185
VAL A 171
ILE A 206
VAL A 199
PHE A 194
 None
 1.32A 1gx9A-2pwzA:
undetectable		 1gx9A-2pwzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r66 GLYCOSYL
TRANSFERASE, GROUP 1

(Halothermothrix
orenii) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		5 LEU A 453
GLU A 458
LYS A 193
ILE A 195
VAL A  42
 None
 1.20A 1gx9A-2r66A:
undetectable		 1gx9A-2r66A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ro9 CALMODULIN-2

(Glycine max) 		PF13499
(EF-hand_7) 		5 LEU A  85
ILE A 136
ILE A 100
VAL A 144
MET A 145
 None
 1.43A 1gx9A-2ro9A:
undetectable		 1gx9A-2ro9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G  86
VAL G  22
ILE G  29
VAL G  68
PHE G  64
 None
 1.43A 1gx9A-2uv8G:
0.0		 1gx9A-2uv8G:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		5 LEU G1931
VAL G1936
GLU G1942
ILE G1922
GLN G1928
 None
 1.15A 1gx9A-2uv8G:
0.0		 1gx9A-2uv8G:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		5 LEU A 504
VAL A 442
ILE A 401
GLU A 429
VAL A 531
 None
 1.20A 1gx9A-2ycbA:
undetectable		 1gx9A-2ycbA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr0 HYPOTHETICAL PROTEIN
TTHA0223

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 LEU A  57
GLU A  40
ILE A  65
VAL A  48
PHE A  77
 None
 1.30A 1gx9A-2yr0A:
undetectable		 1gx9A-2yr0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 376
VAL A 437
VAL A 424
PHE A 434
GLN A 436
 None
 1.23A 1gx9A-2z1aA:
undetectable		 1gx9A-2z1aA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		5 LEU A 283
VAL A 279
ILE A 334
VAL A 320
PHE A 307
 None
 1.37A 1gx9A-3bb7A:
undetectable		 1gx9A-3bb7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A 180
ILE A 162
LYS A 183
ILE A 114
VAL A 146
 None
 1.24A 1gx9A-3bb8A:
undetectable		 1gx9A-3bb8A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1n E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		PF00632
(HECT) 		5 VAL A4021
ILE A4069
GLU A4053
ILE A4068
PHE A4109
 None
 1.00A 1gx9A-3g1nA:
undetectable		 1gx9A-3g1nA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibt 1H-3-HYDROXY-4-OXOQU
INOLINE
2,4-DIOXYGENASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		5 LEU A  43
ILE A 119
GLU A 260
ILE A 211
PHE A  37
 None
 1.38A 1gx9A-3ibtA:
undetectable		 1gx9A-3ibtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		5 LEU A 380
VAL A 375
ILE A 369
ILE A 390
GLN A 379
 None
 1.11A 1gx9A-3icjA:
undetectable		 1gx9A-3icjA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 LEU A 613
VAL A 609
ILE A 427
VAL A 387
MET A 391
 None
 1.25A 1gx9A-3j04A:
undetectable		 1gx9A-3j04A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 LEU A 273
VAL A 277
ILE A 198
VAL A 296
PHE A 316
 None
 1.32A 1gx9A-3js6A:
undetectable		 1gx9A-3js6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 200
VAL A 235
ILE A 217
VAL A 224
PHE A 249
 None
 1.42A 1gx9A-3kb6A:
undetectable		 1gx9A-3kb6A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh9 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBE

(Pseudomonas
aeruginosa) 		PF08534
(Redoxin) 		5 LEU A 128
ILE A 143
GLU A 139
LYS A 152
ILE A 149
 None
 1.42A 1gx9A-3kh9A:
undetectable		 1gx9A-3kh9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 128
VAL A 132
ILE A 141
VAL A  15
PHE A 156
 NAP  A 512 (-4.4A)
None
None
NAP  A 512 (-3.9A)
None
 1.16A 1gx9A-3kjrA:
undetectable		 1gx9A-3kjrA:
17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
ILE A  56
LYS A  60
ILE A  71
GLN A 120
 None
 0.83A 1gx9A-3kzaA:
26.2		 1gx9A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
ILE A  56
LYS A  60
VAL A  92
GLN A 120
 None
 0.66A 1gx9A-3kzaA:
26.2		 1gx9A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		5 LEU A  39
VAL A  41
LYS A  60
VAL A  92
MET A 107
 None
 1.03A 1gx9A-3kzaA:
26.2		 1gx9A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 VAL A  41
ILE A  56
LYS A  60
ILE A  71
PHE A 105
GLN A 120
 None
 0.97A 1gx9A-3kzaA:
26.2		 1gx9A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Bos taurus;
Equus caballus) 		PF00061
(Lipocalin) 		6 VAL A  41
ILE A  56
LYS A  60
VAL A  92
PHE A 105
GLN A 120
 None
 0.82A 1gx9A-3kzaA:
26.2		 1gx9A-3kzaA:
81.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		5 LEU A 425
ILE A 260
GLU A 380
ILE A 219
PHE A 257
 None
 1.38A 1gx9A-3lggA:
undetectable		 1gx9A-3lggA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nze PUTATIVE
TRANSCRIPTIONAL
REGULATOR,
SUGAR-BINDING FAMILY

(Paenarthrobacter
aurescens) 		PF04198
(Sugar-bind) 		5 VAL A 106
ILE A 207
ILE A 279
VAL A 123
PHE A 161
 None
 1.33A 1gx9A-3nzeA:
undetectable		 1gx9A-3nzeA:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		8 LEU A  55
VAL A  57
ILE A  72
LYS A  76
GLU A  78
LYS A  85
ILE A  87
GLN A 136
 None
 0.68A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		8 LEU A  55
VAL A  57
ILE A  72
LYS A  76
GLU A  78
LYS A  85
VAL A 108
GLN A 136
 None
 0.60A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  55
VAL A  57
ILE A  87
LYS A  76
VAL A 108
 None
 1.38A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		7 LEU A  55
VAL A  57
LYS A  76
GLU A  78
LYS A  85
VAL A 108
MET A 123
 None
 0.97A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		8 VAL A  57
ILE A  72
LYS A  76
GLU A  78
LYS A  85
ILE A  87
PHE A 121
GLN A 136
 None
 0.80A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		8 VAL A  57
ILE A  72
LYS A  76
GLU A  78
LYS A  85
VAL A 108
PHE A 121
GLN A 136
 None
 0.75A 1gx9A-3ph5A:
29.7		 1gx9A-3ph5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlb ENANTIO-PYOCHELIN
RECEPTOR

(Pseudomonas
fluorescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A  68
ILE A  58
GLU A 123
ILE A 130
GLN A  66
 None
 1.34A 1gx9A-3qlbA:
undetectable		 1gx9A-3qlbA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		5 LEU A 207
VAL A 200
ILE A 109
VAL A 184
PHE A 188
 None
 1.35A 1gx9A-3tqrA:
undetectable		 1gx9A-3tqrA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 427
VAL A 426
ILE A 385
ILE A 367
VAL A   3
 None
 1.21A 1gx9A-3v4pA:
undetectable		 1gx9A-3v4pA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 LEU B 141
ILE B 250
ILE B 151
MET B 144
GLN B 140
 None
 1.41A 1gx9A-3vrdB:
undetectable		 1gx9A-3vrdB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Coprinopsis
cinerea) 		no annotation 5 VAL A  82
GLU A 231
ILE A 118
VAL A 238
PHE A  27
 None
 1.43A 1gx9A-3w9aA:
undetectable		 1gx9A-3w9aA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		5 LEU A 210
GLU A 216
VAL A 296
PHE A 196
MET A 190
 None
 1.33A 1gx9A-3wpwA:
undetectable		 1gx9A-3wpwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac1 ENDO-N-ACETYL-BETA-D
-GLUCOSAMINIDASE

(Trichoderma
reesei) 		PF00704
(Glyco_hydro_18) 		5 LEU X  27
LYS X  33
ILE X  35
VAL X  80
MET X  75
 None
None
None
ACT  X1290 (-4.3A)
None
 1.38A 1gx9A-4ac1X:
undetectable		 1gx9A-4ac1X:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00352
(TBP) 		5 VAL A 333
ILE A 270
ILE A 306
VAL A 266
PHE A 268
 None
 1.34A 1gx9A-4b0aA:
2.0		 1gx9A-4b0aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bl3 PENICILLIN BINDING
PROTEIN 2 PRIME

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF05223
(MecA_N) 		5 VAL A 131
ILE A  34
ILE A  80
VAL A  95
PHE A 116
 None
 1.07A 1gx9A-4bl3A:
undetectable		 1gx9A-4bl3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvq GLUTAMATE-PYRUVATE
AMINOTRANSFERASE
ALAA

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 LEU A 332
VAL A 380
ILE A  17
ILE A  40
PHE A 369
 None
None
ACT  A1405 ( 4.6A)
ACT  A1405 (-4.7A)
None
 1.40A 1gx9A-4cvqA:
undetectable		 1gx9A-4cvqA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 179
ILE A 218
GLU A 188
MET A 212
GLN A 178
 None
 1.37A 1gx9A-4e4uA:
undetectable		 1gx9A-4e4uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 VAL A 208
GLU A 202
ILE A 384
VAL A 426
MET A 427
 None
 1.25A 1gx9A-4eppA:
1.1		 1gx9A-4eppA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		5 ILE A 238
GLU A 242
ILE A 251
VAL A 295
PHE A 284
 None
 1.31A 1gx9A-4ftdA:
undetectable		 1gx9A-4ftdA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 363
GLU A 543
ILE A 369
VAL A 527
PHE A 421
 None
 1.40A 1gx9A-4h1sA:
undetectable		 1gx9A-4h1sA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3e SUPEROXIDE DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A 212
VAL A 193
ILE A 117
ILE A 219
VAL A  50
 None
 1.41A 1gx9A-4h3eA:
undetectable		 1gx9A-4h3eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		5 VAL A 187
ILE A 202
ILE A 204
VAL A 246
PHE A 217
 None
 1.24A 1gx9A-4mxnA:
undetectable		 1gx9A-4mxnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw0 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Chitinophaga
pinensis) 		PF00561
(Abhydrolase_1) 		5 LEU A  63
ILE A  93
ILE A  98
VAL A 103
PHE A  39
 None
 1.37A 1gx9A-4pw0A:
undetectable		 1gx9A-4pw0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 LEU A 342
ILE A 354
LYS A 390
VAL A 336
PHE A 366
 None
 1.42A 1gx9A-4q0gA:
1.6		 1gx9A-4q0gA:
13.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		6 LEU A  39
VAL A  41
ILE A  56
GLU A  62
LYS A  69
GLN A 120
 None
 0.86A 1gx9A-4r0bA:
21.6		 1gx9A-4r0bA:
41.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 LEU A1023
ILE A1072
LYS A1094
ILE A1096
VAL A1105
 None
 1.36A 1gx9A-4s0vA:
undetectable		 1gx9A-4s0vA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v17 CARBOHYDRATE BINDING
MODULE

(Ruminococcus
flavefaciens) 		no annotation 5 LEU A 551
VAL A 457
ILE A 463
ILE A 578
PHE A 486
 None
 1.27A 1gx9A-4v17A:
undetectable		 1gx9A-4v17A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 LEU A 624
ILE A 581
ILE A 584
VAL A 593
PHE A 555
 None
 1.39A 1gx9A-4xhbA:
undetectable		 1gx9A-4xhbA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 VAL A  11
ILE A 338
ILE A 337
VAL A 362
PHE A 363
 None
 1.11A 1gx9A-4y2wA:
undetectable		 1gx9A-4y2wA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU A 238
ILE A 124
ILE A 196
MET A 241
GLN A 237
 EDO  A 404 (-4.1A)
None
None
None
None
 1.37A 1gx9A-4yu9A:
0.7		 1gx9A-4yu9A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmm DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 LEU A 250
VAL A 268
ILE A 215
GLU A 275
PHE A 195
 C2E  A 500 (-4.4A)
C2E  A 500 (-4.1A)
None
C2E  A 500 (-3.7A)
None
 1.41A 1gx9A-4zmmA:
undetectable		 1gx9A-4zmmA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A 340
ILE A 355
LYS A 352
VAL A 288
PHE A 383
 None
 1.32A 1gx9A-5bwaA:
undetectable		 1gx9A-5bwaA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 132
LYS A 340
ILE A 335
VAL A  64
PHE A  95
 None
 1.32A 1gx9A-5ceeA:
undetectable		 1gx9A-5ceeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co1 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin) 		5 VAL A 311
ILE A 275
ILE A 235
VAL A 293
PHE A 254
 None
 1.13A 1gx9A-5co1A:
undetectable		 1gx9A-5co1A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9c HEPARANASE

(Homo sapiens) 		PF03662
(Glyco_hydro_79n) 		5 VAL A 293
ILE A 377
GLU A 221
VAL A 323
PHE A 327
 None
 1.28A 1gx9A-5e9cA:
undetectable		 1gx9A-5e9cA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkm AT5G51070/K3K7_27

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 LEU A 200
ILE A  91
GLU A 194
VAL A 106
PHE A 168
 None
 1.43A 1gx9A-5gkmA:
undetectable		 1gx9A-5gkmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp4 GLUTAMATE
DECARBOXYLASE

(Lactobacillus
brevis) 		no annotation 5 LEU C 327
VAL C 287
ILE C 106
GLU C 128
PHE C 334
 None
 1.39A 1gx9A-5gp4C:
undetectable		 1gx9A-5gp4C:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		5 LEU A 326
VAL A 325
LYS A 248
VAL A 267
GLN A 328
 None
 1.21A 1gx9A-5hyhA:
undetectable		 1gx9A-5hyhA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 LEU A 397
ILE A 358
GLU A 479
ILE A 344
PHE A 352
 None
 1.22A 1gx9A-5id6A:
undetectable		 1gx9A-5id6A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A 311
ILE A 275
ILE A 235
VAL A 293
PHE A 254
 None
 1.15A 1gx9A-5iu9A:
undetectable		 1gx9A-5iu9A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 39 KDA
SUBUNIT

(Ovis aries) 		no annotation 5 LEU d  94
VAL d  95
ILE d 117
VAL d  91
PHE d 129
 NDP  d 401 ( 4.7A)
NDP  d 401 (-4.4A)
None
None
None
 1.35A 1gx9A-5lnkd:
undetectable		 1gx9A-5lnkd:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqc VP1

(Black queen
cell virus) 		PF08762
(CRPV_capsid) 		5 LEU A 106
VAL A 214
ILE A 172
ILE A  70
MET A 220
 None
 1.21A 1gx9A-5mqcA:
undetectable		 1gx9A-5mqcA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 5 LEU A 152
VAL A   5
ILE A 110
ILE A  82
VAL A 160
 None
 1.26A 1gx9A-5oshA:
undetectable		 1gx9A-5oshA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		5 LEU A 306
VAL A 307
ILE A 273
VAL A 291
PHE A 253
 None
 1.33A 1gx9A-5szqA:
undetectable		 1gx9A-5szqA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 531
GLU A 548
LYS A 489
ILE A 525
VAL A 471
 None
 1.43A 1gx9A-5u2aA:
undetectable		 1gx9A-5u2aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uif PS01740

(Pseudomonas sp.
UW4) 		no annotation 5 LEU A   2
VAL A  41
ILE A  83
ILE A  63
VAL A 102
 None
 1.35A 1gx9A-5uifA:
undetectable		 1gx9A-5uifA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4l ADENYLOSUCCINATE
LYASE

(Cryptococcus
neoformans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 167
ILE A 271
LYS A 257
VAL A 161
PHE A 138
 None
 1.36A 1gx9A-5v4lA:
undetectable		 1gx9A-5v4lA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 564
VAL A 598
ILE A 459
ILE A 475
VAL A 492
 None
 1.38A 1gx9A-5v8fA:
undetectable		 1gx9A-5v8fA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 5 LEU A 408
VAL A 362
ILE A 349
VAL A 472
MET A 475
 None
 1.18A 1gx9A-6gnfA:
undetectable		 1gx9A-6gnfA:
undetectable