SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_P_TRPP81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 213
THR A  32
ILE A   4
SER A  58
 None
 0.81A 1gtnP-1ajkA:
0.0
1gtnQ-1ajkA:
0.0		 1gtnP-1ajkA:
16.82
1gtnQ-1ajkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.78A 1gtnP-1ajoA:
1.2
1gtnQ-1ajoA:
0.0		 1gtnP-1ajoA:
18.54
1gtnQ-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.76A 1gtnP-1axkA:
0.9
1gtnQ-1axkA:
0.0		 1gtnP-1axkA:
11.17
1gtnQ-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.71A 1gtnP-1c3xA:
undetectable
1gtnQ-1c3xA:
undetectable		 1gtnP-1c3xA:
14.98
1gtnQ-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp2 NITROGENASE IRON
PROTEIN

(Clostridium
pasteurianum) 		PF00142
(Fer4_NifH) 		4 GLY A 164
ALA A 169
ILE A 165
SER A 171
 None
 0.81A 1gtnP-1cp2A:
0.0
1gtnQ-1cp2A:
0.0		 1gtnP-1cp2A:
14.48
1gtnQ-1cp2A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.77A 1gtnP-1cpnA:
0.0
1gtnQ-1cpnA:
0.0		 1gtnP-1cpnA:
15.35
1gtnQ-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		4 GLY C  55
ALA A 350
ILE C  57
SER A 348
 None
None
HEM  C 901 ( 4.2A)
None
 0.82A 1gtnP-1fcdC:
undetectable
1gtnQ-1fcdC:
undetectable		 1gtnP-1fcdC:
18.93
1gtnQ-1fcdC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 194
THR A 356
ILE A 197
SER A 137
 SF4  A 582 (-3.9A)
None
None
None
 0.67A 1gtnP-1fehA:
undetectable
1gtnQ-1fehA:
0.0		 1gtnP-1fehA:
9.41
1gtnQ-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.66A 1gtnP-1flgA:
0.0
1gtnQ-1flgA:
undetectable		 1gtnP-1flgA:
8.63
1gtnQ-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqs ISOCITRATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00180
(Iso_dh) 		4 GLY A 310
ALA A 286
THR A 305
ILE A 313
 None
 0.71A 1gtnP-1hqsA:
undetectable
1gtnQ-1hqsA:
undetectable		 1gtnP-1hqsA:
11.90
1gtnQ-1hqsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itz TRANSKETOLASE

(Zea mays) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 427
HIS A 424
ALA A 179
ILE A 429
 None
 0.83A 1gtnP-1itzA:
undetectable
1gtnQ-1itzA:
undetectable		 1gtnP-1itzA:
7.56
1gtnQ-1itzA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		4 GLY A  41
ALA A  34
THR A  67
ILE A  42
 None
 0.83A 1gtnP-1ixpA:
undetectable
1gtnQ-1ixpA:
undetectable		 1gtnP-1ixpA:
14.46
1gtnQ-1ixpA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		4 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 ADP  A   1 (-3.0A)
ADP  A   1 (-4.1A)
None
None
 0.81A 1gtnP-1iy1A:
undetectable
1gtnQ-1iy1A:
undetectable		 1gtnP-1iy1A:
13.39
1gtnQ-1iy1A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		4 GLY A 201
HIS A 204
ALA A 161
ILE A 323
 SO4  A 101 (-3.5A)
None
None
None
 0.81A 1gtnP-1iy2A:
undetectable
1gtnQ-1iy2A:
undetectable		 1gtnP-1iy2A:
13.60
1gtnQ-1iy2A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.11A 1gtnP-1l5jA:
undetectable
1gtnQ-1l5jA:
undetectable		 1gtnP-1l5jA:
7.07
1gtnQ-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 GLY A 307
ALA A 313
ILE A 309
SER A 315
 None
 0.78A 1gtnP-1l8wA:
undetectable
1gtnQ-1l8wA:
undetectable		 1gtnP-1l8wA:
11.14
1gtnQ-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PO4  A 655 (-3.6A)
None
None
None
 0.77A 1gtnP-1lw3A:
undetectable
1gtnQ-1lw3A:
undetectable		 1gtnP-1lw3A:
7.46
1gtnQ-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.81A 1gtnP-1macA:
undetectable
1gtnQ-1macA:
0.9		 1gtnP-1macA:
17.79
1gtnQ-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzh DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aquifex
aeolicus) 		PF01791
(DeoC) 		4 GLY A 306
ALA A 290
THR A 303
ILE A 108
 None
 0.82A 1gtnP-1mzhA:
undetectable
1gtnQ-1mzhA:
undetectable		 1gtnP-1mzhA:
19.53
1gtnQ-1mzhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.34A 1gtnP-1n0wA:
undetectable
1gtnQ-1n0wA:
undetectable		 1gtnP-1n0wA:
14.40
1gtnQ-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  33
ALA B  24
THR B  52
ILE B  34
 None
 0.73A 1gtnP-1ob1B:
1.2
1gtnQ-1ob1B:
undetectable		 1gtnP-1ob1B:
12.50
1gtnQ-1ob1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.73A 1gtnP-1oh2Q:
undetectable
1gtnQ-1oh2Q:
undetectable		 1gtnP-1oh2Q:
12.04
1gtnQ-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		4 GLY A 131
ALA A 174
THR A  33
ILE A  22
 None
 0.83A 1gtnP-1p3cA:
undetectable
1gtnQ-1p3cA:
undetectable		 1gtnP-1p3cA:
16.00
1gtnQ-1p3cA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus;
Bean pod mottle
virus) 		PF02248
(Como_SCP)
PF02247
(Como_LCP) 		5 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
 None
 0.99A 1gtnP-1pgw2:
2.0
1gtnQ-1pgw2:
0.8		 1gtnP-1pgw2:
11.68
1gtnQ-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
 None
 1.38A 1gtnP-1ps9A:
undetectable
1gtnQ-1ps9A:
undetectable		 1gtnP-1ps9A:
8.10
1gtnQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1gtnP-1ptjA:
undetectable
1gtnQ-1ptjA:
undetectable		 1gtnP-1ptjA:
13.14
1gtnQ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		4 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.79A 1gtnP-1q0pA:
undetectable
1gtnQ-1q0pA:
undetectable		 1gtnP-1q0pA:
13.90
1gtnQ-1q0pA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.83A 1gtnP-1rtkA:
undetectable
1gtnQ-1rtkA:
undetectable		 1gtnP-1rtkA:
10.28
1gtnQ-1rtkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00378
(ECH_1) 		4 GLY A 156
HIS A 157
ALA A 163
ILE A 155
 None
 0.82A 1gtnP-1sg4A:
undetectable
1gtnQ-1sg4A:
undetectable		 1gtnP-1sg4A:
13.69
1gtnQ-1sg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 422
HIS A 419
ALA A 168
ILE A 424
 None
 0.82A 1gtnP-1tkcA:
undetectable
1gtnQ-1tkcA:
undetectable		 1gtnP-1tkcA:
7.54
1gtnQ-1tkcA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		4 GLY A 186
HIS A 146
ALA A 199
ILE A 187
 HH2  A 282 ( 4.9A)
None
None
None
 0.76A 1gtnP-1twwA:
undetectable
1gtnQ-1twwA:
undetectable		 1gtnP-1twwA:
13.47
1gtnQ-1twwA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		5 GLY A 283
HIS A 297
THR A 308
ILE A 294
THR A 300
 None
EOH  A 403 ( 4.1A)
None
None
None
 1.45A 1gtnP-1u7nA:
undetectable
1gtnQ-1u7nA:
undetectable		 1gtnP-1u7nA:
14.15
1gtnQ-1u7nA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 GLY A 207
ALA A 191
THR A 204
ILE A   7
 None
None
HPD  A 801 (-4.4A)
None
 0.83A 1gtnP-1ub3A:
undetectable
1gtnQ-1ub3A:
undetectable		 1gtnP-1ub3A:
18.43
1gtnQ-1ub3A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukv GTP-BINDING PROTEIN
YPT1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 GLY Y  83
HIS Y  82
ALA Y 110
ILE Y  84
 None
 0.73A 1gtnP-1ukvY:
undetectable
1gtnQ-1ukvY:
undetectable		 1gtnP-1ukvY:
17.14
1gtnQ-1ukvY:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 GLY A 203
THR A 112
THR A 114
ILE A 204
SER A 198
 None
 1.43A 1gtnP-1v1pA:
undetectable
1gtnQ-1v1pA:
undetectable		 1gtnP-1v1pA:
19.02
1gtnQ-1v1pA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.82A 1gtnP-1vb4A:
0.4
1gtnQ-1vb4A:
undetectable		 1gtnP-1vb4A:
14.55
1gtnQ-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 GLY A  90
ALA A 121
THR A 104
ILE A  91
SER A  98
 None
 1.36A 1gtnP-1vpxA:
undetectable
1gtnQ-1vpxA:
undetectable		 1gtnP-1vpxA:
18.53
1gtnQ-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.69A 1gtnP-1wkmA:
undetectable
1gtnQ-1wkmA:
undetectable		 1gtnP-1wkmA:
15.29
1gtnQ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.79A 1gtnP-1x9jA:
undetectable
1gtnQ-1x9jA:
undetectable		 1gtnP-1x9jA:
13.28
1gtnQ-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 GLY A 185
HIS A 186
ALA A 192
ILE A 184
 None
 0.83A 1gtnP-1xx4A:
undetectable
1gtnQ-1xx4A:
undetectable		 1gtnP-1xx4A:
17.62
1gtnQ-1xx4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 1.04A 1gtnP-1yy5A:
undetectable
1gtnQ-1yy5A:
undetectable		 1gtnP-1yy5A:
9.73
1gtnQ-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 GLY A 238
HIS A 237
THR A 172
ILE A 183
THR A 271
 None
None
FLC  A 501 (-4.7A)
None
ZN  A 500 ( 4.4A)
 1.18A 1gtnP-1zb7A:
undetectable
1gtnQ-1zb7A:
undetectable		 1gtnP-1zb7A:
9.28
1gtnQ-1zb7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.71A 1gtnP-1zsqA:
undetectable
1gtnQ-1zsqA:
undetectable		 1gtnP-1zsqA:
12.02
1gtnQ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLY A 152
THR A 143
ILE A 163
THR A 399
 None
 0.72A 1gtnP-2ahwA:
undetectable
1gtnQ-2ahwA:
undetectable		 1gtnP-2ahwA:
9.98
1gtnQ-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1gtnP-2amhA:
undetectable
1gtnQ-2amhA:
undetectable		 1gtnP-2amhA:
19.19
1gtnQ-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.83A 1gtnP-2c2iA:
undetectable
1gtnQ-2c2iA:
undetectable		 1gtnP-2c2iA:
22.14
1gtnQ-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 GLY A 803
HIS A 801
ALA A 745
ILE A 806
 None
 0.77A 1gtnP-2cbzA:
undetectable
1gtnQ-2cbzA:
undetectable		 1gtnP-2cbzA:
16.83
1gtnQ-2cbzA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.95A 1gtnP-2dw4A:
undetectable
1gtnQ-2dw4A:
undetectable		 1gtnP-2dw4A:
8.15
1gtnQ-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.78A 1gtnP-2e28A:
undetectable
1gtnQ-2e28A:
undetectable		 1gtnP-2e28A:
9.86
1gtnQ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 GLY A 210
HIS A 269
ALA A  65
THR A  62
THR A  20
 None
ZN  A 401 (-3.6A)
ZN  A 401 ( 4.9A)
None
None
 1.44A 1gtnP-2fk6A:
undetectable
1gtnQ-2fk6A:
undetectable		 1gtnP-2fk6A:
12.30
1gtnQ-2fk6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.64A 1gtnP-2jifA:
undetectable
1gtnQ-2jifA:
undetectable		 1gtnP-2jifA:
10.55
1gtnQ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldx APO-LACTATE
DEHYDROGENASE

(Mus musculus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A  33
THR A 256
ILE A 251
SER A  37
 None
 0.73A 1gtnP-2ldxA:
undetectable
1gtnQ-2ldxA:
undetectable		 1gtnP-2ldxA:
14.69
1gtnQ-2ldxA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  90
ALA A  96
THR A 297
ILE A  92
SER A  98
 None
 1.36A 1gtnP-2o56A:
undetectable
1gtnQ-2o56A:
undetectable		 1gtnP-2o56A:
11.99
1gtnQ-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		4 GLY A  30
ALA A  56
THR A  91
ILE A  31
 None
 0.82A 1gtnP-2p0oA:
undetectable
1gtnQ-2p0oA:
undetectable		 1gtnP-2p0oA:
12.84
1gtnQ-2p0oA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		4 ALA A  70
THR A  77
THR A  79
ILE A  81
 None
 0.81A 1gtnP-2p97A:
undetectable
1gtnQ-2p97A:
undetectable		 1gtnP-2p97A:
18.13
1gtnQ-2p97A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A 122
ALA A 154
THR A 147
ILE A 121
 None
None
None
FMN  A 322 (-4.2A)
 0.77A 1gtnP-2piaA:
undetectable
1gtnQ-2piaA:
undetectable		 1gtnP-2piaA:
12.10
1gtnQ-2piaA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.35A 1gtnP-2q1yA:
undetectable
1gtnQ-2q1yA:
undetectable		 1gtnP-2q1yA:
12.94
1gtnQ-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLY A 358
THR A 207
ILE A 361
SER A 337
 None
 0.64A 1gtnP-2qveA:
undetectable
1gtnQ-2qveA:
undetectable		 1gtnP-2qveA:
11.96
1gtnQ-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 GLY A 258
HIS A 257
ALA A 281
THR A 259
SER A 278
 None
None
EDO  A 331 ( 3.7A)
None
EDO  A 331 (-3.3A)
 1.38A 1gtnP-2rbcA:
undetectable
1gtnQ-2rbcA:
undetectable		 1gtnP-2rbcA:
11.54
1gtnQ-2rbcA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhd SMALL GTP BINDING
PROTEIN RAB1A

(Cryptosporidium
parvum) 		PF00071
(Ras) 		4 GLY A  84
HIS A  83
ALA A 111
ILE A  85
 None
 0.82A 1gtnP-2rhdA:
undetectable
1gtnQ-2rhdA:
undetectable		 1gtnP-2rhdA:
21.51
1gtnQ-2rhdA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.75A 1gtnP-2vq0A:
0.5
1gtnQ-2vq0A:
undetectable		 1gtnP-2vq0A:
13.28
1gtnQ-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 GLY A 124
ALA A 221
ILE A 218
SER A 225
 None
 0.74A 1gtnP-2yikA:
undetectable
1gtnQ-2yikA:
undetectable		 1gtnP-2yikA:
8.51
1gtnQ-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 GLY A 293
HIS A 290
ALA A 353
ILE A 324
 None
 0.77A 1gtnP-2zu0A:
undetectable
1gtnQ-2zu0A:
undetectable		 1gtnP-2zu0A:
10.40
1gtnQ-2zu0A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 GLY A 128
HIS A 123
ALA A  58
ILE A 129
SER A  62
 None
 1.28A 1gtnP-2zy2A:
undetectable
1gtnQ-2zy2A:
undetectable		 1gtnP-2zy2A:
8.61
1gtnQ-2zy2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.34A 1gtnP-3a1nA:
undetectable
1gtnQ-3a1nA:
undetectable		 1gtnP-3a1nA:
13.02
1gtnQ-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7l GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Escherichia
coli) 		PF01597
(GCV_H) 		4 GLY A  27
ALA A  60
ILE A 101
SER A  67
 None
 0.77A 1gtnP-3a7lA:
undetectable
1gtnQ-3a7lA:
undetectable		 1gtnP-3a7lA:
18.94
1gtnQ-3a7lA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.08A 1gtnP-3b9gA:
undetectable
1gtnQ-3b9gA:
undetectable		 1gtnP-3b9gA:
13.11
1gtnQ-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 HIS A 567
ALA A 468
ILE A 539
THR A 565
 None
 0.77A 1gtnP-3bc9A:
1.7
1gtnQ-3bc9A:
1.5		 1gtnP-3bc9A:
7.95
1gtnQ-3bc9A:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.80A 1gtnP-3cb5A:
undetectable
1gtnQ-3cb5A:
undetectable		 1gtnP-3cb5A:
9.95
1gtnQ-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dms ISOCITRATE
DEHYDROGENASE [NADP]

(Burkholderia
pseudomallei) 		PF00180
(Iso_dh) 		4 GLY A 308
ALA A 284
THR A 303
ILE A 311
 None
 0.75A 1gtnP-3dmsA:
undetectable
1gtnQ-3dmsA:
undetectable		 1gtnP-3dmsA:
11.24
1gtnQ-3dmsA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.28A 1gtnP-3e7dA:
undetectable
1gtnQ-3e7dA:
undetectable		 1gtnP-3e7dA:
17.31
1gtnQ-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 GLY A 270
ALA A 238
THR A 267
ILE A 235
THR A 173
 None
None
None
None
MYR  A 315 ( 4.9A)
 1.35A 1gtnP-3ee4A:
undetectable
1gtnQ-3ee4A:
undetectable		 1gtnP-3ee4A:
12.95
1gtnQ-3ee4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF03740
(PdxJ) 		4 GLY A  41
ALA A  34
THR A  67
ILE A  42
 None
 0.80A 1gtnP-3f4nA:
undetectable
1gtnQ-3f4nA:
undetectable		 1gtnP-3f4nA:
13.58
1gtnQ-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.65A 1gtnP-3faoA:
undetectable
1gtnQ-3faoA:
undetectable		 1gtnP-3faoA:
18.44
1gtnQ-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.83A 1gtnP-3fmqA:
undetectable
1gtnQ-3fmqA:
undetectable		 1gtnP-3fmqA:
13.14
1gtnQ-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.72A 1gtnP-3fpzA:
undetectable
1gtnQ-3fpzA:
undetectable		 1gtnP-3fpzA:
16.03
1gtnQ-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A  56
ILE A  54
THR A 173
SER A 141
 NA  A 358 (-4.0A)
None
None
None
 0.81A 1gtnP-3h84A:
undetectable
1gtnQ-3h84A:
undetectable		 1gtnP-3h84A:
12.99
1gtnQ-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A  66
ALA A   4
ILE A  65
THR A  95
 None
 0.74A 1gtnP-3hn2A:
undetectable
1gtnQ-3hn2A:
undetectable		 1gtnP-3hn2A:
12.99
1gtnQ-3hn2A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 174
ALA A 140
THR A 457
ILE A 173
THR A 442
 None
 1.20A 1gtnP-3hpaA:
undetectable
1gtnQ-3hpaA:
undetectable		 1gtnP-3hpaA:
10.65
1gtnQ-3hpaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1gtnP-3i4iA:
undetectable
1gtnQ-3i4iA:
undetectable		 1gtnP-3i4iA:
16.44
1gtnQ-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1gtnP-3ip1A:
undetectable
1gtnQ-3ip1A:
undetectable		 1gtnP-3ip1A:
11.50
1gtnQ-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLY F 366
THR F 364
ILE F 401
THR F 333
 None
 0.76A 1gtnP-3jbrF:
undetectable
1gtnQ-3jbrF:
undetectable		 1gtnP-3jbrF:
5.20
1gtnQ-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.18A 1gtnP-3jskA:
undetectable
1gtnQ-3jskA:
undetectable		 1gtnP-3jskA:
13.37
1gtnQ-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 GLY A 171
ALA A 200
ILE A 172
THR A 192
 None
 0.82A 1gtnP-3k6jA:
undetectable
1gtnQ-3k6jA:
undetectable		 1gtnP-3k6jA:
12.65
1gtnQ-3k6jA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 GLY A  58
ALA A 109
ILE A 128
SER A 107
 None
 0.82A 1gtnP-3ktoA:
undetectable
1gtnQ-3ktoA:
undetectable		 1gtnP-3ktoA:
18.94
1gtnQ-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 333
THR A 302
ILE A 352
THR A 322
 None
 0.82A 1gtnP-3kumA:
undetectable
1gtnQ-3kumA:
undetectable		 1gtnP-3kumA:
11.40
1gtnQ-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		4 GLY A  23
ALA A 123
THR A 200
ILE A  22
 None
 0.83A 1gtnP-3kwpA:
undetectable
1gtnQ-3kwpA:
undetectable		 1gtnP-3kwpA:
15.00
1gtnQ-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.24A 1gtnP-3l8kA:
undetectable
1gtnQ-3l8kA:
undetectable		 1gtnP-3l8kA:
11.76
1gtnQ-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		4 GLY A 266
ALA A 116
THR A 269
ILE A 265
 None
PHE  A 601 (-4.6A)
None
None
 0.82A 1gtnP-3lkvA:
undetectable
1gtnQ-3lkvA:
undetectable		 1gtnP-3lkvA:
13.76
1gtnQ-3lkvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE

(Idiomarina
loihiensis) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 GLY A 337
HIS A 338
ALA A   9
THR A  13
 None
CL  A 377 (-4.3A)
None
None
 0.76A 1gtnP-3llxA:
undetectable
1gtnQ-3llxA:
undetectable		 1gtnP-3llxA:
12.02
1gtnQ-3llxA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.70A 1gtnP-3myxA:
3.4
1gtnQ-3myxA:
3.5		 1gtnP-3myxA:
16.88
1gtnQ-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.72A 1gtnP-3or2B:
undetectable
1gtnQ-3or2B:
undetectable		 1gtnP-3or2B:
11.35
1gtnQ-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p24 BFT-3

(Bacteroides
fragilis) 		PF13583
(Reprolysin_4)
PF16376
(fragilysinNterm) 		4 GLY A 351
HIS A 348
ILE A 353
SER A 336
 None
ZN  A 999 (-3.2A)
None
None
 0.82A 1gtnP-3p24A:
undetectable
1gtnQ-3p24A:
undetectable		 1gtnP-3p24A:
15.07
1gtnQ-3p24A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.66A 1gtnP-3rotA:
undetectable
1gtnQ-3rotA:
undetectable		 1gtnP-3rotA:
13.47
1gtnQ-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.22A 1gtnP-3rwbA:
undetectable
1gtnQ-3rwbA:
undetectable		 1gtnP-3rwbA:
16.06
1gtnQ-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 GLY A  64
ALA A 118
THR A  75
THR A  74
 None
 0.83A 1gtnP-3slkA:
undetectable
1gtnQ-3slkA:
undetectable		 1gtnP-3slkA:
6.42
1gtnQ-3slkA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.67A 1gtnP-3snhA:
undetectable
1gtnQ-3snhA:
undetectable		 1gtnP-3snhA:
6.70
1gtnQ-3snhA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 GLY A  92
ALA A 145
THR A 131
ILE A  89
 None
 0.79A 1gtnP-3sqlA:
undetectable
1gtnQ-3sqlA:
undetectable		 1gtnP-3sqlA:
9.02
1gtnQ-3sqlA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.65A 1gtnP-3t63M:
0.6
1gtnQ-3t63M:
0.8		 1gtnP-3t63M:
12.18
1gtnQ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 325
ALA A 212
THR A 320
ILE A 326
SER A 215
 None
 1.20A 1gtnP-3u0oA:
undetectable
1gtnQ-3u0oA:
undetectable		 1gtnP-3u0oA:
13.79
1gtnQ-3u0oA:
13.79