SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTI_F_CCSF47

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 THR A 531
LEU A 529
GLY A 356
TYR A 526
 None
 1.21A 1gtiF-1aqlA:
0.0		 1gtiF-1aqlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 THR A  22
LEU A  94
GLY A  96
LYS A  99
 VO3  A1001 (-4.4A)
None
None
VO3  A1001 (-2.9A)
 1.33A 1gtiF-1e59A:
0.0		 1gtiF-1e59A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		4 THR A  27
LEU A  99
GLY A 101
LYS A 104
 None
 0.86A 1gtiF-1fztA:
0.0		 1gtiF-1fztA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gjj LAP2

(Homo sapiens) 		PF03020
(LEM)
PF08198
(Thymopoietin) 		4 THR A  46
LEU A 149
GLY A 153
TYR A 127
 None
 1.39A 1gtiF-1gjjA:
undetectable		 1gtiF-1gjjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		4 LEU A 245
GLY A 243
LYS A 163
TYR A 164
 None
 1.23A 1gtiF-1jbkA:
undetectable		 1gtiF-1jbkA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqr VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 THR A 186
LEU A 158
GLY A 156
TYR A 165
 GOL  A4000 (-2.8A)
None
MNA  A1000 ( 4.5A)
None
 1.38A 1gtiF-1kqrA:
undetectable		 1gtiF-1kqrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 LEU A 339
GLY A 351
LYS A   1
TYR A   3
 None
 1.14A 1gtiF-1ks8A:
2.1		 1gtiF-1ks8A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  48
GLY A  50
LYS A  54
TYR A  63
 None
 0.28A 1gtiF-1lbkA:
33.1		 1gtiF-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od5 GLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 THR A 239
LEU A 244
GLY A 243
TYR A 134
 None
 1.36A 1gtiF-1od5A:
0.0		 1gtiF-1od5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		5 THR A   5
LEU A  73
GLY A  75
LYS A 166
TYR A 167
 None
PCA  A   1 ( 4.9A)
None
None
None
 1.42A 1gtiF-1q2eA:
0.0		 1gtiF-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		4 THR A   5
LEU A  73
GLY A  75
TYR A 164
 None
PCA  A   1 ( 4.5A)
None
None
 1.29A 1gtiF-1q9hA:
undetectable		 1gtiF-1q9hA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 THR A  20
LEU A  92
GLY A  94
LYS A  97
 SO4  A 248 ( 3.1A)
None
None
SO4  A 251 (-3.5A)
 1.22A 1gtiF-1qhfA:
1.7		 1gtiF-1qhfA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 THR A  56
LEU A 240
GLY A 165
TYR A 241
 None
 1.28A 1gtiF-1r2fA:
1.7		 1gtiF-1r2fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v31 HYPOTHETICAL PROTEIN
RAFL11-05-P19

(Arabidopsis
thaliana) 		PF02201
(SWIB) 		4 THR A  16
LEU A  18
GLY A  23
LYS A  13
 None
 1.34A 1gtiF-1v31A:
undetectable		 1gtiF-1v31A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yck PEPTIDOGLYCAN
RECOGNITION PROTEIN

(Homo sapiens) 		PF01510
(Amidase_2) 		4 THR A  48
LEU A  83
GLY A  79
TYR A  85
 None
 1.17A 1gtiF-1yckA:
undetectable		 1gtiF-1yckA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 THR A 206
LEU A 208
GLY A 210
TYR A  75
 None
 1.11A 1gtiF-1z0xA:
undetectable		 1gtiF-1z0xA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		5 THR A   5
LEU A  73
GLY A  75
LYS A 163
TYR A 164
 None
PCA  A   1 ( 4.4A)
None
None
None
 1.49A 1gtiF-1z3vA:
undetectable		 1gtiF-1z3vA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahq RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD) 		4 LEU A  21
GLY A  19
LYS A  61
TYR A  62
 None
 1.26A 1gtiF-2ahqA:
undetectable		 1gtiF-2ahqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		4 THR A 181
LEU A 178
LYS A 229
TYR A 230
 None
None
SO4  A 302 ( 4.2A)
None
 1.28A 1gtiF-2csnA:
undetectable		 1gtiF-2csnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4

(Homo sapiens) 		PF13410
(GST_C_2) 		4 LEU A  99
GLY A  49
LYS A 103
TYR A 104
 None
 1.18A 1gtiF-2d2zA:
13.6		 1gtiF-2d2zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A 128
GLY A 133
LYS A  54
TYR A  55
 None
 1.03A 1gtiF-2dj0A:
undetectable		 1gtiF-2dj0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		4 THR A  42
LEU A  44
GLY A 333
TYR A 132
 None
 1.37A 1gtiF-2dutA:
undetectable		 1gtiF-2dutA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 THR A 143
LEU A 145
GLY A 149
TYR A 162
 None
 1.30A 1gtiF-2eyqA:
undetectable		 1gtiF-2eyqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiF-2f9rA:
undetectable		 1gtiF-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i88 COLICIN-E1

(Escherichia
coli) 		PF01024
(Colicin) 		4 THR A 490
GLY A 493
LYS A 362
TYR A 363
 None
 1.32A 1gtiF-2i88A:
undetectable		 1gtiF-2i88A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jem ENDO-BETA-1,4-GLUCAN
ASE

(Bacillus
licheniformis) 		PF01670
(Glyco_hydro_12) 		4 THR A 259
GLY A 105
LYS A  42
TYR A  46
 None
 1.24A 1gtiF-2jemA:
undetectable		 1gtiF-2jemA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 THR A 109
LEU A 107
GLY A 104
TYR A 349
 None
 0.92A 1gtiF-2nz9A:
undetectable		 1gtiF-2nz9A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 THR A  20
LEU A  22
GLY A  28
TYR A  32
 None
 1.25A 1gtiF-2okcA:
0.8		 1gtiF-2okcA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 LEU A 120
GLY A 118
LYS A 113
TYR A 114
 None
 1.38A 1gtiF-2qpqA:
undetectable		 1gtiF-2qpqA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A 160
GLY A 162
LYS A   1
TYR A 159
 None
 1.22A 1gtiF-2qriA:
undetectable		 1gtiF-2qriA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv2 INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 THR A  85
LEU A  87
GLY A  90
TYR A 116
 THR  A  85 ( 0.8A)
LEU  A  87 ( 0.6A)
GLY  A  90 ( 0.0A)
TYR  A 116 ( 1.3A)
 1.19A 1gtiF-2qv2A:
undetectable		 1gtiF-2qv2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 LEU A 344
GLY A 324
LYS A 331
TYR A 327
 None
 1.28A 1gtiF-2v1uA:
undetectable		 1gtiF-2v1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 LEU A  84
GLY A 148
LYS A 105
TYR A 118
 None
 1.25A 1gtiF-2vy0A:
undetectable		 1gtiF-2vy0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 THR A   5
LEU A  73
GLY A  75
TYR A 169
 None
PCA  A   1 ( 4.3A)
None
None
 1.25A 1gtiF-2yg1A:
undetectable		 1gtiF-2yg1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		5 THR A  22
LEU A  89
GLY A  91
LYS A 179
TYR A 180
 None
PCA  A  18 ( 4.5A)
None
None
None
 1.46A 1gtiF-2yokA:
undetectable		 1gtiF-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		4 THR A 143
LEU A 211
GLY A 209
TYR A 175
 None
 1.32A 1gtiF-2z8zA:
undetectable		 1gtiF-2z8zA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb9 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 THR A 116
LEU A 118
GLY A 120
TYR A 132
 None
 1.14A 1gtiF-2zb9A:
undetectable		 1gtiF-2zb9A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1j OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00106
(adh_short) 		4 THR A 236
LEU A 230
GLY A 232
TYR A 229
 None
 1.07A 1gtiF-3i1jA:
undetectable		 1gtiF-3i1jA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 THR A 212
LEU A 214
GLY A 217
TYR A 117
 None
EDO  A 230 ( 4.4A)
None
None
 1.07A 1gtiF-3mvuA:
undetectable		 1gtiF-3mvuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA

(Escherichia
coli) 		no annotation 4 THR B  56
LEU B 240
GLY B 165
TYR B 241
 None
 1.37A 1gtiF-3n3bB:
1.6		 1gtiF-3n3bB:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 THR A  46
LEU A  48
GLY A  50
LYS A  54
TYR A  63
 None
 0.50A 1gtiF-3o76A:
34.8		 1gtiF-3o76A:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 THR A  48
GLY A 305
LYS A 317
TYR A 162
 None
 1.30A 1gtiF-3pquA:
undetectable		 1gtiF-3pquA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro8 ENDO-1,4-BETA-XYLANA
SE

(Paenibacillus
sp. JDR-2) 		PF00331
(Glyco_hydro_10) 		4 THR A 266
LEU A 284
GLY A 280
TYR A 285
 None
 1.37A 1gtiF-3ro8A:
undetectable		 1gtiF-3ro8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 148
GLY A 152
LYS A 134
TYR A 142
 None
 1.38A 1gtiF-3smtA:
undetectable		 1gtiF-3smtA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujm RASPUTIN

(Drosophila
melanogaster) 		PF02136
(NTF2) 		4 LEU A 112
GLY A  87
LYS A 118
TYR A 120
 None
 1.28A 1gtiF-3ujmA:
undetectable		 1gtiF-3ujmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 THR A 134
LEU A 245
GLY A 247
TYR A 244
 None
 1.05A 1gtiF-3vr1A:
undetectable		 1gtiF-3vr1A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 THR A 205
LEU A 203
GLY A 200
LYS A 294
 None
 1.22A 1gtiF-3wjoA:
undetectable		 1gtiF-3wjoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		4 LEU A 745
GLY A 747
LYS A 730
TYR A 682
 None
 0.99A 1gtiF-3wsyA:
undetectable		 1gtiF-3wsyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 THR A  77
LEU A  71
GLY A  75
TYR A  44
 None
 1.22A 1gtiF-4azvA:
undetectable		 1gtiF-4azvA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 THR A  77
LEU A  71
GLY A  75
TYR A  44
 None
 1.31A 1gtiF-4azwA:
undetectable		 1gtiF-4azwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 THR A 608
LEU A 693
GLY A 606
LYS A 711
 None
 1.39A 1gtiF-4b56A:
undetectable		 1gtiF-4b56A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqu JAPANIN

(Rhipicephalus
appendiculatus) 		no annotation 4 THR A 113
LEU A 104
LYS A  89
TYR A  92
 None
CLR  A 575 ( 4.7A)
None
CLR  A 575 ( 3.4A)
 1.29A 1gtiF-4bquA:
undetectable		 1gtiF-4bquA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cym ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 THR D 583
LEU D 585
GLY D 588
TYR D 617
 None
 1.26A 1gtiF-4cymD:
undetectable		 1gtiF-4cymD:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiF-4djeD:
undetectable		 1gtiF-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 LEU A 167
GLY A 169
LYS A 107
TYR A 108
 None
 1.10A 1gtiF-4dwsA:
undetectable		 1gtiF-4dwsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		4 LEU A 234
GLY A 140
LYS A   7
TYR A   9
 None
 1.19A 1gtiF-4fs3A:
undetectable		 1gtiF-4fs3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 LEU A 290
GLY A 179
LYS A  78
TYR A  73
 None
 1.17A 1gtiF-4gedA:
undetectable		 1gtiF-4gedA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		4 THR A 208
GLY A  70
LYS A  67
TYR A  69
 None
 1.39A 1gtiF-4jqtA:
undetectable		 1gtiF-4jqtA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwc CHAPERONE PROTEIN
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 THR A 410
LEU A 441
GLY A 443
LYS A 446
 None
 1.35A 1gtiF-4jwcA:
undetectable		 1gtiF-4jwcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		4 LEU A 209
GLY A 212
LYS A 144
TYR A 146
 None
 1.01A 1gtiF-4kk2A:
undetectable		 1gtiF-4kk2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 LEU A 183
GLY A  87
LYS A  90
TYR A  89
 None
 1.26A 1gtiF-4mfzA:
undetectable		 1gtiF-4mfzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		4 THR A 260
LEU A 263
LYS A 253
TYR A 250
 None
 1.37A 1gtiF-4nkyA:
undetectable		 1gtiF-4nkyA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 LEU A 204
GLY A 332
LYS A 369
TYR A 374
 None
 1.34A 1gtiF-4nz6A:
undetectable		 1gtiF-4nz6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU B 102
GLY B 105
LYS B  40
TYR B 101
 ADP  B 500 (-4.3A)
None
None
ADP  B 500 ( 4.7A)
 1.36A 1gtiF-4o27B:
undetectable		 1gtiF-4o27B:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 329
LEU A 331
GLY A 185
LYS A 150
 None
 1.16A 1gtiF-4o38A:
undetectable		 1gtiF-4o38A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 LEU A 291
GLY A 293
LYS A  71
TYR A  72
 None
 1.25A 1gtiF-4oqqA:
undetectable		 1gtiF-4oqqA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		4 THR A 166
LEU A 163
GLY A 204
TYR A 247
 None
 1.25A 1gtiF-4pzvA:
undetectable		 1gtiF-4pzvA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 LEU A  50
GLY A  46
LYS A 220
TYR A  41
 None
 1.06A 1gtiF-4qtsA:
undetectable		 1gtiF-4qtsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqm PROTEIN BICAUDAL C
HOMOLOG 1

(Homo sapiens) 		PF00536
(SAM_1) 		4 THR A 919
GLY A 916
LYS A 889
TYR A 890
 None
 1.27A 1gtiF-4rqmA:
undetectable		 1gtiF-4rqmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A 457
GLY A 713
LYS A 462
TYR A 456
 None
 1.12A 1gtiF-4ufcA:
1.7		 1gtiF-4ufcA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 THR A   5
LEU A  73
GLY A  75
TYR A 167
 ACT  A1444 (-3.9A)
PCA  A   1 ( 4.5A)
None
None
 1.26A 1gtiF-4v20A:
undetectable		 1gtiF-4v20A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v39 SIALYLTRANSFERASE

(Pasteurella
dagmatis) 		PF11477
(PM0188) 		4 THR A 189
LEU A 191
GLY A 193
TYR A 195
 None
 1.37A 1gtiF-4v39A:
undetectable		 1gtiF-4v39A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1k OUTER MEMBRANE
PROTEIN OPRM

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 THR A 378
LEU A 373
GLY A  25
TYR A  24
 None
 1.38A 1gtiF-4y1kA:
undetectable		 1gtiF-4y1kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5r METHYLAMINE
UTILIZATION PROTEIN
MAUG

(Paracoccus
denitrificans) 		PF03150
(CCP_MauG) 		4 LEU A 249
GLY A 248
LYS A 265
TYR A 223
 None
None
HEC  A 402 (-3.3A)
None
 1.39A 1gtiF-4y5rA:
undetectable		 1gtiF-4y5rA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 THR B  82
LEU B  86
LYS B 426
TYR B 428
 None
 1.29A 1gtiF-5cyrB:
undetectable		 1gtiF-5cyrB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwf PEPTIDOGLYCAN
RECOGNITION PROTEIN
1

(Camelus
dromedarius) 		PF01510
(Amidase_2) 		4 THR A  45
LEU A  80
GLY A  76
TYR A  82
 None
 1.23A 1gtiF-5dwfA:
undetectable		 1gtiF-5dwfA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9g ISOCITRATE LYASE

(Magnaporthe
oryzae) 		PF00463
(ICL) 		4 THR A 186
LEU A 191
GLY A 183
TYR A 129
 None
 1.09A 1gtiF-5e9gA:
undetectable		 1gtiF-5e9gA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9h ISOCITRATE LYASE

(Fusarium
graminearum) 		PF00463
(ICL) 		4 THR A 186
LEU A 191
GLY A 183
TYR A 129
 None
 1.04A 1gtiF-5e9hA:
undetectable		 1gtiF-5e9hA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evm FUSION GLYCOPROTEIN
F0

(Nipah
henipavirus) 		PF00523
(Fusion_gly) 		4 THR A  81
LEU A  83
GLY A  85
TYR A 274
 None
 1.23A 1gtiF-5evmA:
undetectable		 1gtiF-5evmA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 THR A 128
GLY A 126
LYS A  33
TYR A 134
 None
 1.02A 1gtiF-5f7uA:
undetectable		 1gtiF-5f7uA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CLADE A/E 93TH057
HIV-1 GP120 CORE
CH235.9 HEAVY CHAIN

(Human
immunodeficiency
virus 1;
Homo sapiens) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 THR G 430
LEU G 122
GLY G 124
LYS H  74
 None
 1.23A 1gtiF-5f9oG:
undetectable		 1gtiF-5f9oG:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 LEU A  52
GLY A  50
LYS A 221
TYR A 223
 None
 1.20A 1gtiF-5fjnA:
undetectable		 1gtiF-5fjnA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 LEU A  23
GLY A  25
LYS A  73
TYR A  62
 None
 1.05A 1gtiF-5gv1A:
undetectable		 1gtiF-5gv1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzh RAS-RELATED C3
BOTULINUM TOXIN
SUBSTRATE
1,NPH1-1,RAS-RELATED
C3 BOTULINUM TOXIN
SUBSTRATE 1

(Avena sativa;
Homo sapiens) 		PF00071
(Ras)
PF13426
(PAS_9) 		4 THR A  35
LEU A 210
GLY A 209
TYR A 213
 MG  A 403 ( 3.3A)
None
GTP  A 401 (-4.3A)
None
 1.26A 1gtiF-5hzhA:
undetectable		 1gtiF-5hzhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 LEU A 458
GLY A 460
LYS A 388
TYR A 457
 None
 1.10A 1gtiF-5i6rA:
undetectable		 1gtiF-5i6rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 THR B 336
LEU B 338
GLY B 362
TYR B 674
 None
 1.38A 1gtiF-5iz5B:
undetectable		 1gtiF-5iz5B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 LEU A 220
GLY A 140
LYS A 469
TYR A 139
 None
 1.34A 1gtiF-5izdA:
undetectable		 1gtiF-5izdA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrj PROTEIN RECA

(Herbaspirillum
seropedicae) 		PF00154
(RecA) 		4 LEU A 282
GLY A 285
LYS A 293
TYR A 298
 None
 1.37A 1gtiF-5jrjA:
undetectable		 1gtiF-5jrjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 THR A  74
LEU A 425
GLY A 422
LYS A 442
 None
None
None
HCA  A 501 ( 4.2A)
 1.36A 1gtiF-5kojA:
undetectable		 1gtiF-5kojA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		4 LEU A  16
GLY A  14
LYS A 370
TYR A 403
 None
 1.16A 1gtiF-5ldtA:
undetectable		 1gtiF-5ldtA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 4 THR A   5
LEU A  73
GLY A  75
TYR A 167
 None
PCA  A   1 ( 4.6A)
None
None
 1.30A 1gtiF-5o5dA:
undetectable		 1gtiF-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 467
GLY A 470
LYS A 520
TYR A 466
 None
 1.27A 1gtiF-5tc3A:
undetectable		 1gtiF-5tc3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 THR A  74
LEU A 131
GLY A 133
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 1.37A 1gtiF-5ufvA:
undetectable		 1gtiF-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 THR A  74
LEU A 131
GLY A 134
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 0.93A 1gtiF-5ufvA:
undetectable		 1gtiF-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um0 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Neisseria
gonorrhoeae) 		PF00300
(His_Phos_1) 		4 THR A  20
LEU A  92
GLY A  94
LYS A  97
 TLA  A 300 (-3.9A)
None
None
TLA  A 300 (-2.9A)
 1.23A 1gtiF-5um0A:
undetectable		 1gtiF-5um0A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vve PHOSPHOGLYCERATE
MUTASE

(Naegleria
fowleri) 		PF00300
(His_Phos_1) 		4 THR A  22
LEU A  94
GLY A  96
LYS A  99
 GOL  A 300 (-2.8A)
None
None
None
 1.23A 1gtiF-5vveA:
undetectable		 1gtiF-5vveA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 THR A   5
GLY A  75
LYS A 167
TYR A 168
 None
 1.33A 1gtiF-5w11A:
undetectable		 1gtiF-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 THR A 810
LEU A 852
GLY A 851
TYR A 894
 None
 1.12A 1gtiF-5w21A:
undetectable		 1gtiF-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 THR A 952
LEU A 904
GLY A 906
LYS A 899
 None
 1.07A 1gtiF-6cnhA:
undetectable		 1gtiF-6cnhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 THR X 227
LEU X 225
GLY X 222
TYR X 162
 None
 1.17A 1gtiF-6elqX:
undetectable		 1gtiF-6elqX:
undetectable