SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_H_TRPH81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 THR A 417
SER A 245
GLY A 412
ALA A 510
THR A 500
 TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
None
None
None
 1.15A 1gtnG-1l5jA:
0.0
1gtnH-1l5jA:
0.0		 1gtnG-1l5jA:
7.07
1gtnH-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 SER A 121
GLY A 116
ALA A 262
THR A 123
ILE A 102
 None
MG  A 401 (-3.8A)
None
None
None
 1.30A 1gtnG-1n0wA:
0.0
1gtnH-1n0wA:
0.0		 1gtnG-1n0wA:
14.40
1gtnH-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
 None
 1.38A 1gtnG-1ps9A:
undetectable
1gtnH-1ps9A:
undetectable		 1gtnG-1ps9A:
8.10
1gtnH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		5 HIS A 110
ALA A  86
THR A  59
THR A  58
ILE A  50
 None
None
A3P  A 352 (-3.5A)
A3P  A 352 (-3.7A)
None
 1.19A 1gtnG-1q1qA:
undetectable
1gtnH-1q1qA:
undetectable		 1gtnG-1q1qA:
13.61
1gtnH-1q1qA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.07A 1gtnG-1q8fA:
undetectable
1gtnH-1q8fA:
undetectable		 1gtnG-1q8fA:
13.50
1gtnH-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 THR A 344
SER A 531
HIS A 477
THR A 370
ILE A 366
 None
None
None
None
AMP  A 720 (-4.9A)
 1.35A 1gtnG-1ry2A:
undetectable
1gtnH-1ry2A:
undetectable		 1gtnG-1ry2A:
7.99
1gtnH-1ry2A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 THR A  40
GLY A 188
ALA A 196
THR A  49
THR A 183
 None
 1.16A 1gtnG-1v9cA:
0.0
1gtnH-1v9cA:
undetectable		 1gtnG-1v9cA:
19.25
1gtnH-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 SER A  98
GLY A  90
ALA A 121
THR A 104
ILE A  91
 None
 1.38A 1gtnG-1vpxA:
undetectable
1gtnH-1vpxA:
0.0		 1gtnG-1vpxA:
18.53
1gtnH-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.43A 1gtnG-1xmbA:
undetectable
1gtnH-1xmbA:
undetectable		 1gtnG-1xmbA:
10.98
1gtnH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 SER A 495
GLY A  15
ALA A  23
THR A 252
ILE A  13
 None
FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
 0.97A 1gtnG-1yy5A:
undetectable
1gtnH-1yy5A:
undetectable		 1gtnG-1yy5A:
9.73
1gtnH-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 THR A 200
SER A 209
GLY A 341
THR A 376
ILE A 340
 None
 1.26A 1gtnG-1z6rA:
undetectable
1gtnH-1z6rA:
undetectable		 1gtnG-1z6rA:
11.00
1gtnH-1z6rA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb7 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 THR A 271
GLY A 238
HIS A 237
THR A 172
ILE A 183
 ZN  A 500 ( 4.4A)
None
None
FLC  A 501 (-4.7A)
None
 1.26A 1gtnG-1zb7A:
undetectable
1gtnH-1zb7A:
undetectable		 1gtnG-1zb7A:
9.28
1gtnH-1zb7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 SER A 817
GLY A 285
ALA A 293
THR A 624
ILE A 283
 None
FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
 0.90A 1gtnG-2dw4A:
undetectable
1gtnH-2dw4A:
undetectable		 1gtnG-2dw4A:
8.15
1gtnH-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk6 RIBONUCLEASE Z

(Bacillus
subtilis) 		PF12706
(Lactamase_B_2) 		5 THR A  20
GLY A 210
HIS A 269
ALA A  65
THR A  62
 None
None
ZN  A 401 (-3.6A)
ZN  A 401 ( 4.9A)
None
 1.38A 1gtnG-2fk6A:
undetectable
1gtnH-2fk6A:
undetectable		 1gtnG-2fk6A:
12.30
1gtnH-2fk6A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 GLY B 195
HIS A   9
ALA A  67
THR B 225
THR B 209
 None
None
NA  A 401 (-4.6A)
None
None
 1.33A 1gtnG-2gezB:
undetectable
1gtnH-2gezB:
undetectable		 1gtnG-2gezB:
20.15
1gtnH-2gezB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 GLY A 215
ALA A 239
THR A  26
THR A 217
ILE A 243
 ADP  A 301 (-3.2A)
None
None
None
ADP  A 301 (-4.1A)
 1.30A 1gtnG-2i5bA:
undetectable
1gtnH-2i5bA:
undetectable		 1gtnG-2i5bA:
18.03
1gtnH-2i5bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A  98
GLY A  90
ALA A  96
THR A 297
ILE A  92
 None
 1.33A 1gtnG-2o56A:
undetectable
1gtnH-2o56A:
undetectable		 1gtnG-2o56A:
11.99
1gtnH-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prx THIOESTERASE
SUPERFAMILY PROTEIN

(Shewanella
loihica) 		PF03061
(4HBT) 		5 GLY A 117
HIS A  68
ALA A  76
THR A  39
ILE A 119
 None
 1.31A 1gtnG-2prxA:
undetectable
1gtnH-2prxA:
undetectable		 1gtnG-2prxA:
18.54
1gtnH-2prxA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.34A 1gtnG-2q1yA:
undetectable
1gtnH-2q1yA:
undetectable		 1gtnG-2q1yA:
12.94
1gtnH-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		5 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.31A 1gtnG-2r6fA:
2.3
1gtnH-2r6fA:
undetectable		 1gtnG-2r6fA:
6.07
1gtnH-2r6fA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rbc SUGAR KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		5 SER A 278
GLY A 258
HIS A 257
ALA A 281
THR A 259
 EDO  A 331 (-3.3A)
None
None
EDO  A 331 ( 3.7A)
None
 1.40A 1gtnG-2rbcA:
undetectable
1gtnH-2rbcA:
undetectable		 1gtnG-2rbcA:
11.54
1gtnH-2rbcA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 SER A 402
GLY A 435
ALA A 407
THR A 442
THR A 439
 None
ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
 1.17A 1gtnG-2xzlA:
undetectable
1gtnH-2xzlA:
undetectable		 1gtnG-2xzlA:
7.24
1gtnH-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		5 SER A  62
GLY A 128
HIS A 123
ALA A  58
ILE A 129
 None
 1.30A 1gtnG-2zy2A:
undetectable
1gtnH-2zy2A:
undetectable		 1gtnG-2zy2A:
8.61
1gtnH-2zy2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.37A 1gtnG-3a1nA:
undetectable
1gtnH-3a1nA:
undetectable		 1gtnG-3a1nA:
13.02
1gtnH-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 THR A 295
GLY A 166
ALA A 194
THR A 284
ILE A 187
 None
 0.99A 1gtnG-3b9gA:
undetectable
1gtnH-3b9gA:
undetectable		 1gtnG-3b9gA:
13.11
1gtnH-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqp OXIDOREDUCTASE YLBE

(Lactococcus
lactis) 		PF13460
(NAD_binding_10) 		5 THR A 187
HIS A 189
ALA A 207
THR A 180
ILE A 164
 None
 1.39A 1gtnG-3dqpA:
undetectable
1gtnH-3dqpA:
undetectable		 1gtnG-3dqpA:
18.06
1gtnH-3dqpA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 SER A 126
ALA A 130
THR A 147
THR A 176
ILE A 190
 None
 1.49A 1gtnG-3e03A:
undetectable
1gtnH-3e03A:
undetectable		 1gtnG-3e03A:
15.33
1gtnH-3e03A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 THR A 173
GLY A 270
ALA A 238
THR A 267
ILE A 235
 MYR  A 315 ( 4.9A)
None
None
None
None
 1.38A 1gtnG-3ee4A:
undetectable
1gtnH-3ee4A:
undetectable		 1gtnG-3ee4A:
12.95
1gtnH-3ee4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 THR A  90
GLY A 113
ALA A 331
THR A 107
ILE A 335
 None
 1.34A 1gtnG-3gdoA:
undetectable
1gtnH-3gdoA:
undetectable		 1gtnG-3gdoA:
12.11
1gtnH-3gdoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 THR A 442
GLY A 174
ALA A 140
THR A 457
ILE A 173
 None
 1.18A 1gtnG-3hpaA:
undetectable
1gtnH-3hpaA:
undetectable		 1gtnG-3hpaA:
10.65
1gtnH-3hpaA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 THR A 189
SER A 342
GLY A 393
THR A 355
ILE A 394
 None
 1.38A 1gtnG-3hq2A:
undetectable
1gtnH-3hq2A:
undetectable		 1gtnG-3hq2A:
8.96
1gtnH-3hq2A:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kos HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR

(Citrobacter
freundii) 		PF03466
(LysR_substrate) 		5 GLY A  99
HIS A 130
THR A 267
THR A 144
ILE A  98
 None
 1.31A 1gtnG-3kosA:
undetectable
1gtnH-3kosA:
undetectable		 1gtnG-3kosA:
15.42
1gtnH-3kosA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.17A 1gtnG-3l6cA:
undetectable
1gtnH-3l6cA:
undetectable		 1gtnG-3l6cA:
14.11
1gtnH-3l6cA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLY A  88
HIS A  87
ALA A 102
THR A  81
ILE A 104
 None
 1.17A 1gtnG-3l6rA:
undetectable
1gtnH-3l6rA:
undetectable		 1gtnG-3l6rA:
12.84
1gtnH-3l6rA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLY A  14
HIS A  16
ALA A 325
THR A 304
ILE A 135
 None
 1.29A 1gtnG-3l8kA:
undetectable
1gtnH-3l8kA:
undetectable		 1gtnG-3l8kA:
11.76
1gtnH-3l8kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 THR A 165
SER A 138
GLY A 160
ALA A 140
THR A 116
 None
 1.24A 1gtnG-3rwbA:
undetectable
1gtnH-3rwbA:
undetectable		 1gtnG-3rwbA:
16.06
1gtnH-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryk DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Bacillus
anthracis) 		PF00908
(dTDP_sugar_isom) 		5 SER A  50
GLY A  60
HIS A  62
HIS A 119
ILE A  58
 None
None
POP  A 182 ( 4.5A)
None
None
 1.37A 1gtnG-3rykA:
1.3
1gtnH-3rykA:
2.3		 1gtnG-3rykA:
18.40
1gtnH-3rykA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A  58
GLY A 124
HIS A 130
THR A 132
ILE A 122
 None
 1.22A 1gtnG-3txxA:
undetectable
1gtnH-3txxA:
undetectable		 1gtnG-3txxA:
11.21
1gtnH-3txxA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 SER A 215
GLY A 325
ALA A 212
THR A 320
ILE A 326
 None
 1.26A 1gtnG-3u0oA:
undetectable
1gtnH-3u0oA:
undetectable		 1gtnG-3u0oA:
13.79
1gtnH-3u0oA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 HIS A 518
HIS A 886
ALA A 634
THR A 928
ILE A 891
 None
 1.24A 1gtnG-3ux8A:
undetectable
1gtnH-3ux8A:
undetectable		 1gtnG-3ux8A:
7.91
1gtnH-3ux8A:
7.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
THR A  49
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
None
TRP  A  80 ( 4.9A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.27A 1gtnG-3zteA:
15.3
1gtnH-3zteA:
15.4		 1gtnG-3zteA:
78.21
1gtnH-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 4.7A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.22A 1gtnG-3zzlA:
13.1
1gtnH-3zzlA:
13.2		 1gtnG-3zzlA:
71.43
1gtnH-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.19A 1gtnG-3zzqA:
13.8
1gtnH-3zzqA:
13.8		 1gtnG-3zzqA:
80.00
1gtnH-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 4.7A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.14A 1gtnG-3zzsA:
13.7
1gtnH-3zzsA:
13.7		 1gtnG-3zzsA:
100.00
1gtnH-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 322
GLY A 228
HIS A 313
THR A 318
THR A 314
 None
NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
 1.23A 1gtnG-4a0sA:
undetectable
1gtnH-4a0sA:
undetectable		 1gtnG-4a0sA:
10.76
1gtnH-4a0sA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
HIS  A  34 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.21A 1gtnG-4b27A:
13.2
1gtnH-4b27A:
13.3		 1gtnG-4b27A:
76.32
1gtnH-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 SER A 504
ALA A 500
THR A 572
THR A 545
ILE A 547
 None
 1.13A 1gtnG-4bx9A:
undetectable
1gtnH-4bx9A:
undetectable		 1gtnG-4bx9A:
7.91
1gtnH-4bx9A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 GLY A 289
HIS A 270
HIS A 304
THR A 288
ILE A 331
 None
 1.48A 1gtnG-4ci8A:
undetectable
1gtnH-4ci8A:
undetectable		 1gtnG-4ci8A:
9.19
1gtnH-4ci8A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 GLY A 124
HIS A 123
ALA A 138
THR A 117
ILE A 140
 None
 1.08A 1gtnG-4d9iA:
undetectable
1gtnH-4d9iA:
undetectable		 1gtnG-4d9iA:
11.42
1gtnH-4d9iA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 SO4  A 607 (-3.4A)
None
None
SO4  A 607 (-4.3A)
None
 1.25A 1gtnG-4e6eA:
undetectable
1gtnH-4e6eA:
undetectable		 1gtnG-4e6eA:
12.06
1gtnH-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		5 THR A 108
SER A  20
HIS A  83
ALA A  17
ILE A  96
 None
 1.27A 1gtnG-4fc4A:
undetectable
1gtnH-4fc4A:
undetectable		 1gtnG-4fc4A:
15.23
1gtnH-4fc4A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 GLY A 733
ALA A 728
THR A 771
THR A 774
ILE A 732
 None
 1.37A 1gtnG-4fddA:
undetectable
1gtnH-4fddA:
undetectable		 1gtnG-4fddA:
6.80
1gtnH-4fddA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		5 SER A 811
GLY A 389
ALA A 397
THR A 626
ILE A 387
 None
FAD  A 901 (-3.3A)
None
None
None
 0.95A 1gtnG-4hsuA:
undetectable
1gtnH-4hsuA:
undetectable		 1gtnG-4hsuA:
7.64
1gtnH-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 GLY E 470
HIS E 472
THR E 481
THR E 480
ILE E 469
 None
 1.21A 1gtnG-4kprE:
undetectable
1gtnH-4kprE:
undetectable		 1gtnG-4kprE:
9.64
1gtnH-4kprE:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 SER A 271
GLY A  55
THR A 129
THR A 132
ILE A  58
 None
 1.09A 1gtnG-4lz6A:
undetectable
1gtnH-4lz6A:
undetectable		 1gtnG-4lz6A:
11.37
1gtnH-4lz6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		5 SER A 124
HIS A 117
ALA A 122
THR A  88
ILE A 129
 None
 1.39A 1gtnG-4nq1A:
undetectable
1gtnH-4nq1A:
undetectable		 1gtnG-4nq1A:
15.71
1gtnH-4nq1A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 SER A 384
GLY A 390
ALA A 381
THR A 409
ILE A 407
 None
 1.24A 1gtnG-4ohtA:
undetectable
1gtnH-4ohtA:
undetectable		 1gtnG-4ohtA:
9.89
1gtnH-4ohtA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 172
HIS A 167
ALA A 177
THR A 218
ILE A 174
 None
 1.49A 1gtnG-4zrsA:
undetectable
1gtnH-4zrsA:
undetectable		 1gtnG-4zrsA:
14.43
1gtnH-4zrsA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 SER A 554
GLY A 560
HIS A 492
ALA A 551
ILE A 603
 None
 1.28A 1gtnG-4ztxA:
undetectable
1gtnH-4ztxA:
undetectable		 1gtnG-4ztxA:
6.50
1gtnH-4ztxA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 SER A  67
GLY A 131
HIS A  25
ALA A 250
THR A 134
 None
 1.42A 1gtnG-5ah0A:
undetectable
1gtnH-5ah0A:
undetectable		 1gtnG-5ah0A:
12.03
1gtnH-5ah0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah1 TRIACYLGLYCEROL
LIPASE

(Clostridium
botulinum) 		no annotation 5 SER A 126
GLY A 184
HIS A  84
ALA A 304
THR A 187
 None
 1.32A 1gtnG-5ah1A:
undetectable
1gtnH-5ah1A:
undetectable		 1gtnG-5ah1A:
10.95
1gtnH-5ah1A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 SER A  87
GLY A 245
ALA A  85
THR A 244
ILE A 240
 PLP  A 501 (-3.7A)
None
None
None
None
 1.37A 1gtnG-5dx5A:
undetectable
1gtnH-5dx5A:
undetectable		 1gtnG-5dx5A:
11.50
1gtnH-5dx5A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e57 TRANSCRIPTION
REGULATOR AMTR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		5 THR A 211
GLY A 191
HIS A  99
ALA A 106
ILE A 190
 None
 1.47A 1gtnG-5e57A:
undetectable
1gtnH-5e57A:
undetectable		 1gtnG-5e57A:
14.29
1gtnH-5e57A:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		7 GLY A  23
HIS A  33
HIS A  34
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
 0.13A 1gtnG-5eexA:
15.6
1gtnH-5eexA:
15.3		 1gtnG-5eexA:
100.00
1gtnH-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		5 THR Y 412
GLY Y 178
ALA Y 185
THR Y  21
ILE Y 182
 None
 1.30A 1gtnG-5eulY:
undetectable
1gtnH-5eulY:
undetectable		 1gtnG-5eulY:
10.61
1gtnH-5eulY:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbb NUCLEASE S1

(Aspergillus
oryzae) 		PF02265
(S1-P1_nuclease) 		5 GLY A  25
HIS A  26
ALA A 271
THR A  28
ILE A 268
 None
ZN  A 401 ( 3.2A)
None
None
None
 1.30A 1gtnG-5fbbA:
undetectable
1gtnH-5fbbA:
undetectable		 1gtnG-5fbbA:
14.80
1gtnH-5fbbA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 GLY A  83
HIS A  87
THR A 105
THR A 108
ILE A 112
 None
 1.31A 1gtnG-5habA:
0.0
1gtnH-5habA:
undetectable		 1gtnG-5habA:
12.91
1gtnH-5habA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII
COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens;
Homo sapiens) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		5 SER B1788
GLY B1981
ALA B1836
THR A 667
THR A 669
 None
 1.47A 1gtnG-5k8dB:
undetectable
1gtnH-5k8dB:
1.5		 1gtnG-5k8dB:
5.92
1gtnH-5k8dB:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 SER A 817
GLY A 285
ALA A 293
THR A 624
ILE A 283
 None
FAD  A 901 (-3.3A)
None
None
None
 0.92A 1gtnG-5l3dA:
undetectable
1gtnH-5l3dA:
undetectable		 1gtnG-5l3dA:
6.27
1gtnH-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 SER A2008
GLY A2074
HIS A2081
THR A2083
ILE A2072
 None
 1.19A 1gtnG-5nnnA:
undetectable
1gtnH-5nnnA:
undetectable		 1gtnG-5nnnA:
15.08
1gtnH-5nnnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1m RUBBER OXYGENASE

(Streptomyces
sp. K30) 		PF09995
(DUF2236) 		5 SER A 186
GLY A 172
ALA A 180
THR A 190
ILE A 175
 None
 1.14A 1gtnG-5o1mA:
undetectable
1gtnH-5o1mA:
undetectable		 1gtnG-5o1mA:
12.64
1gtnH-5o1mA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 THR A 199
GLY A 310
ALA A 149
THR A 309
ILE A 147
 EDO  A 504 ( 4.2A)
EDO  A 504 ( 3.9A)
None
None
None
 1.33A 1gtnG-5u2pA:
undetectable
1gtnH-5u2pA:
undetectable		 1gtnG-5u2pA:
11.24
1gtnH-5u2pA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 THR A 210
SER A 132
ALA A 144
THR A 136
THR A 137
 None
 1.49A 1gtnG-5ujuA:
undetectable
1gtnH-5ujuA:
undetectable		 1gtnG-5ujuA:
8.35
1gtnH-5ujuA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 GLY A 568
HIS A 570
THR A 579
THR A 578
ILE A 567
 None
 1.24A 1gtnG-5w1jA:
undetectable
1gtnH-5w1jA:
undetectable		 1gtnG-5w1jA:
8.72
1gtnH-5w1jA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 SER A 346
GLY A 294
ALA A 328
THR A 287
THR A 288
 None
 1.49A 1gtnG-5wh8A:
undetectable
1gtnH-5wh8A:
undetectable		 1gtnG-5wh8A:
undetectable
1gtnH-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 THR A 550
ALA A 929
THR A 685
THR A 687
ILE A 961
 None
 1.47A 1gtnG-5x7sA:
undetectable
1gtnH-5x7sA:
2.1		 1gtnG-5x7sA:
4.73
1gtnH-5x7sA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 5 SER A 618
GLY A 147
ALA A 622
THR A 627
ILE A 148
 None
SO4  A 706 ( 4.4A)
None
None
None
 1.32A 1gtnG-5y6rA:
undetectable
1gtnH-5y6rA:
undetectable		 1gtnG-5y6rA:
undetectable
1gtnH-5y6rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 GLY A 126
ALA A 133
THR A 122
THR A 124
ILE A 159
 PO4  A 504 (-4.5A)
None
None
PO4  A 504 (-3.6A)
None
 0.99A 1gtnG-5ygrA:
undetectable
1gtnH-5ygrA:
undetectable		 1gtnG-5ygrA:
undetectable
1gtnH-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z73 ALR0819 PROTEIN

(Nostoc sp. PCC
7120) 		no annotation 5 SER A  58
GLY A  34
ALA A  60
THR A  35
ILE A  71
 None
 1.26A 1gtnG-5z73A:
undetectable
1gtnH-5z73A:
undetectable		 1gtnG-5z73A:
undetectable
1gtnH-5z73A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 5 GLY A 222
ALA A 691
THR A 214
THR A 215
ILE A 681
 None
 1.20A 1gtnG-6fuyA:
undetectable
1gtnH-6fuyA:
undetectable		 1gtnG-6fuyA:
undetectable
1gtnH-6fuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gef TYPE IV SECRETION
SYSTEM PROTEIN DOTB

(Yersinia
pseudotuberculosis) 		no annotation 5 THR A 266
GLY A 164
HIS A 268
ALA A 260
ILE A 165
 THR  A 266 ( 0.8A)
GLY  A 164 ( 0.0A)
HIS  A 268 ( 1.0A)
ALA  A 260 ( 0.0A)
ILE  A 165 ( 0.7A)
 1.22A 1gtnG-6gefA:
undetectable
1gtnH-6gefA:
undetectable		 1gtnG-6gefA:
undetectable
1gtnH-6gefA:
undetectable