SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTN_A_TRPA181

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 THR A 190
ARG A 202
HIS A 192
HIS A 191
 None
 1.11A 1gtnA-3kyoA:
0.5		 1gtnA-3kyoA:
14.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		4 THR A  25
ARG A  31
HIS A  33
HIS A  51
 None
 0.30A 1gtnA-3zzlA:
13.2		 1gtnA-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		4 THR A  25
ARG A  31
HIS A  33
HIS A  51
 None
 0.36A 1gtnA-3zzsA:
13.6		 1gtnA-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 THR A 711
ARG A 205
HIS A 709
HIS A 710
 None
None
None
G  R   8 ( 4.5A)
 1.46A 1gtnA-4krfA:
0.0		 1gtnA-4krfA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avf HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-7 ALPHA
CHAIN

(Homo sapiens) 		no annotation 4 THR H 190
ARG H 202
HIS H 192
HIS H 191
 None
 1.21A 1gtnA-6avfH:
0.6		 1gtnA-6avfH:
undetectable