SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_D_TRPD81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 VAL B1695
GLY B1735
THR B1761
ILE B1736
 None
 0.88A 1gtnC-1a9xB:
undetectable
1gtnD-1a9xB:
undetectable		 1gtnC-1a9xB:
10.94
1gtnD-1a9xB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A 150
GLY A 148
THR A 200
ILE A 203
 None
 0.46A 1gtnC-1cqjA:
undetectable
1gtnD-1cqjA:
undetectable		 1gtnC-1cqjA:
13.79
1gtnD-1cqjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 VAL A 684
GLY A 653
THR A 640
ILE A 682
 None
B12  A 800 ( 3.9A)
None
None
 0.82A 1gtnC-1e1cA:
undetectable
1gtnD-1e1cA:
undetectable		 1gtnC-1e1cA:
8.54
1gtnD-1e1cA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 SER A 137
GLY A 194
THR A 356
ILE A 197
 None
SF4  A 582 (-3.9A)
None
None
 0.81A 1gtnC-1fehA:
undetectable
1gtnD-1fehA:
undetectable		 1gtnC-1fehA:
9.41
1gtnD-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fez PHOSPHONOACETALDEHYD
E HYDROLASE

(Bacillus cereus) 		PF13419
(HAD_2) 		4 VAL A 202
GLY A 185
THR A  17
THR A  16
 None
 0.80A 1gtnC-1fezA:
undetectable
1gtnD-1fezA:
undetectable		 1gtnC-1fezA:
13.28
1gtnD-1fezA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.64A 1gtnC-1flgA:
0.0
1gtnD-1flgA:
0.0		 1gtnC-1flgA:
8.63
1gtnD-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixp PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Escherichia
coli) 		PF03740
(PdxJ) 		4 VAL A   8
GLY A  41
THR A  67
ILE A  42
 None
 0.68A 1gtnC-1ixpA:
undetectable
1gtnD-1ixpA:
undetectable		 1gtnC-1ixpA:
14.46
1gtnD-1ixpA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		4 SER P  85
VAL P 180
GLY P 182
ILE P 212
 None
 0.74A 1gtnC-1jcmP:
undetectable
1gtnD-1jcmP:
undetectable		 1gtnC-1jcmP:
15.06
1gtnD-1jcmP:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 VAL A 191
GLY A 193
THR A 196
ILE A 213
 None
 0.54A 1gtnC-1k32A:
0.0
1gtnD-1k32A:
0.0		 1gtnC-1k32A:
6.03
1gtnD-1k32A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 SER A 367
VAL A 383
GLY A 358
THR A 332
 None
 0.79A 1gtnC-1kczA:
undetectable
1gtnD-1kczA:
undetectable		 1gtnC-1kczA:
11.62
1gtnD-1kczA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 245
GLY A 412
THR A 417
ILE A 479
 TRA  A 866 (-2.6A)
None
TRA  A 866 (-4.0A)
None
 0.80A 1gtnC-1l5jA:
undetectable
1gtnD-1l5jA:
undetectable		 1gtnC-1l5jA:
7.07
1gtnD-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lar PROTEIN (LAR)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 THR A1461
GLY A1676
THR A1847
ILE A1828
 None
 0.88A 1gtnC-1larA:
undetectable
1gtnD-1larA:
undetectable		 1gtnC-1larA:
9.07
1gtnD-1larA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PO4  A 655 (-3.6A)
None
None
 0.85A 1gtnC-1lw3A:
undetectable
1gtnD-1lw3A:
undetectable		 1gtnC-1lw3A:
7.46
1gtnD-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 180
VAL A 150
GLY A  30
ILE A  34
 None
None
EPU  A 598 (-3.2A)
None
 0.84A 1gtnC-1p31A:
undetectable
1gtnD-1p31A:
undetectable		 1gtnC-1p31A:
9.66
1gtnD-1p31A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 SER A 282
VAL A 245
GLY A 273
ILE A 274
 None
 0.81A 1gtnC-1pe9A:
undetectable
1gtnD-1pe9A:
undetectable		 1gtnC-1pe9A:
10.96
1gtnD-1pe9A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		4 VAL A 166
GLY A 168
THR A  43
ILE A   6
 None
 0.87A 1gtnC-1phpA:
undetectable
1gtnD-1phpA:
undetectable		 1gtnC-1phpA:
11.62
1gtnD-1phpA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		4 SER A  85
VAL A 180
GLY A 182
ILE A 212
 None
 0.74A 1gtnC-1piiA:
undetectable
1gtnD-1piiA:
undetectable		 1gtnC-1piiA:
9.61
1gtnD-1piiA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 186
GLY A 184
THR A 243
ILE A 247
 None
 0.60A 1gtnC-1q1nA:
undetectable
1gtnD-1q1nA:
undetectable		 1gtnC-1q1nA:
12.78
1gtnD-1q1nA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 SER A 241
VAL A 364
THR A 266
THR A 444
 None
 0.77A 1gtnC-1qonA:
undetectable
1gtnD-1qonA:
undetectable		 1gtnC-1qonA:
8.78
1gtnD-1qonA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvv RIBOFLAVIN SYNTHASE

(Bacillus
subtilis) 		no annotation 4 VAL A  18
GLY A  16
THR A  69
ILE A  75
 None
 0.81A 1gtnC-1rvvA:
undetectable
1gtnD-1rvvA:
undetectable		 1gtnC-1rvvA:
23.66
1gtnD-1rvvA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C)
PF13177
(DNA_pol3_delta2) 		4 VAL D 275
GLY D 278
THR E 315
ILE D 283
 None
 0.82A 1gtnC-1sxjD:
undetectable
1gtnD-1sxjD:
undetectable		 1gtnC-1sxjD:
14.74
1gtnD-1sxjD:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		4 THR A 149
VAL A 192
GLY A 190
ILE A 244
 None
 0.74A 1gtnC-1t47A:
undetectable
1gtnD-1t47A:
undetectable		 1gtnC-1t47A:
12.47
1gtnD-1t47A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.81A 1gtnC-1vb4A:
undetectable
1gtnD-1vb4A:
undetectable		 1gtnC-1vb4A:
14.55
1gtnD-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A

(Homo sapiens) 		PF00782
(DSPc) 		4 SER A  88
VAL A  61
THR A  97
ILE A  63
 SO4  A 211 (-2.5A)
None
None
None
 0.86A 1gtnC-1yz4A:
undetectable
1gtnD-1yz4A:
undetectable		 1gtnC-1yz4A:
18.01
1gtnD-1yz4A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.78A 1gtnC-1zsqA:
undetectable
1gtnD-1zsqA:
undetectable		 1gtnC-1zsqA:
12.02
1gtnD-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 THR A 399
GLY A 152
THR A 143
ILE A 163
 None
 0.79A 1gtnC-2ahwA:
undetectable
1gtnD-2ahwA:
undetectable		 1gtnC-2ahwA:
9.98
1gtnD-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.80A 1gtnC-2amhA:
undetectable
1gtnD-2amhA:
undetectable		 1gtnC-2amhA:
19.19
1gtnD-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 SER A 817
GLY A 285
THR A 624
ILE A 283
 None
FAD  A1001 (-3.2A)
FAD  A1001 (-4.9A)
None
 0.84A 1gtnC-2dw4A:
undetectable
1gtnD-2dw4A:
undetectable		 1gtnC-2dw4A:
8.15
1gtnD-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A 159
GLY A 157
THR A 209
ILE A 212
 None
 0.62A 1gtnC-2fpgA:
undetectable
1gtnD-2fpgA:
undetectable		 1gtnC-2fpgA:
13.53
1gtnD-2fpgA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu4 DIHYDROXYACETONE
KINASE

(Lactococcus
lactis) 		PF02733
(Dak1) 		4 VAL A 257
GLY A 259
THR A 263
ILE A 303
 None
 0.74A 1gtnC-2iu4A:
undetectable
1gtnD-2iu4A:
undetectable		 1gtnC-2iu4A:
15.17
1gtnD-2iu4A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.64A 1gtnC-2jifA:
undetectable
1gtnD-2jifA:
undetectable		 1gtnC-2jifA:
10.55
1gtnD-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 GLY X  18
THR X 127
THR X  85
ILE X  21
 None
 0.86A 1gtnC-2p4hX:
undetectable
1gtnD-2p4hX:
undetectable		 1gtnC-2p4hX:
15.70
1gtnD-2p4hX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq0 THYMIDINE KINASE

(Thermotoga
maritima) 		PF00265
(TK) 		4 VAL A 106
GLY A  79
THR A  77
ILE A 104
 None
 0.88A 1gtnC-2qq0A:
undetectable
1gtnD-2qq0A:
undetectable		 1gtnC-2qq0A:
21.98
1gtnD-2qq0A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.72A 1gtnC-2qveA:
undetectable
1gtnD-2qveA:
undetectable		 1gtnC-2qveA:
11.96
1gtnD-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.68A 1gtnC-2vq0A:
undetectable
1gtnD-2vq0A:
undetectable		 1gtnC-2vq0A:
13.28
1gtnD-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wlp COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.87A 1gtnC-2wlpA:
undetectable
1gtnD-2wlpA:
undetectable		 1gtnC-2wlpA:
15.12
1gtnD-2wlpA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y25 MYOMESIN

(Homo sapiens) 		PF07679
(I-set) 		4 SER A1462
VAL A1368
GLY A1370
THR A1482
 None
 0.76A 1gtnC-2y25A:
undetectable
1gtnD-2y25A:
undetectable		 1gtnC-2y25A:
14.05
1gtnD-2y25A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yue PROTEIN NEURALIZED

(Drosophila
melanogaster) 		PF07177
(Neuralized) 		4 VAL A 122
GLY A 120
THR A 140
ILE A 138
 None
 0.87A 1gtnC-2yueA:
undetectable
1gtnD-2yueA:
undetectable		 1gtnC-2yueA:
16.67
1gtnD-2yueA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 THR A 424
VAL A 205
GLY A 207
ILE A 233
 None
 0.59A 1gtnC-3a1iA:
undetectable
1gtnD-3a1iA:
undetectable		 1gtnC-3a1iA:
10.57
1gtnD-3a1iA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		4 THR A 388
VAL A 175
GLY A 177
ILE A 203
 None
 0.79A 1gtnC-3al0A:
undetectable
1gtnD-3al0A:
undetectable		 1gtnC-3al0A:
9.89
1gtnD-3al0A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddh PUTATIVE HALOACID
DEHALOGENASE-LIKE
FAMILY HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13419
(HAD_2) 		4 VAL A 196
GLY A 178
THR A  15
ILE A 198
 None
 0.68A 1gtnC-3ddhA:
undetectable
1gtnD-3ddhA:
undetectable		 1gtnC-3ddhA:
14.68
1gtnD-3ddhA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A 387
GLY A 385
THR A 381
ILE A 332
 None
 0.75A 1gtnC-3dhvA:
undetectable
1gtnD-3dhvA:
undetectable		 1gtnC-3dhvA:
9.22
1gtnD-3dhvA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evt PHOSPHOGLYCERATE
DEHYDROGENASE

(Lactobacillus
plantarum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 163
GLY A 165
THR A 145
ILE A 142
 None
 0.80A 1gtnC-3evtA:
undetectable
1gtnD-3evtA:
undetectable		 1gtnC-3evtA:
13.23
1gtnD-3evtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF03740
(PdxJ) 		4 VAL A   8
GLY A  41
THR A  67
ILE A  42
 None
 0.66A 1gtnC-3f4nA:
undetectable
1gtnD-3f4nA:
undetectable		 1gtnC-3f4nA:
13.58
1gtnD-3f4nA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4f 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Bacillus
thuringiensis) 		PF13561
(adh_short_C2) 		4 VAL A 161
GLY A 170
THR A 272
ILE A 172
 None
 0.86A 1gtnC-3i4fA:
undetectable
1gtnD-3i4fA:
undetectable		 1gtnC-3i4fA:
13.41
1gtnD-3i4fA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 THR F 333
GLY F 366
THR F 364
ILE F 401
 None
 0.78A 1gtnC-3jbrF:
undetectable
1gtnD-3jbrF:
undetectable		 1gtnC-3jbrF:
5.20
1gtnD-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt9 APRATAXIN

(Homo sapiens) 		PF00498
(FHA) 		4 VAL A  45
GLY A  28
THR A  33
ILE A  27
 None
 0.75A 1gtnC-3kt9A:
1.8
1gtnD-3kt9A:
2.0		 1gtnC-3kt9A:
24.04
1gtnD-3kt9A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 VAL A 252
GLY A 181
THR A  50
ILE A 250
 None
 0.76A 1gtnC-3n23A:
undetectable
1gtnD-3n23A:
undetectable		 1gtnC-3n23A:
6.15
1gtnD-3n23A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.79A 1gtnC-3or2B:
undetectable
1gtnD-3or2B:
undetectable		 1gtnC-3or2B:
11.35
1gtnD-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 VAL A  48
GLY A  24
THR A  20
ILE A  22
 None
 0.69A 1gtnC-3q8nA:
undetectable
1gtnD-3q8nA:
undetectable		 1gtnC-3q8nA:
9.98
1gtnD-3q8nA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 VAL A  82
GLY A  84
THR A 119
ILE A  86
 None
 0.86A 1gtnC-3qbdA:
undetectable
1gtnD-3qbdA:
undetectable		 1gtnC-3qbdA:
14.20
1gtnD-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4t 4-AMINOBUTYRATE
AMINOTRANSFERASE
GABT

(Mycobacterium
marinum) 		PF00202
(Aminotran_3) 		4 VAL A  40
GLY A  16
THR A  12
ILE A  14
 None
 0.56A 1gtnC-3r4tA:
undetectable
1gtnD-3r4tA:
undetectable		 1gtnC-3r4tA:
10.89
1gtnD-3r4tA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		4 VAL A 108
GLY A  83
THR A  79
ILE A 106
 None
 0.85A 1gtnC-3rotA:
undetectable
1gtnD-3rotA:
undetectable		 1gtnC-3rotA:
13.47
1gtnD-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		4 SER A  90
VAL A 185
GLY A 187
ILE A 217
 None
 0.87A 1gtnC-3t44A:
undetectable
1gtnD-3t44A:
undetectable		 1gtnC-3t44A:
16.36
1gtnD-3t44A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.60A 1gtnC-3t63M:
undetectable
1gtnD-3t63M:
undetectable		 1gtnC-3t63M:
12.18
1gtnD-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 155
GLY A 149
THR A 273
ILE A 271
 None
 0.81A 1gtnC-3urhA:
undetectable
1gtnD-3urhA:
undetectable		 1gtnC-3urhA:
11.51
1gtnD-3urhA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 THR A 358
VAL A 283
GLY A 287
ILE A 232
 None
 0.87A 1gtnC-3vtrA:
undetectable
1gtnD-3vtrA:
undetectable		 1gtnC-3vtrA:
9.33
1gtnD-3vtrA:
9.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 VAL A  21
GLY A  23
THR A  49
THR A  52
ILE A  55
 None
TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.27A 1gtnC-3zteA:
14.5
1gtnD-3zteA:
15.4		 1gtnC-3zteA:
78.21
1gtnD-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 VAL A  21
GLY A  23
THR A  49
THR A  52
 None
TRP  A  81 (-3.5A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.27A 1gtnC-3zzlA:
13.2
1gtnD-3zzlA:
13.2		 1gtnC-3zzlA:
71.43
1gtnD-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 VAL A  21
GLY A  23
THR A  49
THR A  52
ILE A  55
 None
TRP  A  81 (-3.4A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.27A 1gtnC-3zzqA:
13.7
1gtnD-3zzqA:
13.7		 1gtnC-3zzqA:
80.00
1gtnD-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 VAL A  21
GLY A  23
THR A  49
THR A  52
ILE A  55
 None
TRP  A1072 (-3.5A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.22A 1gtnC-3zzsA:
13.7
1gtnD-3zzsA:
13.6		 1gtnC-3zzsA:
100.00
1gtnD-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 THR A 248
VAL A 103
GLY A 101
ILE A  13
 None
 0.73A 1gtnC-3zzuA:
undetectable
1gtnD-3zzuA:
undetectable		 1gtnC-3zzuA:
7.11
1gtnD-3zzuA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		4 SER A 183
VAL A  60
THR A  11
ILE A  13
 None
 0.63A 1gtnC-4a2bA:
undetectable
1gtnD-4a2bA:
undetectable		 1gtnC-4a2bA:
12.47
1gtnD-4a2bA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auo INTERSTITIAL
COLLAGENASE

(Homo sapiens) 		PF00045
(Hemopexin)
PF00413
(Peptidase_M10) 		4 SER A 299
GLY A 214
THR A 222
ILE A 213
 None
 0.84A 1gtnC-4auoA:
undetectable
1gtnD-4auoA:
undetectable		 1gtnC-4auoA:
14.14
1gtnD-4auoA:
14.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 VAL A  21
GLY A  23
THR A  49
THR A  52
ILE A  55
 VAL  A  21 ( 0.6A)
GLY  A  23 (-0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.30A 1gtnC-4b27A:
13.2
1gtnD-4b27A:
13.2		 1gtnC-4b27A:
76.32
1gtnD-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 THR A 395
GLY A 400
THR A 499
THR A 449
 EDO  A1590 (-4.9A)
None
None
None
 0.81A 1gtnC-4c22A:
undetectable
1gtnD-4c22A:
undetectable		 1gtnC-4c22A:
8.11
1gtnD-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 VAL A  91
GLY A  67
THR A  29
ILE A  68
 None
 0.64A 1gtnC-4c7gA:
undetectable
1gtnD-4c7gA:
undetectable		 1gtnC-4c7gA:
9.09
1gtnD-4c7gA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 THR A 524
VAL A 457
GLY A 459
ILE A 468
 None
 0.80A 1gtnC-4cxkA:
undetectable
1gtnD-4cxkA:
undetectable		 1gtnC-4cxkA:
8.66
1gtnD-4cxkA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 4 VAL A  46
GLY A  44
THR A  85
ILE A  62
 None
 0.80A 1gtnC-4d0kA:
undetectable
1gtnD-4d0kA:
undetectable		 1gtnC-4d0kA:
10.50
1gtnD-4d0kA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 THR A 256
VAL A 110
GLY A 108
ILE A  13
 None
 0.70A 1gtnC-4fn5A:
undetectable
1gtnD-4fn5A:
1.0		 1gtnC-4fn5A:
7.39
1gtnD-4fn5A:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz2 TRNA INTRON
ENDONUCLEASE

(Candidatus
Micrarchaeum
acidiphilum) 		PF01974
(tRNA_int_endo) 		4 VAL A 126
GLY A 128
THR A 137
ILE A 139
 None
 0.61A 1gtnC-4fz2A:
undetectable
1gtnD-4fz2A:
undetectable		 1gtnC-4fz2A:
13.04
1gtnD-4fz2A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdj NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 262
GLY A 260
THR A 190
ILE A 205
 None
 0.65A 1gtnC-4gdjA:
undetectable
1gtnD-4gdjA:
undetectable		 1gtnC-4gdjA:
13.38
1gtnD-4gdjA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		4 VAL A 185
THR A 135
THR A 107
ILE A 105
 None
 0.86A 1gtnC-4ha7A:
undetectable
1gtnD-4ha7A:
undetectable		 1gtnC-4ha7A:
15.58
1gtnD-4ha7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 SER A 811
GLY A 389
THR A 626
ILE A 387
 None
FAD  A 901 (-3.3A)
None
None
 0.85A 1gtnC-4hsuA:
undetectable
1gtnD-4hsuA:
undetectable		 1gtnC-4hsuA:
7.64
1gtnD-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4i 6-PHOSPHOFRUCTOKINAS
E

(Geobacillus
stearothermophilus) 		PF00365
(PFK) 		4 THR A 238
VAL A 201
THR A 163
ILE A 218
 None
 0.85A 1gtnC-4i4iA:
undetectable
1gtnD-4i4iA:
undetectable		 1gtnC-4i4iA:
14.52
1gtnD-4i4iA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 THR B 169
GLY B 191
THR B 339
ILE B 194
 None
 0.82A 1gtnC-4i6mB:
undetectable
1gtnD-4i6mB:
undetectable		 1gtnC-4i6mB:
11.93
1gtnD-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo3 COAGULATION FACTOR
VIII

(Sus scrofa) 		PF00754
(F5_F8_type_C) 		4 SER M2264
VAL M2323
GLY M2242
ILE M2243
 None
 0.86A 1gtnC-4mo3M:
undetectable
1gtnD-4mo3M:
1.3		 1gtnC-4mo3M:
15.34
1gtnD-4mo3M:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 VAL A 232
GLY A 230
THR A 280
ILE A 277
 None
 0.74A 1gtnC-4p22A:
undetectable
1gtnD-4p22A:
undetectable		 1gtnC-4p22A:
10.23
1gtnD-4p22A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 SER A1035
VAL A1107
GLY A1085
ILE A1100
 None
 0.79A 1gtnC-4tsmA:
undetectable
1gtnD-4tsmA:
undetectable		 1gtnC-4tsmA:
10.40
1gtnD-4tsmA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmr PUTATIVE
METHYL-ACCEPTING
CHEMOTAXIS SIGNAL
TRANSDUCTION PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		4 VAL A 192
GLY A 194
THR A 164
THR A 178
 None
 0.82A 1gtnC-4xmrA:
undetectable
1gtnD-4xmrA:
undetectable		 1gtnC-4xmrA:
13.78
1gtnD-4xmrA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5z IMMUNOGLOBULIN
G-BINDING PROTEIN
A,COAT PROTEIN

(Staphylococcus
aureus;
Sesbania mosaic
virus) 		no annotation 4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.83A 1gtnC-4y5zA:
undetectable
1gtnD-4y5zA:
undetectable		 1gtnC-4y5zA:
11.62
1gtnD-4y5zA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 292
GLY A 441
THR A 449
THR A 445
 None
PO4  A 701 (-3.5A)
None
None
 0.74A 1gtnC-5c16A:
undetectable
1gtnD-5c16A:
undetectable		 1gtnC-5c16A:
8.93
1gtnD-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c69 FUSION GLYCOPROTEIN
F0,FIBRITIN

(Enterobacteria
phage Ox2;
Human
orthopneumovirus) 		PF00523
(Fusion_gly) 		4 SER A 323
GLY A 280
THR A 342
THR A  50
 None
 0.79A 1gtnC-5c69A:
0.8
1gtnD-5c69A:
undetectable		 1gtnC-5c69A:
11.00
1gtnD-5c69A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlc PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF03740
(PdxJ) 		4 VAL A  19
GLY A  52
THR A  78
ILE A  53
 None
 0.65A 1gtnC-5dlcA:
undetectable
1gtnD-5dlcA:
undetectable		 1gtnC-5dlcA:
13.67
1gtnD-5dlcA:
13.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 VAL A  21
GLY A  23
THR A  49
THR A  52
ILE A  55
 None
 0.19A 1gtnC-5eexA:
15.6
1gtnD-5eexA:
15.3		 1gtnC-5eexA:
100.00
1gtnD-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 VAL A  58
GLY A  82
THR A 227
ILE A  63
 None
 0.82A 1gtnC-5fg3A:
undetectable
1gtnD-5fg3A:
undetectable		 1gtnC-5fg3A:
8.60
1gtnD-5fg3A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		4 THR A 281
VAL A 353
GLY A 349
ILE A 364
 None
 0.79A 1gtnC-5hy4A:
undetectable
1gtnD-5hy4A:
undetectable		 1gtnC-5hy4A:
11.22
1gtnD-5hy4A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 SER A 817
GLY A 285
THR A 624
ILE A 283
 None
FAD  A 901 (-3.3A)
None
None
 0.86A 1gtnC-5l3dA:
undetectable
1gtnD-5l3dA:
undetectable		 1gtnC-5l3dA:
6.27
1gtnD-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc2 PROTEIN FAM3C

(Homo sapiens) 		PF15711
(ILEI) 		4 SER A 170
VAL A 106
GLY A 148
ILE A 104
 None
 0.85A 1gtnC-5lc2A:
undetectable
1gtnD-5lc2A:
undetectable		 1gtnC-5lc2A:
18.54
1gtnD-5lc2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLY B 390
THR B 445
THR B 406
ILE B 358
 None
 0.79A 1gtnC-5ldrB:
undetectable
1gtnD-5ldrB:
undetectable		 1gtnC-5ldrB:
8.96
1gtnD-5ldrB:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.74A 1gtnC-5olpA:
undetectable
1gtnD-5olpA:
undetectable		 1gtnC-5olpA:
10.47
1gtnD-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbx COLD-INDUCIBLE
RNA-BINDING PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 SER A  22
VAL A  80
GLY A  12
THR A  18
ILE A  78
 None
 1.28A 1gtnC-5tbxA:
undetectable
1gtnD-5tbxA:
undetectable		 1gtnC-5tbxA:
20.00
1gtnD-5tbxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 THR A 256
VAL A 110
GLY A 108
ILE A  13
 None
 0.71A 1gtnC-5tv2A:
undetectable
1gtnD-5tv2A:
undetectable		 1gtnC-5tv2A:
11.89
1gtnD-5tv2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		4 SER A 384
VAL A 317
GLY A 312
ILE A 313
 None
 0.82A 1gtnC-5u4oA:
undetectable
1gtnD-5u4oA:
undetectable		 1gtnC-5u4oA:
13.65
1gtnD-5u4oA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u77 OXYSTEROL-BINDING
PROTEIN-RELATED
PROTEIN 8

(Homo sapiens) 		no annotation 4 VAL A  51
GLY A  49
THR A  95
ILE A  38
 None
NDB  A 201 ( 4.6A)
None
None
 0.85A 1gtnC-5u77A:
undetectable
1gtnD-5u77A:
undetectable		 1gtnC-5u77A:
19.67
1gtnD-5u77A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 VAL B2555
GLY B2557
THR B2584
ILE B2563
 None
 0.62A 1gtnC-5v4bB:
undetectable
1gtnD-5v4bB:
undetectable		 1gtnC-5v4bB:
10.96
1gtnD-5v4bB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 SER A 845
VAL A 863
GLY A 766
ILE A 861
 None
 0.87A 1gtnC-5wvgA:
undetectable
1gtnD-5wvgA:
undetectable		 1gtnC-5wvgA:
undetectable
1gtnD-5wvgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt0 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		no annotation 4 VAL A  58
GLY A  82
THR A 227
ILE A  63
 None
 0.80A 1gtnC-5yt0A:
undetectable
1gtnD-5yt0A:
undetectable		 1gtnC-5yt0A:
undetectable
1gtnD-5yt0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 SER A 323
VAL A 190
GLY A 192
ILE A 236
 None
 0.84A 1gtnC-6eslA:
undetectable
1gtnD-6eslA:
undetectable		 1gtnC-6eslA:
undetectable
1gtnD-6eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g5i RNA-BINDING PROTEIN
PNO1

(Homo sapiens) 		no annotation 4 VAL x 209
THR x 198
THR x 200
ILE x 202
 None
 0.85A 1gtnC-6g5ix:
undetectable
1gtnD-6g5ix:
undetectable		 1gtnC-6g5ix:
undetectable
1gtnD-6g5ix:
undetectable