SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_K_TRPK81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		4 GLY A 231
HIS A 254
THR A 265
ILE A 250
 None
FMN  A 360 ( 3.9A)
None
None
 0.95A 1gtnJ-1al8A:
undetectable
1gtnK-1al8A:
undetectable		 1gtnJ-1al8A:
13.54
1gtnK-1al8A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.85A 1gtnJ-1dl2A:
undetectable
1gtnK-1dl2A:
undetectable		 1gtnJ-1dl2A:
11.11
1gtnK-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 SER A 137
GLY A 194
THR A 356
ILE A 197
 None
SF4  A 582 (-3.9A)
None
None
 0.77A 1gtnJ-1fehA:
undetectable
1gtnK-1fehA:
undetectable		 1gtnJ-1fehA:
9.41
1gtnK-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.65A 1gtnJ-1flgA:
undetectable
1gtnK-1flgA:
undetectable		 1gtnJ-1flgA:
8.63
1gtnK-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 245
GLY A 412
THR A 417
ILE A 479
 TRA  A 866 (-2.6A)
None
TRA  A 866 (-4.0A)
None
 0.79A 1gtnJ-1l5jA:
undetectable
1gtnK-1l5jA:
undetectable		 1gtnJ-1l5jA:
7.07
1gtnK-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnJ-1larA:
0.1
1gtnK-1larA:
0.0		 1gtnJ-1larA:
9.07
1gtnK-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PO4  A 655 (-3.6A)
None
None
 0.80A 1gtnJ-1lw3A:
undetectable
1gtnK-1lw3A:
undetectable		 1gtnJ-1lw3A:
7.46
1gtnK-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 389
SER A 384
GLY A  11
THR A 156
 None
 0.90A 1gtnJ-1mb9A:
0.0
1gtnK-1mb9A:
0.0		 1gtnJ-1mb9A:
9.16
1gtnK-1mb9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 SER A 281
GLY A 285
HIS A 291
ILE A 310
 None
 0.93A 1gtnJ-1pv9A:
0.3
1gtnK-1pv9A:
0.4		 1gtnJ-1pv9A:
13.24
1gtnK-1pv9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		4 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.81A 1gtnJ-1q0pA:
undetectable
1gtnK-1q0pA:
undetectable		 1gtnJ-1q0pA:
13.90
1gtnK-1q0pA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 GLY A 365
HIS A 367
THR A 363
ILE A 414
 None
 0.85A 1gtnJ-1rtkA:
undetectable
1gtnK-1rtkA:
undetectable		 1gtnJ-1rtkA:
10.28
1gtnK-1rtkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.81A 1gtnJ-1vb4A:
undetectable
1gtnK-1vb4A:
undetectable		 1gtnJ-1vb4A:
14.55
1gtnK-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w89 THIOREDOXIN

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 GLY A  50
HIS A  49
THR A   2
THR A   1
 None
 0.91A 1gtnJ-1w89A:
undetectable
1gtnK-1w89A:
undetectable		 1gtnJ-1w89A:
20.69
1gtnK-1w89A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydf HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A 216
THR A 244
THR A 223
ILE A 217
 None
 0.97A 1gtnJ-1ydfA:
undetectable
1gtnK-1ydfA:
undetectable		 1gtnJ-1ydfA:
14.17
1gtnK-1ydfA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 SER A 495
GLY A  15
THR A 252
ILE A  13
 None
FAD  A 803 (-3.2A)
FAD  A 803 (-4.6A)
None
 0.88A 1gtnJ-1yy5A:
undetectable
1gtnK-1yy5A:
undetectable		 1gtnJ-1yy5A:
9.73
1gtnK-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.74A 1gtnJ-1zsqA:
undetectable
1gtnK-1zsqA:
undetectable		 1gtnJ-1zsqA:
12.02
1gtnK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 THR A 399
GLY A 152
THR A 143
ILE A 163
 None
 0.74A 1gtnJ-2ahwA:
undetectable
1gtnK-2ahwA:
undetectable		 1gtnJ-2ahwA:
9.98
1gtnK-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 231
THR A 201
THR A 197
ILE A 230
 None
 0.97A 1gtnJ-2akjA:
undetectable
1gtnK-2akjA:
undetectable		 1gtnJ-2akjA:
9.69
1gtnK-2akjA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.77A 1gtnJ-2amhA:
undetectable
1gtnK-2amhA:
undetectable		 1gtnJ-2amhA:
19.19
1gtnK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1b 216AA LONG
HYPOTHETICAL
ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 SER A 123
GLY A 101
HIS A 103
ILE A  98
 ZN  A 300 ( 4.9A)
None
ZN  A 300 (-4.4A)
None
 0.86A 1gtnJ-2e1bA:
undetectable
1gtnK-2e1bA:
undetectable		 1gtnJ-2e1bA:
18.18
1gtnK-2e1bA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ess ACYL-ACP
THIOESTERASE

(Bacteroides
thetaiotaomicron) 		PF01643
(Acyl-ACP_TE) 		4 THR A  82
SER A 111
GLY A  39
HIS A  41
 None
None
MPD  A 252 (-3.6A)
None
 0.93A 1gtnJ-2essA:
undetectable
1gtnK-2essA:
undetectable		 1gtnJ-2essA:
17.60
1gtnK-2essA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2l PEPTIDOGLYCAN
RECOGNITION
PROTEIN-LC ISOFORM
LCX

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 THR X 422
SER X 429
GLY X 472
HIS X 473
 None
None
None
MLD  X 201 (-3.9A)
 0.98A 1gtnJ-2f2lX:
undetectable
1gtnK-2f2lX:
undetectable		 1gtnJ-2f2lX:
20.75
1gtnK-2f2lX:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz1 COAT PROTEIN

(Turnip yellow
mosaic virus) 		PF00983
(Tymo_coat) 		4 SER A 100
GLY A 113
THR A 110
ILE A 107
 None
 0.90A 1gtnJ-2fz1A:
undetectable
1gtnK-2fz1A:
undetectable		 1gtnJ-2fz1A:
15.62
1gtnK-2fz1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 THR A  40
SER A  60
GLY A 145
THR A 175
 None
None
LDA  A 803 (-4.2A)
None
 0.96A 1gtnJ-2gskA:
undetectable
1gtnK-2gskA:
undetectable		 1gtnJ-2gskA:
7.94
1gtnK-2gskA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiq HYPOTHETICAL PROTEIN
YDHR

(Escherichia
coli) 		PF08803
(ydhR) 		4 GLY A  59
HIS A  15
THR A  49
ILE A  60
 None
 0.97A 1gtnJ-2hiqA:
undetectable
1gtnK-2hiqA:
undetectable		 1gtnJ-2hiqA:
20.56
1gtnK-2hiqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.61A 1gtnJ-2jifA:
undetectable
1gtnK-2jifA:
undetectable		 1gtnJ-2jifA:
10.55
1gtnK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 HIS A 181
THR A 208
THR A 210
ILE A 172
 MGD  A 812 ( 4.6A)
MGD  A 812 ( 4.5A)
None
None
 0.96A 1gtnJ-2jirA:
undetectable
1gtnK-2jirA:
undetectable		 1gtnJ-2jirA:
7.68
1gtnK-2jirA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.90A 1gtnJ-2p4hX:
undetectable
1gtnK-2p4hX:
undetectable		 1gtnJ-2p4hX:
15.70
1gtnK-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 GLY A  69
THR A 299
THR A 304
ILE A  65
 None
 0.99A 1gtnJ-2qfvA:
undetectable
1gtnK-2qfvA:
undetectable		 1gtnJ-2qfvA:
11.53
1gtnK-2qfvA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.62A 1gtnJ-2qveA:
undetectable
1gtnK-2qveA:
undetectable		 1gtnJ-2qveA:
11.96
1gtnK-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.73A 1gtnJ-2vq0A:
undetectable
1gtnK-2vq0A:
undetectable		 1gtnJ-2vq0A:
13.28
1gtnK-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlp COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.90A 1gtnJ-2wlpA:
undetectable
1gtnK-2wlpA:
undetectable		 1gtnJ-2wlpA:
15.12
1gtnK-2wlpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 127
GLY A 213
THR A 151
ILE A 214
 None
 0.96A 1gtnJ-2xf8A:
undetectable
1gtnK-2xf8A:
undetectable		 1gtnJ-2xf8A:
14.86
1gtnK-2xf8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 THR A 192
GLY A 143
THR A 218
ILE A 145
 FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
None
None
 0.88A 1gtnJ-2z6iA:
undetectable
1gtnK-2z6iA:
undetectable		 1gtnJ-2z6iA:
15.21
1gtnK-2z6iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		4 GLY A 194
HIS A 195
THR A 200
THR A 211
 None
FE2  A 276 ( 3.5A)
None
None
 0.90A 1gtnJ-2zoaA:
undetectable
1gtnK-2zoaA:
undetectable		 1gtnJ-2zoaA:
13.50
1gtnK-2zoaA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9c TRANSLATION
INITIATION FACTOR
EIF-2B, DELTA
SUBUNIT

(Thermococcus
kodakarensis) 		PF01008
(IF-2B) 		4 GLY A 295
THR A 236
THR A 292
ILE A 297
 None
 0.96A 1gtnJ-3a9cA:
undetectable
1gtnK-3a9cA:
undetectable		 1gtnJ-3a9cA:
13.90
1gtnK-3a9cA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY A 231
THR A 201
THR A 197
ILE A 230
 None
 0.95A 1gtnJ-3b0hA:
undetectable
1gtnK-3b0hA:
undetectable		 1gtnJ-3b0hA:
9.53
1gtnK-3b0hA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 THR A 116
GLY A 164
HIS A 160
ILE A 167
 None
 0.88A 1gtnJ-3c24A:
undetectable
1gtnK-3c24A:
undetectable		 1gtnJ-3c24A:
12.98
1gtnK-3c24A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 GLY A  81
HIS A  50
THR A 122
ILE A  82
 None
 0.98A 1gtnJ-3cj1A:
undetectable
1gtnK-3cj1A:
undetectable		 1gtnJ-3cj1A:
10.64
1gtnK-3cj1A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g9v INTERLEUKIN 22
RECEPTOR, ALPHA 2

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 THR A  89
HIS A  42
THR A 126
ILE A 128
 None
 0.99A 1gtnJ-3g9vA:
undetectable
1gtnK-3g9vA:
undetectable		 1gtnJ-3g9vA:
16.91
1gtnK-3g9vA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 171
GLY A 127
THR A 173
ILE A  85
 None
 0.93A 1gtnJ-3gweA:
undetectable
1gtnK-3gweA:
undetectable		 1gtnJ-3gweA:
11.88
1gtnK-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A 173
SER A 141
THR A  56
ILE A  54
 None
None
NA  A 358 (-4.0A)
None
 0.78A 1gtnJ-3h84A:
undetectable
1gtnK-3h84A:
undetectable		 1gtnJ-3h84A:
12.99
1gtnK-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 THR F 333
GLY F 366
THR F 364
ILE F 401
 None
 0.77A 1gtnJ-3jbrF:
undetectable
1gtnK-3jbrF:
undetectable		 1gtnJ-3jbrF:
5.20
1gtnK-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		4 THR A 189
GLY A 164
THR A 112
ILE A 116
 None
 0.96A 1gtnJ-3k2wA:
undetectable
1gtnK-3k2wA:
undetectable		 1gtnJ-3k2wA:
10.75
1gtnK-3k2wA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l12 PUTATIVE
GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Ruegeria
pomeroyi) 		PF03009
(GDPD) 		4 THR A 274
GLY A  21
HIS A  22
THR A 300
 None
None
UNL  A 317 ( 3.8A)
None
 0.91A 1gtnJ-3l12A:
undetectable
1gtnK-3l12A:
undetectable		 1gtnJ-3l12A:
13.55
1gtnK-3l12A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 GLY A1437
THR A1457
THR A1456
ILE A1472
 None
 0.98A 1gtnJ-3m1hA:
undetectable
1gtnK-3m1hA:
1.8		 1gtnJ-3m1hA:
20.00
1gtnK-3m1hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.76A 1gtnJ-3or2B:
undetectable
1gtnK-3or2B:
undetectable		 1gtnJ-3or2B:
11.35
1gtnK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 GLY A 217
THR A 245
THR A 224
ILE A 218
 None
 0.92A 1gtnJ-3pdwA:
undetectable
1gtnK-3pdwA:
undetectable		 1gtnJ-3pdwA:
16.79
1gtnK-3pdwA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.73A 1gtnJ-3rotA:
undetectable
1gtnK-3rotA:
undetectable		 1gtnJ-3rotA:
13.47
1gtnK-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.57A 1gtnJ-3t63M:
undetectable
1gtnK-3t63M:
undetectable		 1gtnJ-3t63M:
12.18
1gtnK-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 SER A 163
GLY A  86
THR A 190
ILE A  82
 None
 0.74A 1gtnJ-3v4cA:
undetectable
1gtnK-3v4cA:
undetectable		 1gtnJ-3v4cA:
10.56
1gtnK-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 THR A 933
GLY A 910
THR A1011
ILE A 909
 None
 0.88A 1gtnJ-3w9iA:
undetectable
1gtnK-3w9iA:
undetectable		 1gtnJ-3w9iA:
5.72
1gtnK-3w9iA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		4 SER A 478
GLY A 338
THR A 342
ILE A 337
 None
 0.95A 1gtnJ-3wfzA:
undetectable
1gtnK-3wfzA:
undetectable		 1gtnJ-3wfzA:
7.65
1gtnK-3wfzA:
7.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.28A 1gtnJ-3zteA:
14.6
1gtnK-3zteA:
15.3		 1gtnJ-3zteA:
78.21
1gtnK-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 GLY A  23
HIS A  34
THR A  49
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 4.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.25A 1gtnJ-3zzlA:
13.3
1gtnK-3zzlA:
13.2		 1gtnJ-3zzlA:
71.43
1gtnK-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.22A 1gtnJ-3zzqA:
13.8
1gtnK-3zzqA:
13.8		 1gtnJ-3zzqA:
80.00
1gtnK-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 4.7A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.20A 1gtnJ-3zzsA:
13.8
1gtnK-3zzsA:
13.7		 1gtnJ-3zzsA:
100.00
1gtnK-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.86A 1gtnJ-4auoA:
undetectable
1gtnK-4auoA:
undetectable		 1gtnJ-4auoA:
14.14
1gtnK-4auoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 THR A 384
SER A 416
GLY A 377
ILE A 376
 None
 0.87A 1gtnJ-4av6A:
undetectable
1gtnK-4av6A:
undetectable		 1gtnJ-4av6A:
8.17
1gtnK-4av6A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 THR A 384
SER A 416
GLY A 500
ILE A 503
 None
 0.89A 1gtnJ-4av6A:
undetectable
1gtnK-4av6A:
undetectable		 1gtnJ-4av6A:
8.17
1gtnK-4av6A:
8.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  34 ( 1.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.20A 1gtnJ-4b27A:
13.4
1gtnK-4b27A:
13.3		 1gtnJ-4b27A:
76.32
1gtnK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 GLY A 585
THR A 253
THR A 250
ILE A 246
 None
 0.98A 1gtnJ-4b9yA:
undetectable
1gtnK-4b9yA:
undetectable		 1gtnJ-4b9yA:
7.22
1gtnK-4b9yA:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.77A 1gtnJ-4c22A:
undetectable
1gtnK-4c22A:
undetectable		 1gtnJ-4c22A:
8.11
1gtnK-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyz HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 GLY A  68
HIS A  65
THR A  73
ILE A  71
 None
 0.68A 1gtnJ-4cyzA:
1.8
1gtnK-4cyzA:
1.4		 1gtnJ-4cyzA:
12.13
1gtnK-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyz HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 THR A 164
SER A 129
GLY A 249
HIS A 247
 None
 0.94A 1gtnJ-4cyzA:
1.8
1gtnK-4cyzA:
1.4		 1gtnJ-4cyzA:
12.13
1gtnK-4cyzA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Bacillus
anthracis) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		4 THR A 251
GLY A 290
HIS A 292
THR A 280
 THR  A 251 ( 0.8A)
GLY  A 290 ( 0.0A)
HIS  A 292 ( 1.0A)
THR  A 280 ( 0.8A)
 0.95A 1gtnJ-4dlkA:
undetectable
1gtnK-4dlkA:
undetectable		 1gtnJ-4dlkA:
13.35
1gtnK-4dlkA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		4 GLY A  86
HIS A  83
THR A  94
ILE A  90
 None
 0.74A 1gtnJ-4ehtA:
undetectable
1gtnK-4ehtA:
undetectable		 1gtnJ-4ehtA:
16.30
1gtnK-4ehtA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyg TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 GLY A 312
HIS A 314
THR A 143
ILE A 124
 None
EDO  A 402 (-3.8A)
None
None
 0.76A 1gtnJ-4eygA:
undetectable
1gtnK-4eygA:
undetectable		 1gtnJ-4eygA:
12.23
1gtnK-4eygA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 GLY A  71
THR A 300
THR A 305
ILE A  67
 None
 0.91A 1gtnJ-4hcxA:
undetectable
1gtnK-4hcxA:
undetectable		 1gtnJ-4hcxA:
11.49
1gtnK-4hcxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 SER A 811
GLY A 389
THR A 626
ILE A 387
 None
FAD  A 901 (-3.3A)
None
None
 0.82A 1gtnJ-4hsuA:
undetectable
1gtnK-4hsuA:
undetectable		 1gtnJ-4hsuA:
7.64
1gtnK-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		4 SER A 428
GLY A 200
HIS A 201
ILE A 198
 None
None
GOL  A 502 (-3.9A)
None
 0.97A 1gtnJ-4hu8A:
undetectable
1gtnK-4hu8A:
undetectable		 1gtnJ-4hu8A:
10.91
1gtnK-4hu8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 339
ILE B 194
 None
 0.82A 1gtnJ-4i6mB:
undetectable
1gtnK-4i6mB:
undetectable		 1gtnJ-4i6mB:
11.93
1gtnK-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 340
THR B 339
 None
 0.92A 1gtnJ-4i6mB:
undetectable
1gtnK-4i6mB:
undetectable		 1gtnJ-4i6mB:
11.93
1gtnK-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 GLY A 129
HIS A 132
THR A 160
ILE A 125
 NAI  A 502 (-3.6A)
None
None
NAI  A 502 (-3.7A)
 0.96A 1gtnJ-4im7A:
undetectable
1gtnK-4im7A:
undetectable		 1gtnJ-4im7A:
9.09
1gtnK-4im7A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 GLY A  84
HIS A  83
THR A 186
THR A 188
 None
 0.96A 1gtnJ-4kmaA:
undetectable
1gtnK-4kmaA:
undetectable		 1gtnJ-4kmaA:
8.63
1gtnK-4kmaA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ook METHIONINE
AMINOPEPTIDASE 2

(Mycobacterium
tuberculosis) 		PF00557
(Peptidase_M24) 		4 GLY A 141
HIS A 140
THR A 236
THR A 271
 NA  A 305 (-3.2A)
None
CO  A 302 (-3.4A)
NA  A 305 ( 3.9A)
 0.99A 1gtnJ-4ookA:
undetectable
1gtnK-4ookA:
undetectable		 1gtnJ-4ookA:
13.69
1gtnK-4ookA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 4 GLY A 157
HIS A 159
THR A  27
THR A  29
 None
 0.98A 1gtnJ-4rkzA:
undetectable
1gtnK-4rkzA:
undetectable		 1gtnJ-4rkzA:
13.62
1gtnK-4rkzA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.88A 1gtnJ-4ud8A:
undetectable
1gtnK-4ud8A:
undetectable		 1gtnJ-4ud8A:
10.22
1gtnK-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Staphylococcus
aureus;
Sesbania mosaic
virus) 		no annotation 4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.86A 1gtnJ-4y5zA:
undetectable
1gtnK-4y5zA:
undetectable		 1gtnJ-4y5zA:
11.62
1gtnK-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azw TRANSMEMBRANE EMP24
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF01105
(EMP24_GP25L) 		4 GLY A 113
THR A  38
THR A  41
ILE A 112
 None
 0.91A 1gtnJ-5azwA:
undetectable
1gtnK-5azwA:
2.3		 1gtnJ-5azwA:
22.35
1gtnK-5azwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.68A 1gtnJ-5c16A:
undetectable
1gtnK-5c16A:
undetectable		 1gtnJ-5c16A:
8.93
1gtnK-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 SER A 323
GLY A 280
THR A 342
THR A  50
 None
 0.87A 1gtnJ-5c69A:
undetectable
1gtnK-5c69A:
undetectable		 1gtnJ-5c69A:
11.00
1gtnK-5c69A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 GLY A 192
THR A 324
THR A 331
ILE A 333
 None
 0.84A 1gtnJ-5cdjA:
undetectable
1gtnK-5cdjA:
undetectable		 1gtnJ-5cdjA:
16.20
1gtnK-5cdjA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgt BENZOYLFORMATE
DECARBOXYLASE

(Pseudomonas
putida) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 THR A 379
GLY A 427
THR A 523
ILE A 452
 TZD  A 605 ( 4.7A)
TZD  A 605 (-3.2A)
None
None
 0.99A 1gtnJ-5dgtA:
undetectable
1gtnK-5dgtA:
undetectable		 1gtnJ-5dgtA:
11.31
1gtnK-5dgtA:
11.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  34
THR A  49
THR A  52
ILE A  55
 None
 0.20A 1gtnJ-5eexA:
15.4
1gtnK-5eexA:
15.3		 1gtnJ-5eexA:
100.00
1gtnK-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		4 THR A 194
GLY A 145
THR A 220
ILE A 147
 FMN  A 402 (-3.5A)
FMN  A 402 ( 4.3A)
None
None
 0.90A 1gtnJ-5gvhA:
undetectable
1gtnK-5gvhA:
undetectable		 1gtnJ-5gvhA:
12.70
1gtnK-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B

(Homo sapiens) 		PF00386
(C1q) 		4 GLY A 254
HIS A 154
THR A 200
ILE A 255
 None
 1.00A 1gtnJ-5hkjA:
1.3
1gtnK-5hkjA:
0.6		 1gtnJ-5hkjA:
11.08
1gtnK-5hkjA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 THR A 377
SER A 315
GLY A 381
ILE A 382
 None
 1.00A 1gtnJ-5j84A:
undetectable
1gtnK-5j84A:
undetectable		 1gtnJ-5j84A:
8.03
1gtnK-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7

(Saccharomyces
cerevisiae) 		PF00160
(Pro_isomerase)
PF00515
(TPR_1) 		4 SER A 142
GLY A  61
HIS A  63
ILE A 191
 None
 0.85A 1gtnJ-5jheA:
undetectable
1gtnK-5jheA:
undetectable		 1gtnJ-5jheA:
11.20
1gtnK-5jheA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLY B 390
THR B 445
THR B 406
ILE B 358
 None
 0.83A 1gtnJ-5ldrB:
undetectable
1gtnK-5ldrB:
undetectable		 1gtnJ-5ldrB:
8.96
1gtnK-5ldrB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		4 SER A 179
THR A 156
THR A 145
ILE A 170
 None
 0.88A 1gtnJ-5lgcA:
undetectable
1gtnK-5lgcA:
undetectable		 1gtnJ-5lgcA:
17.89
1gtnK-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.89A 1gtnJ-5o0sA:
undetectable
1gtnK-5o0sA:
undetectable		 1gtnJ-5o0sA:
6.51
1gtnK-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 SER A 493
GLY A 467
THR A 478
ILE A 470
 None
 1.00A 1gtnJ-5oglA:
undetectable
1gtnK-5oglA:
undetectable		 1gtnJ-5oglA:
8.23
1gtnK-5oglA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.69A 1gtnJ-5olpA:
undetectable
1gtnK-5olpA:
undetectable		 1gtnJ-5olpA:
10.47
1gtnK-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY D  96
THR D 119
THR D 121
ILE D 123
 None
 0.86A 1gtnJ-5tpzD:
undetectable
1gtnK-5tpzD:
undetectable		 1gtnJ-5tpzD:
11.46
1gtnK-5tpzD:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 THR A  20
GLY A 225
THR A 278
ILE A 269
 None
 0.85A 1gtnJ-5u6fA:
1.9
1gtnK-5u6fA:
undetectable		 1gtnJ-5u6fA:
undetectable
1gtnK-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usc PREPHENATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF02153
(PDH) 		4 GLY A 131
THR A 187
THR A 158
ILE A 156
 None
 1.00A 1gtnJ-5uscA:
undetectable
1gtnK-5uscA:
undetectable		 1gtnJ-5uscA:
12.40
1gtnK-5uscA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 4 GLY A 297
THR A 238
THR A 294
ILE A 299
 None
 0.87A 1gtnJ-5yg7A:
undetectable
1gtnK-5yg7A:
undetectable		 1gtnJ-5yg7A:
undetectable
1gtnK-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 4 SER A 411
GLY A 327
HIS A 345
THR A 396
 None
EE1  A 501 ( 3.7A)
EE1  A 501 (-3.6A)
None
 0.95A 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable		 1gtnJ-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 THR A 188
GLY A   9
THR A 118
THR A  91
 None
 0.99A 1gtnJ-6c4nA:
undetectable
1gtnK-6c4nA:
undetectable		 1gtnJ-6c4nA:
undetectable
1gtnK-6c4nA:
undetectable