SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTI_E_CCSE47

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 114
LEU A 116
GLY A 157
LEU A 170
 None
None
ANP  A 400 (-4.3A)
ANP  A 400 (-4.0A)
 1.00A 1gtiE-1cm8A:
0.0		 1gtiE-1cm8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 THR A 135
LEU A 142
GLY A 144
LEU A 162
 None
 1.03A 1gtiE-1dy6A:
0.0		 1gtiE-1dy6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzt PHOSPHOGLYCERATE
MUTASE

(Schizosaccharomyces
pombe) 		PF00300
(His_Phos_1) 		4 THR A  27
LEU A  99
GLY A 101
LYS A 104
 None
 1.00A 1gtiE-1fztA:
0.0		 1gtiE-1fztA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 THR A 313
LEU A 317
GLY A 307
LEU A 299
 None
 1.05A 1gtiE-1gm5A:
undetectable		 1gtiE-1gm5A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 THR B2263
LEU B2265
GLY B2268
LEU B2270
 None
 1.04A 1gtiE-1i4eB:
0.4		 1gtiE-1i4eB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		4 LEU A  33
GLY A  29
LEU A  24
TYR A  20
 None
 0.82A 1gtiE-1iufA:
undetectable		 1gtiE-1iufA:
20.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		6 TRP A  38
LEU A  48
GLY A  50
LEU A  52
LYS A  54
TYR A  63
 GSH  A 504 (-3.9A)
None
None
GSH  A 504 (-4.7A)
None
None
 0.35A 1gtiE-1lbkA:
33.1		 1gtiE-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or7 RNA POLYMERASE
SIGMA-E FACTOR
SIGMA-E FACTOR
NEGATIVE REGULATORY
PROTEIN

(Escherichia
coli;
Escherichia
coli) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF03872
(RseA_N) 		4 TRP C  33
THR C  14
LEU A   5
LEU A  10
 None
 0.99A 1gtiE-1or7C:
undetectable		 1gtiE-1or7C:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 THR A 210
LEU A 178
GLY A 156
LEU A 162
 None
 0.96A 1gtiE-1q1rA:
undetectable		 1gtiE-1q1rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 THR A 670
LEU A 637
GLY A 635
LEU A 479
 None
 1.03A 1gtiE-1q3xA:
undetectable		 1gtiE-1q3xA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 THR A  35
LEU A  33
GLY A  29
LEU A  96
 None
 0.95A 1gtiE-1sb8A:
undetectable		 1gtiE-1sb8A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		4 TRP A 176
LEU A 130
GLY A 132
LEU A 177
 None
 1.03A 1gtiE-1tltA:
undetectable		 1gtiE-1tltA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 LEU C 851
GLY C 853
LEU C 855
LYS C 858
 None
 0.91A 1gtiE-1u6gC:
2.6		 1gtiE-1u6gC:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 THR A 234
LEU A 232
GLY A 228
LEU A 176
 None
 0.95A 1gtiE-1vi1A:
undetectable		 1gtiE-1vi1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE
5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		4 THR A 183
LEU B 241
GLY B 238
LEU B 246
 None
 0.96A 1gtiE-1w2wA:
undetectable		 1gtiE-1w2wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		4 THR A  71
LEU A  78
GLY A  76
LEU A  23
 None
 1.01A 1gtiE-1yw4A:
undetectable		 1gtiE-1yw4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjk MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 THR A 670
LEU A 637
GLY A 635
LEU A 479
 None
 1.02A 1gtiE-1zjkA:
undetectable		 1gtiE-1zjkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.96A 1gtiE-2amlA:
undetectable		 1gtiE-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TRP A 392
THR A 429
GLY A  48
LEU A 481
 None
 1.00A 1gtiE-2cn3A:
undetectable		 1gtiE-2cn3A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwa SINGLE-STRAND
BINDING PROTEIN

(Thermus
thermophilus) 		PF00436
(SSB) 		4 TRP A  52
THR A  33
GLY A  12
LEU A  10
 None
 0.98A 1gtiE-2cwaA:
undetectable		 1gtiE-2cwaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		4 THR A 110
LEU A 108
GLY A 105
LEU A 102
 None
None
None
FAD  A 699 (-4.4A)
 1.00A 1gtiE-2ddhA:
undetectable		 1gtiE-2ddhA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A 128
GLY A 133
LYS A  54
TYR A  55
 None
 1.03A 1gtiE-2dj0A:
undetectable		 1gtiE-2dj0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiE-2f9rA:
undetectable		 1gtiE-2f9rA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		4 LEU A 290
GLY A 294
LEU A 296
TYR A 262
 None
 1.05A 1gtiE-2fiyA:
undetectable		 1gtiE-2fiyA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  46
LEU A  50
LYS A  52
TYR A  61
 GTS  A 208 (-3.9A)
None
GTS  A 208 (-4.8A)
None
None
 0.35A 1gtiE-2gsrA:
34.6		 1gtiE-2gsrA:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 THR A 129
LEU A  31
GLY A   9
LEU A  15
 None
None
FAD  A 501 (-3.3A)
None
 1.02A 1gtiE-2i0zA:
undetectable		 1gtiE-2i0zA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 THR A 109
LEU A 107
GLY A 104
TYR A 349
 None
 1.04A 1gtiE-2nz9A:
2.3		 1gtiE-2nz9A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		4 THR A 389
LEU A 391
GLY A 394
LEU A 396
 None
 1.02A 1gtiE-2ojqA:
undetectable		 1gtiE-2ojqA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 THR A 151
LEU A 145
GLY A 148
LEU A 342
 None
 0.95A 1gtiE-2puzA:
undetectable		 1gtiE-2puzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 THR A 128
LEU A  34
GLY A  11
LEU A  17
 None
None
FAD  A 403 (-3.2A)
None
 0.77A 1gtiE-2rgjA:
undetectable		 1gtiE-2rgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 THR A  84
LEU A  94
GLY A  91
LEU A 300
 GDP  A1696 (-3.8A)
None
None
None
 1.03A 1gtiE-2w6dA:
undetectable		 1gtiE-2w6dA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF03244
(PSI_PsaH) 		4 THR H  66
LEU H  64
GLY H  61
LEU H  59
 None
CLA  H1079 ( 3.9A)
None
None
 0.95A 1gtiE-2wscH:
undetectable		 1gtiE-2wscH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 0.94A 1gtiE-2ww9A:
undetectable		 1gtiE-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		4 THR A  34
LEU A  32
GLY A  26
LEU A  57
 None
 1.03A 1gtiE-2ybqA:
undetectable		 1gtiE-2ybqA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 0.80A 1gtiE-2yquA:
undetectable		 1gtiE-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.90A 1gtiE-3a74A:
undetectable		 1gtiE-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brk GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Agrobacterium
tumefaciens) 		PF00483
(NTP_transferase) 		4 THR X  66
LEU X  18
GLY X 134
LEU X  51
 None
 0.89A 1gtiE-3brkX:
undetectable		 1gtiE-3brkX:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dan CYTOCHROME P450 74A2

(Parthenium
argentatum) 		PF00067
(p450) 		4 THR A 288
GLY A 293
LEU A 299
TYR A 392
 None
 1.00A 1gtiE-3danA:
undetectable		 1gtiE-3danA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR X 252
GLY X 257
LEU X 259
TYR X 308
 None
 1.01A 1gtiE-3e3bX:
undetectable		 1gtiE-3e3bX:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Burkholderia
pseudomallei) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 LEU A 152
GLY A 154
LEU A 157
LYS A 160
 None
 0.94A 1gtiE-3gnnA:
undetectable		 1gtiE-3gnnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9r CD1B3

(Bos taurus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 THR A 165
LEU A 170
GLY A 101
LEU A  12
 None
None
None
L9R  A 284 ( 4.1A)
 1.04A 1gtiE-3l9rA:
undetectable		 1gtiE-3l9rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 THR A 213
LEU A 181
GLY A 159
LEU A 165
 None
 0.83A 1gtiE-3lxdA:
undetectable		 1gtiE-3lxdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		4 THR A 212
LEU A 214
GLY A 217
TYR A 117
 None
EDO  A 230 ( 4.4A)
None
None
 0.90A 1gtiE-3mvuA:
undetectable		 1gtiE-3mvuA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 TRP A  23
LEU A 183
GLY A 209
LEU A 281
 None
 0.91A 1gtiE-3n2tA:
undetectable		 1gtiE-3n2tA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 TRP B 278
THR B  36
LEU B  38
GLY B  41
 None
 1.01A 1gtiE-3nndB:
undetectable		 1gtiE-3nndB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 4 TRP B 278
THR B 295
LEU B  38
GLY B  41
 None
 0.91A 1gtiE-3nndB:
undetectable		 1gtiE-3nndB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		4 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 0.75A 1gtiE-3nrnA:
undetectable		 1gtiE-3nrnA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		7 TRP A  38
THR A  46
LEU A  48
GLY A  50
LEU A  52
LYS A  54
TYR A  63
 GTB  A 210 (-4.0A)
None
None
None
GTB  A 210 (-4.9A)
None
None
 0.62A 1gtiE-3o76A:
34.7		 1gtiE-3o76A:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		4 THR A 109
LEU A  49
GLY A  47
LEU A  73
 None
None
MLY  A  45 ( 3.8A)
None
 0.99A 1gtiE-3oixA:
undetectable		 1gtiE-3oixA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TRP A 423
THR A 353
LEU A 351
GLY A 366
 SM5  A   1 (-4.3A)
None
None
None
 0.88A 1gtiE-3omvA:
undetectable		 1gtiE-3omvA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LEU A 285
GLY A 283
LEU A 280
TYR A 137
 None
 0.94A 1gtiE-3p54A:
undetectable		 1gtiE-3p54A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 276
LEU A 278
GLY A 281
LEU A 354
 None
 0.83A 1gtiE-3qtgA:
undetectable		 1gtiE-3qtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr6 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacteroides
abscessus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 LEU A 178
GLY A 139
LEU A   3
LYS A   1
 None
 0.96A 1gtiE-3rr6A:
undetectable		 1gtiE-3rr6A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		4 LEU A 246
GLY A 248
LEU A 138
TYR A 143
 CL  A 403 (-4.6A)
None
None
IPM  A 401 (-4.5A)
 1.02A 1gtiE-3vmlA:
undetectable		 1gtiE-3vmlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		4 LEU A 745
GLY A 747
LYS A 730
TYR A 682
 None
 0.98A 1gtiE-3wsyA:
undetectable		 1gtiE-3wsyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 TRP A 351
THR A  77
GLY A 364
LEU A 361
 None
 0.96A 1gtiE-3zk4A:
undetectable		 1gtiE-3zk4A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		4 THR A 152
LEU A 154
GLY A 157
LEU A 159
 None
 1.01A 1gtiE-4a01A:
1.0		 1gtiE-4a01A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 THR A 191
LEU A  36
GLY A  14
LEU A  20
 None
None
FAD  A 551 (-3.3A)
None
 0.81A 1gtiE-4c3yA:
undetectable		 1gtiE-4c3yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.94A 1gtiE-4cnsA:
undetectable		 1gtiE-4cnsA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 THR A 384
LEU A 328
GLY A 330
LEU A 283
 None
 0.96A 1gtiE-4cntA:
undetectable		 1gtiE-4cntA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuo BANYAN PEROXIDASE

(Ficus
benghalensis) 		PF00141
(peroxidase) 		4 THR A 245
GLY A 241
LEU A 220
TYR A 232
 HEM  A1307 (-3.5A)
None
None
None
 0.96A 1gtiE-4cuoA:
undetectable		 1gtiE-4cuoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiE-4djeD:
undetectable		 1gtiE-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.95A 1gtiE-4dpgA:
undetectable		 1gtiE-4dpgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 THR A 504
GLY A 454
LEU A 456
TYR A 459
 None
0SB  A 701 (-3.5A)
None
None
 1.01A 1gtiE-4f4pA:
undetectable		 1gtiE-4f4pA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 THR A 135
LEU A 146
GLY A 185
LEU A 114
 None
None
C8E  A 406 ( 4.0A)
None
 0.86A 1gtiE-4fspA:
undetectable		 1gtiE-4fspA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 THR H 670
LEU H 637
GLY H 635
LEU H 479
 None
 0.99A 1gtiE-4fxgH:
undetectable		 1gtiE-4fxgH:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqy CBS
DOMAIN-CONTAINING
PROTEIN CBSX2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00571
(CBS) 		4 THR A 178
LEU A 176
GLY A 174
LYS A 163
 AMP  A 301 (-3.4A)
None
None
None
 1.01A 1gtiE-4gqyA:
undetectable		 1gtiE-4gqyA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		4 LEU A 209
GLY A 212
LYS A 144
TYR A 146
 None
 1.01A 1gtiE-4kk2A:
undetectable		 1gtiE-4kk2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldq METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Homo sapiens) 		PF01008
(IF-2B) 		4 THR A 170
LEU A 211
GLY A 208
LEU A 216
 None
 0.97A 1gtiE-4ldqA:
undetectable		 1gtiE-4ldqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		4 GLY A 370
LEU A 451
LYS A 488
TYR A 417
 None
 0.93A 1gtiE-4pspA:
undetectable		 1gtiE-4pspA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvg SIBL

(Streptosporangium
sibiricum) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 THR A  63
LEU A  67
GLY A  78
LEU A  33
 None
 0.88A 1gtiE-4qvgA:
undetectable		 1gtiE-4qvgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 186
GLY A 190
LEU A 192
TYR A 244
 None
 1.00A 1gtiE-4up7A:
undetectable		 1gtiE-4up7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 THR A 362
GLY A 355
LEU A 432
TYR A 344
 None
 1.02A 1gtiE-4uyaA:
undetectable		 1gtiE-4uyaA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 TRP A 174
THR A 522
GLY A 526
LEU A 528
 None
 0.96A 1gtiE-4wboA:
undetectable		 1gtiE-4wboA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF01946
(Thi4) 		4 THR A 134
LEU A  65
GLY A  43
LEU A  49
 None
None
48F  A 301 (-3.4A)
None
 0.79A 1gtiE-4y4mA:
undetectable		 1gtiE-4y4mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.73A 1gtiE-4y4nA:
undetectable		 1gtiE-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		4 THR A 204
LEU A 241
GLY A 240
LEU A 232
 None
 1.03A 1gtiE-5bzaA:
undetectable		 1gtiE-5bzaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 TRP A  91
THR A 224
LEU A 226
LEU A 231
 None
 0.99A 1gtiE-5d1rA:
undetectable		 1gtiE-5d1rA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dcq FIBRONECTIN-BINDING
PROTEIN

(Streptococcus
equi) 		PF08341
(TED) 		4 LEU D  66
LEU D   2
LYS D  23
TYR D   4
 None
 1.05A 1gtiE-5dcqD:
undetectable		 1gtiE-5dcqD:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 TRP A 392
THR A 261
GLY A 433
LEU A 254
 None
 1.04A 1gtiE-5fq6A:
1.2		 1gtiE-5fq6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 4 TRP A 201
THR A 171
GLY A 143
LEU A 145
 None
 0.79A 1gtiE-5fzpA:
undetectable		 1gtiE-5fzpA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgq LYSINE--TRNA LIGASE

(Loa loa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 190
GLY A 194
LEU A 196
TYR A 248
 None
 1.02A 1gtiE-5hgqA:
undetectable		 1gtiE-5hgqA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 GLY A 408
LEU A 293
LYS A 254
TYR A 264
 PEG  A 702 ( 4.8A)
None
None
None
 0.94A 1gtiE-5i67A:
undetectable		 1gtiE-5i67A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 TRP A 256
LEU A 219
GLY A 221
LEU A 200
 None
 0.98A 1gtiE-5ie2A:
undetectable		 1gtiE-5ie2A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens) 		no annotation 4 TRP A1249
THR A1354
LEU A1356
LEU A1250
 None
 0.90A 1gtiE-5j1iA:
3.9		 1gtiE-5j1iA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		4 LEU A2375
GLY A2369
LEU A2344
TYR A2341
 None
 0.89A 1gtiE-5lkiA:
undetectable		 1gtiE-5lkiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		4 THR A 534
LEU A 536
GLY A 539
LEU A 541
 None
 0.97A 1gtiE-5mrwA:
undetectable		 1gtiE-5mrwA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 THR A 965
LEU A 967
GLY A 970
LEU A 980
 None
 0.91A 1gtiE-5u70A:
undetectable		 1gtiE-5u70A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufv GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN

(Thermothelomyces
thermophila) 		PF03443
(Glyco_hydro_61) 		4 THR A  74
LEU A 131
GLY A 134
LYS A   2
 HIC  A   1 (-3.7A)
None
None
HIC  A   1 ( 3.6A)
 0.89A 1gtiE-5ufvA:
undetectable		 1gtiE-5ufvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu6 NADPH-FLAVIN
OXIDOREDUCTASE

(Vibrio
parahaemolyticus) 		PF00881
(Nitroreductase) 		4 THR A 149
LEU A 232
GLY A 234
TYR A 231
 None
 0.92A 1gtiE-5uu6A:
undetectable		 1gtiE-5uu6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 GLY A  72
LEU A 213
LYS A  97
TYR A  99
 None
None
GOL  A 306 (-3.1A)
GOL  A 306 (-3.8A)
 0.88A 1gtiE-5vbbA:
undetectable		 1gtiE-5vbbA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w21 KLOTHO

(Homo sapiens) 		no annotation 4 THR A 810
LEU A 852
GLY A 851
TYR A 894
 None
 1.01A 1gtiE-5w21A:
undetectable		 1gtiE-5w21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 TRP A  89
LEU A 504
GLY A  47
LEU A 661
 None
 0.80A 1gtiE-5xqoA:
1.4		 1gtiE-5xqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 4 THR A  77
LEU A  75
GLY A   8
LEU A  33
 None
 0.98A 1gtiE-5z2eA:
undetectable		 1gtiE-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 4 THR A 520
LEU A 402
GLY A 400
LEU A 398
 None
 1.00A 1gtiE-5ze4A:
undetectable		 1gtiE-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 4 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.92A 1gtiE-6chdA:
undetectable		 1gtiE-6chdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9z SULFATE TRANSPORTER
CYSZ

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		no annotation 4 LEU F  10
GLY F 230
LEU F  16
LYS F  15
 None
 0.89A 1gtiE-6d9zF:
2.5		 1gtiE-6d9zF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 4 TRP A 291
THR A  77
LEU A  70
GLY A  72
 None
 0.93A 1gtiE-6f5uA:
undetectable		 1gtiE-6f5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 4 TRP A 291
THR A  77
LEU A  70
GLY A  72
 None
GOL  A 506 (-4.2A)
GOL  A 506 (-4.8A)
None
 0.94A 1gtiE-6f6sA:
undetectable		 1gtiE-6f6sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml INO80

(Chaetomium
thermophilum) 		no annotation 4 TRP G 982
LEU G1133
GLY G 993
LEU G 983
 None
 0.81A 1gtiE-6fmlG:
undetectable		 1gtiE-6fmlG:
undetectable