SIMILAR PATTERNS OF AMINO ACIDS FOR 1GX8_A_RTLA1163

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		5 LEU A 227
LEU A 178
GLU A 212
ILE A 163
VAL A 192
 None
 1.42A 1gx8A-1b8gA:
0.0		 1gx8A-1b8gA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bpo PROTEIN (CLATHRIN)

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link)
PF13838
(Clathrin_H_link) 		5 LEU A 325
LEU A  15
ILE A  38
VAL A 305
PHE A 304
 None
 1.34A 1gx8A-1bpoA:
0.0		 1gx8A-1bpoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 LEU A  93
LEU A  34
ILE A 106
MET A  96
GLN A  91
 None
 1.31A 1gx8A-1c4xA:
0.0		 1gx8A-1c4xA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		5 LEU A 325
LEU A  15
ILE A  38
VAL A 305
PHE A 304
 None
 1.31A 1gx8A-1c9lA:
0.5		 1gx8A-1c9lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		5 LEU A 141
LEU A 135
GLU A  69
ILE A 165
PHE A 156
 None
 1.33A 1gx8A-1cjbA:
0.0		 1gx8A-1cjbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dd5 RIBOSOME RECYCLING
FACTOR

(Thermotoga
maritima) 		PF01765
(RRF) 		5 LEU A 163
LEU A 136
GLU A   8
ILE A 139
GLN A 161
 None
ACY  A 280 ( 4.7A)
None
None
None
 1.47A 1gx8A-1dd5A:
undetectable		 1gx8A-1dd5A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  70
LEU A  66
LYS A  56
ILE A  52
VAL A  35
 None
 1.14A 1gx8A-1h4lA:
undetectable		 1gx8A-1h4lA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus) 		PF01322
(Cytochrom_C_2) 		5 LEU A 114
GLU A  39
LYS A  42
ILE A  46
MET A  88
 HEM  A 130 ( 4.7A)
None
None
None
HEM  A 130 ( 4.2A)
 1.24A 1gx8A-1nbbA:
undetectable		 1gx8A-1nbbA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN

(Phaseolus
vulgaris) 		PF08263
(LRRNT_2) 		5 LEU A 209
LYS A 189
ILE A 190
VAL A 202
MET A 179
 None
 1.14A 1gx8A-1ogqA:
undetectable		 1gx8A-1ogqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tve HOMOSERINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A 285
GLU A 281
LYS A 304
ILE A 302
PHE A 194
 None
 1.35A 1gx8A-1tveA:
0.0		 1gx8A-1tveA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		5 LEU A 525
LEU A 453
GLU A 519
ILE A 457
PHE A 552
 None
 1.38A 1gx8A-1u2lA:
undetectable		 1gx8A-1u2lA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		5 LEU A 119
LEU A 127
ILE A 185
VAL A 135
PHE A 154
 None
 1.31A 1gx8A-1wstA:
undetectable		 1gx8A-1wstA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 137
LEU A  32
ILE A 103
VAL A 113
PHE A  54
 None
 1.42A 1gx8A-2ewyA:
undetectable		 1gx8A-2ewyA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		5 LEU A 103
GLU A  58
ILE A  69
VAL A  79
MET A  81
 None
 1.44A 1gx8A-2gezA:
undetectable		 1gx8A-2gezA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7v RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF04545
(Sigma70_r4) 		5 LEU B 573
LEU B 559
ILE B 590
VAL B 582
PHE B 580
 None
 1.24A 1gx8A-2p7vB:
undetectable		 1gx8A-2p7vB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 LEU B 185
LEU B 192
ILE B 256
VAL B 242
PHE B 217
 None
 0.86A 1gx8A-2xdqB:
undetectable		 1gx8A-2xdqB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw5 MULTICOPPER OXIDASE

(Pyrobaculum
aerophilum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A  81
ILE A  69
VAL A  77
PHE A 120
MET A  79
 None
 1.48A 1gx8A-3aw5A:
undetectable		 1gx8A-3aw5A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		5 LEU A  84
LEU A 215
GLU A  81
ILE A 145
PHE A 224
 None
 1.35A 1gx8A-3bhoA:
undetectable		 1gx8A-3bhoA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs5 CONNECTOR ENHANCER
OF KINASE SUPPRESSOR
OF RAS 2

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU B 132
LEU B 157
GLU B 169
ILE B 152
VAL B 121
 None
 1.41A 1gx8A-3bs5B:
undetectable		 1gx8A-3bs5B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffv PROTEIN SYD

(Escherichia
coli) 		PF07348
(Syd) 		5 LEU A 101
LEU A 116
GLU A 156
ILE A  77
PHE A 109
 None
 1.46A 1gx8A-3ffvA:
undetectable		 1gx8A-3ffvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		5 LEU A  13
LEU A  73
GLU A  80
LYS A  39
ILE A  35
 None
 1.50A 1gx8A-3g5aA:
undetectable		 1gx8A-3g5aA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc7 GENE 12 PROTEIN

(Mycobacterium
virus D29) 		PF01083
(Cutinase) 		5 LEU A 207
LEU A 218
GLU A 178
ILE A 222
PHE A 193
 None
 1.49A 1gx8A-3hc7A:
undetectable		 1gx8A-3hc7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hly FLAVODOXIN-LIKE
DOMAIN

(Synechococcus
elongatus) 		no annotation 5 LEU A 268
LEU A 317
GLU A 356
ILE A 335
VAL A 300
 None
 1.45A 1gx8A-3hlyA:
undetectable		 1gx8A-3hlyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 243
GLU A 216
LYS A  85
ILE A  83
VAL A 316
 MOS  B 920 ( 4.9A)
None
None
NIO  B5661 ( 4.7A)
NO3  A5658 (-4.6A)
 1.32A 1gx8A-3hrdA:
undetectable		 1gx8A-3hrdA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hx6 TYPE 4 FIMBRIAL
BIOGENESIS PROTEIN
PILY1

(Pseudomonas
aeruginosa) 		PF05567
(Neisseria_PilC) 		5 LEU A1123
ILE A1047
VAL A1144
PHE A1089
GLN A1117
 None
 1.49A 1gx8A-3hx6A:
undetectable		 1gx8A-3hx6A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 LEU W 457
LEU W 644
ILE W 445
VAL W 631
PHE W 627
 None
 1.37A 1gx8A-3iylW:
undetectable		 1gx8A-3iylW:
9.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  39
LEU A  58
ILE A  71
VAL A  92
GLN A 120
 None
 0.61A 1gx8A-3kzaA:
26.4		 1gx8A-3kzaA:
81.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kza BETA-LACTOGLOBULIN

(Equus caballus;
Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  58
ILE A  71
VAL A  92
PHE A 105
GLN A 120
 None
 0.93A 1gx8A-3kzaA:
26.4		 1gx8A-3kzaA:
81.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		5 LEU A 146
LEU A  90
GLU A 125
ILE A   8
VAL A  98
 None
 1.21A 1gx8A-3l3bA:
undetectable		 1gx8A-3l3bA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  55
GLU A  78
ILE A  87
VAL A 108
MET A 123
 None
 0.96A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		5 LEU A  55
GLU A  78
LYS A  85
VAL A 108
MET A 123
 None
 1.06A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  55
LEU A  74
GLU A  78
ILE A  87
VAL A 108
GLN A 136
 None
 0.58A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  55
LEU A  74
GLU A  78
LYS A  85
VAL A 108
GLN A 136
 None
 0.73A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  74
GLU A  78
ILE A  87
VAL A 108
PHE A 121
GLN A 136
 None
 0.85A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ph5 BETA-LACTOGLOBULIN

(Bos taurus) 		PF00061
(Lipocalin) 		6 LEU A  74
GLU A  78
LYS A  85
VAL A 108
PHE A 121
GLN A 136
 None
 0.93A 1gx8A-3ph5A:
29.9		 1gx8A-3ph5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbf GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Francisella
tularensis) 		PF01380
(SIS) 		5 LEU A 419
LEU A 273
GLU A 438
ILE A 269
PHE A 391
 None
 1.36A 1gx8A-3tbfA:
undetectable		 1gx8A-3tbfA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpw POMB

(Vibrio
alginolyticus) 		PF00691
(OmpA) 		5 LEU A 210
GLU A 216
VAL A 296
PHE A 196
MET A 190
 None
 1.24A 1gx8A-3wpwA:
undetectable		 1gx8A-3wpwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		5 LEU A 720
LEU A 723
GLU A 508
LYS A 512
ILE A 458
 None
 1.06A 1gx8A-4bs9A:
undetectable		 1gx8A-4bs9A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 LEU A1376
GLU A1349
LYS A1315
ILE A1317
VAL A1335
 None
 1.23A 1gx8A-4fbqA:
undetectable		 1gx8A-4fbqA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifs FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		PF08512
(Rtt106) 		5 LEU A 242
LEU A 275
ILE A 216
VAL A 317
MET A 318
 None
 1.38A 1gx8A-4ifsA:
undetectable		 1gx8A-4ifsA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Flavobacterium
johnsoniae) 		PF01884
(PcrB) 		5 LEU A 176
LYS A 175
ILE A 130
VAL A  81
PHE A  54
 None
 1.37A 1gx8A-4jejA:
undetectable		 1gx8A-4jejA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6z SERINE
HYDROXYMETHYLTRANSFE
RASE

(Plasmodium
falciparum) 		PF00464
(SHMT) 		5 LEU A 395
LEU A 428
GLU A 403
LYS A 424
PHE A 389
 None
 0.96A 1gx8A-4o6zA:
undetectable		 1gx8A-4o6zA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlo HOMOSERINE
O-ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		5 LEU A 189
LEU A 233
GLU A 169
ILE A 175
PHE A 220
 None
 1.28A 1gx8A-4qloA:
undetectable		 1gx8A-4qloA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 LEU A 310
GLU A 123
ILE A 130
VAL A 208
MET A 290
 None
 1.48A 1gx8A-4qnyA:
undetectable		 1gx8A-4qnyA:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0b GLYCODELIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 LEU A  39
LEU A  58
GLU A  62
LYS A  69
GLN A 120
 None
 1.10A 1gx8A-4r0bA:
21.5		 1gx8A-4r0bA:
41.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2b EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Ochrobactrum
anthropi) 		PF01547
(SBP_bac_1) 		5 LEU A 176
LEU A 158
GLU A 171
ILE A 153
VAL A 259
 None
 1.49A 1gx8A-4r2bA:
undetectable		 1gx8A-4r2bA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmu RECQ

(Cronobacter
sakazakii) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF09382
(RQC)
PF16124
(RecQ_Zn_bind) 		5 LEU A 196
LEU A 126
ILE A  69
VAL A 175
PHE A 172
 None
 1.46A 1gx8A-4tmuA:
undetectable		 1gx8A-4tmuA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v33 POLYSACCHARIDE
DEACETYLASE-LIKE
PROTEIN

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 LEU A 288
LYS A 287
ILE A 291
VAL A 254
GLN A 262
 None
 1.46A 1gx8A-4v33A:
undetectable		 1gx8A-4v33A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 549
LYS A 516
ILE A 514
VAL A 415
PHE A 568
 None
 1.24A 1gx8A-4w7sA:
undetectable		 1gx8A-4w7sA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpj EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Sphaerobacter
thermophilus) 		PF13458
(Peripla_BP_6) 		5 LEU A 194
LEU A 392
GLU A 170
LYS A 388
GLN A 414
 None
 1.21A 1gx8A-4zpjA:
undetectable		 1gx8A-4zpjA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  57
LEU A  37
ILE A  93
VAL A  66
MET A  61
 None
 1.39A 1gx8A-4zyjA:
undetectable		 1gx8A-4zyjA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3f DYNAMIN 3

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A 561
LEU A 541
GLU A 544
VAL A 568
PHE A 582
 None
 1.29A 1gx8A-5a3fA:
undetectable		 1gx8A-5a3fA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		5 LEU A 574
LEU A 492
GLU A 528
ILE A 495
MET A 501
 None
 1.29A 1gx8A-5by3A:
undetectable		 1gx8A-5by3A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens;
Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3)
PF00169
(PH)
PF16746
(BAR_3) 		5 LEU B  40
GLU A  69
ILE A  93
VAL B  47
MET B  44
 None
 1.09A 1gx8A-5c5bB:
undetectable		 1gx8A-5c5bB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 132
LYS A 340
ILE A 335
VAL A  64
PHE A  95
 None
 1.40A 1gx8A-5ceeA:
undetectable		 1gx8A-5ceeA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs0 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 1.05A 1gx8A-5cs0A:
undetectable		 1gx8A-5cs0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 0.97A 1gx8A-5cslA:
undetectable		 1gx8A-5cslA:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxi TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		5 LEU A  23
GLU A 190
ILE A 244
VAL A 263
MET A 225
 None
 1.41A 1gx8A-5dxiA:
undetectable		 1gx8A-5dxiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		5 LEU A 151
LEU A 193
ILE A 207
VAL A 144
PHE A 145
 None
 1.36A 1gx8A-5eywA:
undetectable		 1gx8A-5eywA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		5 LEU A 259
LEU A 249
GLU A 266
VAL A 423
GLN A 255
 None
 1.43A 1gx8A-5fgnA:
undetectable		 1gx8A-5fgnA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4e MYOSIN-14,ALPHA-ACTI
NIN A

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 451
LEU A 459
GLU A 361
ILE A 244
PHE A 262
 None
 1.34A 1gx8A-5i4eA:
undetectable		 1gx8A-5i4eA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		5 LEU A 884
LEU A 907
ILE A 847
VAL A 866
PHE A 876
 None
 1.01A 1gx8A-5i6eA:
0.9		 1gx8A-5i6eA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjs TUBULIN ALPHA-1
CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU E 263
LEU E 171
ILE E 242
VAL E 254
GLN E 260
 None
 1.30A 1gx8A-5mjsE:
undetectable		 1gx8A-5mjsE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 LEU A 405
LEU A 151
GLU A 413
VAL A 273
MET A 274
 None
 1.43A 1gx8A-5mrwA:
undetectable		 1gx8A-5mrwA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 5 LEU A 325
LEU A  15
ILE A  38
VAL A 305
PHE A 304
 None
 1.32A 1gx8A-5odsA:
undetectable		 1gx8A-5odsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 531
GLU A 548
LYS A 489
ILE A 525
VAL A 471
 None
 1.45A 1gx8A-5u2aA:
undetectable		 1gx8A-5u2aA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ums FACT COMPLEX SUBUNIT
SSRP1

(Homo sapiens) 		no annotation 5 LEU A 242
LEU A 275
ILE A 216
VAL A 317
MET A 318
 None
 1.27A 1gx8A-5umsA:
undetectable		 1gx8A-5umsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 5 LEU A 278
LEU A 271
ILE A  30
VAL A 105
PHE A 133
 None
 1.37A 1gx8A-6bk7A:
undetectable		 1gx8A-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blb HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVB

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 270
LEU A 291
ILE A 298
VAL A 282
PHE A 277
 None
 1.22A 1gx8A-6blbA:
undetectable		 1gx8A-6blbA:
20.89