SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_A_TRPA81

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajo CIRCULARLY PERMUTED
(1-3,1-4)-BETA-D-GLU
CAN
4-GLUCANOHYDROLASE
CPA16M-127

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A 170
THR A 203
ILE A 175
SER A  15
 None
 0.78A 1gtnA-1ajoA:
undetectable
1gtnK-1ajoA:
undetectable		 1gtnA-1ajoA:
18.54
1gtnK-1ajoA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axk GLUXYN-1

(Bacillus
subtilis) 		PF00457
(Glyco_hydro_11)
PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.77A 1gtnA-1axkA:
1.1
1gtnK-1axkA:
1.2		 1gtnA-1axkA:
11.17
1gtnK-1axkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.72A 1gtnA-1c3xA:
undetectable
1gtnK-1c3xA:
undetectable		 1gtnA-1c3xA:
14.98
1gtnK-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpn CIRCULARLY PERMUTED

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  24
THR A  57
ILE A  29
SER A  83
 None
 0.78A 1gtnA-1cpnA:
2.3
1gtnK-1cpnA:
1.0		 1gtnA-1cpnA:
15.35
1gtnK-1cpnA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl2 CLASS I
ALPHA-1,2-MANNOSIDAS
E

(Saccharomyces
cerevisiae) 		PF01532
(Glyco_hydro_47) 		4 GLY A 261
THR A 205
THR A 256
ILE A 181
 None
 0.83A 1gtnA-1dl2A:
undetectable
1gtnK-1dl2A:
undetectable		 1gtnA-1dl2A:
11.11
1gtnK-1dl2A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)

(Allochromatium
vinosum;
Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		4 GLY C  55
ALA A 350
ILE C  57
SER A 348
 None
None
HEM  C 901 ( 4.2A)
None
 0.76A 1gtnA-1fcdC:
undetectable
1gtnK-1fcdC:
undetectable		 1gtnA-1fcdC:
18.93
1gtnK-1fcdC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C)
PF12838
(Fer4_7)
PF13510
(Fer2_4) 		4 GLY A 194
THR A 356
ILE A 197
SER A 137
 SF4  A 582 (-3.9A)
None
None
None
 0.80A 1gtnA-1fehA:
undetectable
1gtnK-1fehA:
undetectable		 1gtnA-1fehA:
9.41
1gtnK-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 GLY A 295
THR A 257
THR A 259
ILE A 261
 None
 0.63A 1gtnA-1flgA:
undetectable
1gtnK-1flgA:
0.0		 1gtnA-1flgA:
8.63
1gtnK-1flgA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 GLY A  11
ALA A  20
ILE A  33
THR A 428
 FAD  A 579 (-3.1A)
None
None
None
 0.80A 1gtnA-1h81A:
undetectable
1gtnK-1h81A:
undetectable		 1gtnA-1h81A:
9.76
1gtnK-1h81A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 GLY A 412
THR A 417
ILE A 479
SER A 245
 None
TRA  A 866 (-4.0A)
None
TRA  A 866 (-2.6A)
 0.82A 1gtnA-1l5jA:
undetectable
1gtnK-1l5jA:
undetectable		 1gtnA-1l5jA:
7.07
1gtnK-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		4 GLY A 307
ALA A 313
ILE A 309
SER A 315
 None
 0.66A 1gtnA-1l8wA:
undetectable
1gtnK-1l8wA:
undetectable		 1gtnA-1l8wA:
11.14
1gtnK-1l8wA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PO4  A 655 (-3.6A)
None
None
None
 0.79A 1gtnA-1lw3A:
undetectable
1gtnK-1lw3A:
undetectable		 1gtnA-1lw3A:
7.46
1gtnK-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ALA A  80
THR A 113
ILE A  85
SER A 139
 None
 0.81A 1gtnA-1macA:
undetectable
1gtnK-1macA:
undetectable		 1gtnA-1macA:
17.79
1gtnK-1macA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsh CALGIZZARIN

(Oryctolagus
cuniculus) 		PF00036
(EF-hand_1)
PF01023
(S_100) 		4 THR A   4
THR A   6
ILE A  10
SER A   1
 None
 0.83A 1gtnA-1nshA:
undetectable
1gtnK-1nshA:
undetectable		 1gtnA-1nshA:
22.86
1gtnK-1nshA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.76A 1gtnA-1oh2Q:
undetectable
1gtnK-1oh2Q:
undetectable		 1gtnA-1oh2Q:
12.04
1gtnK-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Rhodospirillum
rubrum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1gtnA-1ptjA:
undetectable
1gtnK-1ptjA:
undetectable		 1gtnA-1ptjA:
13.14
1gtnK-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 GLY A  10
ALA A  23
ILE A  36
THR A 312
 None
 0.83A 1gtnA-1qmhA:
undetectable
1gtnK-1qmhA:
undetectable		 1gtnA-1qmhA:
15.23
1gtnK-1qmhA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		4 GLY A 296
ALA A 183
THR A 291
ILE A 298
 None
 0.83A 1gtnA-1vliA:
undetectable
1gtnK-1vliA:
undetectable		 1gtnA-1vliA:
13.01
1gtnK-1vliA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		4 GLY A 195
ALA A  60
THR A 191
ILE A 147
 None
 0.65A 1gtnA-1wkmA:
undetectable
1gtnK-1wkmA:
undetectable		 1gtnA-1wkmA:
15.29
1gtnK-1wkmA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 GLY A 335
ALA A 324
THR A 295
ILE A 293
 None
 0.83A 1gtnA-1xrsA:
undetectable
1gtnK-1xrsA:
undetectable		 1gtnA-1xrsA:
9.30
1gtnK-1xrsA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1gtnA-1zsqA:
undetectable
1gtnK-1zsqA:
undetectable		 1gtnA-1zsqA:
12.02
1gtnK-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLY A 152
THR A 143
ILE A 163
THR A 399
 None
 0.75A 1gtnA-2ahwA:
undetectable
1gtnK-2ahwA:
undetectable		 1gtnA-2ahwA:
9.98
1gtnK-2ahwA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		4 GLY A 187
THR A 122
THR A 143
ILE A 185
 None
 0.74A 1gtnA-2amhA:
undetectable
1gtnK-2amhA:
undetectable		 1gtnA-2amhA:
19.19
1gtnK-2amhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 GLY A 103
ALA A  61
ILE A  26
THR A  58
 None
 0.81A 1gtnA-2c2iA:
undetectable
1gtnK-2c2iA:
undetectable		 1gtnA-2c2iA:
22.14
1gtnK-2c2iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		4 ALA A  22
ILE A  67
THR A 189
SER A  18
 None
None
None
SO4  A5001 (-2.7A)
 0.76A 1gtnA-2detA:
undetectable
1gtnK-2detA:
undetectable		 1gtnA-2detA:
11.89
1gtnK-2detA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 GLY A 285
THR A 624
ILE A 283
SER A 817
 FAD  A1001 (-3.2A)
FAD  A1001 (-4.9A)
None
None
 0.80A 1gtnA-2dw4A:
undetectable
1gtnK-2dw4A:
undetectable		 1gtnA-2dw4A:
8.15
1gtnK-2dw4A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 GLY A 546
ALA A 528
ILE A 551
THR A 517
 None
 0.71A 1gtnA-2e28A:
undetectable
1gtnK-2e28A:
undetectable		 1gtnA-2e28A:
9.86
1gtnK-2e28A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
ALA A 208
THR A 185
THR A 319
 NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
 0.77A 1gtnA-2eerA:
undetectable
1gtnK-2eerA:
undetectable		 1gtnA-2eerA:
13.02
1gtnK-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		4 GLY A 145
ALA A  92
THR A  84
ILE A 149
 None
 0.83A 1gtnA-2g02A:
undetectable
1gtnK-2g02A:
undetectable		 1gtnA-2g02A:
9.83
1gtnK-2g02A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		4 GLY A 200
ALA A 208
ILE A 198
THR A  25
 None
 0.75A 1gtnA-2ij9A:
undetectable
1gtnK-2ij9A:
undetectable		 1gtnA-2ij9A:
17.14
1gtnK-2ij9A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 GLY A 293
THR A 121
ILE A 295
THR A 148
 None
 0.62A 1gtnA-2jifA:
undetectable
1gtnK-2jifA:
undetectable		 1gtnA-2jifA:
10.55
1gtnK-2jifA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0o HYPOTHETICAL PROTEIN
DUF871

(Enterococcus
faecalis) 		PF05913
(DUF871) 		4 GLY A  30
ALA A  56
THR A  91
ILE A  31
 None
 0.82A 1gtnA-2p0oA:
undetectable
1gtnK-2p0oA:
undetectable		 1gtnA-2p0oA:
12.84
1gtnK-2p0oA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pia PHTHALATE
DIOXYGENASE
REDUCTASE

(Burkholderia
cepacia) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A 122
ALA A 154
THR A 147
ILE A 121
 None
None
None
FMN  A 322 (-4.2A)
 0.79A 1gtnA-2piaA:
undetectable
1gtnK-2piaA:
undetectable		 1gtnA-2piaA:
12.10
1gtnK-2piaA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 GSP  A 401 (-3.6A)
None
GSP  A 401 (-4.5A)
None
 0.79A 1gtnA-2q1yA:
undetectable
1gtnK-2q1yA:
undetectable		 1gtnA-2q1yA:
12.94
1gtnK-2q1yA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 GLY A 358
THR A 207
ILE A 361
SER A 337
 None
 0.64A 1gtnA-2qveA:
undetectable
1gtnK-2qveA:
undetectable		 1gtnA-2qveA:
11.96
1gtnK-2qveA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq0 COAT PROTEIN

(Sesbania mosaic
virus) 		PF00729
(Viral_coat) 		4 GLY A 175
THR A 126
ILE A 128
SER A  80
 None
 0.79A 1gtnA-2vq0A:
undetectable
1gtnK-2vq0A:
undetectable		 1gtnA-2vq0A:
13.28
1gtnK-2vq0A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.72A 1gtnA-2wghA:
undetectable
1gtnK-2wghA:
undetectable		 1gtnA-2wghA:
8.38
1gtnK-2wghA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7l GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Escherichia
coli) 		PF01597
(GCV_H) 		4 GLY A  27
ALA A  60
ILE A 101
SER A  67
 None
 0.80A 1gtnA-3a7lA:
undetectable
1gtnK-3a7lA:
undetectable		 1gtnA-3a7lA:
18.94
1gtnK-3a7lA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ALA A 187
THR A 426
THR A 414
ILE A 184
 None
 0.80A 1gtnA-3cb5A:
undetectable
1gtnK-3cb5A:
undetectable		 1gtnA-3cb5A:
9.95
1gtnK-3cb5A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 GLY A 251
ALA A 107
THR A 247
ILE A 204
 None
 0.77A 1gtnA-3fmqA:
undetectable
1gtnK-3fmqA:
undetectable		 1gtnA-3fmqA:
13.14
1gtnK-3fmqA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.82A 1gtnA-3fpzA:
undetectable
1gtnK-3fpzA:
undetectable		 1gtnA-3fpzA:
16.03
1gtnK-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		4 GLY A 184
ALA A 280
ILE A 188
THR A 272
 None
 0.80A 1gtnA-3fvrA:
undetectable
1gtnK-3fvrA:
undetectable		 1gtnA-3fvrA:
14.60
1gtnK-3fvrA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		4 THR A  56
ILE A  54
THR A 173
SER A 141
 NA  A 358 (-4.0A)
None
None
None
 0.77A 1gtnA-3h84A:
undetectable
1gtnK-3h84A:
undetectable		 1gtnA-3h84A:
12.99
1gtnK-3h84A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		4 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.78A 1gtnA-3i4iA:
undetectable
1gtnK-3i4iA:
undetectable		 1gtnA-3i4iA:
16.44
1gtnK-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icy SENSOR PROTEIN

(Chlorobaculum
tepidum) 		PF08447
(PAS_3) 		4 GLY A 109
ALA A   0
THR A  75
SER A  -2
 None
 0.83A 1gtnA-3icyA:
undetectable
1gtnK-3icyA:
undetectable		 1gtnA-3icyA:
23.66
1gtnK-3icyA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ip1 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  31
ALA A   8
THR A  87
ILE A  81
 None
 0.80A 1gtnA-3ip1A:
undetectable
1gtnK-3ip1A:
undetectable		 1gtnA-3ip1A:
11.50
1gtnK-3ip1A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbr VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLY F 366
THR F 364
ILE F 401
THR F 333
 None
 0.77A 1gtnA-3jbrF:
undetectable
1gtnK-3jbrF:
undetectable		 1gtnA-3jbrF:
5.20
1gtnK-3jbrF:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwp PREDICTED
METHYLTRANSFERASE

(Lactobacillus
brevis) 		PF00590
(TP_methylase) 		4 GLY A  23
ALA A 123
THR A 200
ILE A  22
 None
 0.79A 1gtnA-3kwpA:
undetectable
1gtnK-3kwpA:
undetectable		 1gtnA-3kwpA:
15.00
1gtnK-3kwpA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		4 GLY A 266
ALA A 116
THR A 269
ILE A 265
 None
PHE  A 601 (-4.6A)
None
None
 0.81A 1gtnA-3lkvA:
undetectable
1gtnK-3lkvA:
undetectable		 1gtnA-3lkvA:
13.76
1gtnK-3lkvA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244

(Pseudomonas
syringae group
genomosp. 3) 		PF05899
(Cupin_3) 		4 GLY A  49
ALA A  10
THR A  19
ILE A  50
 None
 0.69A 1gtnA-3myxA:
4.0
1gtnK-3myxA:
4.0		 1gtnA-3myxA:
16.88
1gtnK-3myxA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 GLY B 205
THR B 156
ILE B 281
THR B 145
 None
None
None
SF4  B 803 (-3.9A)
 0.72A 1gtnA-3or2B:
undetectable
1gtnK-3or2B:
undetectable		 1gtnA-3or2B:
11.35
1gtnK-3or2B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLY A  53
ALA A 251
THR A 274
ILE A 248
 None
 0.74A 1gtnA-3snhA:
undetectable
1gtnK-3snhA:
undetectable		 1gtnA-3snhA:
6.70
1gtnK-3snhA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t63 PROTOCATECHUATE
3,4-DIOXYGENASE BETA
CHAIN

(Pseudomonas
putida) 		PF00775
(Dioxygenase_C)
PF12391
(PCDO_beta_N) 		4 GLY M 467
THR M 431
THR M 395
ILE M 465
 None
 0.58A 1gtnA-3t63M:
undetectable
1gtnK-3t63M:
undetectable		 1gtnA-3t63M:
12.18
1gtnK-3t63M:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 GLY A  86
THR A 190
ILE A  82
SER A 163
 None
 0.71A 1gtnA-3v4cA:
undetectable
1gtnK-3v4cA:
undetectable		 1gtnA-3v4cA:
10.56
1gtnK-3v4cA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh0 UNCHARACTERIZED
PROTEIN YNCE

(Escherichia
coli) 		no annotation 4 GLY A 172
ALA A 115
ILE A 174
THR A 100
 None
 0.72A 1gtnA-3vh0A:
undetectable
1gtnK-3vh0A:
undetectable		 1gtnA-3vh0A:
12.50
1gtnK-3vh0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
HEME SUBUNIT
FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum;
Thermochromatium
tepidum) 		no annotation
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		4 GLY A  55
ALA B 350
ILE A  57
SER B 348
 None
None
HEC  A 201 ( 4.4A)
None
 0.76A 1gtnA-3vrdA:
undetectable
1gtnK-3vrdA:
undetectable		 1gtnA-3vrdA:
19.33
1gtnK-3vrdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 GLY A 391
ALA A 382
THR A 410
SER A 385
 None
 0.81A 1gtnA-3vz0A:
undetectable
1gtnK-3vz0A:
undetectable		 1gtnA-3vz0A:
10.20
1gtnK-3vz0A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvj BETA-GLUCANASE

(Ruminiclostridium
thermocellum) 		PF00722
(Glyco_hydro_16) 		4 ALA A 113
THR A 146
ILE A 118
SER A 172
 None
 0.77A 1gtnA-3wvjA:
undetectable
1gtnK-3wvjA:
undetectable		 1gtnA-3wvjA:
16.90
1gtnK-3wvjA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		4 GLY A  23
THR A  49
THR A  52
ILE A  55
 TRP  A  80 (-3.5A)
TRP  A  80 (-2.8A)
TRP  A  80 (-3.6A)
TRP  A  80 ( 4.6A)
 0.23A 1gtnA-3zteA:
14.5
1gtnK-3zteA:
15.3		 1gtnA-3zteA:
78.21
1gtnK-3zteA:
78.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 GLY A  23
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.5A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.7A)
 0.18A 1gtnA-3zzlA:
13.2
1gtnK-3zzlA:
13.2		 1gtnA-3zzlA:
71.43
1gtnK-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A  81 (-3.4A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
TRP  A  81 ( 4.4A)
 0.15A 1gtnA-3zzqA:
13.8
1gtnK-3zzqA:
13.8		 1gtnA-3zzqA:
80.00
1gtnK-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 TRP  A1072 (-3.5A)
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
TRP  A1072 (-3.8A)
TRP  A1072 ( 4.4A)
 0.11A 1gtnA-3zzsA:
13.6
1gtnK-3zzsA:
13.7		 1gtnA-3zzsA:
100.00
1gtnK-3zzsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 GLY  A  23 (-0.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
THR  A  52 (-0.8A)
ILE  A  55 ( 0.6A)
 0.23A 1gtnA-4b27A:
13.2
1gtnK-4b27A:
13.3		 1gtnA-4b27A:
76.32
1gtnK-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 400
THR A 499
THR A 449
THR A 395
 None
None
None
EDO  A1590 (-4.9A)
 0.75A 1gtnA-4c22A:
undetectable
1gtnK-4c22A:
undetectable		 1gtnA-4c22A:
8.11
1gtnK-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		4 ALA A  18
THR A  29
THR A   6
ILE A 159
 None
 0.75A 1gtnA-4cnkA:
undetectable
1gtnK-4cnkA:
undetectable		 1gtnA-4cnkA:
12.76
1gtnK-4cnkA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 GLY A 179
ALA A 188
THR A 246
ILE A 177
 None
 0.76A 1gtnA-4dvjA:
undetectable
1gtnK-4dvjA:
undetectable		 1gtnA-4dvjA:
12.98
1gtnK-4dvjA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 107
ALA A  79
THR A  42
ILE A  16
 SO4  A 607 (-3.4A)
None
None
None
 0.72A 1gtnA-4e6eA:
undetectable
1gtnK-4e6eA:
undetectable		 1gtnA-4e6eA:
12.06
1gtnK-4e6eA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eow MB007 HUMAN IGG1 FAB
FRAGMENT HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H  33
ALA H  24
THR H  53
ILE H  34
 None
 0.69A 1gtnA-4eowH:
1.4
1gtnK-4eowH:
undetectable		 1gtnA-4eowH:
14.91
1gtnK-4eowH:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		4 GLY B 206
ALA B  95
ILE B  92
THR B 176
 None
 0.83A 1gtnA-4f0aB:
undetectable
1gtnK-4f0aB:
undetectable		 1gtnA-4f0aB:
13.38
1gtnK-4f0aB:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW) 		4 GLY A 389
THR A 626
ILE A 387
SER A 811
 FAD  A 901 (-3.3A)
None
None
None
 0.79A 1gtnA-4hsuA:
undetectable
1gtnK-4hsuA:
undetectable		 1gtnA-4hsuA:
7.64
1gtnK-4hsuA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		4 GLY B 191
THR B 339
ILE B 194
THR B 169
 None
 0.81A 1gtnA-4i6mB:
undetectable
1gtnK-4i6mB:
undetectable		 1gtnA-4i6mB:
11.93
1gtnK-4i6mB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isy CYSTEINE DESULFURASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 GLY A  78
ALA A 198
ILE A  79
SER A 200
 None
 0.69A 1gtnA-4isyA:
undetectable
1gtnK-4isyA:
undetectable		 1gtnA-4isyA:
11.50
1gtnK-4isyA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 GLY A  45
ALA A  53
THR A 328
ILE A  43
 FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.8A)
None
 0.82A 1gtnA-4iv9A:
undetectable
1gtnK-4iv9A:
undetectable		 1gtnA-4iv9A:
9.93
1gtnK-4iv9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 GLY A 771
ALA A 596
THR A 207
ILE A 770
 None
 0.72A 1gtnA-4lglA:
undetectable
1gtnK-4lglA:
undetectable		 1gtnA-4lglA:
5.61
1gtnK-4lglA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 GLY A  55
THR A 129
THR A 132
ILE A  58
 None
 0.82A 1gtnA-4lz6A:
undetectable
1gtnK-4lz6A:
undetectable		 1gtnA-4lz6A:
11.37
1gtnK-4lz6A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0l NADPH-DEPENDENT
3-QUINUCLIDINONE
REDUCTASE

(Rhodotorula
mucilaginosa) 		PF13561
(adh_short_C2) 		4 GLY A  35
ALA A  44
THR A 164
ILE A  33
 NDP  A 300 (-3.3A)
None
NDP  A 300 (-4.0A)
None
 0.83A 1gtnA-4o0lA:
undetectable
1gtnK-4o0lA:
undetectable		 1gtnA-4o0lA:
15.27
1gtnK-4o0lA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obm UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		no annotation 4 GLY A 113
ALA A 274
THR A 280
THR A  67
 None
 0.64A 1gtnA-4obmA:
undetectable
1gtnK-4obmA:
undetectable		 1gtnA-4obmA:
16.02
1gtnK-4obmA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqu ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 264
ALA A 199
THR A 261
ILE A 257
 None
 0.84A 1gtnA-4rquA:
undetectable
1gtnK-4rquA:
undetectable		 1gtnA-4rquA:
11.52
1gtnK-4rquA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 ALA A  46
THR A 143
THR A 158
ILE A 167
 None
 0.79A 1gtnA-4ufcA:
undetectable
1gtnK-4ufcA:
undetectable		 1gtnA-4ufcA:
6.66
1gtnK-4ufcA:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 ALA A 115
THR A 326
THR A  67
ILE A 123
 None
 0.71A 1gtnA-4v1yA:
undetectable
1gtnK-4v1yA:
undetectable		 1gtnA-4v1yA:
10.51
1gtnK-4v1yA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6z ALCOHOL
DEHYDROGENASE 1

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A  68
ALA A 129
ILE A  90
THR A 345
 None
 0.68A 1gtnA-4w6zA:
undetectable
1gtnK-4w6zA:
undetectable		 1gtnA-4w6zA:
11.53
1gtnK-4w6zA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		4 GLY A  58
ALA A   8
THR A  82
ILE A  52
 None
 0.82A 1gtnA-4wjmA:
undetectable
1gtnK-4wjmA:
undetectable		 1gtnA-4wjmA:
13.11
1gtnK-4wjmA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 ALA A  68
THR A 290
ILE A  51
SER A  64
 None
 0.80A 1gtnA-4wr2A:
undetectable
1gtnK-4wr2A:
undetectable		 1gtnA-4wr2A:
11.64
1gtnK-4wr2A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		4 GLY E 167
ALA E 172
ILE E 168
SER E 174
 None
 0.83A 1gtnA-4wzbE:
undetectable
1gtnK-4wzbE:
undetectable		 1gtnA-4wzbE:
15.38
1gtnK-4wzbE:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 4 GLY A 375
ALA A  92
THR A 432
ILE A 378
 None
 0.72A 1gtnA-4zh7A:
undetectable
1gtnK-4zh7A:
undetectable		 1gtnA-4zh7A:
8.78
1gtnK-4zh7A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 441
THR A 449
THR A 445
SER A 292
 PO4  A 701 (-3.5A)
None
None
None
 0.66A 1gtnA-5c16A:
undetectable
1gtnK-5c16A:
undetectable		 1gtnA-5c16A:
8.93
1gtnK-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cct DUTPASE

(Staphylococcus
virus 80alpha) 		PF00692
(dUTPase) 		4 GLY A  89
ALA A 136
THR A  47
ILE A  90
 DUP  A 201 (-4.0A)
None
None
None
 0.79A 1gtnA-5cctA:
undetectable
1gtnK-5cctA:
undetectable		 1gtnA-5cctA:
18.90
1gtnK-5cctA:
18.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		5 GLY A  23
ALA A  46
THR A  49
THR A  52
ILE A  55
 None
 0.13A 1gtnA-5eexA:
15.3
1gtnK-5eexA:
15.3		 1gtnA-5eexA:
100.00
1gtnK-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 4 GLY A 369
ALA A  92
THR A 426
ILE A 372
 None
 0.71A 1gtnA-5f9aA:
undetectable
1gtnK-5f9aA:
undetectable		 1gtnA-5f9aA:
11.67
1gtnK-5f9aA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftx SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 GLY A 522
ALA A 487
THR A 455
THR A 484
 None
 0.84A 1gtnA-5ftxA:
undetectable
1gtnK-5ftxA:
undetectable		 1gtnA-5ftxA:
7.99
1gtnK-5ftxA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 4 GLY A  28
ALA A 114
THR A  98
ILE A  96
 None
 0.77A 1gtnA-5h7jA:
undetectable
1gtnK-5h7jA:
undetectable		 1gtnA-5h7jA:
undetectable
1gtnK-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 274
ALA A 400
THR A 377
THR A 308
 None
 0.80A 1gtnA-5j84A:
undetectable
1gtnK-5j84A:
undetectable		 1gtnA-5j84A:
8.03
1gtnK-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		4 GLY A 285
THR A 624
ILE A 283
SER A 817
 FAD  A 901 (-3.3A)
None
None
None
 0.81A 1gtnA-5l3dA:
undetectable
1gtnK-5l3dA:
undetectable		 1gtnA-5l3dA:
6.27
1gtnK-5l3dA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLY A 409
THR A 339
THR A 368
ILE A 366
 None
 0.72A 1gtnA-5olpA:
undetectable
1gtnK-5olpA:
undetectable		 1gtnA-5olpA:
10.47
1gtnK-5olpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy4 CHAPERONE YAJL

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		4 GLY A 165
ALA A 103
THR A  21
ILE A 168
 None
 0.70A 1gtnA-5sy4A:
undetectable
1gtnK-5sy4A:
undetectable		 1gtnA-5sy4A:
17.62
1gtnK-5sy4A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnx ALCOHOL
DEHYDROGENASE
ZINC-BINDING DOMAIN
PROTEIN

(Burkholderia
ambifaria) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 261
ALA A 198
THR A 258
ILE A 254
 None
 0.68A 1gtnA-5tnxA:
undetectable
1gtnK-5tnxA:
undetectable		 1gtnA-5tnxA:
11.17
1gtnK-5tnxA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.72A 1gtnA-5tusA:
undetectable
1gtnK-5tusA:
undetectable		 1gtnA-5tusA:
7.41
1gtnK-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		4 GLY A 237
ALA A 242
ILE A 238
SER A 244
 None
 0.79A 1gtnA-5wayA:
undetectable
1gtnK-5wayA:
undetectable		 1gtnA-5wayA:
9.85
1gtnK-5wayA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 4 GLY A  71
ALA A 132
ILE A  93
THR A 348
 None
 0.66A 1gtnA-5yatA:
undetectable
1gtnK-5yatA:
undetectable		 1gtnA-5yatA:
undetectable
1gtnK-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 4 GLY A 360
ALA A 415
ILE A 363
THR A 396
 None
 0.79A 1gtnA-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable		 1gtnA-6c0eA:
undetectable
1gtnK-6c0eA:
undetectable