SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_L_TRPL81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 256
GLY A 235
ALA A 171
THR A 231
ILE A 255
 None
 1.10A 1gtnL-1bxzA:
undetectable
1gtnM-1bxzA:
undetectable		 1gtnL-1bxzA:
15.35
1gtnM-1bxzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		5 GLY A 431
ALA A 378
THR A 370
THR A 394
SER A 374
 None
 1.33A 1gtnL-1fc9A:
0.0
1gtnM-1fc9A:
0.2		 1gtnL-1fc9A:
12.11
1gtnM-1fc9A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 VAL A 217
GLY A 463
THR A 156
ILE A 467
SER A 158
 None
 1.34A 1gtnL-1ig8A:
undetectable
1gtnM-1ig8A:
undetectable		 1gtnL-1ig8A:
8.75
1gtnM-1ig8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.14A 1gtnL-1l5jA:
undetectable
1gtnM-1l5jA:
undetectable		 1gtnL-1l5jA:
7.07
1gtnM-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 GLY A 116
ALA A 262
THR A 123
ILE A 102
SER A 121
 MG  A 401 (-3.8A)
None
None
None
None
 1.25A 1gtnL-1n0wA:
undetectable
1gtnM-1n0wA:
0.0		 1gtnL-1n0wA:
14.40
1gtnM-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 VAL A 204
GLY A 148
ALA A 160
THR A 171
ILE A 149
 None
 1.21A 1gtnL-1oi7A:
undetectable
1gtnM-1oi7A:
undetectable		 1gtnL-1oi7A:
14.98
1gtnM-1oi7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus;
Bean pod mottle
virus) 		PF02248
(Como_SCP)
PF02247
(Como_LCP) 		5 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
 None
 1.03A 1gtnL-1pgw2:
1.7
1gtnM-1pgw2:
2.0		 1gtnL-1pgw2:
11.68
1gtnM-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.16A 1gtnL-1v9cA:
undetectable
1gtnM-1v9cA:
undetectable		 1gtnL-1v9cA:
19.25
1gtnM-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		5 VAL A1162
GLY A1119
THR A1085
ILE A1160
THR A1012
 None
 1.29A 1gtnL-1wc5A:
undetectable
1gtnM-1wc5A:
undetectable		 1gtnL-1wc5A:
18.18
1gtnM-1wc5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 VAL A 397
GLY A 430
ALA A 468
ILE A 431
SER A 471
 None
 1.08A 1gtnL-1wmrA:
undetectable
1gtnM-1wmrA:
undetectable		 1gtnL-1wmrA:
9.54
1gtnM-1wmrA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 VAL A 178
ALA A 162
THR A 182
ILE A 254
SER A 158
 None
 1.33A 1gtnL-1ys4A:
0.2
1gtnM-1ys4A:
undetectable		 1gtnL-1ys4A:
12.50
1gtnM-1ys4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 GLY A  15
ALA A  23
THR A 252
ILE A  13
SER A 495
 FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
None
 1.06A 1gtnL-1yy5A:
undetectable
1gtnM-1yy5A:
undetectable		 1gtnL-1yy5A:
9.73
1gtnM-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 127
HIS A 134
THR A 136
ILE A 125
SER A  59
 None
 1.11A 1gtnL-2be7A:
undetectable
1gtnM-2be7A:
undetectable		 1gtnL-2be7A:
13.19
1gtnM-2be7A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buf ACETYLGLUTAMATE
KINASE

(Pseudomonas
aeruginosa) 		PF00696
(AA_kinase) 		5 VAL A 159
GLY A 157
ILE A 156
THR A  96
SER A  83
 NLG  A1302 ( 4.5A)
None
None
None
None
 1.23A 1gtnL-2bufA:
undetectable
1gtnM-2bufA:
undetectable		 1gtnL-2bufA:
15.67
1gtnM-2bufA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		5 VAL A 507
GLY A 503
ALA A 489
ILE A 533
SER A 744
 None
 1.16A 1gtnL-2ce9A:
undetectable
1gtnM-2ce9A:
undetectable		 1gtnL-2ce9A:
10.95
1gtnM-2ce9A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
None
 0.96A 1gtnL-2dw4A:
undetectable
1gtnM-2dw4A:
undetectable		 1gtnL-2dw4A:
8.15
1gtnM-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1f ACETOLACTATE
SYNTHASE ISOZYME III
SMALL SUBUNIT

(Escherichia
coli) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		5 GLY A 154
THR A  34
THR A  47
ILE A   4
SER A 150
 None
 1.19A 1gtnL-2f1fA:
undetectable
1gtnM-2f1fA:
undetectable		 1gtnL-2f1fA:
20.48
1gtnM-2f1fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 GLY A  55
HIS A 157
THR A  11
THR A 154
ILE A  57
 None
 1.32A 1gtnL-2ok8A:
undetectable
1gtnM-2ok8A:
undetectable		 1gtnL-2ok8A:
12.05
1gtnM-2ok8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 VAL A 156
GLY A 159
ALA A 245
ILE A 242
SER A 249
 None
 1.32A 1gtnL-2po4A:
undetectable
1gtnM-2po4A:
undetectable		 1gtnL-2po4A:
5.73
1gtnM-2po4A:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 VAL A 556
GLY A 956
ALA A 462
ILE A 960
THR A 552
 None
 0.99A 1gtnL-2po4A:
undetectable
1gtnM-2po4A:
undetectable		 1gtnL-2po4A:
5.73
1gtnM-2po4A:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prx THIOESTERASE
SUPERFAMILY PROTEIN

(Shewanella
loihica) 		PF03061
(4HBT) 		5 GLY A 117
HIS A  68
ALA A  76
THR A  39
ILE A 119
 None
 1.35A 1gtnL-2prxA:
undetectable
1gtnM-2prxA:
undetectable		 1gtnL-2prxA:
18.54
1gtnM-2prxA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.24A 1gtnL-2xzlA:
undetectable
1gtnM-2xzlA:
undetectable		 1gtnL-2xzlA:
7.24
1gtnM-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.36A 1gtnL-3a1nA:
undetectable
1gtnM-3a1nA:
undetectable		 1gtnL-3a1nA:
13.02
1gtnM-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7l GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Escherichia
coli) 		PF01597
(GCV_H) 		5 VAL A  91
GLY A  27
ALA A  60
ILE A 101
SER A  67
 None
 0.99A 1gtnL-3a7lA:
undetectable
1gtnM-3a7lA:
undetectable		 1gtnL-3a7lA:
18.94
1gtnM-3a7lA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 166
ALA A 194
THR A 284
ILE A 187
THR A 295
 None
 1.11A 1gtnL-3b9gA:
undetectable
1gtnM-3b9gA:
undetectable		 1gtnL-3b9gA:
13.11
1gtnM-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Bacillus
subtilis) 		PF06508
(QueC) 		5 VAL A  47
GLY A  12
THR A  17
ILE A  51
THR A 185
 None
None
None
None
PO4  A 500 (-3.1A)
 1.36A 1gtnL-3bl5A:
undetectable
1gtnM-3bl5A:
undetectable		 1gtnL-3bl5A:
22.86
1gtnM-3bl5A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ALA A 187
THR A 426
THR A 414
ILE A 184
SER A 191
 None
 0.94A 1gtnL-3cb5A:
undetectable
1gtnM-3cb5A:
undetectable		 1gtnL-3cb5A:
9.95
1gtnM-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 VAL A1218
GLY A1212
ALA A1252
THR A1199
ILE A1238
 None
 1.25A 1gtnL-3dm0A:
undetectable
1gtnM-3dm0A:
undetectable		 1gtnL-3dm0A:
8.24
1gtnM-3dm0A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 146
GLY A 124
ALA A 133
THR A 182
ILE A 122
 None
 1.26A 1gtnL-3dooA:
undetectable
1gtnM-3dooA:
undetectable		 1gtnL-3dooA:
13.83
1gtnM-3dooA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		5 GLY A 111
ALA A 117
THR A 138
ILE A 110
SER A 115
 None
 1.27A 1gtnL-3e7dA:
undetectable
1gtnM-3e7dA:
undetectable		 1gtnL-3e7dA:
17.31
1gtnM-3e7dA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 256
GLY A 235
ALA A 171
THR A 231
ILE A 255
 None
 1.13A 1gtnL-3fplA:
undetectable
1gtnM-3fplA:
undetectable		 1gtnL-3fplA:
15.35
1gtnM-3fplA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0o 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Salmonella
enterica) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 VAL A  68
GLY A  10
ALA A  21
THR A  32
ILE A  11
 None
 1.23A 1gtnL-3g0oA:
undetectable
1gtnM-3g0oA:
undetectable		 1gtnL-3g0oA:
11.84
1gtnM-3g0oA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		5 VAL A 322
HIS A  27
ALA A 369
ILE A 367
THR A 315
 None
 1.28A 1gtnL-3g7tA:
undetectable
1gtnM-3g7tA:
0.7		 1gtnL-3g7tA:
12.00
1gtnM-3g7tA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 117
GLY A 127
THR A 173
ILE A  85
SER A 171
 None
 1.26A 1gtnL-3gweA:
undetectable
1gtnM-3gweA:
undetectable		 1gtnL-3gweA:
11.88
1gtnM-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 174
ALA A 140
THR A 457
ILE A 173
THR A 442
 None
 1.22A 1gtnL-3hpaA:
undetectable
1gtnM-3hpaA:
undetectable		 1gtnL-3hpaA:
10.65
1gtnM-3hpaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j97 VESICLE-FUSING
ATPASE

(Cricetulus
griseus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 VAL A 391
GLY A 255
ALA A 234
ILE A 256
SER A 237
 None
 1.32A 1gtnL-3j97A:
undetectable
1gtnM-3j97A:
undetectable		 1gtnL-3j97A:
7.26
1gtnM-3j97A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 GLY A  86
ALA A  94
THR A 246
ILE A  84
SER A 322
 AHZ  A 500 (-3.0A)
None
None
None
None
 1.19A 1gtnL-3jskA:
undetectable
1gtnM-3jskA:
undetectable		 1gtnL-3jskA:
13.37
1gtnM-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 330
GLY A 333
THR A 302
ILE A 352
THR A 322
 None
 1.16A 1gtnL-3kumA:
undetectable
1gtnM-3kumA:
undetectable		 1gtnL-3kumA:
11.40
1gtnM-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03483
(B3_4)
PF03484
(B5) 		5 VAL B 318
GLY A 385
HIS A 386
THR B 380
ILE B 377
 None
 1.19A 1gtnL-3l4gB:
undetectable
1gtnM-3l4gB:
undetectable		 1gtnL-3l4gB:
9.95
1gtnM-3l4gB:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.21A 1gtnL-3l6cA:
undetectable
1gtnM-3l6cA:
undetectable		 1gtnL-3l6cA:
14.11
1gtnM-3l6cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.22A 1gtnL-3l6rA:
undetectable
1gtnM-3l6rA:
undetectable		 1gtnL-3l6rA:
12.84
1gtnM-3l6rA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.23A 1gtnL-3rwbA:
undetectable
1gtnM-3rwbA:
undetectable		 1gtnL-3rwbA:
16.06
1gtnM-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF00106
(adh_short) 		5 VAL A  97
GLY A 152
ALA A 158
ILE A 154
SER A 160
 None
 1.33A 1gtnL-3tl3A:
undetectable
1gtnM-3tl3A:
undetectable		 1gtnL-3tl3A:
17.67
1gtnM-3tl3A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A 124
HIS A 130
THR A 132
ILE A 122
SER A  58
 None
 1.17A 1gtnL-3txxA:
undetectable
1gtnM-3txxA:
undetectable		 1gtnL-3txxA:
11.21
1gtnM-3txxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc7 PUTATIVE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 VAL A 111
GLY A 115
ALA A  89
THR A 119
ILE A  62
 None
 1.35A 1gtnL-3vc7A:
undetectable
1gtnM-3vc7A:
undetectable		 1gtnL-3vc7A:
15.26
1gtnM-3vc7A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		5 VAL A 231
GLY A 246
ALA A 182
THR A 248
SER A 174
 None
 1.16A 1gtnL-3wj9A:
undetectable
1gtnM-3wj9A:
undetectable		 1gtnL-3wj9A:
12.10
1gtnM-3wj9A:
12.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		6 VAL A  21
GLY A  23
HIS A  33
THR A  49
THR A  52
ILE A  55
 None
TRP  A  80 (-3.5A)
None
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.31A 1gtnL-3zteA:
14.1
1gtnM-3zteA:
14.8		 1gtnL-3zteA:
78.21
1gtnM-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
 None
TRP  A  81 (-3.5A)
None
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.35A 1gtnL-3zzlA:
13.0
1gtnM-3zzlA:
12.8		 1gtnL-3zzlA:
71.43
1gtnM-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.29A 1gtnL-3zzqA:
13.5
1gtnM-3zzqA:
13.3		 1gtnL-3zzqA:
80.00
1gtnM-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
TRP  A1072 (-3.5A)
None
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.24A 1gtnL-3zzsA:
13.3
1gtnM-3zzsA:
13.1		 1gtnL-3zzsA:
100.00
1gtnM-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 228
HIS A 313
THR A 318
THR A 314
SER A 322
 NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
None
 1.31A 1gtnL-4a0sA:
undetectable
1gtnM-4a0sA:
undetectable		 1gtnL-4a0sA:
10.76
1gtnM-4a0sA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
ILE A  55
 VAL  A  21 ( 0.6A)
GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.29A 1gtnL-4b27A:
13.0
1gtnM-4b27A:
12.9		 1gtnL-4b27A:
76.32
1gtnM-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 ALA A 500
THR A 572
THR A 545
ILE A 547
SER A 504
 None
 1.16A 1gtnL-4bx9A:
undetectable
1gtnM-4bx9A:
undetectable		 1gtnL-4bx9A:
7.91
1gtnM-4bx9A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 VAL A  91
GLY A  67
THR A  26
THR A  29
ILE A  68
 None
 1.08A 1gtnL-4c7gA:
undetectable
1gtnM-4c7gA:
undetectable		 1gtnL-4c7gA:
9.09
1gtnM-4c7gA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 VAL A 559
GLY A 557
ALA A 657
THR A 553
ILE A 551
 None
 1.16A 1gtnL-4ccdA:
undetectable
1gtnM-4ccdA:
undetectable		 1gtnL-4ccdA:
8.25
1gtnM-4ccdA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
HIS A 123
ALA A 138
THR A 117
ILE A 140
 None
 1.15A 1gtnL-4d9iA:
undetectable
1gtnM-4d9iA:
undetectable		 1gtnL-4d9iA:
11.42
1gtnM-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00701
(DHDPS) 		5 VAL A 136
GLY A 138
THR A 152
THR A 140
ILE A 123
 None
 1.21A 1gtnL-4dppA:
undetectable
1gtnM-4dppA:
undetectable		 1gtnL-4dppA:
13.95
1gtnM-4dppA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 SO4  A 607 (-3.4A)
None
None
SO4  A 607 (-4.3A)
None
 1.27A 1gtnL-4e6eA:
undetectable
1gtnM-4e6eA:
undetectable		 1gtnL-4e6eA:
12.06
1gtnM-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghk GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		5 VAL A 203
GLY A 121
THR A 145
ILE A 122
SER A 141
 None
 1.15A 1gtnL-4ghkA:
undetectable
1gtnM-4ghkA:
undetectable		 1gtnL-4ghkA:
10.36
1gtnM-4ghkA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnn DIHYDRODIPICOLINATE
SYNTHASE

(Vitis vinifera) 		PF00701
(DHDPS) 		5 VAL A  98
GLY A 100
THR A 114
THR A 102
ILE A  85
 None
 1.22A 1gtnL-4hnnA:
undetectable
1gtnM-4hnnA:
undetectable		 1gtnL-4hnnA:
13.64
1gtnM-4hnnA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 GLY A 389
ALA A 397
THR A 626
ILE A 387
SER A 811
 FAD  A 901 (-3.3A)
None
None
None
None
 1.02A 1gtnL-4hsuA:
undetectable
1gtnM-4hsuA:
undetectable		 1gtnL-4hsuA:
7.64
1gtnM-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 ALA A 820
THR A 680
ILE A 817
THR A 900
SER A 824
 None
 1.21A 1gtnL-4i15A:
undetectable
1gtnM-4i15A:
undetectable		 1gtnL-4i15A:
12.79
1gtnM-4i15A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		5 GLY B 191
THR B 340
THR B 339
ILE B 194
THR B 169
 None
 1.04A 1gtnL-4i6mB:
undetectable
1gtnM-4i6mB:
undetectable		 1gtnL-4i6mB:
11.93
1gtnM-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre IMMUNOGLOBULIN
GAMMA-2A, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  33
ALA B  79
THR B  53
ILE B  51
SER B  77
 None
 1.09A 1gtnL-4jreB:
undetectable
1gtnM-4jreB:
undetectable		 1gtnL-4jreB:
15.89
1gtnM-4jreB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 HIS A  66
ALA A 103
THR A  44
THR A  40
ILE A  34
 None
 1.22A 1gtnL-4kpoA:
undetectable
1gtnM-4kpoA:
undetectable		 1gtnL-4kpoA:
15.07
1gtnM-4kpoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 GLY A 127
ALA A  58
THR A 106
THR A 130
SER A  56
 FMT  A 501 (-3.4A)
None
None
None
None
 1.32A 1gtnL-4kv7A:
undetectable
1gtnM-4kv7A:
undetectable		 1gtnL-4kv7A:
13.40
1gtnM-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln1 L-LACTATE
DEHYDROGENASE 1

(Bacillus cereus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  16
GLY A 237
ALA A 121
THR A 149
ILE A 236
 None
 1.27A 1gtnL-4ln1A:
undetectable
1gtnM-4ln1A:
undetectable		 1gtnL-4ln1A:
14.59
1gtnM-4ln1A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		5 VAL A 111
GLY A 113
ALA A 132
THR A 116
ILE A 127
 None
 1.25A 1gtnL-4mtnA:
undetectable
1gtnM-4mtnA:
undetectable		 1gtnL-4mtnA:
9.27
1gtnM-4mtnA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		5 VAL A 395
GLY A 357
ALA A 274
THR A 353
ILE A 394
 None
 1.28A 1gtnL-4n49A:
undetectable
1gtnM-4n49A:
undetectable		 1gtnL-4n49A:
11.49
1gtnM-4n49A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 VAL A 230
GLY A 228
ILE A 246
THR A 210
SER A 269
 None
 1.22A 1gtnL-4nsxA:
undetectable
1gtnM-4nsxA:
undetectable		 1gtnL-4nsxA:
6.52
1gtnM-4nsxA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE

(Brucella
abortus) 		PF01370
(Epimerase) 		5 VAL A 265
GLY A 269
ALA A 200
THR A 272
ILE A 268
 None
 1.28A 1gtnL-4twrA:
undetectable
1gtnM-4twrA:
undetectable		 1gtnL-4twrA:
12.20
1gtnM-4twrA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 VAL A 490
ALA A 519
THR A 514
THR A 509
SER A 517
 None
 1.36A 1gtnL-4xb3A:
undetectable
1gtnM-4xb3A:
undetectable		 1gtnL-4xb3A:
8.99
1gtnM-4xb3A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 GLY A 164
ALA A 144
THR A 115
THR A 169
SER A 142
 None
 1.16A 1gtnL-4xgnA:
undetectable
1gtnM-4xgnA:
undetectable		 1gtnL-4xgnA:
13.85
1gtnM-4xgnA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		5 VAL A 261
HIS A 248
THR A 293
THR A 241
ILE A 239
 None
 1.28A 1gtnL-4xukA:
undetectable
1gtnM-4xukA:
undetectable		 1gtnL-4xukA:
15.12
1gtnM-4xukA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		5 VAL A  29
GLY A 245
ALA A 163
THR A 242
ILE A 165
 None
 1.34A 1gtnL-4zbtA:
undetectable
1gtnM-4zbtA:
undetectable		 1gtnL-4zbtA:
16.33
1gtnM-4zbtA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 GLY A 245
ALA A  85
THR A 244
ILE A 240
SER A  87
 None
None
None
None
PLP  A 501 (-3.7A)
 1.32A 1gtnL-5dx5A:
undetectable
1gtnM-5dx5A:
undetectable		 1gtnL-5dx5A:
11.50
1gtnM-5dx5A:
11.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 VAL A  21
GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
 0.26A 1gtnL-5eexA:
15.2
1gtnM-5eexA:
15.0		 1gtnL-5eexA:
100.00
1gtnM-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		5 VAL B 278
GLY B 190
ALA B 198
THR B  89
ILE B 189
 None
 1.27A 1gtnL-5ej1B:
undetectable
1gtnM-5ej1B:
undetectable		 1gtnL-5ej1B:
8.18
1gtnM-5ej1B:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hrm HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 VAL A 149
GLY A 563
THR A 522
ILE A 131
SER A 525
 None
 1.33A 1gtnL-5hrmA:
undetectable
1gtnM-5hrmA:
undetectable		 1gtnL-5hrmA:
9.68
1gtnM-5hrmA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3e PUTATIVE
DEOXYRIBONUCLEASE-2

(Burkholderia
thailandensis) 		PF03265
(DNase_II) 		5 VAL A 291
GLY A 283
THR A 324
ILE A 284
THR A 140
 None
 1.28A 1gtnL-5i3eA:
undetectable
1gtnM-5i3eA:
undetectable		 1gtnL-5i3eA:
13.07
1gtnM-5i3eA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		5 VAL A  34
GLY A  59
ALA A  76
ILE A  58
THR A  62
 None
 0.89A 1gtnL-5ig2A:
undetectable
1gtnM-5ig2A:
undetectable		 1gtnL-5ig2A:
15.59
1gtnM-5ig2A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE EPSILON
CHAIN

(Caldalkalibacillus
thermarum) 		PF02823
(ATP-synt_DE_N) 		5 VAL H  63
GLY H  66
ALA H  25
THR H  43
ILE H  77
 None
 1.17A 1gtnL-5ik2H:
undetectable
1gtnM-5ik2H:
undetectable		 1gtnL-5ik2H:
22.46
1gtnM-5ik2H:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ioj HALOALKYLPHOSPHORUS
HYDROLASE

(Sphingobium sp.
TCM1) 		no annotation 5 VAL A 149
GLY A 563
THR A 522
ILE A 131
SER A 525
 None
 1.33A 1gtnL-5iojA:
undetectable
1gtnM-5iojA:
undetectable		 1gtnL-5iojA:
8.40
1gtnM-5iojA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 VAL A 383
GLY A 381
ILE A 382
THR A 377
SER A 315
 None
 1.26A 1gtnL-5j84A:
undetectable
1gtnM-5j84A:
undetectable		 1gtnL-5j84A:
8.03
1gtnM-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		5 VAL A 323
ALA A  78
THR A 304
ILE A 327
THR A  31
 None
 1.34A 1gtnL-5knnA:
undetectable
1gtnM-5knnA:
undetectable		 1gtnL-5knnA:
10.49
1gtnM-5knnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 GLY A 285
ALA A 293
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
None
 0.99A 1gtnL-5l3dA:
undetectable
1gtnM-5l3dA:
undetectable		 1gtnL-5l3dA:
6.27
1gtnM-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 VAL A 371
GLY A 286
ALA A 485
THR A 482
ILE A 463
 None
 1.35A 1gtnL-5lhkA:
undetectable
1gtnM-5lhkA:
undetectable		 1gtnL-5lhkA:
9.98
1gtnM-5lhkA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 5 VAL A 157
GLY A 165
ALA A 310
ILE A  76
THR A 209
 None
 1.24A 1gtnL-5ngjA:
undetectable
1gtnM-5ngjA:
undetectable		 1gtnL-5ngjA:
undetectable
1gtnM-5ngjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLY A2074
HIS A2081
THR A2083
ILE A2072
SER A2008
 None
 1.16A 1gtnL-5nnnA:
undetectable
1gtnM-5nnnA:
undetectable		 1gtnL-5nnnA:
15.08
1gtnM-5nnnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 GLY A 172
ALA A 180
THR A 190
ILE A 175
SER A 186
 None
 1.16A 1gtnL-5o1mA:
undetectable
1gtnM-5o1mA:
undetectable		 1gtnL-5o1mA:
12.64
1gtnM-5o1mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbx COLD-INDUCIBLE
RNA-BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 VAL A  80
GLY A  12
THR A  18
ILE A  78
SER A  22
 None
 1.32A 1gtnL-5tbxA:
undetectable
1gtnM-5tbxA:
undetectable		 1gtnL-5tbxA:
20.00
1gtnM-5tbxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 GLY A 310
ALA A 149
THR A 309
ILE A 147
THR A 199
 EDO  A 504 ( 3.9A)
None
None
None
EDO  A 504 ( 4.2A)
 1.30A 1gtnL-5u2pA:
undetectable
1gtnM-5u2pA:
undetectable		 1gtnL-5u2pA:
11.24
1gtnM-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 VAL A 364
THR A 314
THR A 264
ILE A 333
SER A 345
 None
 0.91A 1gtnL-5vhaA:
undetectable
1gtnM-5vhaA:
undetectable		 1gtnL-5vhaA:
undetectable
1gtnM-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 VAL C 258
GLY C 489
ALA C 486
THR C 490
ILE C 488
 None
MCN  C 802 (-3.3A)
None
MCN  C 802 (-3.6A)
MCN  C 802 (-4.3A)
 1.24A 1gtnL-5y6qC:
undetectable
1gtnM-5y6qC:
undetectable		 1gtnL-5y6qC:
undetectable
1gtnM-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 GLY A 147
ALA A 622
THR A 627
ILE A 148
SER A 618
 SO4  A 706 ( 4.4A)
None
None
None
None
 1.33A 1gtnL-5y6rA:
undetectable
1gtnM-5y6rA:
undetectable		 1gtnL-5y6rA:
undetectable
1gtnM-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 GLY A 126
ALA A 133
THR A 122
THR A 124
ILE A 159
 PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-3.6A)
None
 1.08A 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable		 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 VAL A  86
GLY A  82
HIS A 128
ALA A 136
THR A 122
 None
LLP  A  78 ( 4.2A)
None
None
None
 1.26A 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable		 1gtnL-5ygrA:
undetectable
1gtnM-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 GLY A  34
ALA A  60
THR A  35
ILE A  71
SER A  58
 None
 1.23A 1gtnL-5z73A:
undetectable
1gtnM-5z73A:
undetectable		 1gtnL-5z73A:
undetectable
1gtnM-5z73A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 VAL A  31
GLY A  34
ALA A  76
THR A  38
ILE A  73
 None
 1.20A 1gtnL-6bjaA:
undetectable
1gtnM-6bjaA:
undetectable		 1gtnL-6bjaA:
undetectable
1gtnM-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 5 VAL A 184
GLY A 163
THR A 124
ILE A 161
SER A 174
 None
 1.34A 1gtnL-6brmA:
undetectable
1gtnM-6brmA:
undetectable		 1gtnL-6brmA:
undetectable
1gtnM-6brmA:
undetectable