SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_B_TRPB81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajk CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A  58
ALA A 213
THR A  32
ILE A   4
 None
 0.79A 1gtnA-1ajkA:
0.1
1gtnB-1ajkA:
0.0		 1gtnA-1ajkA:
16.82
1gtnB-1ajkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A  15
ALA A 170
THR A 203
ILE A 175
 None
 0.76A 1gtnA-1ajoA:
0.0
1gtnB-1ajoA:
0.7		 1gtnA-1ajoA:
18.54
1gtnB-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.74A 1gtnA-1axkA:
0.9
1gtnB-1axkA:
2.1		 1gtnA-1axkA:
11.17
1gtnB-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 THR A  82
GLY A 118
ALA A  25
THR A 125
 None
 0.72A 1gtnA-1c3xA:
0.0
1gtnB-1c3xA:
undetectable		 1gtnA-1c3xA:
14.98
1gtnB-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A  83
ALA A  24
THR A  57
ILE A  29
 None
 0.76A 1gtnA-1cpnA:
2.1
1gtnB-1cpnA:
1.2		 1gtnA-1cpnA:
15.35
1gtnB-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		4 THR A 154
GLY A  65
HIS A 146
ILE A  67
 None
None
None
RNS  A1462 (-4.0A)
 0.75A 1gtnA-1de6A:
undetectable
1gtnB-1de6A:
0.0		 1gtnA-1de6A:
11.89
1gtnB-1de6A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.72A 1gtnA-1f26A:
0.0
1gtnB-1f26A:
0.0		 1gtnA-1f26A:
11.72
1gtnB-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 SER A 137
GLY A 194
THR A 356
ILE A 197
 None
SF4  A 582 (-3.9A)
None
None
 0.81A 1gtnA-1fehA:
undetectable
1gtnB-1fehA:
0.0		 1gtnA-1fehA:
9.41
1gtnB-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.63A 1gtnA-1flgA:
0.0
1gtnB-1flgA:
0.0		 1gtnA-1flgA:
8.63
1gtnB-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 THR A  82
ALA A 131
HIS A  77
ILE A 138
 None
 0.80A 1gtnA-1gw1A:
undetectable
1gtnB-1gw1A:
undetectable		 1gtnA-1gw1A:
14.09
1gtnB-1gw1A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3q SEDLIN

(Mus musculus) 		PF04628
(Sedlin_N) 		4 GLY A  11
THR A  77
HIS A  80
ILE A   9
 None
 0.80A 1gtnA-1h3qA:
undetectable
1gtnB-1h3qA:
undetectable		 1gtnA-1h3qA:
19.12
1gtnB-1h3qA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 THR A 428
GLY A  11
ALA A  20
ILE A  33
 None
FAD  A 579 (-3.1A)
None
None
 0.81A 1gtnA-1h81A:
undetectable
1gtnB-1h81A:
undetectable		 1gtnA-1h81A:
9.76
1gtnB-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 SER A 245
GLY A 412
THR A 417
ILE A 479
 TRA  A 866 (-2.6A)
None
TRA  A 866 (-4.0A)
None
 0.78A 1gtnA-1l5jA:
undetectable
1gtnB-1l5jA:
undetectable		 1gtnA-1l5jA:
7.07
1gtnB-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 THR A 417
SER A 245
GLY A 412
ALA A 510
THR A 500
 TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
None
None
None
 1.19A 1gtnA-1l5jA:
undetectable
1gtnB-1l5jA:
undetectable		 1gtnA-1l5jA:
7.07
1gtnB-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 SER A 315
GLY A 307
ALA A 313
ILE A 309
 None
 0.70A 1gtnA-1l8wA:
undetectable
1gtnB-1l8wA:
undetectable		 1gtnA-1l8wA:
11.14
1gtnB-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 THR A 591
THR A 688
HIS A 652
THR A 655
ILE A 679
 None
 1.34A 1gtnA-1lzxA:
undetectable
1gtnB-1lzxA:
undetectable		 1gtnA-1lzxA:
10.02
1gtnB-1lzxA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		5 THR A 360
THR A 457
HIS A 421
THR A 424
ILE A 448
 None
 1.33A 1gtnA-1m9qA:
undetectable
1gtnB-1m9qA:
undetectable		 1gtnA-1m9qA:
9.88
1gtnB-1m9qA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 SER A 139
ALA A  80
THR A 113
ILE A  85
 None
 0.79A 1gtnA-1macA:
undetectable
1gtnB-1macA:
undetectable		 1gtnA-1macA:
17.79
1gtnB-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.32A 1gtnA-1mioB:
undetectable
1gtnB-1mioB:
undetectable		 1gtnA-1mioB:
9.76
1gtnB-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		5 SER A 121
GLY A 116
ALA A 262
THR A 123
ILE A 102
 None
MG  A 401 (-3.8A)
None
None
None
 1.28A 1gtnA-1n0wA:
undetectable
1gtnB-1n0wA:
undetectable		 1gtnA-1n0wA:
14.40
1gtnB-1n0wA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsh CALGIZZARIN

(Oryctolagus
cuniculus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 SER A   1
THR A   4
THR A   6
ILE A  10
 None
 0.81A 1gtnA-1nshA:
undetectable
1gtnB-1nshA:
undetectable		 1gtnA-1nshA:
22.86
1gtnB-1nshA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B  33
ALA B  24
THR B  52
ILE B  34
 None
 0.76A 1gtnA-1ob1B:
undetectable
1gtnB-1ob1B:
undetectable		 1gtnA-1ob1B:
12.50
1gtnB-1ob1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 THR Q 376
GLY Q 105
ALA Q  96
THR Q  99
 None
 0.80A 1gtnA-1oh2Q:
undetectable
1gtnB-1oh2Q:
undetectable		 1gtnA-1oh2Q:
12.04
1gtnB-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
 None
 1.41A 1gtnA-1ps9A:
undetectable
1gtnB-1ps9A:
undetectable		 1gtnA-1ps9A:
8.10
1gtnB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1gtnA-1ptjA:
undetectable
1gtnB-1ptjA:
undetectable		 1gtnA-1ptjA:
13.14
1gtnB-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 THR A 287
GLY A 152
ALA A 174
THR A 273
ILE A 167
 None
 1.05A 1gtnA-1q8fA:
undetectable
1gtnB-1q8fA:
undetectable		 1gtnA-1q8fA:
13.50
1gtnB-1q8fA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 THR A 312
GLY A  10
ALA A  23
ILE A  36
 None
 0.81A 1gtnA-1qmhA:
undetectable
1gtnB-1qmhA:
undetectable		 1gtnA-1qmhA:
15.23
1gtnB-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 THR A  87
GLY A  54
ALA A  80
ILE A  58
 None
 0.81A 1gtnA-1t5oA:
undetectable
1gtnB-1t5oA:
undetectable		 1gtnA-1t5oA:
13.33
1gtnB-1t5oA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v1p EXOTOXIN 1

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 SER A 198
GLY A 203
THR A 112
THR A 114
ILE A 204
 None
 1.49A 1gtnA-1v1pA:
undetectable
1gtnB-1v1pA:
undetectable		 1gtnA-1v1pA:
19.02
1gtnB-1v1pA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 THR A  40
GLY A 188
ALA A 196
THR A  49
THR A 183
 None
 1.16A 1gtnA-1v9cA:
undetectable
1gtnB-1v9cA:
undetectable		 1gtnA-1v9cA:
19.25
1gtnB-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb4 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.80A 1gtnA-1vb4A:
undetectable
1gtnB-1vb4A:
undetectable		 1gtnA-1vb4A:
14.55
1gtnB-1vb4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpx PROTEIN
(TRANSALDOLASE (EC
2.2.1.2))

(Thermotoga
maritima) 		PF00923
(TAL_FSA) 		5 SER A  98
GLY A  90
ALA A 121
THR A 104
ILE A  91
 None
 1.37A 1gtnA-1vpxA:
undetectable
1gtnB-1vpxA:
undetectable		 1gtnA-1vpxA:
18.53
1gtnB-1vpxA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 GLY A 296
ALA A 197
HIS A 194
ILE A 291
 None
 0.62A 1gtnA-1wd3A:
undetectable
1gtnB-1wd3A:
undetectable		 1gtnA-1wd3A:
9.13
1gtnB-1wd3A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.62A 1gtnA-1wkmA:
undetectable
1gtnB-1wkmA:
undetectable		 1gtnA-1wkmA:
15.29
1gtnB-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 GLY A 109
ALA A  54
THR A  14
ILE A   7
 None
 0.71A 1gtnA-1x9jA:
undetectable
1gtnB-1x9jA:
undetectable		 1gtnA-1x9jA:
13.28
1gtnB-1x9jA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A  14
ALA A  22
THR A  81
ILE A  12
 None
 0.79A 1gtnA-1y6jA:
undetectable
1gtnB-1y6jA:
undetectable		 1gtnA-1y6jA:
15.48
1gtnB-1y6jA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 SER A 495
ALA A  23
HIS A 480
THR A 252
ILE A  13
 None
None
None
FAD  A 803 (-4.6A)
None
 1.28A 1gtnA-1yy5A:
undetectable
1gtnB-1yy5A:
undetectable		 1gtnA-1yy5A:
9.73
1gtnB-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		5 SER A 495
GLY A  15
ALA A  23
THR A 252
ILE A  13
 None
FAD  A 803 (-3.2A)
None
FAD  A 803 (-4.6A)
None
 0.96A 1gtnA-1yy5A:
undetectable
1gtnB-1yy5A:
undetectable		 1gtnA-1yy5A:
9.73
1gtnB-1yy5A:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 SER A 271
GLY A 420
THR A 428
THR A 424
 None
PIB  A3632 (-3.7A)
None
None
 0.74A 1gtnA-1zsqA:
undetectable
1gtnB-1zsqA:
undetectable		 1gtnA-1zsqA:
12.02
1gtnB-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwx SPHINGOMYELINASE-C

(Listeria
ivanovii) 		PF03372
(Exo_endo_phos) 		5 GLY A 227
THR A 186
HIS A 185
THR A 184
ILE A 226
 None
 1.26A 1gtnA-1zwxA:
undetectable
1gtnB-1zwxA:
undetectable		 1gtnA-1zwxA:
13.62
1gtnB-1zwxA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 THR A 399
GLY A 152
THR A 143
ILE A 163
 None
 0.78A 1gtnA-2ahwA:
undetectable
1gtnB-2ahwA:
undetectable		 1gtnA-2ahwA:
9.98
1gtnB-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.75A 1gtnA-2amhA:
undetectable
1gtnB-2amhA:
undetectable		 1gtnA-2amhA:
19.19
1gtnB-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 THR A 189
SER A  18
ALA A  22
ILE A  67
 None
SO4  A5001 (-2.7A)
None
None
 0.76A 1gtnA-2detA:
undetectable
1gtnB-2detA:
undetectable		 1gtnA-2detA:
11.89
1gtnB-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		5 SER A 817
GLY A 285
ALA A 293
THR A 624
ILE A 283
 None
FAD  A1001 (-3.2A)
None
FAD  A1001 (-4.9A)
None
 0.88A 1gtnA-2dw4A:
undetectable
1gtnB-2dw4A:
undetectable		 1gtnA-2dw4A:
8.15
1gtnB-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 THR A 517
GLY A 546
ALA A 528
ILE A 551
 None
 0.73A 1gtnA-2e28A:
undetectable
1gtnB-2e28A:
undetectable		 1gtnA-2e28A:
9.86
1gtnB-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 319
GLY A 182
ALA A 208
THR A 185
 None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
 0.72A 1gtnA-2eerA:
undetectable
1gtnB-2eerA:
undetectable		 1gtnA-2eerA:
13.02
1gtnB-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fff PENICILLIN-BINDING
PROTEIN 1B

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 GLY B 677
ALA B 688
THR B 417
HIS B 682
ILE B 676
 None
None
None
NI  B 901 (-2.8A)
None
 1.11A 1gtnA-2fffB:
undetectable
1gtnB-2fffB:
undetectable		 1gtnA-2fffB:
11.03
1gtnB-2fffB:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5b PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacillus
subtilis) 		PF08543
(Phos_pyr_kin) 		5 GLY A 215
ALA A 239
THR A  26
THR A 217
ILE A 243
 ADP  A 301 (-3.2A)
None
None
None
ADP  A 301 (-4.1A)
 1.28A 1gtnA-2i5bA:
undetectable
1gtnB-2i5bA:
undetectable		 1gtnA-2i5bA:
18.03
1gtnB-2i5bA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 THR A  25
GLY A 200
ALA A 208
ILE A 198
 None
 0.79A 1gtnA-2ij9A:
undetectable
1gtnB-2ij9A:
undetectable		 1gtnA-2ij9A:
17.14
1gtnB-2ij9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 THR A 148
GLY A 293
THR A 121
ILE A 295
 None
 0.66A 1gtnA-2jifA:
undetectable
1gtnB-2jifA:
undetectable		 1gtnA-2jifA:
10.55
1gtnB-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 SER A  98
GLY A  90
ALA A  96
THR A 297
ILE A  92
 None
 1.31A 1gtnA-2o56A:
undetectable
1gtnB-2o56A:
undetectable		 1gtnA-2o56A:
11.99
1gtnB-2o56A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		4 GLY A  30
ALA A  56
THR A  91
ILE A  31
 None
 0.81A 1gtnA-2p0oA:
undetectable
1gtnB-2p0oA:
undetectable		 1gtnA-2p0oA:
12.84
1gtnB-2p0oA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5u UDP-GLUCOSE
4-EPIMERASE

(Thermus
thermophilus) 		PF01370
(Epimerase) 		5 GLY A 299
ALA A 258
HIS A 306
THR A 303
ILE A 300
 None
 1.40A 1gtnA-2p5uA:
undetectable
1gtnB-2p5uA:
undetectable		 1gtnA-2p5uA:
12.68
1gtnB-2p5uA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		4 ALA A  70
THR A  77
THR A  79
ILE A  81
 None
 0.81A 1gtnA-2p97A:
undetectable
1gtnB-2p97A:
undetectable		 1gtnA-2p97A:
18.13
1gtnB-2p97A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 107
ALA A  79
THR A  42
THR A 106
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
GSP  A 401 (-3.6A)
None
 1.32A 1gtnA-2q1yA:
undetectable
1gtnB-2q1yA:
undetectable		 1gtnA-2q1yA:
12.94
1gtnB-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 ALA A 111
THR A  61
HIS A  62
THR A 124
ILE A 153
 None
None
ZN  A 501 (-3.3A)
None
None
 1.09A 1gtnA-2qt3A:
undetectable
1gtnB-2qt3A:
undetectable		 1gtnA-2qt3A:
14.29
1gtnB-2qt3A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 SER A 337
GLY A 358
THR A 207
ILE A 361
 None
 0.66A 1gtnA-2qveA:
undetectable
1gtnB-2qveA:
undetectable		 1gtnA-2qveA:
11.96
1gtnB-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 SER A  80
GLY A 175
THR A 126
ILE A 128
 None
 0.70A 1gtnA-2vq0A:
undetectable
1gtnB-2vq0A:
undetectable		 1gtnA-2vq0A:
13.28
1gtnB-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 ALA A 368
THR A   4
THR A  50
ILE A 385
 None
 0.75A 1gtnA-2vunA:
undetectable
1gtnB-2vunA:
undetectable		 1gtnA-2vunA:
12.90
1gtnB-2vunA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.77A 1gtnA-2wghA:
undetectable
1gtnB-2wghA:
undetectable		 1gtnA-2wghA:
8.38
1gtnB-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 SER A 402
GLY A 435
ALA A 407
THR A 442
THR A 439
 None
ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
 1.20A 1gtnA-2xzlA:
undetectable
1gtnB-2xzlA:
undetectable		 1gtnA-2xzlA:
7.24
1gtnB-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yik ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9) 		4 SER A 225
GLY A 124
ALA A 221
ILE A 218
 None
 0.77A 1gtnA-2yikA:
undetectable
1gtnB-2yikA:
undetectable		 1gtnA-2yikA:
8.51
1gtnB-2yikA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 SER A  62
ALA A  60
HIS A  83
THR A  84
 None
 0.81A 1gtnA-2yk0A:
undetectable
1gtnB-2yk0A:
undetectable		 1gtnA-2yk0A:
6.32
1gtnB-2yk0A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 THR A 112
SER A  74
GLY A 166
THR A 178
THR A 179
 NAD  A3001 ( 4.5A)
None
NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
 1.38A 1gtnA-3a1nA:
undetectable
1gtnB-3a1nA:
undetectable		 1gtnA-3a1nA:
13.02
1gtnB-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		5 SER A 411
GLY A 417
ALA A 408
THR A 436
ILE A 434
 None
 1.29A 1gtnA-3b4wA:
undetectable
1gtnB-3b4wA:
undetectable		 1gtnA-3b4wA:
10.29
1gtnB-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 THR A 295
GLY A 166
ALA A 194
THR A 284
ILE A 187
 None
 1.01A 1gtnA-3b9gA:
undetectable
1gtnB-3b9gA:
undetectable		 1gtnA-3b9gA:
13.11
1gtnB-3b9gA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 SER A 191
ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.93A 1gtnA-3cb5A:
undetectable
1gtnB-3cb5A:
undetectable		 1gtnA-3cb5A:
9.95
1gtnB-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 110
HIS A 134
THR A 135
ILE A 164
 None
 0.72A 1gtnA-3cq5A:
undetectable
1gtnB-3cq5A:
undetectable		 1gtnA-3cq5A:
13.50
1gtnB-3cq5A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e03 SHORT CHAIN
DEHYDROGENASE

(Xanthomonas
campestris) 		PF13561
(adh_short_C2) 		5 SER A 126
ALA A 130
THR A 147
THR A 176
ILE A 190
 None
 1.48A 1gtnA-3e03A:
undetectable
1gtnB-3e03A:
undetectable		 1gtnA-3e03A:
15.33
1gtnB-3e03A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee4 PROBABLE
RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		5 THR A 173
GLY A 270
ALA A 238
THR A 267
ILE A 235
 MYR  A 315 ( 4.9A)
None
None
None
None
 1.41A 1gtnA-3ee4A:
undetectable
1gtnB-3ee4A:
undetectable		 1gtnA-3ee4A:
12.95
1gtnB-3ee4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 SER A 214
GLY A 208
ALA A 212
THR A 239
HIS A 204
 None
 1.36A 1gtnA-3eegA:
undetectable
1gtnB-3eegA:
undetectable		 1gtnA-3eegA:
17.23
1gtnB-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 SER A 385
ALA A 389
THR A 349
HIS A 348
ILE A 364
 None
None
None
MG  A   7 (-3.6A)
None
 1.39A 1gtnA-3f2bA:
undetectable
1gtnB-3f2bA:
undetectable		 1gtnA-3f2bA:
6.36
1gtnB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2b DNA-DIRECTED DNA
POLYMERASE III ALPHA
CHAIN

(Geobacillus
kaustophilus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 THR A1067
HIS A1084
THR A1083
ILE A1055
 None
 0.76A 1gtnA-3f2bA:
undetectable
1gtnB-3f2bA:
undetectable		 1gtnA-3f2bA:
6.36
1gtnB-3f2bA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.59A 1gtnA-3faoA:
undetectable
1gtnB-3faoA:
undetectable		 1gtnA-3faoA:
18.44
1gtnB-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.76A 1gtnA-3fmqA:
undetectable
1gtnB-3fmqA:
undetectable		 1gtnA-3fmqA:
13.14
1gtnB-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 SER A 277
GLY A  77
ALA A 316
THR A 234
 None
 0.78A 1gtnA-3fpzA:
undetectable
1gtnB-3fpzA:
undetectable		 1gtnA-3fpzA:
16.03
1gtnB-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 THR A 272
GLY A 184
ALA A 280
ILE A 188
 None
 0.79A 1gtnA-3fvrA:
undetectable
1gtnB-3fvrA:
undetectable		 1gtnA-3fvrA:
14.60
1gtnB-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A 173
SER A 141
THR A  56
ILE A  54
 None
None
NA  A 358 (-4.0A)
None
 0.79A 1gtnA-3h84A:
undetectable
1gtnB-3h84A:
undetectable		 1gtnA-3h84A:
12.99
1gtnB-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLY B 204
ALA B 148
HIS B 209
ILE B 203
 None
None
CU  B 686 (-3.1A)
None
 0.69A 1gtnA-3hhsB:
undetectable
1gtnB-3hhsB:
undetectable		 1gtnA-3hhsB:
8.46
1gtnB-3hhsB:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 SER A 143
ALA A  84
THR A 117
ILE A  89
 None
 0.77A 1gtnA-3i4iA:
undetectable
1gtnB-3i4iA:
undetectable		 1gtnA-3i4iA:
16.44
1gtnB-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9g SONEPCIZUMAB
ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  24
ALA H  78
HIS H  32
ILE H  51
 None
 0.77A 1gtnA-3i9gH:
undetectable
1gtnB-3i9gH:
1.3		 1gtnA-3i9gH:
12.83
1gtnB-3i9gH:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 SER A  66
GLY A 116
THR A  70
HIS A 121
 None
 0.68A 1gtnA-3ihaA:
undetectable
1gtnB-3ihaA:
undetectable		 1gtnA-3ihaA:
7.68
1gtnB-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1gtnA-3ip1A:
undetectable
1gtnB-3ip1A:
undetectable		 1gtnA-3ip1A:
11.50
1gtnB-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipw HYDROLASE TATD
FAMILY PROTEIN

(Entamoeba
histolytica) 		PF01026
(TatD_DNase) 		4 GLY A   9
ALA A 110
THR A  49
ILE A  47
 None
 0.81A 1gtnA-3ipwA:
undetectable
1gtnB-3ipwA:
undetectable		 1gtnA-3ipwA:
13.78
1gtnB-3ipwA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 THR F 333
GLY F 366
THR F 364
ILE F 401
 None
 0.76A 1gtnA-3jbrF:
undetectable
1gtnB-3jbrF:
undetectable		 1gtnA-3jbrF:
5.20
1gtnB-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 SER A 322
GLY A  86
ALA A  94
THR A 246
ILE A  84
 None
AHZ  A 500 (-3.0A)
None
None
None
 1.12A 1gtnA-3jskA:
undetectable
1gtnB-3jskA:
undetectable		 1gtnA-3jskA:
13.37
1gtnB-3jskA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k55 BETA-HEMOLYSIN

(Staphylococcus
aureus) 		PF03372
(Exo_endo_phos) 		5 GLY A 192
THR A 151
HIS A 150
THR A 149
ILE A 191
 None
 1.24A 1gtnA-3k55A:
undetectable
1gtnB-3k55A:
undetectable		 1gtnA-3k55A:
13.73
1gtnB-3k55A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		5 SER A 107
GLY A  58
ALA A 109
HIS A  85
ILE A 128
 None
 1.19A 1gtnA-3ktoA:
undetectable
1gtnB-3ktoA:
undetectable		 1gtnA-3ktoA:
18.94
1gtnB-3ktoA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d) 		5 SER A 332
GLY A 458
THR A 328
HIS A 327
ILE A 373
 None
PHE  A 509 (-3.6A)
None
None
None
 1.38A 1gtnA-3l4gA:
undetectable
1gtnB-3l4gA:
undetectable		 1gtnA-3l4gA:
9.81
1gtnB-3l4gA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3liu PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		4 GLY A  68
ALA A 122
HIS A 104
ILE A  78
 None
 0.75A 1gtnA-3liuA:
1.7
1gtnB-3liuA:
undetectable		 1gtnA-3liuA:
12.19
1gtnB-3liuA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A 466
ALA A 403
THR A 442
ILE A 467
 None
EDO  A 619 (-3.5A)
None
None
 0.80A 1gtnA-3mosA:
undetectable
1gtnB-3mosA:
undetectable		 1gtnA-3mosA:
8.81
1gtnB-3mosA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.68A 1gtnA-3myxA:
4.0
1gtnB-3myxA:
2.1		 1gtnA-3myxA:
16.88
1gtnB-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 THR A 293
GLY A  12
ALA A  21
ILE A  33
 None
FAD  A 501 (-3.2A)
None
None
 0.79A 1gtnA-3nixA:
undetectable
1gtnB-3nixA:
undetectable		 1gtnA-3nixA:
11.11
1gtnB-3nixA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 143
ALA A  82
HIS A  76
ILE A 105
 None
 0.72A 1gtnA-3o04A:
undetectable
1gtnB-3o04A:
undetectable		 1gtnA-3o04A:
12.22
1gtnB-3o04A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 THR B 145
GLY B 205
THR B 156
ILE B 281
 SF4  B 803 (-3.9A)
None
None
None
 0.76A 1gtnA-3or2B:
undetectable
1gtnB-3or2B:
undetectable		 1gtnA-3or2B:
11.35
1gtnB-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pas TETR FAMILY
TRANSCRIPTION
REGULATOR

(Marinobacter
hydrocarbonoclasticus) 		PF00440
(TetR_N)
PF16295
(TetR_C_10) 		4 SER A  73
ALA A  69
HIS A  89
ILE A  94
 None
 0.81A 1gtnA-3pasA:
undetectable
1gtnB-3pasA:
undetectable		 1gtnA-3pasA:
17.01
1gtnB-3pasA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbd 3-DEHYDROQUINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF01761
(DHQ_synthase) 		4 GLY A  94
ALA A  41
HIS A  38
ILE A  93
 None
 0.77A 1gtnA-3qbdA:
undetectable
1gtnB-3qbdA:
undetectable		 1gtnA-3qbdA:
14.20
1gtnB-3qbdA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.72A 1gtnA-3snhA:
undetectable
1gtnB-3snhA:
undetectable		 1gtnA-3snhA:
6.70
1gtnB-3snhA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.57A 1gtnA-3t63M:
undetectable
1gtnB-3t63M:
0.6		 1gtnA-3t63M:
12.18
1gtnB-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0o SELENIDE, WATER
DIKINASE

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 SER A 215
GLY A 325
ALA A 212
THR A 320
ILE A 326
 None
 1.26A 1gtnA-3u0oA:
undetectable
1gtnB-3u0oA:
undetectable		 1gtnA-3u0oA:
13.79
1gtnB-3u0oA:
13.79