SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_J_TRPJ81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 ALA A 498
GLY A 405
ALA A 500
THR A 622
 None
 0.73A 1gtnI-1c30A:
0.7
1gtnJ-1c30A:
0.0		 1gtnI-1c30A:
5.50
1gtnJ-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.68A 1gtnI-1flgA:
undetectable
1gtnJ-1flgA:
undetectable		 1gtnI-1flgA:
8.63
1gtnJ-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hi9 DIPEPTIDE TRANSPORT
PROTEIN DPPA

(Bacillus
subtilis) 		PF04951
(Peptidase_M55) 		4 ALA A 232
GLY A 120
THR A 271
ILE A 118
 None
 0.72A 1gtnI-1hi9A:
0.4
1gtnJ-1hi9A:
0.2		 1gtnI-1hi9A:
15.08
1gtnJ-1hi9A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 ALA A 180
GLY A 173
ALA A 179
THR A 211
 None
 0.69A 1gtnI-1jkmA:
undetectable
1gtnJ-1jkmA:
undetectable		 1gtnI-1jkmA:
12.43
1gtnJ-1jkmA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 ALA A 253
GLY A 439
ALA A 247
THR A 405
ILE A 220
 None
 1.31A 1gtnI-1kqfA:
undetectable
1gtnJ-1kqfA:
undetectable		 1gtnI-1kqfA:
5.42
1gtnJ-1kqfA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 SER A 315
GLY A 307
ALA A 313
ILE A 309
 None
 0.65A 1gtnI-1l8wA:
undetectable
1gtnJ-1l8wA:
undetectable		 1gtnI-1l8wA:
11.14
1gtnJ-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 SER A 121
GLY A 116
ALA A 262
THR A 123
ILE A 102
 None
MG  A 401 (-3.8A)
None
None
None
 1.31A 1gtnI-1n0wA:
undetectable
1gtnJ-1n0wA:
undetectable		 1gtnI-1n0wA:
14.40
1gtnJ-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		5 SER A  95
ALA A  94
GLY A 151
ALA A 177
ILE A 104
 None
 0.96A 1gtnI-1odiA:
undetectable
1gtnJ-1odiA:
undetectable		 1gtnI-1odiA:
14.71
1gtnJ-1odiA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1gtnI-1ptjA:
undetectable
1gtnJ-1ptjA:
0.0		 1gtnI-1ptjA:
13.14
1gtnJ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 THR A 139
ALA A 355
ALA A 352
ILE A 323
 None
 0.70A 1gtnI-1q1lA:
undetectable
1gtnJ-1q1lA:
undetectable		 1gtnI-1q1lA:
11.83
1gtnJ-1q1lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 SER A 554
ALA A 553
GLY A 733
ALA A 552
 None
 0.72A 1gtnI-1qb4A:
undetectable
1gtnJ-1qb4A:
undetectable		 1gtnI-1qb4A:
6.68
1gtnJ-1qb4A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		4 ALA A  34
GLY A  26
ALA A  35
ILE A  48
 None
 0.67A 1gtnI-1r5jA:
undetectable
1gtnJ-1r5jA:
undetectable		 1gtnI-1r5jA:
14.20
1gtnJ-1r5jA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 156
GLY A 177
THR A 237
ILE A 170
 None
 0.74A 1gtnI-1rjwA:
undetectable
1gtnJ-1rjwA:
undetectable		 1gtnI-1rjwA:
12.39
1gtnJ-1rjwA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 THR A 269
ALA A  47
GLY A 232
THR A 166
 None
 0.59A 1gtnI-1t5oA:
undetectable
1gtnJ-1t5oA:
undetectable		 1gtnI-1t5oA:
13.33
1gtnJ-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 326
ALA A 389
GLY A 370
THR A 330
 None
 0.71A 1gtnI-1v0zA:
undetectable
1gtnJ-1v0zA:
undetectable		 1gtnI-1v0zA:
11.56
1gtnJ-1v0zA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhx PUTATIVE HOLLIDAY
JUNCTION RESOLVASE

(Bacillus
subtilis) 		PF03652
(RuvX) 		5 ALA A 126
GLY A   9
ALA A 125
THR A  30
THR A  12
 None
 1.27A 1gtnI-1vhxA:
undetectable
1gtnJ-1vhxA:
undetectable		 1gtnI-1vhxA:
20.41
1gtnJ-1vhxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.69A 1gtnI-1wkmA:
undetectable
1gtnJ-1wkmA:
undetectable		 1gtnI-1wkmA:
15.29
1gtnJ-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ALA A 202
GLY A 223
THR A 218
ILE A 114
 None
 0.70A 1gtnI-1wpwA:
undetectable
1gtnJ-1wpwA:
undetectable		 1gtnI-1wpwA:
12.54
1gtnJ-1wpwA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 321
ALA A 383
GLY A 364
THR A 325
 None
 0.67A 1gtnI-1xogA:
undetectable
1gtnJ-1xogA:
undetectable		 1gtnI-1xogA:
11.26
1gtnJ-1xogA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysx SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		4 SER A 579
ALA A 578
GLY A 572
ALA A 577
 None
 0.74A 1gtnI-1ysxA:
undetectable
1gtnJ-1ysxA:
undetectable		 1gtnI-1ysxA:
15.26
1gtnJ-1ysxA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5a TYPE II DNA
TOPOISOMERASE VI
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF05833
(FbpA)
PF09239
(Topo-VIb_trans) 		4 ALA A 335
GLY A 360
ALA A 357
ILE A 362
 None
 0.70A 1gtnI-1z5aA:
undetectable
1gtnJ-1z5aA:
undetectable		 1gtnI-1z5aA:
11.18
1gtnJ-1z5aA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.73A 1gtnI-1zsqA:
undetectable
1gtnJ-1zsqA:
undetectable		 1gtnI-1zsqA:
12.02
1gtnJ-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN

(Salmonella
enterica) 		PF00480
(ROK) 		4 SER A  84
ALA A  83
GLY A   9
ALA A  82
 None
 0.72A 1gtnI-2ap1A:
undetectable
1gtnJ-2ap1A:
undetectable		 1gtnI-2ap1A:
12.30
1gtnJ-2ap1A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ALA A 126
GLY A 259
ALA A 254
THR A 181
 None
 0.73A 1gtnI-2axcA:
undetectable
1gtnJ-2axcA:
undetectable		 1gtnI-2axcA:
14.02
1gtnJ-2axcA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.75A 1gtnI-2detA:
undetectable
1gtnJ-2detA:
undetectable		 1gtnI-2detA:
11.89
1gtnJ-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 ALA A 220
GLY A 202
ALA A 229
ILE A 204
 None
 0.62A 1gtnI-2dulA:
undetectable
1gtnJ-2dulA:
undetectable		 1gtnI-2dulA:
11.70
1gtnJ-2dulA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.73A 1gtnI-2e28A:
undetectable
1gtnJ-2e28A:
undetectable		 1gtnI-2e28A:
9.86
1gtnJ-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 319
GLY A 182
ALA A 208
THR A 185
 None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
 0.74A 1gtnI-2eerA:
undetectable
1gtnJ-2eerA:
undetectable		 1gtnI-2eerA:
13.02
1gtnJ-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 THR A 443
ALA A 579
GLY A 511
ALA A 174
 None
 0.69A 1gtnI-2eidA:
undetectable
1gtnJ-2eidA:
undetectable		 1gtnI-2eidA:
7.00
1gtnJ-2eidA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 SER B 146
ALA B 145
ALA B 144
ILE B 140
 None
 0.73A 1gtnI-2fpgB:
undetectable
1gtnJ-2fpgB:
undetectable		 1gtnI-2fpgB:
11.39
1gtnJ-2fpgB:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.60A 1gtnI-2jifA:
undetectable
1gtnJ-2jifA:
undetectable		 1gtnI-2jifA:
10.55
1gtnJ-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 SER A  94
ALA A  93
GLY A  87
ALA A  92
THR A  60
 None
None
SAM  A 300 (-3.2A)
None
None
 1.20A 1gtnI-2oxtA:
undetectable
1gtnJ-2oxtA:
undetectable		 1gtnI-2oxtA:
11.76
1gtnJ-2oxtA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcn S-ADENOSYLMETHIONINE
:2-DEMETHYLMENAQUINO
NE METHYLTRANSFERASE

(Geobacillus
kaustophilus) 		PF03737
(RraA-like) 		4 ALA A  82
GLY A  27
ALA A  79
ILE A 102
 None
 0.72A 1gtnI-2pcnA:
undetectable
1gtnJ-2pcnA:
undetectable		 1gtnI-2pcnA:
18.90
1gtnJ-2pcnA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.68A 1gtnI-2qveA:
undetectable
1gtnJ-2qveA:
undetectable		 1gtnI-2qveA:
11.96
1gtnJ-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rp4 TRANSCRIPTION FACTOR
P53

(Drosophila
melanogaster) 		PF11619
(P53_C) 		4 ALA A 356
GLY A 349
ALA A 355
ILE A 351
 None
 0.70A 1gtnI-2rp4A:
undetectable
1gtnJ-2rp4A:
undetectable		 1gtnI-2rp4A:
22.37
1gtnJ-2rp4A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		4 ALA A 173
GLY A 169
ALA A 153
ILE A 138
 None
 0.66A 1gtnI-2v82A:
undetectable
1gtnJ-2v82A:
undetectable		 1gtnI-2v82A:
17.13
1gtnJ-2v82A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.70A 1gtnI-2vq0A:
undetectable
1gtnJ-2vq0A:
undetectable		 1gtnI-2vq0A:
13.28
1gtnJ-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 SER A  96
ALA A  97
GLY A 283
ILE A 160
 None
 0.69A 1gtnI-2xymA:
undetectable
1gtnJ-2xymA:
undetectable		 1gtnI-2xymA:
10.38
1gtnJ-2xymA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		4 SER A 299
ALA A 298
ALA A 297
THR A 294
 None
 0.69A 1gtnI-2y2wA:
undetectable
1gtnJ-2y2wA:
undetectable		 1gtnI-2y2wA:
9.33
1gtnJ-2y2wA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 SER A 203
ALA A 202
GLY A 195
ALA A 201
 None
 0.74A 1gtnI-2z3tA:
undetectable
1gtnJ-2z3tA:
undetectable		 1gtnI-2z3tA:
8.41
1gtnJ-2z3tA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbk TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Sulfolobus
shibatae) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 ALA B 335
GLY B 360
ALA B 357
ILE B 362
 None
 0.74A 1gtnI-2zbkB:
undetectable
1gtnJ-2zbkB:
undetectable		 1gtnI-2zbkB:
11.13
1gtnJ-2zbkB:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze3 DFA0005

(Deinococcus
ficus) 		PF13714
(PEP_mutase) 		4 ALA A 134
GLY A  86
ALA A 135
THR A  97
 None
 0.72A 1gtnI-2ze3A:
undetectable
1gtnJ-2ze3A:
undetectable		 1gtnI-2ze3A:
15.81
1gtnJ-2ze3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF01842
(ACT)
PF13840
(ACT_7) 		4 ALA B 149
GLY B  96
ALA B 148
ILE B 140
 None
 0.70A 1gtnI-3ab4B:
undetectable
1gtnJ-3ab4B:
undetectable		 1gtnI-3ab4B:
17.14
1gtnJ-3ab4B:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		4 ALA A  67
GLY A  86
ALA A 188
ILE A 169
 None
 0.74A 1gtnI-3bywA:
undetectable
1gtnJ-3bywA:
undetectable		 1gtnI-3bywA:
22.45
1gtnJ-3bywA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 ALA A  50
GLY A 172
ALA A  49
THR A  79
 None
None
None
ADP  A 411 (-3.6A)
 0.74A 1gtnI-3c4nA:
undetectable
1gtnJ-3c4nA:
undetectable		 1gtnI-3c4nA:
12.17
1gtnJ-3c4nA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1r FRUCTOSE-1,6-BISPHOS
PHATASE CLASS II
GLPX

(Escherichia
coli) 		PF03320
(FBPase_glpX) 		4 ALA A 102
GLY A 293
ALA A  17
ILE A 294
 None
 0.70A 1gtnI-3d1rA:
undetectable
1gtnJ-3d1rA:
undetectable		 1gtnI-3d1rA:
15.76
1gtnJ-3d1rA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 ALA A  51
ALA A  48
THR A 353
THR A 341
 None
 0.74A 1gtnI-3fmqA:
undetectable
1gtnJ-3fmqA:
undetectable		 1gtnI-3fmqA:
13.14
1gtnJ-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE

(Bacillus
subtilis) 		PF03358
(FMN_red) 		4 SER A  21
ALA A  20
ALA A  19
ILE A 141
 None
 0.64A 1gtnI-3gfqA:
undetectable
1gtnJ-3gfqA:
undetectable		 1gtnI-3gfqA:
17.16
1gtnJ-3gfqA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 SER A  96
ALA A  97
GLY A 283
ILE A 160
 None
 0.69A 1gtnI-3gszA:
undetectable
1gtnJ-3gszA:
undetectable		 1gtnI-3gszA:
9.96
1gtnJ-3gszA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilv GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE

(Cytophaga
hutchinsonii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 THR A 371
ALA A 318
GLY A 395
THR A 365
 None
 0.75A 1gtnI-3ilvA:
undetectable
1gtnJ-3ilvA:
undetectable		 1gtnI-3ilvA:
9.03
1gtnJ-3ilvA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io0 ETUB PROTEIN

(Clostridium
kluyveri) 		PF00936
(BMC) 		4 ALA A 281
GLY A 221
ALA A 238
ILE A 267
 None
 0.63A 1gtnI-3io0A:
undetectable
1gtnJ-3io0A:
undetectable		 1gtnI-3io0A:
15.65
1gtnJ-3io0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ALA A 104
GLY A 414
ALA A 105
ILE A 250
 None
 0.68A 1gtnI-3juxA:
undetectable
1gtnJ-3juxA:
undetectable		 1gtnI-3juxA:
6.31
1gtnJ-3juxA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 THR E 109
ALA E 146
GLY E  36
THR E 120
THR E 128
 None
 1.39A 1gtnI-3kfuE:
undetectable
1gtnJ-3kfuE:
undetectable		 1gtnI-3kfuE:
9.27
1gtnJ-3kfuE:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1c KINESIN-14 NCD

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 SER A 666
ALA A 665
ALA A 664
ILE A 645
 None
 0.72A 1gtnI-3l1cA:
undetectable
1gtnJ-3l1cA:
undetectable		 1gtnI-3l1cA:
10.65
1gtnJ-3l1cA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.69A 1gtnI-3myxA:
4.0
1gtnJ-3myxA:
undetectable		 1gtnI-3myxA:
16.88
1gtnJ-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 SER A  18
ALA A  17
ALA A  16
ILE A  12
 None
 0.71A 1gtnI-3nksA:
undetectable
1gtnJ-3nksA:
undetectable		 1gtnI-3nksA:
9.85
1gtnJ-3nksA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgh RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 SER A  96
ALA A  97
GLY A 283
ILE A 160
 None
 0.74A 1gtnI-3qghA:
undetectable
1gtnJ-3qghA:
undetectable		 1gtnI-3qghA:
9.96
1gtnJ-3qghA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.50A 1gtnI-3t63M:
undetectable
1gtnJ-3t63M:
undetectable		 1gtnI-3t63M:
12.18
1gtnJ-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1h 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus sp.
(in: Bacteria)) 		PF00180
(Iso_dh) 		4 ALA A 224
GLY A 245
THR A 240
ILE A 132
 None
 0.74A 1gtnI-3u1hA:
undetectable
1gtnJ-3u1hA:
undetectable		 1gtnI-3u1hA:
11.63
1gtnJ-3u1hA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubo ADENOSINE KINASE

(Sinorhizobium
meliloti) 		PF00294
(PfkB) 		4 ALA A 281
GLY A  62
ALA A 282
THR A   8
 None
 0.68A 1gtnI-3uboA:
undetectable
1gtnJ-3uboA:
undetectable		 1gtnI-3uboA:
12.15
1gtnJ-3uboA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v3t CELL DIVISION GTPASE
FTSZ, DIVERGED

(Clostridium
botulinum) 		PF00091
(Tubulin) 		4 ALA A  69
GLY A 101
THR A  35
ILE A  10
 None
 0.73A 1gtnI-3v3tA:
undetectable
1gtnJ-3v3tA:
undetectable		 1gtnI-3v3tA:
18.53
1gtnJ-3v3tA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 SER A 163
GLY A  86
THR A 190
ILE A  82
 None
 0.72A 1gtnI-3v4cA:
undetectable
1gtnJ-3v4cA:
undetectable		 1gtnI-3v4cA:
10.56
1gtnJ-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 THR A 100
GLY A 172
ALA A 115
ILE A 174
 None
 0.70A 1gtnI-3vh0A:
undetectable
1gtnJ-3vh0A:
undetectable		 1gtnI-3vh0A:
12.50
1gtnJ-3vh0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 SER A 385
GLY A 391
ALA A 382
THR A 410
 None
 0.72A 1gtnI-3vz0A:
undetectable
1gtnJ-3vz0A:
undetectable		 1gtnI-3vz0A:
10.20
1gtnJ-3vz0A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zg8 PENICILLIN-BINDING
PROTEIN 4

(Listeria
monocytogenes) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 ALA B 630
GLY B 574
ALA B 565
ILE B 557
 None
 0.69A 1gtnI-3zg8B:
undetectable
1gtnJ-3zg8B:
undetectable		 1gtnI-3zg8B:
9.41
1gtnJ-3zg8B:
9.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.31A 1gtnI-3zteA:
15.4
1gtnJ-3zteA:
14.6		 1gtnI-3zteA:
78.21
1gtnJ-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 ALA A  46
GLY A  23
THR A  49
THR A  52
 TRP  A  81 ( 3.7A)
TRP  A  81 (-3.5A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.70A 1gtnI-3zzlA:
13.3
1gtnJ-3zzlA:
13.3		 1gtnI-3zzlA:
71.43
1gtnJ-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 GLY A  23
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.23A 1gtnI-3zzlA:
13.3
1gtnJ-3zzlA:
13.3		 1gtnI-3zzlA:
71.43
1gtnJ-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.26A 1gtnI-3zzqA:
13.8
1gtnJ-3zzqA:
13.8		 1gtnI-3zzqA:
80.00
1gtnJ-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.22A 1gtnI-3zzsA:
13.8
1gtnJ-3zzsA:
13.8		 1gtnI-3zzsA:
100.00
1gtnJ-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 SER A  35
ALA A  34
GLY A  28
ALA A  33
THR A 120
 None
 1.29A 1gtnI-4avcA:
undetectable
1gtnJ-4avcA:
undetectable		 1gtnI-4avcA:
11.71
1gtnJ-4avcA:
11.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.28A 1gtnI-4b27A:
13.3
1gtnJ-4b27A:
13.4		 1gtnI-4b27A:
76.32
1gtnJ-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cta CINA-LIKE PROTEIN

(Thermus
thermophilus) 		PF00994
(MoCF_biosynth)
PF02464
(CinA) 		5 THR A 271
ALA A 388
GLY A 276
THR A 266
ILE A 279
 None
 1.14A 1gtnI-4ctaA:
undetectable
1gtnJ-4ctaA:
undetectable		 1gtnI-4ctaA:
12.96
1gtnJ-4ctaA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0b MALATE DEHYDROGENASE

(Vibrio
vulnificus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 129
GLY A 145
ALA A 128
ILE A 116
 None
 0.63A 1gtnI-4e0bA:
undetectable
1gtnJ-4e0bA:
undetectable		 1gtnI-4e0bA:
15.81
1gtnJ-4e0bA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 SO4  A 607 (-3.4A)
None
None
None
 0.69A 1gtnI-4e6eA:
undetectable
1gtnJ-4e6eA:
undetectable		 1gtnI-4e6eA:
12.06
1gtnJ-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
ALA H  24
THR H  53
ILE H  34
 None
 0.71A 1gtnI-4eowH:
undetectable
1gtnJ-4eowH:
undetectable		 1gtnI-4eowH:
14.91
1gtnJ-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggv CYTOCHROME P450
SUPERFAMILY PROTEIN

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 THR A 244
ALA A 352
GLY A 338
ALA A 349
 HEM  A 401 (-3.4A)
HEM  A 401 ( 3.7A)
None
None
 0.74A 1gtnI-4ggvA:
undetectable
1gtnJ-4ggvA:
undetectable		 1gtnI-4ggvA:
10.28
1gtnJ-4ggvA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		4 ALA A 224
GLY A 245
THR A 240
ILE A 126
 None
 0.72A 1gtnI-4iwhA:
undetectable
1gtnJ-4iwhA:
undetectable		 1gtnI-4iwhA:
12.67
1gtnJ-4iwhA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLY A 771
ALA A 596
THR A 207
ILE A 770
 None
 0.72A 1gtnI-4lglA:
undetectable
1gtnJ-4lglA:
undetectable		 1gtnI-4lglA:
5.61
1gtnJ-4lglA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		4 THR A 148
ALA A 155
GLY A 176
ALA A 156
 None
 0.68A 1gtnI-4lx4A:
undetectable
1gtnJ-4lx4A:
undetectable		 1gtnI-4lx4A:
13.42
1gtnJ-4lx4A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA

(Escherichia
coli) 		PF01081
(Aldolase)
PF01346
(FKBP_N) 		4 ALA A 173
GLY A 169
ALA A 153
ILE A 138
 None
 0.66A 1gtnI-4qccA:
undetectable
1gtnJ-4qccA:
undetectable		 1gtnI-4qccA:
14.84
1gtnJ-4qccA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgs ALCOHOL
DEHYDROGENASE YQHD

(Escherichia
coli) 		PF00465
(Fe-ADH) 		4 ALA A 130
GLY A 124
ALA A 106
ILE A 119
 None
 0.56A 1gtnI-4qgsA:
undetectable
1gtnJ-4qgsA:
undetectable		 1gtnI-4qgsA:
11.89
1gtnJ-4qgsA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		4 ALA A 227
GLY A 217
ALA A 228
THR A 198
 None
FMN  A 401 (-3.3A)
None
None
 0.69A 1gtnI-4qiuA:
undetectable
1gtnJ-4qiuA:
undetectable		 1gtnI-4qiuA:
14.39
1gtnJ-4qiuA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		4 ALA A 267
GLY A 428
ALA A 266
ILE A 429
 None
 0.72A 1gtnI-4r8fA:
undetectable
1gtnJ-4r8fA:
undetectable		 1gtnI-4r8fA:
10.21
1gtnJ-4r8fA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 152
GLY A 173
THR A 236
ILE A 166
 None
 0.68A 1gtnI-4uekA:
undetectable
1gtnJ-4uekA:
undetectable		 1gtnI-4uekA:
15.16
1gtnJ-4uekA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 345
GLY A  68
ALA A 129
ILE A  90
 None
 0.72A 1gtnI-4w6zA:
undetectable
1gtnJ-4w6zA:
undetectable		 1gtnI-4w6zA:
11.53
1gtnJ-4w6zA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		4 SER A  37
ALA A  38
THR A  55
ILE A  85
 None
 0.66A 1gtnI-4ydsA:
undetectable
1gtnJ-4ydsA:
undetectable		 1gtnI-4ydsA:
18.72
1gtnJ-4ydsA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b8i SERINE/THREONINE-PRO
TEIN PHOSPHATASE

(Coccidioides
immitis) 		PF00149
(Metallophos) 		4 ALA A 282
GLY A 219
ALA A 283
ILE A 295
 None
 0.71A 1gtnI-5b8iA:
undetectable
1gtnJ-5b8iA:
undetectable		 1gtnI-5b8iA:
12.43
1gtnJ-5b8iA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.69A 1gtnI-5c16A:
undetectable
1gtnJ-5c16A:
undetectable		 1gtnI-5c16A:
8.93
1gtnJ-5c16A:
8.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
 0.18A 1gtnI-5eexA:
15.3
1gtnJ-5eexA:
15.4		 1gtnI-5eexA:
100.00
1gtnJ-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eum LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		4 ALA A 512
GLY A 489
THR A 518
ILE A 524
 None
 0.64A 1gtnI-5eumA:
undetectable
1gtnJ-5eumA:
undetectable		 1gtnI-5eumA:
15.66
1gtnJ-5eumA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 ALA A  91
GLY A  62
THR A  84
THR A  48
 None
 0.73A 1gtnI-5gkxA:
undetectable
1gtnJ-5gkxA:
undetectable		 1gtnI-5gkxA:
16.60
1gtnJ-5gkxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans) 		PF00876
(Innexin) 		4 ALA A 139
GLY A 176
ALA A 140
ILE A 173
 None
 0.67A 1gtnI-5h1qA:
undetectable
1gtnJ-5h1qA:
undetectable		 1gtnI-5h1qA:
11.34
1gtnJ-5h1qA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i39 L-AMINO ACID
DEAMINASE

(Proteus
vulgaris) 		PF01266
(DAO) 		4 ALA A  89
GLY A  46
THR A 223
ILE A 221
 None
 0.64A 1gtnI-5i39A:
undetectable
1gtnJ-5i39A:
undetectable		 1gtnI-5i39A:
11.39
1gtnJ-5i39A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE

(Shewanella
oneidensis) 		PF03060
(NMO) 		4 ALA A 226
GLY A 216
ALA A 227
THR A 197
 None
FMN  A 401 (-3.5A)
None
None
 0.67A 1gtnI-5lsmA:
undetectable
1gtnJ-5lsmA:
undetectable		 1gtnI-5lsmA:
10.86
1gtnJ-5lsmA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.66A 1gtnI-5olpA:
undetectable
1gtnJ-5olpA:
undetectable		 1gtnI-5olpA:
10.47
1gtnJ-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.62A 1gtnI-5tnxA:
undetectable
1gtnJ-5tnxA:
undetectable		 1gtnI-5tnxA:
11.17
1gtnJ-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 SER A  23
ALA A  22
GLY A  15
ALA A  21
 None
 0.66A 1gtnI-5tvjA:
undetectable
1gtnJ-5tvjA:
undetectable		 1gtnI-5tvjA:
12.06
1gtnJ-5tvjA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 THR A 348
GLY A  71
ALA A 132
ILE A  93
 None
 0.71A 1gtnI-5yatA:
undetectable
1gtnJ-5yatA:
undetectable		 1gtnI-5yatA:
undetectable
1gtnJ-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A 129
GLY A 145
ALA A 128
ILE A 116
 None
 0.66A 1gtnI-6aooA:
undetectable
1gtnJ-6aooA:
undetectable		 1gtnI-6aooA:
14.16
1gtnJ-6aooA:
14.16