SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_Q_TRPQ81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 GLY A 431
ALA A 378
THR A 370
THR A 394
SER A 374
 None
 1.33A 1gtnQ-1fc9A:
0.0
1gtnR-1fc9A:
undetectable		 1gtnQ-1fc9A:
12.11
1gtnR-1fc9A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 GLY A 329
HIS A 330
ALA A 420
THR A 197
ALA A 335
 None
 1.49A 1gtnQ-1gk2A:
undetectable
1gtnR-1gk2A:
undetectable		 1gtnQ-1gk2A:
10.18
1gtnR-1gk2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 GLY B  67
ALA B  60
THR B  68
THR B 103
ALA B  56
 None
 1.47A 1gtnQ-1hr7B:
undetectable
1gtnR-1hr7B:
undetectable		 1gtnQ-1hr7B:
9.26
1gtnR-1hr7B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 GLY A 264
THR A 119
THR A 259
SER A 389
ALA A 388
 None
None
CL  A 541 (-3.9A)
FAD  A 800 (-4.3A)
None
 1.22A 1gtnQ-1knrA:
undetectable
1gtnR-1knrA:
undetectable		 1gtnQ-1knrA:
9.07
1gtnR-1knrA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.10A 1gtnQ-1l5jA:
undetectable
1gtnR-1l5jA:
undetectable		 1gtnQ-1l5jA:
7.07
1gtnR-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		5 GLY A 226
ALA A 221
THR A 133
THR A  10
ALA A 155
 None
 1.35A 1gtnQ-1olpA:
3.1
1gtnR-1olpA:
2.9		 1gtnQ-1olpA:
11.35
1gtnR-1olpA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 GLY A 280
HIS A  57
THR A 278
SER A 248
ALA A 227
 None
NI  A9001 (-3.3A)
None
None
None
 1.36A 1gtnQ-1p1mA:
undetectable
1gtnR-1p1mA:
0.0		 1gtnQ-1p1mA:
11.70
1gtnR-1p1mA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.49A 1gtnQ-1sb3A:
undetectable
1gtnR-1sb3A:
undetectable		 1gtnQ-1sb3A:
7.84
1gtnR-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE

(Bacillus
subtilis) 		PF03652
(RuvX) 		5 GLY A   9
ALA A 125
THR A  30
THR A  12
ALA A 126
 None
 1.27A 1gtnQ-1vhxA:
undetectable
1gtnR-1vhxA:
undetectable		 1gtnQ-1vhxA:
20.41
1gtnR-1vhxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 GLY A 273
ALA A 280
THR A 272
THR A 406
ALA A 251
 None
 1.26A 1gtnQ-1xr4A:
undetectable
1gtnR-1xr4A:
undetectable		 1gtnQ-1xr4A:
11.26
1gtnR-1xr4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5l TRP REPRESSOR
BINDING PROTEIN WRBA

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 GLY A  15
HIS A  14
ALA A 166
THR A  17
ALA A 116
 None
 1.14A 1gtnQ-2a5lA:
undetectable
1gtnR-2a5lA:
undetectable		 1gtnQ-2a5lA:
19.29
1gtnR-2a5lA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		5 GLY A 140
HIS A 139
HIS A  99
THR A 240
ALA A 123
 None
None
MN  A 301 ( 3.2A)
None
MN  A 302 ( 4.5A)
 1.41A 1gtnQ-2cevA:
undetectable
1gtnR-2cevA:
undetectable		 1gtnQ-2cevA:
14.81
1gtnR-2cevA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc3 50S RIBOSOMAL
PROTEIN L7AE

(Aeropyrum
pernix) 		PF01248
(Ribosomal_L7Ae) 		5 HIS A  65
THR A  39
THR A  40
SER A  98
ALA A  97
 None
 1.23A 1gtnQ-2fc3A:
undetectable
1gtnR-2fc3A:
undetectable		 1gtnQ-2fc3A:
21.31
1gtnR-2fc3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 GLY A 210
HIS A 269
ALA A  65
THR A  62
THR A  20
 None
ZN  A 401 (-3.6A)
ZN  A 401 ( 4.9A)
None
None
 1.42A 1gtnQ-2fk6A:
undetectable
1gtnR-2fk6A:
undetectable		 1gtnQ-2fk6A:
12.30
1gtnR-2fk6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 GLY B 195
HIS A   9
ALA A  67
THR B 225
THR B 209
 None
None
NA  A 401 (-4.6A)
None
None
 1.40A 1gtnQ-2gezB:
undetectable
1gtnR-2gezB:
undetectable		 1gtnQ-2gezB:
20.15
1gtnR-2gezB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h32 IMMUNOGLOBULIN HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY H  35
ALA H  79
THR H  58
SER H  71
ALA H  72
 None
 1.45A 1gtnQ-2h32H:
undetectable
1gtnR-2h32H:
undetectable		 1gtnQ-2h32H:
15.28
1gtnR-2h32H:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  28
ALA A  36
THR A 138
THR A  97
ALA A 251
 None
 1.14A 1gtnQ-2hlpA:
undetectable
1gtnR-2hlpA:
undetectable		 1gtnQ-2hlpA:
14.62
1gtnR-2hlpA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 GLY A  87
ALA A  92
THR A  60
SER A  94
ALA A  93
 SAM  A 300 (-3.2A)
None
None
None
None
 1.18A 1gtnQ-2oxtA:
undetectable
1gtnR-2oxtA:
undetectable		 1gtnQ-2oxtA:
11.76
1gtnR-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 GLY A 258
HIS A 257
ALA A 281
THR A 259
SER A 278
 None
None
EDO  A 331 ( 3.7A)
None
EDO  A 331 (-3.3A)
 1.34A 1gtnQ-2rbcA:
undetectable
1gtnR-2rbcA:
undetectable		 1gtnQ-2rbcA:
11.54
1gtnR-2rbcA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		5 GLY A  87
ALA A 250
THR A  93
THR A 151
ALA A 253
 None
 1.35A 1gtnQ-2xrmA:
undetectable
1gtnR-2xrmA:
undetectable		 1gtnQ-2xrmA:
15.72
1gtnR-2xrmA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.26A 1gtnQ-2xzlA:
undetectable
1gtnR-2xzlA:
undetectable		 1gtnQ-2xzlA:
7.24
1gtnR-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.33A 1gtnQ-3a1nA:
undetectable
1gtnR-3a1nA:
undetectable		 1gtnQ-3a1nA:
13.02
1gtnR-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		5 GLY A 191
ALA A 200
THR A 219
THR A 193
ALA A 231
 None
 1.46A 1gtnQ-3egjA:
undetectable
1gtnR-3egjA:
undetectable		 1gtnQ-3egjA:
12.82
1gtnR-3egjA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 GLY A 146
ALA A 152
THR A 134
SER A 154
ALA A 153
 None
 1.49A 1gtnQ-3h0lA:
undetectable
1gtnR-3h0lA:
undetectable		 1gtnQ-3h0lA:
10.90
1gtnR-3h0lA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h86 ADENYLATE KINASE

(Methanococcus
maripaludis) 		no annotation 5 GLY B  10
HIS B 151
ALA B 159
THR B   9
ALA B 158
 None
 1.41A 1gtnQ-3h86B:
undetectable
1gtnR-3h86B:
undetectable		 1gtnQ-3h86B:
18.65
1gtnR-3h86B:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjw 50S RIBOSOMAL
PROTEIN L7AE

(Pyrococcus
furiosus) 		PF01248
(Ribosomal_L7Ae) 		5 HIS C  66
THR C  40
THR C  41
SER C  99
ALA C  98
 None
None
None
None
U  D  30 ( 3.5A)
 1.27A 1gtnQ-3hjwC:
undetectable
1gtnR-3hjwC:
undetectable		 1gtnQ-3hjwC:
24.79
1gtnR-3hjwC:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		5 GLY A 122
HIS A 156
THR A 150
THR A 260
ALA A 226
 None
 1.24A 1gtnQ-3io0A:
undetectable
1gtnR-3io0A:
undetectable		 1gtnQ-3io0A:
15.65
1gtnR-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9d ALDEHYDE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF00171
(Aldedh) 		5 GLY A  47
ALA A 161
THR A 129
SER A 159
ALA A 162
 None
 1.31A 1gtnQ-3k9dA:
undetectable
1gtnR-3k9dA:
undetectable		 1gtnQ-3k9dA:
9.13
1gtnR-3k9dA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 GLY E  36
THR E 120
THR E 128
THR E 109
ALA E 146
 None
 1.44A 1gtnQ-3kfuE:
undetectable
1gtnR-3kfuE:
undetectable		 1gtnQ-3kfuE:
9.27
1gtnR-3kfuE:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 GLY A  72
ALA A 103
THR A  88
SER A 107
ALA A 106
 None
 1.19A 1gtnQ-3ktoA:
undetectable
1gtnR-3ktoA:
undetectable		 1gtnQ-3ktoA:
18.94
1gtnR-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ot5 UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Listeria
monocytogenes) 		PF02350
(Epimerase_2) 		5 ALA A 105
THR A 100
THR A  40
SER A 103
ALA A 106
 None
 1.37A 1gtnQ-3ot5A:
undetectable
1gtnR-3ot5A:
undetectable		 1gtnQ-3ot5A:
13.22
1gtnR-3ot5A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 GLY A 237
HIS A 234
ALA A 173
THR A 416
THR A 194
 None
 1.16A 1gtnQ-3q8nA:
undetectable
1gtnR-3q8nA:
undetectable		 1gtnQ-3q8nA:
9.98
1gtnR-3q8nA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		5 GLY A 229
ALA A 224
THR A 177
SER A 222
ALA A 223
 None
 1.50A 1gtnQ-3qomA:
undetectable
1gtnR-3qomA:
undetectable		 1gtnQ-3qomA:
11.23
1gtnR-3qomA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpc CUTINASE

(Fusarium solani) 		PF01083
(Cutinase) 		5 GLY A 122
ALA A 127
THR A  90
SER A 129
ALA A 128
 MIR  A 120 ( 4.0A)
None
None
None
None
 1.49A 1gtnQ-3qpcA:
undetectable
1gtnR-3qpcA:
undetectable		 1gtnQ-3qpcA:
17.77
1gtnR-3qpcA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.18A 1gtnQ-3rwbA:
undetectable
1gtnR-3rwbA:
undetectable		 1gtnQ-3rwbA:
16.06
1gtnR-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE

(Brucella
abortus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 332
HIS A 333
ALA A 219
THR A 327
ALA A 297
 None
 1.41A 1gtnQ-3u0fA:
undetectable
1gtnR-3u0fA:
undetectable		 1gtnQ-3u0fA:
10.22
1gtnR-3u0fA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 GLY A 569
HIS A 568
ALA A 545
THR A 539
ALA A 546
 None
 1.21A 1gtnQ-3w5nA:
2.1
1gtnR-3w5nA:
1.7		 1gtnQ-3w5nA:
5.72
1gtnR-3w5nA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		5 GLY A 164
HIS A 135
ALA A 190
THR A 185
ALA A 170
 None
 1.40A 1gtnQ-3zrpA:
undetectable
1gtnR-3zrpA:
undetectable		 1gtnQ-3zrpA:
12.03
1gtnR-3zrpA:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
 TRP  A  80 (-3.5A)
None
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
 0.31A 1gtnQ-3zteA:
14.2
1gtnR-3zteA:
14.2		 1gtnQ-3zteA:
78.21
1gtnR-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.29A 1gtnQ-3zzlA:
13.0
1gtnR-3zzlA:
12.9		 1gtnQ-3zzlA:
71.43
1gtnR-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
TRP  A  81 ( 3.7A)
 0.96A 1gtnQ-3zzlA:
13.0
1gtnR-3zzlA:
12.9		 1gtnQ-3zzlA:
71.43
1gtnR-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 0.26A 1gtnQ-3zzqA:
13.5
1gtnR-3zzqA:
13.5		 1gtnQ-3zzqA:
80.00
1gtnR-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 3.7A)
 1.08A 1gtnQ-3zzqA:
13.5
1gtnR-3zzqA:
13.5		 1gtnQ-3zzqA:
80.00
1gtnR-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
 0.21A 1gtnQ-3zzsA:
13.3
1gtnR-3zzsA:
13.4		 1gtnQ-3zzsA:
100.00
1gtnR-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 3.8A)
 1.08A 1gtnQ-3zzsA:
13.3
1gtnR-3zzsA:
13.4		 1gtnQ-3zzsA:
100.00
1gtnR-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 228
HIS A 313
THR A 318
THR A 314
SER A 322
 NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
None
 1.31A 1gtnQ-4a0sA:
undetectable
1gtnR-4a0sA:
undetectable		 1gtnQ-4a0sA:
10.76
1gtnR-4a0sA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 GLY A  28
ALA A  33
THR A 120
SER A  35
ALA A  34
 None
 1.24A 1gtnQ-4avcA:
undetectable
1gtnR-4avcA:
undetectable		 1gtnQ-4avcA:
11.71
1gtnR-4avcA:
11.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
 0.23A 1gtnQ-4b27A:
13.0
1gtnR-4b27A:
13.1		 1gtnQ-4b27A:
76.32
1gtnR-4b27A:
76.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ALA  A  46 ( 0.0A)
 1.11A 1gtnQ-4b27A:
13.0
1gtnR-4b27A:
13.1		 1gtnQ-4b27A:
76.32
1gtnR-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6y BETA-LACTAMASE

(synthetic
construct) 		PF13354
(Beta-lactamase2) 		5 GLY A  62
ALA A 187
THR A 181
THR A 182
ALA A 188
 None
PEG  A 301 ( 3.6A)
None
None
PEG  A 294 (-2.5A)
 1.32A 1gtnQ-4c6yA:
undetectable
1gtnR-4c6yA:
undetectable		 1gtnQ-4c6yA:
15.18
1gtnR-4c6yA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
HIS A 123
ALA A 138
THR A 117
ALA A 131
 None
 1.22A 1gtnQ-4d9iA:
undetectable
1gtnR-4d9iA:
undetectable		 1gtnQ-4d9iA:
11.42
1gtnR-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dz4 AGMATINASE

(Burkholderia
thailandensis) 		PF00491
(Arginase) 		5 GLY A 176
HIS A 175
HIS A 135
THR A 256
ALA A 160
 UNK  A 409 ( 3.4A)
UNK  A 407 ( 3.8A)
MN  A 402 (-3.3A)
UNK  A 408 ( 3.5A)
MN  A 401 ( 4.8A)
 1.43A 1gtnQ-4dz4A:
undetectable
1gtnR-4dz4A:
undetectable		 1gtnQ-4dz4A:
11.56
1gtnR-4dz4A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 AMP  A 602 (-3.6A)
ZN  A 601 (-3.4A)
None
None
None
 1.33A 1gtnQ-4gvlA:
undetectable
1gtnR-4gvlA:
undetectable		 1gtnQ-4gvlA:
10.47
1gtnR-4gvlA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx0 TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		5 GLY A 358
HIS A 359
ALA A 366
THR A 418
ALA A 365
 None
ZN  A 606 (-3.5A)
None
None
None
 1.26A 1gtnQ-4gx0A:
undetectable
1gtnR-4gx0A:
undetectable		 1gtnQ-4gx0A:
8.70
1gtnR-4gx0A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 GLY A 294
ALA A 309
THR A 270
SER A 290
ALA A 289
 None
 1.30A 1gtnQ-4hdsA:
undetectable
1gtnR-4hdsA:
undetectable		 1gtnQ-4hdsA:
12.75
1gtnR-4hdsA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp8 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 GLY A 158
HIS A 157
ALA A 138
THR A 163
ALA A 181
 None
 1.39A 1gtnQ-4hp8A:
undetectable
1gtnR-4hp8A:
undetectable		 1gtnQ-4hp8A:
15.26
1gtnR-4hp8A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4huc PROBABLE CONSERVED
LIPOPROTEIN LPPS

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 None
 1.40A 1gtnQ-4hucA:
undetectable
1gtnR-4hucA:
undetectable		 1gtnQ-4hucA:
14.94
1gtnR-4hucA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 HIS A  66
ALA A 103
THR A  44
THR A  40
ALA A  62
 None
 1.47A 1gtnQ-4kpoA:
undetectable
1gtnR-4kpoA:
undetectable		 1gtnQ-4kpoA:
15.07
1gtnR-4kpoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
 FMT  A 501 (-3.4A)
None
None
None
None
 1.33A 1gtnQ-4kv7A:
undetectable
1gtnR-4kv7A:
undetectable		 1gtnQ-4kv7A:
13.40
1gtnR-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		5 GLY A 604
ALA A 593
THR A 596
SER A 607
ALA A 646
 None
 1.36A 1gtnQ-4lm8A:
undetectable
1gtnR-4lm8A:
undetectable		 1gtnQ-4lm8A:
8.09
1gtnR-4lm8A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A  84
ALA A  71
THR A 115
THR A  87
ALA A  68
 None
 1.32A 1gtnQ-4q0gA:
undetectable
1gtnR-4q0gA:
undetectable		 1gtnQ-4q0gA:
9.33
1gtnR-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 3V5  A 502 (-3.7A)
None
None
None
None
 1.41A 1gtnQ-4qtfA:
undetectable
1gtnR-4qtfA:
undetectable		 1gtnQ-4qtfA:
12.89
1gtnR-4qtfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 GLY A 164
ALA A 144
THR A 115
THR A 169
SER A 142
 None
 1.12A 1gtnQ-4xgnA:
undetectable
1gtnR-4xgnA:
undetectable		 1gtnQ-4xgnA:
13.85
1gtnR-4xgnA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 GLY A 184
HIS A  84
ALA A 304
THR A 187
SER A 126
 None
 1.33A 1gtnQ-5ah1A:
undetectable
1gtnR-5ah1A:
undetectable		 1gtnQ-5ah1A:
10.95
1gtnR-5ah1A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e2e BETA-LACTAMASE

(Yersinia
enterocolitica) 		PF13354
(Beta-lactamase2) 		5 GLY A  39
ALA A 164
THR A 158
THR A 159
ALA A 165
 None
 1.29A 1gtnQ-5e2eA:
undetectable
1gtnR-5e2eA:
undetectable		 1gtnQ-5e2eA:
12.88
1gtnR-5e2eA:
12.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 None
 0.22A 1gtnQ-5eexA:
15.2
1gtnR-5eexA:
15.3		 1gtnQ-5eexA:
100.00
1gtnR-5eexA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ALA A  46
 None
 1.07A 1gtnQ-5eexA:
15.2
1gtnR-5eexA:
15.3		 1gtnQ-5eexA:
100.00
1gtnR-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 120
THR A  53
THR A 127
SER A 347
ALA A 143
 None
 1.47A 1gtnQ-5epgA:
undetectable
1gtnR-5epgA:
undetectable		 1gtnQ-5epgA:
4.77
1gtnR-5epgA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin 50S RIBOSOMAL
PROTEIN L7AE

(Sulfolobus
solfataricus) 		PF01248
(Ribosomal_L7Ae) 		5 HIS C  68
THR C  42
THR C  43
SER C 101
ALA C 100
 None
None
None
None
U  H  11 ( 3.7A)
 1.21A 1gtnQ-5ginC:
undetectable
1gtnR-5ginC:
undetectable		 1gtnQ-5ginC:
22.31
1gtnR-5ginC:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpn PERMUTED PDUA

(synthetic
construct) 		PF00936
(BMC) 		5 GLY A  28
ALA A  74
THR A  79
SER A  48
ALA A  49
 None
 1.18A 1gtnQ-5hpnA:
undetectable
1gtnR-5hpnA:
undetectable		 1gtnQ-5hpnA:
23.16
1gtnR-5hpnA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 GLY A 274
ALA A 400
THR A 377
THR A 308
ALA A 401
 None
 0.94A 1gtnQ-5j84A:
undetectable
1gtnR-5j84A:
undetectable		 1gtnQ-5j84A:
8.03
1gtnR-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjc CYSTEINE SYNTHASE

(Brucella
abortus) 		PF00291
(PALP) 		5 GLY A  76
THR A  88
THR A  78
THR A  69
ALA A 147
 LLP  A  42 ( 4.6A)
None
None
None
None
 1.36A 1gtnQ-5jjcA:
undetectable
1gtnR-5jjcA:
undetectable		 1gtnQ-5jjcA:
12.87
1gtnR-5jjcA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k69 L,D-TRANSPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 GLY A 353
THR A 380
THR A 287
THR A 278
ALA A 257
 6QR  A 503 (-3.9A)
None
None
None
None
 1.41A 1gtnQ-5k69A:
undetectable
1gtnR-5k69A:
undetectable		 1gtnQ-5k69A:
11.27
1gtnR-5k69A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 GLY A  30
THR A 580
THR A  23
SER A 563
ALA A 173
 F3S  A2005 (-4.1A)
None
None
None
MGD  A2001 ( 4.7A)
 1.36A 1gtnQ-5nqdA:
undetectable
1gtnR-5nqdA:
undetectable		 1gtnQ-5nqdA:
undetectable
1gtnR-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 930
ALA A 781
THR A 902
SER A 779
ALA A 780
 None
 1.27A 1gtnQ-5ur2A:
undetectable
1gtnR-5ur2A:
undetectable		 1gtnQ-5ur2A:
6.57
1gtnR-5ur2A:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 GLY A 874
ALA A 726
THR A 846
SER A 724
ALA A 725
 None
None
None
SO4  A2003 (-2.4A)
None
 1.20A 1gtnQ-5ux5A:
undetectable
1gtnR-5ux5A:
undetectable		 1gtnQ-5ux5A:
5.76
1gtnR-5ux5A:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 GLY A 292
THR A 287
THR A 288
SER A 346
ALA A 329
 EDO  A 411 ( 3.9A)
None
None
None
None
 1.44A 1gtnQ-5wh8A:
undetectable
1gtnR-5wh8A:
undetectable		 1gtnQ-5wh8A:
undetectable
1gtnR-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wka BETA-GLUCOSIDASE

(metagenome) 		no annotation 5 GLY A 213
HIS A 196
ALA A 203
THR A 158
ALA A 202
 None
 1.47A 1gtnQ-5wkaA:
undetectable
1gtnR-5wkaA:
undetectable		 1gtnQ-5wkaA:
undetectable
1gtnR-5wkaA:
undetectable