SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_V_TRPV81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A  78
ALA A 123
GLY A 208
HIS A 209
THR A 115
 None
 1.03A 1gtnL-1dgfA:
undetectable
1gtnV-1dgfA:
undetectable		 1gtnL-1dgfA:
9.73
1gtnV-1dgfA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		5 GLY A  11
HIS A  12
THR A  77
HIS A  80
ILE A   9
 None
 0.99A 1gtnL-1h3qA:
0.1
1gtnV-1h3qA:
0.2		 1gtnL-1h3qA:
19.12
1gtnV-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktc ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Gallus gallus) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		5 GLY A 104
THR A 117
ALA A 126
GLY A 152
ALA A 159
 None
 1.04A 1gtnL-1ktcA:
undetectable
1gtnV-1ktcA:
undetectable		 1gtnL-1ktcA:
11.41
1gtnV-1ktcA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 915
GLY A1006
HIS A 884
ALA A1079
ILE A1007
 None
None
None
TEI  A3006 ( 3.8A)
None
 0.98A 1gtnL-1n5xA:
0.0
1gtnV-1n5xA:
0.0		 1gtnL-1n5xA:
4.96
1gtnV-1n5xA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 225
ALA A 741
GLY A 723
ALA A 740
ILE A 725
 6FA  A 801 (-3.3A)
None
None
None
None
 1.00A 1gtnL-1naaA:
undetectable
1gtnV-1naaA:
undetectable		 1gtnL-1naaA:
7.39
1gtnV-1naaA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 160
THR A 162
ALA A 294
GLY A 125
ALA A 295
 None
 0.98A 1gtnL-1o8cA:
undetectable
1gtnV-1o8cA:
undetectable		 1gtnL-1o8cA:
13.12
1gtnV-1o8cA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus;
Bean pod mottle
virus) 		PF02248
(Como_SCP)
PF02247
(Como_LCP) 		5 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
 None
 1.03A 1gtnL-1pgw2:
1.3
1gtnV-1pgw2:
1.7		 1gtnL-1pgw2:
11.68
1gtnV-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pwe L-SERINE DEHYDRATASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  46
ALA A  76
GLY A  69
ALA A  83
ILE A  85
 None
 1.00A 1gtnL-1pweA:
undetectable
1gtnV-1pweA:
undetectable		 1gtnL-1pweA:
13.98
1gtnV-1pweA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 GLY B 262
GLY B 209
HIS B 219
THR B 223
ILE B 248
 None
None
MGM  B 379 (-3.7A)
None
None
 0.95A 1gtnL-1tnuB:
undetectable
1gtnV-1tnuB:
undetectable		 1gtnL-1tnuB:
12.68
1gtnV-1tnuB:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		5 GLY A 193
GLY A 296
ALA A 197
HIS A 194
ILE A 291
 None
 0.79A 1gtnL-1wd3A:
undetectable
1gtnV-1wd3A:
undetectable		 1gtnL-1wd3A:
9.13
1gtnV-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c79 GLYCOSIDE HYDROLASE,
FAMILY
11:CLOSTRIDIUM
CELLULOSOME ENZYME,
DOCKERIN TYPE
I:POLYSACCHARIDE

(Ruminiclostridium
thermocellum) 		PF01522
(Polysacc_deac_1) 		5 GLY A 533
GLY A 537
THR A 659
HIS A 534
THR A 510
 None
 1.00A 1gtnL-2c79A:
undetectable
1gtnV-2c79A:
undetectable		 1gtnL-2c79A:
14.85
1gtnV-2c79A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 GLY A 239
ALA A 123
GLY A 140
HIS A 139
HIS A  99
 None
MN  A 302 ( 4.5A)
None
None
MN  A 301 ( 3.2A)
 0.97A 1gtnL-2cevA:
undetectable
1gtnV-2cevA:
undetectable		 1gtnL-2cevA:
14.81
1gtnV-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		5 GLY A  14
THR A 189
SER A  18
ALA A  22
ILE A  67
 SO4  A5001 (-4.0A)
None
SO4  A5001 (-2.7A)
None
None
 1.00A 1gtnL-2detA:
undetectable
1gtnV-2detA:
undetectable		 1gtnL-2detA:
11.89
1gtnV-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 SER A 817
GLY A 285
ALA A 293
THR A 624
ILE A 283
 None
FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
 0.98A 1gtnL-2dw4A:
undetectable
1gtnV-2dw4A:
undetectable		 1gtnL-2dw4A:
8.15
1gtnV-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwu GLUTAMATE RACEMASE

(Bacillus
anthracis) 		PF01177
(Asp_Glu_race) 		5 GLY A 187
THR A 189
ALA A  80
THR A 124
THR A 121
 None
DGL  A 278 (-3.0A)
None
None
DGL  A 278 (-3.6A)
 0.95A 1gtnL-2dwuA:
undetectable
1gtnV-2dwuA:
undetectable		 1gtnL-2dwuA:
16.50
1gtnV-2dwuA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 GLY A 477
SER A 323
ALA A 324
GLY A 309
ALA A 325
 None
 0.99A 1gtnL-2ehqA:
undetectable
1gtnV-2ehqA:
undetectable		 1gtnL-2ehqA:
9.82
1gtnV-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn9 RIBOSE ABC
TRANSPORTER,
PERIPLASMIC
RIBOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13407
(Peripla_BP_4) 		5 GLY A 138
ALA A 177
GLY A 221
ALA A 205
ILE A 219
 None
 0.98A 1gtnL-2fn9A:
undetectable
1gtnV-2fn9A:
undetectable		 1gtnL-2fn9A:
16.13
1gtnV-2fn9A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtx METHIONINE
AMINOPEPTIDASE

(Escherichia
coli) 		PF00557
(Peptidase_M24) 		5 GLY A 172
GLY A 107
HIS A 106
THR A 202
THR A 237
 None
None
None
MN  A   1 ( 3.7A)
None
 0.97A 1gtnL-2gtxA:
undetectable
1gtnV-2gtxA:
undetectable		 1gtnL-2gtxA:
18.59
1gtnV-2gtxA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		5 GLY A  98
GLY A 102
THR A 233
HIS A  99
THR A  71
 None
 1.03A 1gtnL-2iw0A:
undetectable
1gtnV-2iw0A:
undetectable		 1gtnL-2iw0A:
14.57
1gtnV-2iw0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjp CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		5 GLY B   2
GLY B 109
HIS B 111
ALA B 159
HIS A 291
 None
 1.03A 1gtnL-2qjpB:
undetectable
1gtnV-2qjpB:
undetectable		 1gtnL-2qjpB:
14.45
1gtnV-2qjpB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhe ACETYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep) 		5 GLY A 172
SER A 157
ALA A 139
HIS A 134
ILE A 129
 COA  A 300 (-3.5A)
None
None
None
None
 0.97A 1gtnL-2vheA:
undetectable
1gtnV-2vheA:
undetectable		 1gtnL-2vheA:
15.62
1gtnV-2vheA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY B 345
GLY B 456
HIS B 314
ALA B 529
ILE B 457
 None
None
None
HPA  B1780 ( 3.2A)
None
 0.92A 1gtnL-2w55B:
undetectable
1gtnV-2w55B:
undetectable		 1gtnL-2w55B:
7.21
1gtnV-2w55B:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8u CHITIN DEACETYLASE

(Aspergillus
nidulans) 		PF01522
(Polysacc_deac_1) 		5 GLY A  91
GLY A  95
THR A 223
HIS A  92
THR A  69
 None
 0.96A 1gtnL-2y8uA:
undetectable
1gtnV-2y8uA:
undetectable		 1gtnL-2y8uA:
14.60
1gtnV-2y8uA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 289
SER A 300
ALA A 266
GLY A 125
THR A 332
 None
 1.01A 1gtnL-2zviA:
undetectable
1gtnV-2zviA:
undetectable		 1gtnL-2zviA:
10.43
1gtnV-2zviA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 ALA A 293
GLY A 187
ALA A 292
THR A 317
ILE A 241
 None
AN7  A1001 (-3.5A)
None
AN7  A1001 (-2.8A)
AN7  A1001 (-4.7A)
 1.04A 1gtnL-3aexA:
undetectable
1gtnV-3aexA:
undetectable		 1gtnL-3aexA:
11.36
1gtnV-3aexA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 SER A 191
ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.92A 1gtnL-3cb5A:
undetectable
1gtnV-3cb5A:
undetectable		 1gtnL-3cb5A:
9.95
1gtnV-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8x THIOREDOXIN
REDUCTASE 1

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		5 GLY A 220
GLY A 138
ALA A 216
THR A 133
ILE A 139
 None
 1.00A 1gtnL-3d8xA:
undetectable
1gtnV-3d8xA:
undetectable		 1gtnL-3d8xA:
13.12
1gtnV-3d8xA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdi UNCHARACTERIZED
PROTEIN

(Eubacterium
ventriosum) 		PF13189
(Cytidylate_kin2) 		5 ALA A  24
GLY A  16
HIS A  17
THR A 186
ILE A   8
 None
SO4  A2003 (-3.6A)
None
None
None
 1.03A 1gtnL-3fdiA:
undetectable
1gtnV-3fdiA:
undetectable		 1gtnL-3fdiA:
22.44
1gtnV-3fdiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		5 GLY A 332
GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.91A 1gtnL-3fmqA:
undetectable
1gtnV-3fmqA:
undetectable		 1gtnL-3fmqA:
13.14
1gtnV-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 GLY A 117
SER A 269
ALA A 270
THR A  92
ILE A  96
 PRP  A 401 (-3.2A)
None
None
PRP  A 401 (-4.2A)
None
 0.98A 1gtnL-3gbrA:
undetectable
1gtnV-3gbrA:
undetectable		 1gtnL-3gbrA:
14.29
1gtnV-3gbrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwj PUTATIVE
AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 396
GLY A 363
ALA A 352
THR A 378
ILE A 359
 None
 0.93A 1gtnL-3iwjA:
undetectable
1gtnV-3iwjA:
undetectable		 1gtnL-3iwjA:
10.54
1gtnV-3iwjA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		5 GLY A 396
GLY A 363
ALA A 352
THR A 378
ILE A 359
 None
 0.92A 1gtnL-3iwkA:
undetectable
1gtnV-3iwkA:
undetectable		 1gtnL-3iwkA:
10.34
1gtnV-3iwkA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		6 SER A 107
ALA A 108
GLY A  58
ALA A 109
HIS A  85
ILE A 128
 None
 1.21A 1gtnL-3ktoA:
undetectable
1gtnV-3ktoA:
undetectable		 1gtnL-3ktoA:
18.94
1gtnV-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 GLY A 131
ALA A 174
GLY A 220
ALA A 203
ILE A 218
 None
 1.01A 1gtnL-3m9xA:
undetectable
1gtnV-3m9xA:
undetectable		 1gtnL-3m9xA:
12.87
1gtnV-3m9xA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 160
THR A 162
ALA A 294
GLY A 125
ALA A 295
 None
 0.97A 1gtnL-3nx4A:
undetectable
1gtnV-3nx4A:
undetectable		 1gtnL-3nx4A:
13.89
1gtnV-3nx4A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on3 KETO/OXOACID
FERREDOXIN
OXIDOREDUCTASE,
GAMMA SUBUNIT

(Geobacter
sulfurreducens) 		PF01558
(POR) 		5 SER A  29
ALA A  28
GLY A  21
ALA A  27
ILE A  23
 None
 1.03A 1gtnL-3on3A:
undetectable
1gtnV-3on3A:
undetectable		 1gtnL-3on3A:
15.68
1gtnV-3on3A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvs REPLICATION-ASSOCIAT
ED RECOMBINATION
PROTEIN A

(Escherichia
coli) 		PF00004
(AAA)
PF12002
(MgsA_C)
PF16193
(AAA_assoc_2) 		5 GLY A  60
ALA A  17
ALA A  18
THR A  65
THR A  64
 PO4  A 448 (-3.1A)
None
None
None
PO4  A 448 (-3.8A)
 1.04A 1gtnL-3pvsA:
undetectable
1gtnV-3pvsA:
undetectable		 1gtnL-3pvsA:
10.93
1gtnV-3pvsA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		5 GLY A 410
THR A 412
ALA A 235
ALA A 381
ILE A 378
 None
 1.03A 1gtnL-3rosA:
undetectable
1gtnV-3rosA:
undetectable		 1gtnL-3rosA:
9.47
1gtnV-3rosA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6l HEP_HAG FAMILY

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 GLY A  94
ALA A  97
GLY A 120
ALA A 111
HIS A 108
 None
None
None
None
ZN  A 186 (-3.3A)
 0.85A 1gtnL-3s6lA:
undetectable
1gtnV-3s6lA:
undetectable		 1gtnL-3s6lA:
18.71
1gtnV-3s6lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE

(Salmonella
enterica) 		PF01177
(Asp_Glu_race) 		5 GLY A 192
THR A 194
ALA A  86
THR A 127
THR A 124
 None
SIN  A 300 (-3.3A)
None
None
SIN  A 300 (-4.0A)
 0.99A 1gtnL-3s7zA:
undetectable
1gtnV-3s7zA:
undetectable		 1gtnL-3s7zA:
12.92
1gtnV-3s7zA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY C 915
GLY C1006
HIS C 884
ALA C1079
ILE C1007
 None
None
None
RMO  C1317 ( 3.6A)
None
 0.95A 1gtnL-3sr6C:
undetectable
1gtnV-3sr6C:
undetectable		 1gtnL-3sr6C:
7.93
1gtnV-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A  94
SER A 120
ALA A 121
ALA A 124
THR A  14
 NAP  A 601 (-3.2A)
None
None
None
None
 1.00A 1gtnL-3toxA:
undetectable
1gtnV-3toxA:
undetectable		 1gtnL-3toxA:
15.71
1gtnV-3toxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tox SHORT CHAIN
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 GLY A  94
SER A 120
ALA A 124
THR A  14
ILE A  12
 NAP  A 601 (-3.2A)
None
None
None
None
 0.96A 1gtnL-3toxA:
undetectable
1gtnV-3toxA:
undetectable		 1gtnL-3toxA:
15.71
1gtnV-3toxA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trh PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CARBOXYLTRANSFERASE
SUBUNIT

(Coxiella
burnetii) 		PF00731
(AIRC) 		5 GLY A 118
ALA A  22
GLY A  86
THR A 115
ILE A  85
 None
 0.92A 1gtnL-3trhA:
undetectable
1gtnV-3trhA:
undetectable		 1gtnL-3trhA:
18.79
1gtnV-3trhA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpz GLUCOKINASE

(Pseudoalteromonas
sp. AS-131) 		PF02685
(Glucokinase) 		5 GLY A 170
ALA A 256
GLY A 146
ALA A 257
ILE A 272
 None
 0.99A 1gtnL-3vpzA:
undetectable
1gtnV-3vpzA:
undetectable		 1gtnL-3vpzA:
12.77
1gtnV-3vpzA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
None
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.33A 1gtnL-3zteA:
14.1
1gtnV-3zteA:
14.2		 1gtnL-3zteA:
78.21
1gtnV-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		7 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 TRP  A  81 ( 3.7A)
TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 1.01A 1gtnL-3zzlA:
13.0
1gtnV-3zzlA:
13.0		 1gtnL-3zzlA:
71.43
1gtnV-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.36A 1gtnL-3zzlA:
13.0
1gtnV-3zzlA:
13.0		 1gtnL-3zzlA:
71.43
1gtnV-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
 TRP  A  81 ( 3.7A)
TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 1.08A 1gtnL-3zzqA:
13.5
1gtnV-3zzqA:
13.5		 1gtnL-3zzqA:
80.00
1gtnV-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.32A 1gtnL-3zzqA:
13.5
1gtnV-3zzqA:
13.5		 1gtnL-3zzqA:
80.00
1gtnV-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 TRP  A1072 ( 3.8A)
TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
 1.11A 1gtnL-3zzsA:
13.3
1gtnV-3zzsA:
13.3		 1gtnL-3zzsA:
100.00
1gtnV-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.28A 1gtnL-3zzsA:
13.3
1gtnV-3zzsA:
13.3		 1gtnL-3zzsA:
100.00
1gtnV-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0m BETAINE ALDEHYDE
DEHYDROGENASE,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00171
(Aldedh) 		5 GLY A 393
GLY A 360
ALA A 349
THR A 375
ILE A 356
 None
 1.03A 1gtnL-4a0mA:
undetectable
1gtnV-4a0mA:
undetectable		 1gtnL-4a0mA:
9.68
1gtnV-4a0mA:
9.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 ALA A  46
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 ALA  A  46 ( 0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 1.14A 1gtnL-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnL-4b27A:
76.32
1gtnV-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.36A 1gtnL-4b27A:
13.0
1gtnV-4b27A:
13.0		 1gtnL-4b27A:
76.32
1gtnV-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 GLY A  26
ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.83A 1gtnL-4cnkA:
undetectable
1gtnV-4cnkA:
undetectable		 1gtnL-4cnkA:
12.76
1gtnV-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 GLY A 381
GLY A 350
ALA A 338
THR A 363
ILE A 346
 GOL  A 600 (-4.6A)
None
None
None
None
 0.98A 1gtnL-4dalA:
undetectable
1gtnV-4dalA:
undetectable		 1gtnL-4dalA:
9.83
1gtnV-4dalA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A 140
ALA A 135
ALA A 132
THR A 393
THR A 143
 None
 0.93A 1gtnL-4dioA:
undetectable
1gtnV-4dioA:
undetectable		 1gtnL-4dioA:
11.11
1gtnV-4dioA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 GLY A 255
ALA A 160
GLY A 176
HIS A 175
HIS A 135
 None
MN  A 401 ( 4.8A)
UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
 0.97A 1gtnL-4dz4A:
undetectable
1gtnV-4dz4A:
undetectable		 1gtnL-4dz4A:
11.56
1gtnV-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo7 METHIONINE
AMINOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF00557
(Peptidase_M24) 		5 GLY A 171
GLY A 106
HIS A 105
THR A 201
THR A 236
 None
None
None
MN  A 301 ( 3.8A)
None
 1.00A 1gtnL-4fo7A:
undetectable
1gtnV-4fo7A:
undetectable		 1gtnL-4fo7A:
15.30
1gtnV-4fo7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuk METHIONINE
AMINOPEPTIDASE

(Trypanosoma
brucei) 		PF00557
(Peptidase_M24) 		5 GLY A 286
GLY A 221
HIS A 220
THR A 316
THR A 351
 None
None
None
ZN  A 401 ( 3.6A)
None
 1.04A 1gtnL-4fukA:
undetectable
1gtnV-4fukA:
undetectable		 1gtnL-4fukA:
11.94
1gtnV-4fukA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A 197
ALA A 220
GLY A 168
ALA A 269
HIS A 199
 None
None
LLP  A  41 ( 3.5A)
LLP  A  41 ( 3.6A)
None
 1.02A 1gtnL-4h27A:
undetectable
1gtnV-4h27A:
undetectable		 1gtnL-4h27A:
13.46
1gtnV-4h27A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxx METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 ( 3.6A)
None
 1.02A 1gtnL-4hxxA:
undetectable
1gtnV-4hxxA:
undetectable		 1gtnL-4hxxA:
11.80
1gtnV-4hxxA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8p AMINOALDEHYDE
DEHYDROGENASE 1

(Zea mays) 		PF00171
(Aldedh) 		5 GLY A 398
GLY A 365
ALA A 354
THR A 380
ILE A 361
 None
 0.97A 1gtnL-4i8pA:
undetectable
1gtnV-4i8pA:
undetectable		 1gtnL-4i8pA:
9.81
1gtnV-4i8pA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		5 GLY A 397
GLY A 364
ALA A 353
THR A 379
ILE A 360
 None
 0.95A 1gtnL-4i8qA:
undetectable
1gtnV-4i8qA:
undetectable		 1gtnL-4i8qA:
9.01
1gtnV-4i8qA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 GLY A  85
SER A  88
GLY A 109
HIS A 133
THR A  81
 LMS  A 401 ( 4.7A)
None
None
LMS  A 401 (-3.9A)
None
 1.04A 1gtnL-4injA:
undetectable
1gtnV-4injA:
undetectable		 1gtnL-4injA:
10.80
1gtnV-4injA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu6 METHIONINE
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24) 		5 GLY A 304
GLY A 239
HIS A 238
THR A 334
THR A 369
 None
None
None
CO  A 401 (-3.5A)
None
 1.01A 1gtnL-4iu6A:
undetectable
1gtnV-4iu6A:
undetectable		 1gtnL-4iu6A:
12.50
1gtnV-4iu6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		5 GLY A 206
THR A 174
GLY A 191
ALA A 119
ILE A 190
 None
 1.03A 1gtnL-4m7gA:
undetectable
1gtnV-4m7gA:
undetectable		 1gtnL-4m7gA:
17.16
1gtnV-4m7gA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		5 GLY A  52
ALA A  47
ALA A  44
THR A  31
ILE A 111
 None
 0.90A 1gtnL-4o0lA:
undetectable
1gtnV-4o0lA:
undetectable		 1gtnL-4o0lA:
15.27
1gtnV-4o0lA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o48 UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF01112
(Asparaginase_2) 		5 GLY A   9
ALA A  12
GLY A 188
THR A 219
ILE A 189
 None
None
ASP  A 402 (-3.6A)
ASP  A 402 (-3.7A)
ASP  A 402 (-4.5A)
 1.02A 1gtnL-4o48A:
undetectable
1gtnV-4o48A:
undetectable		 1gtnL-4o48A:
14.56
1gtnV-4o48A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		5 GLY A 206
GLY A 141
HIS A 140
THR A 236
THR A 271
 None
NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.96A 1gtnL-4ookA:
undetectable
1gtnV-4ookA:
undetectable		 1gtnL-4ookA:
13.69
1gtnV-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		6 THR A  87
ALA A  68
GLY A  84
ALA A  71
HIS A 119
THR A 115
 None
 1.39A 1gtnL-4q0gA:
undetectable
1gtnV-4q0gA:
undetectable		 1gtnL-4q0gA:
9.33
1gtnV-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7t DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3A

(Homo sapiens) 		PF00145
(DNA_methylase) 		5 GLY A 646
SER A 638
ALA A 662
GLY A 673
ILE A 670
 None
 1.02A 1gtnL-4u7tA:
undetectable
1gtnV-4u7tA:
undetectable		 1gtnL-4u7tA:
9.89
1gtnV-4u7tA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxx DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		5 GLY A1302
THR A1309
ALA A1335
GLY A1521
THR A1364
 None
 0.88A 1gtnL-4wxxA:
undetectable
1gtnV-4wxxA:
undetectable		 1gtnL-4wxxA:
4.84
1gtnV-4wxxA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yra L-THREONINE
3-DEHYDROGENASE,
MITOCHONDRIAL

(Mus musculus) 		PF01370
(Epimerase) 		5 GLY A 172
THR A 193
SER A 330
ALA A 326
THR A 236
 None
 1.00A 1gtnL-4yraA:
undetectable
1gtnV-4yraA:
undetectable		 1gtnL-4yraA:
12.91
1gtnV-4yraA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 915
GLY A1006
HIS A 884
ALA A1079
ILE A1007
 BCT  A3006 (-3.9A)
None
None
URC  A3007 (-3.4A)
None
 0.93A 1gtnL-4yswA:
undetectable
1gtnV-4yswA:
undetectable		 1gtnL-4yswA:
5.06
1gtnV-4yswA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 GLY A 154
ALA A 197
GLY A 243
ALA A 226
ILE A 241
 None
 0.99A 1gtnL-4ywhA:
undetectable
1gtnV-4ywhA:
undetectable		 1gtnL-4ywhA:
12.05
1gtnV-4ywhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwl BETAINE-ALDEHYDE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		5 GLY A 393
GLY A 358
ALA A 347
THR A 375
ILE A 354
 None
 0.98A 1gtnL-4zwlA:
undetectable
1gtnV-4zwlA:
undetectable		 1gtnL-4zwlA:
9.48
1gtnV-4zwlA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 GLY A  87
ALA A  82
ALA A  79
THR A  90
ILE A  58
 None
 0.89A 1gtnL-5a5gA:
undetectable
1gtnV-5a5gA:
undetectable		 1gtnL-5a5gA:
10.41
1gtnV-5a5gA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7n MTA/SAH NUCLEOSIDASE

(Aeromonas
hydrophila) 		PF01048
(PNP_UDP_1) 		5 ALA A 217
GLY A 115
ALA A 105
THR A 245
HIS A 248
 None
 0.99A 1gtnL-5b7nA:
undetectable
1gtnV-5b7nA:
undetectable		 1gtnL-5b7nA:
15.74
1gtnV-5b7nA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cde PROLINE DIPEPTIDASE

(Xanthomonas
campestris) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 GLY A 330
ALA A 307
HIS A 327
ALA A 286
ILE A 363
 None
None
SO4  A 401 ( 4.8A)
None
None
 1.04A 1gtnL-5cdeA:
undetectable
1gtnV-5cdeA:
undetectable		 1gtnL-5cdeA:
10.71
1gtnV-5cdeA:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 ALA A  46
GLY A  23
HIS A  33
HIS A  34
THR A  49
HIS A  51
THR A  52
 None
 1.13A 1gtnL-5eexA:
15.2
1gtnV-5eexA:
15.2		 1gtnL-5eexA:
100.00
1gtnV-5eexA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		8 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
HIS A  51
THR A  52
ILE A  55
 None
 0.29A 1gtnL-5eexA:
15.2
1gtnV-5eexA:
15.2		 1gtnL-5eexA:
100.00
1gtnV-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF03071
(GNT-I)
PF15711
(ILEI) 		5 ALA A 189
GLY A 181
HIS A 184
THR A 151
ILE A 131
 None
 1.03A 1gtnL-5gggA:
2.0
1gtnV-5gggA:
2.0		 1gtnL-5gggA:
8.92
1gtnV-5gggA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		5 ALA A 189
GLY A 181
HIS A 184
THR A 151
ILE A 131
 None
 1.04A 1gtnL-5ggkA:
1.4
1gtnV-5ggkA:
1.4		 1gtnL-5ggkA:
23.23
1gtnV-5ggkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 GLY A  83
ALA A 181
GLY A 232
ALA A 180
ILE A 236
 None
2OH  A 402 (-3.9A)
2OH  A 402 ( 3.8A)
2OH  A 402 ( 3.8A)
None
 0.90A 1gtnL-5it1A:
undetectable
1gtnV-5it1A:
undetectable		 1gtnL-5it1A:
9.04
1gtnV-5it1A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 SER A 817
GLY A 285
ALA A 293
THR A 624
ILE A 283
 None
FAD  A 901 (-3.3A)
None
None
None
 1.01A 1gtnL-5l3dA:
undetectable
1gtnV-5l3dA:
undetectable		 1gtnL-5l3dA:
6.27
1gtnV-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		6 GLY A  76
GLY A  80
THR A 199
HIS A  77
THR A  54
ILE A 118
 None
 1.03A 1gtnL-5lgcA:
undetectable
1gtnV-5lgcA:
undetectable		 1gtnL-5lgcA:
17.89
1gtnV-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 GLY A 383
ALA A 380
GLY A 335
ALA A 379
THR A 361
 None
 0.94A 1gtnL-5oj3A:
undetectable
1gtnV-5oj3A:
undetectable		 1gtnL-5oj3A:
undetectable
1gtnV-5oj3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 ALA A 104
GLY A 165
ALA A 103
THR A  21
ILE A 168
 None
 1.00A 1gtnL-5sy4A:
undetectable
1gtnV-5sy4A:
undetectable		 1gtnL-5sy4A:
17.62
1gtnV-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 5 GLY A  22
THR A  20
GLY A 225
THR A 278
ILE A 269
 None
 0.90A 1gtnL-5u6fA:
2.1
1gtnV-5u6fA:
1.8		 1gtnL-5u6fA:
undetectable
1gtnV-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 933
SER A 779
ALA A 780
GLY A 765
ALA A 781
 None
 0.96A 1gtnL-5ur2A:
undetectable
1gtnV-5ur2A:
undetectable		 1gtnL-5ur2A:
6.57
1gtnV-5ur2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4c THIOREDOXIN
REDUCTASE

(Cryptococcus
neoformans) 		no annotation 5 GLY A 248
GLY A 166
ALA A 244
THR A 161
ILE A 167
 None
 0.96A 1gtnL-5w4cA:
undetectable
1gtnV-5w4cA:
undetectable		 1gtnL-5w4cA:
undetectable
1gtnV-5w4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 5 GLY A 222
GLY A  73
HIS A  72
HIS A  75
ILE A  37
 None
 1.03A 1gtnL-5wslA:
undetectable
1gtnV-5wslA:
undetectable		 1gtnL-5wslA:
12.21
1gtnV-5wslA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		5 GLY A 429
ALA A 371
GLY A 163
ALA A 372
HIS A 183
 None
None
GLY  A 951 (-4.9A)
None
None
 1.04A 1gtnL-5x2qA:
undetectable
1gtnV-5x2qA:
undetectable		 1gtnL-5x2qA:
10.77
1gtnV-5x2qA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		5 GLY A 387
GLY A 356
ALA A 345
THR A 369
ILE A 352
 None
 0.95A 1gtnL-5x5tA:
undetectable
1gtnV-5x5tA:
undetectable		 1gtnL-5x5tA:
10.44
1gtnV-5x5tA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z72 CCPC

(Bacillus
velezensis) 		no annotation 5 GLY A 148
THR A 262
SER A 129
ALA A  98
ILE A 218
 None
None
FLC  A 303 ( 2.1A)
FLC  A 303 (-3.1A)
FLC  A 303 ( 4.5A)
 0.98A 1gtnL-5z72A:
undetectable
1gtnV-5z72A:
undetectable		 1gtnL-5z72A:
undetectable
1gtnV-5z72A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 GLY B 180
ALA B 208
HIS B 402
THR B 403
ILE B 405
 None
 1.01A 1gtnL-6btmB:
undetectable
1gtnV-6btmB:
undetectable		 1gtnL-6btmB:
undetectable
1gtnV-6btmB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 GLY A 413
ALA A 389
GLY A 360
THR A 396
ILE A 328
 None
 0.99A 1gtnL-6c0eA:
undetectable
1gtnV-6c0eA:
undetectable		 1gtnL-6c0eA:
undetectable
1gtnV-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 GLY A 123
THR A 182
ALA A 239
HIS A 233
THR A 234
 None
 1.03A 1gtnL-6fc0A:
undetectable
1gtnV-6fc0A:
undetectable		 1gtnL-6fc0A:
undetectable
1gtnV-6fc0A:
undetectable