SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_E_TRPE81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 THR A  48
GLY A  39
THR A  43
ILE A 411
 None
 0.82A 1gtnD-1d9zA:
undetectable
1gtnE-1d9zA:
0.0		 1gtnD-1d9zA:
7.86
1gtnE-1d9zA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.82A 1gtnD-1dl2A:
undetectable
1gtnE-1dl2A:
undetectable		 1gtnD-1dl2A:
11.11
1gtnE-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 SER A 137
GLY A 194
THR A 356
ILE A 197
 None
SF4  A 582 (-3.9A)
None
None
 0.80A 1gtnD-1fehA:
undetectable
1gtnE-1fehA:
undetectable		 1gtnD-1fehA:
9.41
1gtnE-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.66A 1gtnD-1flgA:
0.0
1gtnE-1flgA:
0.0		 1gtnD-1flgA:
8.63
1gtnE-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 245
GLY A 412
THR A 417
ILE A 479
 TRA  A 866 (-2.6A)
None
TRA  A 866 (-4.0A)
None
 0.81A 1gtnD-1l5jA:
undetectable
1gtnE-1l5jA:
undetectable		 1gtnD-1l5jA:
7.07
1gtnE-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnD-1larA:
0.0
1gtnE-1larA:
0.1		 1gtnD-1larA:
9.07
1gtnE-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PO4  A 655 (-3.6A)
None
None
 0.81A 1gtnD-1lw3A:
undetectable
1gtnE-1lw3A:
undetectable		 1gtnD-1lw3A:
7.46
1gtnE-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 THR A 389
SER A 384
GLY A  11
THR A 156
 None
 0.91A 1gtnD-1mb9A:
0.0
1gtnE-1mb9A:
undetectable		 1gtnD-1mb9A:
9.16
1gtnE-1mb9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsh CALGIZZARIN

(Oryctolagus
cuniculus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 SER A   1
THR A   4
THR A   6
ILE A  10
 None
 0.82A 1gtnD-1nshA:
undetectable
1gtnE-1nshA:
undetectable		 1gtnD-1nshA:
22.86
1gtnE-1nshA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o54 SAM-DEPENDENT
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF08704
(GCD14) 		4 SER A  22
GLY A  39
THR A  36
ILE A  41
 None
 0.89A 1gtnD-1o54A:
0.5
1gtnE-1o54A:
0.5		 1gtnD-1o54A:
13.78
1gtnE-1o54A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
 None
 1.43A 1gtnD-1ps9A:
undetectable
1gtnE-1ps9A:
undetectable		 1gtnD-1ps9A:
8.10
1gtnE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 THR A 287
GLY A 152
THR A 273
ILE A 167
 None
 0.91A 1gtnD-1q8fA:
undetectable
1gtnE-1q8fA:
undetectable		 1gtnD-1q8fA:
13.50
1gtnE-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.80A 1gtnD-1vb4A:
undetectable
1gtnE-1vb4A:
undetectable		 1gtnD-1vb4A:
14.55
1gtnE-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		4 SER A 272
GLY A  94
THR A 129
ILE A  93
 None
 0.92A 1gtnD-1xa0A:
undetectable
1gtnE-1xa0A:
undetectable		 1gtnD-1xa0A:
16.03
1gtnE-1xa0A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		4 SER A 495
GLY A  15
THR A 252
ILE A  13
 None
FAD  A 803 (-3.2A)
FAD  A 803 (-4.6A)
None
 0.90A 1gtnD-1yy5A:
undetectable
1gtnE-1yy5A:
undetectable		 1gtnD-1yy5A:
9.73
1gtnE-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		5 THR A 200
SER A 209
GLY A 341
THR A 376
ILE A 340
 None
 1.35A 1gtnD-1z6rA:
undetectable
1gtnE-1z6rA:
undetectable		 1gtnD-1z6rA:
11.00
1gtnE-1z6rA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.75A 1gtnD-1zsqA:
undetectable
1gtnE-1zsqA:
undetectable		 1gtnD-1zsqA:
12.02
1gtnE-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Saccharomyces
cerevisiae) 		PF00977
(His_biosynth) 		4 SER A 136
GLY A  84
THR A 104
ILE A 102
 EDO  A1005 (-3.0A)
None
EDO  A1005 (-3.8A)
None
 0.89A 1gtnD-2agkA:
undetectable
1gtnE-2agkA:
undetectable		 1gtnD-2agkA:
16.40
1gtnE-2agkA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 THR A 399
GLY A 152
THR A 143
ILE A 163
 None
 0.79A 1gtnD-2ahwA:
undetectable
1gtnE-2ahwA:
undetectable		 1gtnD-2ahwA:
9.98
1gtnE-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.80A 1gtnD-2amhA:
undetectable
1gtnE-2amhA:
undetectable		 1gtnD-2amhA:
19.19
1gtnE-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 SER A 257
GLY A 534
THR A 295
THR A 438
 None
 0.93A 1gtnD-2b3xA:
undetectable
1gtnE-2b3xA:
undetectable		 1gtnD-2b3xA:
6.19
1gtnE-2b3xA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 SER A 817
GLY A 285
THR A 624
ILE A 283
 None
FAD  A1001 (-3.2A)
FAD  A1001 (-4.9A)
None
 0.84A 1gtnD-2dw4A:
undetectable
1gtnE-2dw4A:
undetectable		 1gtnD-2dw4A:
8.15
1gtnE-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgq OUTER MEMBRANE PORIN
PROTEIN 32

(Delftia
acidovorans) 		PF13609
(Porin_4) 		4 GLY X 126
THR X 201
THR X 194
ILE X 162
 None
 0.92A 1gtnD-2fgqX:
undetectable
1gtnE-2fgqX:
undetectable		 1gtnD-2fgqX:
11.04
1gtnE-2fgqX:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz1 COAT PROTEIN

(Turnip yellow
mosaic virus) 		PF00983
(Tymo_coat) 		4 THR A  81
GLY A  43
THR A  89
ILE A 157
 None
 0.91A 1gtnD-2fz1A:
undetectable
1gtnE-2fz1A:
undetectable		 1gtnD-2fz1A:
15.62
1gtnE-2fz1A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.60A 1gtnD-2jifA:
undetectable
1gtnE-2jifA:
undetectable		 1gtnD-2jifA:
10.55
1gtnE-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.89A 1gtnD-2p4hX:
undetectable
1gtnE-2p4hX:
undetectable		 1gtnD-2p4hX:
15.70
1gtnE-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1w PUTATIVE NUCLEOTIDE
SUGAR EPIMERASE/
DEHYDRATASE

(Bordetella
bronchiseptica) 		PF01370
(Epimerase) 		4 THR A 211
GLY A  14
THR A  76
ILE A   9
 None
None
NAD  A 501 (-4.5A)
None
 0.88A 1gtnD-2q1wA:
undetectable
1gtnE-2q1wA:
undetectable		 1gtnD-2q1wA:
18.01
1gtnE-2q1wA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjt NICOTINAMIDE-NUCLEOT
IDE
ADENYLYLTRANSFERASE

(Francisella
tularensis) 		no annotation 4 SER B 280
GLY B 235
THR B 285
THR B 205
 None
AMP  B 602 (-3.3A)
None
None
 0.92A 1gtnD-2qjtB:
undetectable
1gtnE-2qjtB:
undetectable		 1gtnD-2qjtB:
13.29
1gtnE-2qjtB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.65A 1gtnD-2qveA:
undetectable
1gtnE-2qveA:
undetectable		 1gtnD-2qveA:
11.96
1gtnE-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.69A 1gtnD-2vq0A:
undetectable
1gtnE-2vq0A:
undetectable		 1gtnD-2vq0A:
13.28
1gtnE-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlp COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.87A 1gtnD-2wlpA:
undetectable
1gtnE-2wlpA:
undetectable		 1gtnD-2wlpA:
15.12
1gtnE-2wlpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6i TRANS-2-ENOYL-ACP
REDUCTASE II

(Streptococcus
pneumoniae) 		PF03060
(NMO) 		4 THR A 192
GLY A 143
THR A 218
ILE A 145
 FMN  A 401 (-3.7A)
FMN  A 401 ( 4.7A)
None
None
 0.89A 1gtnD-2z6iA:
undetectable
1gtnE-2z6iA:
undetectable		 1gtnD-2z6iA:
15.21
1gtnE-2z6iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.37A 1gtnD-3a1nA:
undetectable
1gtnE-3a1nA:
undetectable		 1gtnD-3a1nA:
13.02
1gtnE-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9k FAB HEAVY CHAIN

(Rattus rattus) 		no annotation 4 SER H  28
GLY H  55
THR H  73
ILE H  51
 None
 0.84A 1gtnD-3b9kH:
1.5
1gtnE-3b9kH:
1.4		 1gtnD-3b9kH:
16.67
1gtnE-3b9kH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4l PUTATIVE
OXIDOREDUCTASE YHHX

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 GLY A   9
THR A  15
THR A  14
ILE A  34
 None
 0.93A 1gtnD-3f4lA:
undetectable
1gtnE-3f4lA:
undetectable		 1gtnD-3f4lA:
13.91
1gtnE-3f4lA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 171
GLY A 127
THR A 173
ILE A  85
 None
 0.89A 1gtnD-3gweA:
undetectable
1gtnE-3gweA:
undetectable		 1gtnD-3gweA:
11.88
1gtnE-3gweA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 THR A 357
GLY B 966
THR A 360
ILE B 965
 None
 0.92A 1gtnD-3h0gA:
undetectable
1gtnE-3h0gA:
undetectable		 1gtnD-3h0gA:
3.79
1gtnE-3h0gA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 SER A 284
GLY A 306
THR A 303
ILE A 407
 None
 0.91A 1gtnD-3h5lA:
undetectable
1gtnE-3h5lA:
undetectable		 1gtnD-3h5lA:
13.00
1gtnE-3h5lA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A 173
SER A 141
THR A  56
ILE A  54
 None
None
NA  A 358 (-4.0A)
None
 0.80A 1gtnD-3h84A:
undetectable
1gtnE-3h84A:
undetectable		 1gtnD-3h84A:
12.99
1gtnE-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL

(Plasmodium
falciparum) 		PF01180
(DHO_dh) 		4 THR A 249
SER A 345
THR A 348
ILE A 321
 FMN  A1002 (-3.8A)
ORO  A1003 (-3.2A)
None
None
 0.89A 1gtnD-3i6rA:
undetectable
1gtnE-3i6rA:
undetectable		 1gtnD-3i6rA:
10.60
1gtnE-3i6rA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 THR F 333
GLY F 366
THR F 364
ILE F 401
 None
 0.75A 1gtnD-3jbrF:
undetectable
1gtnE-3jbrF:
undetectable		 1gtnD-3jbrF:
5.20
1gtnE-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 322
GLY A 333
THR A 302
ILE A 352
 None
 0.82A 1gtnD-3kumA:
undetectable
1gtnE-3kumA:
undetectable		 1gtnD-3kumA:
11.40
1gtnE-3kumA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1h LYSINE SPECIFIC
CYSTEINE PROTEASE

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		4 GLY A1437
THR A1457
THR A1456
ILE A1472
 None
 0.92A 1gtnD-3m1hA:
undetectable
1gtnE-3m1hA:
undetectable		 1gtnD-3m1hA:
20.00
1gtnE-3m1hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.78A 1gtnD-3or2B:
undetectable
1gtnE-3or2B:
undetectable		 1gtnD-3or2B:
11.35
1gtnE-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q88 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Francisella
tularensis) 		PF00342
(PGI) 		5 SER A 200
GLY A 144
THR A 203
THR A 206
ILE A 196
 RI2  A 601 (-2.6A)
None
RI2  A 601 (-3.3A)
RI2  A 601 ( 4.6A)
None
 1.44A 1gtnD-3q88A:
undetectable
1gtnE-3q88A:
undetectable		 1gtnD-3q88A:
10.28
1gtnE-3q88A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgm P-NITROPHENYL
PHOSPHATASE (PHO2)

(Archaeoglobus
fulgidus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 147
GLY A  94
THR A  92
ILE A  99
 None
 0.91A 1gtnD-3qgmA:
undetectable
1gtnE-3qgmA:
undetectable		 1gtnD-3qgmA:
15.73
1gtnE-3qgmA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 THR A 377
SER A 136
GLY A 370
ILE A 369
 None
 0.91A 1gtnD-3qlvA:
undetectable
1gtnE-3qlvA:
undetectable		 1gtnD-3qlvA:
9.82
1gtnE-3qlvA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M

(Escherichia
coli) 		no annotation 4 THR M  94
SER M  43
GLY M 125
ILE M   7
 None
 0.80A 1gtnD-3rkoM:
undetectable
1gtnE-3rkoM:
undetectable		 1gtnD-3rkoM:
9.84
1gtnE-3rkoM:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1gtnD-3rotA:
undetectable
1gtnE-3rotA:
undetectable		 1gtnD-3rotA:
13.47
1gtnE-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 SER A 218
GLY A 249
THR A 214
ILE A 276
 None
 0.88A 1gtnD-3t5bA:
undetectable
1gtnE-3t5bA:
undetectable		 1gtnD-3t5bA:
11.62
1gtnE-3t5bA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.55A 1gtnD-3t63M:
undetectable
1gtnE-3t63M:
undetectable		 1gtnD-3t63M:
12.18
1gtnE-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 SER A 203
GLY A 279
THR A 363
ILE A 359
 None
 0.88A 1gtnD-3uhjA:
undetectable
1gtnE-3uhjA:
undetectable		 1gtnD-3uhjA:
12.46
1gtnE-3uhjA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 GLY A  68
THR A 295
THR A 300
ILE A  64
 None
 0.92A 1gtnD-3us8A:
undetectable
1gtnE-3us8A:
undetectable		 1gtnD-3us8A:
12.77
1gtnE-3us8A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 SER A 163
GLY A  86
THR A 190
ILE A  82
 None
 0.73A 1gtnD-3v4cA:
undetectable
1gtnE-3v4cA:
undetectable		 1gtnD-3v4cA:
10.56
1gtnE-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 THR A 933
GLY A 910
THR A1011
ILE A 909
 None
 0.90A 1gtnD-3w9iA:
undetectable
1gtnE-3w9iA:
undetectable		 1gtnD-3w9iA:
5.72
1gtnE-3w9iA:
5.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.22A 1gtnD-3zteA:
15.4
1gtnE-3zteA:
14.6		 1gtnD-3zteA:
78.21
1gtnE-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.16A 1gtnD-3zzqA:
13.7
1gtnE-3zzqA:
13.8		 1gtnD-3zzqA:
80.00
1gtnE-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.13A 1gtnD-3zzsA:
13.6
1gtnE-3zzsA:
13.8		 1gtnD-3zzsA:
100.00
1gtnE-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.92A 1gtnD-4auoA:
undetectable
1gtnE-4auoA:
undetectable		 1gtnD-4auoA:
14.14
1gtnE-4auoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 THR A 384
SER A 416
GLY A 377
ILE A 376
 None
 0.89A 1gtnD-4av6A:
undetectable
1gtnE-4av6A:
undetectable		 1gtnD-4av6A:
8.17
1gtnE-4av6A:
8.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.16A 1gtnD-4b27A:
13.2
1gtnE-4b27A:
13.3		 1gtnD-4b27A:
76.32
1gtnE-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.78A 1gtnD-4c22A:
undetectable
1gtnE-4c22A:
undetectable		 1gtnD-4c22A:
8.11
1gtnE-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cza NA+/H+ ANTIPORTER,
PUTATIVE

(Pyrococcus
abyssi) 		PF00999
(Na_H_Exchanger) 		4 THR A 100
GLY A 360
THR A 129
ILE A 151
 None
 0.93A 1gtnD-4czaA:
undetectable
1gtnE-4czaA:
undetectable		 1gtnD-4czaA:
11.24
1gtnE-4czaA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN

(Clostridioides
difficile) 		PF02567
(PhzC-PhzF) 		4 THR A 200
SER A 186
GLY A 172
ILE A 173
 BTB  A 302 ( 3.8A)
None
None
None
 0.86A 1gtnD-4dunA:
undetectable
1gtnE-4dunA:
undetectable		 1gtnD-4dunA:
14.71
1gtnE-4dunA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ghn UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF03572
(Peptidase_S41) 		4 THR A 118
SER A 109
GLY A 101
ILE A 103
 None
 0.90A 1gtnD-4ghnA:
undetectable
1gtnE-4ghnA:
undetectable		 1gtnD-4ghnA:
11.20
1gtnE-4ghnA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 GLY A  71
THR A 300
THR A 305
ILE A  67
 None
 0.92A 1gtnD-4hcxA:
undetectable
1gtnE-4hcxA:
undetectable		 1gtnD-4hcxA:
11.49
1gtnE-4hcxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 SER A 811
GLY A 389
THR A 626
ILE A 387
 None
FAD  A 901 (-3.3A)
None
None
 0.84A 1gtnD-4hsuA:
undetectable
1gtnE-4hsuA:
undetectable		 1gtnD-4hsuA:
7.64
1gtnE-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 339
ILE B 194
 None
 0.79A 1gtnD-4i6mB:
undetectable
1gtnE-4i6mB:
undetectable		 1gtnD-4i6mB:
11.93
1gtnE-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 340
THR B 339
 None
 0.91A 1gtnD-4i6mB:
undetectable
1gtnE-4i6mB:
undetectable		 1gtnD-4i6mB:
11.93
1gtnE-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 SER A 512
GLY A  29
THR A 288
ILE A  27
 None
 0.82A 1gtnD-4ia5A:
undetectable
1gtnE-4ia5A:
undetectable		 1gtnD-4ia5A:
9.19
1gtnE-4ia5A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 THR A 239
GLY A 267
THR A 229
THR A 270
 ADP  A 601 (-2.9A)
ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
 0.76A 1gtnD-4ihqA:
undetectable
1gtnE-4ihqA:
undetectable		 1gtnD-4ihqA:
11.31
1gtnE-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 THR A3154
GLY A3253
THR A3415
ILE A3235
 None
 0.87A 1gtnD-4kc5A:
undetectable
1gtnE-4kc5A:
undetectable		 1gtnD-4kc5A:
5.95
1gtnE-4kc5A:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 THR A  38
SER A  63
GLY A 103
ILE A 102
 None
 0.88A 1gtnD-4l9aA:
undetectable
1gtnE-4l9aA:
undetectable		 1gtnD-4l9aA:
13.49
1gtnE-4l9aA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvn NIMP.M7 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER C  28
GLY C  56
THR C  74
ILE C  52
 None
 0.84A 1gtnD-4lvnC:
undetectable
1gtnE-4lvnC:
undetectable		 1gtnD-4lvnC:
15.28
1gtnE-4lvnC:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 SER A 271
GLY A  55
THR A 129
THR A 132
ILE A  58
 None
 1.10A 1gtnD-4lz6A:
undetectable
1gtnE-4lz6A:
undetectable		 1gtnD-4lz6A:
11.37
1gtnE-4lz6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 SER A 181
GLY A 208
THR A 212
ILE A 209
 SAM  A 401 (-3.6A)
SAM  A 401 ( 4.1A)
SAM  A 401 (-4.1A)
None
 0.92A 1gtnD-4pghA:
undetectable
1gtnE-4pghA:
undetectable		 1gtnD-4pghA:
12.97
1gtnE-4pghA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 SER A 312
GLY A 356
THR A 262
ILE A 354
 PE5  A 901 (-3.6A)
PE5  A 901 ( 3.8A)
None
None
 0.79A 1gtnD-4ud8A:
undetectable
1gtnE-4ud8A:
undetectable		 1gtnD-4ud8A:
10.22
1gtnE-4ud8A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ure CYCLOHEXANOL
DEHYDROGENASE

(Aromatoleum
aromaticum) 		PF13561
(adh_short_C2) 		4 SER A 141
GLY A 148
THR A 156
ILE A 149
 None
 0.81A 1gtnD-4ureA:
undetectable
1gtnE-4ureA:
undetectable		 1gtnD-4ureA:
17.32
1gtnE-4ureA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		4 THR A 388
THR A 395
THR A 325
ILE A 321
 None
 0.92A 1gtnD-4xydA:
undetectable
1gtnE-4xydA:
undetectable		 1gtnD-4xydA:
10.67
1gtnE-4xydA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Staphylococcus
aureus;
Sesbania mosaic
virus) 		no annotation 4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.84A 1gtnD-4y5zA:
undetectable
1gtnE-4y5zA:
undetectable		 1gtnD-4y5zA:
11.62
1gtnE-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azw TRANSMEMBRANE EMP24
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF01105
(EMP24_GP25L) 		4 GLY A 113
THR A  38
THR A  41
ILE A 112
 None
 0.92A 1gtnD-5azwA:
3.5
1gtnE-5azwA:
3.5		 1gtnD-5azwA:
22.35
1gtnE-5azwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.70A 1gtnD-5c16A:
undetectable
1gtnE-5c16A:
undetectable		 1gtnD-5c16A:
8.93
1gtnE-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 SER A 323
GLY A 280
THR A 342
THR A  50
 None
 0.86A 1gtnD-5c69A:
undetectable
1gtnE-5c69A:
undetectable		 1gtnD-5c69A:
11.00
1gtnE-5c69A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdj RUBISCO LARGE
SUBUNIT-BINDING
PROTEIN SUBUNIT
ALPHA, CHLOROPLASTIC

(Chlamydomonas
reinhardtii) 		PF00118
(Cpn60_TCP1) 		4 GLY A 192
THR A 324
THR A 331
ILE A 333
 None
 0.91A 1gtnD-5cdjA:
undetectable
1gtnE-5cdjA:
undetectable		 1gtnD-5cdjA:
16.20
1gtnE-5cdjA:
16.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 None
 0.10A 1gtnD-5eexA:
15.3
1gtnE-5eexA:
15.4		 1gtnD-5eexA:
100.00
1gtnE-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 HEAVY CHAIN
(ANTI-LID)

(Mus musculus) 		no annotation 4 SER X  28
GLY X  56
THR X  74
ILE X  52
 None
 0.92A 1gtnD-5gs0X:
undetectable
1gtnE-5gs0X:
undetectable		 1gtnD-5gs0X:
20.93
1gtnE-5gs0X:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvh ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[FMN]

(Thermotoga
maritima) 		PF03060
(NMO) 		4 THR A 194
GLY A 145
THR A 220
ILE A 147
 FMN  A 402 (-3.5A)
FMN  A 402 ( 4.3A)
None
None
 0.89A 1gtnD-5gvhA:
undetectable
1gtnE-5gvhA:
undetectable		 1gtnD-5gvhA:
12.70
1gtnE-5gvhA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4a ARGONAUTE PROTEIN

(Marinitoga
piezophila) 		no annotation 4 SER A 144
GLY A 578
THR A 546
ILE A 567
 None
 0.93A 1gtnD-5i4aA:
undetectable
1gtnE-5i4aA:
undetectable		 1gtnD-5i4aA:
7.50
1gtnE-5i4aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 SER A 817
GLY A 285
THR A 624
ILE A 283
 None
FAD  A 901 (-3.3A)
None
None
 0.85A 1gtnD-5l3dA:
undetectable
1gtnE-5l3dA:
undetectable		 1gtnD-5l3dA:
6.27
1gtnE-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLY B 390
THR B 445
THR B 406
ILE B 358
 None
 0.82A 1gtnD-5ldrB:
undetectable
1gtnE-5ldrB:
undetectable		 1gtnD-5ldrB:
8.96
1gtnE-5ldrB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgc ARCE4A

(Arthrobacter
sp. AW19M34-1) 		PF01522
(Polysacc_deac_1) 		4 SER A 179
THR A 156
THR A 145
ILE A 170
 None
 0.85A 1gtnD-5lgcA:
undetectable
1gtnE-5lgcA:
undetectable		 1gtnD-5lgcA:
17.89
1gtnE-5lgcA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 THR A 311
GLY A 317
THR A 286
THR A 285
 None
 0.88A 1gtnD-5o0sA:
undetectable
1gtnE-5o0sA:
undetectable		 1gtnD-5o0sA:
6.51
1gtnE-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.69A 1gtnD-5olpA:
undetectable
1gtnE-5olpA:
undetectable		 1gtnD-5olpA:
10.47
1gtnE-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY D  96
THR D 119
THR D 121
ILE D 123
 None
 0.85A 1gtnD-5tpzD:
undetectable
1gtnE-5tpzD:
undetectable		 1gtnD-5tpzD:
11.46
1gtnE-5tpzD:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6f LPXTG-MOTIF CELL
WALL ANCHOR DOMAIN
PROTEIN

(Mobiluncus
mulieris) 		no annotation 4 THR A  20
GLY A 225
THR A 278
ILE A 269
 None
 0.85A 1gtnD-5u6fA:
1.4
1gtnE-5u6fA:
1.9		 1gtnD-5u6fA:
undetectable
1gtnE-5u6fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 SER A 358
GLY A  44
THR A 129
ILE A  42
 None
 0.89A 1gtnD-5um6A:
undetectable
1gtnE-5um6A:
undetectable		 1gtnD-5um6A:
5.27
1gtnE-5um6A:
5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 4 SER A 345
THR A 314
THR A 264
ILE A 333
 None
 0.90A 1gtnD-5vhaA:
undetectable
1gtnE-5vhaA:
undetectable		 1gtnD-5vhaA:
undetectable
1gtnE-5vhaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		4 GLY A1237
THR A 930
THR A1156
ILE A1239
 None
 0.87A 1gtnD-5wvrA:
undetectable
1gtnE-5wvrA:
undetectable		 1gtnD-5wvrA:
11.11
1gtnE-5wvrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 4 GLY A 297
THR A 238
THR A 294
ILE A 299
 None
 0.84A 1gtnD-5yg7A:
undetectable
1gtnE-5yg7A:
undetectable		 1gtnD-5yg7A:
undetectable
1gtnE-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpe TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE

(Thermotoga
maritima) 		no annotation 4 GLY B  89
THR B  13
THR B   8
ILE B   6
 None
 0.73A 1gtnD-6fpeB:
undetectable
1gtnE-6fpeB:
undetectable		 1gtnD-6fpeB:
undetectable
1gtnE-6fpeB:
undetectable