SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTI_C_CCSC47

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cgs IGG2B-KAPPA NC6.8
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 THR H 113
LEU H 173
GLY H 176
TYR H 178
 None
 1.00A 1gtiC-1cgsH:
undetectable		 1gtiC-1cgsH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jbk CLPB PROTEIN

(Escherichia
coli) 		PF00004
(AAA) 		4 LEU A 245
GLY A 243
LYS A 163
TYR A 164
 None
 1.23A 1gtiC-1jbkA:
undetectable		 1gtiC-1jbkA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
CYTOCHROME B556(FDN)
SUBUNIT

(Escherichia
coli) 		PF01292
(Ni_hydr_CYTB) 		4 TRP C 192
THR C  10
LYS C 108
TYR C 109
 None
None
None
HEM  C 810 (-3.8A)
 1.29A 1gtiC-1kqfC:
undetectable		 1gtiC-1kqfC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 LEU A 339
GLY A 351
LYS A   1
TYR A   3
 None
 1.14A 1gtiC-1ks8A:
2.1		 1gtiC-1ks8A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  48
GLY A  50
LYS A  54
TYR A  63
 GSH  A 504 (-3.9A)
None
None
None
None
 0.56A 1gtiC-1lbkA:
33.2		 1gtiC-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 THR A   5
GLY A  75
LYS A 166
TYR A 167
 None
 1.23A 1gtiC-1q2eA:
undetectable		 1gtiC-1q2eA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		4 THR A  91
LEU A 114
GLY A 118
TYR A  83
 None
 1.32A 1gtiC-1ta9A:
0.0		 1gtiC-1ta9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v31 HYPOTHETICAL PROTEIN
RAFL11-05-P19

(Arabidopsis
thaliana) 		PF02201
(SWIB) 		4 THR A  16
LEU A  18
GLY A  23
LYS A  13
 None
 1.22A 1gtiC-1v31A:
undetectable		 1gtiC-1v31A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 THR A  78
LEU A  51
GLY A  76
LYS A  26
 EDO  A 204 ( 4.5A)
None
None
EDO  A 209 (-2.8A)
 1.29A 1gtiC-1vqtA:
undetectable		 1gtiC-1vqtA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9z VP9

(Banna virus) 		PF08978
(Reoviridae_Vp9) 		4 THR A 177
LEU A 170
GLY A 245
LYS A 140
 None
 1.35A 1gtiC-1w9zA:
undetectable		 1gtiC-1w9zA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhu GIANT HEMOGLOBINS B
CHAIN

(Riftia
pachyptila) 		PF00042
(Globin) 		4 THR B  66
LEU B  69
GLY B  71
TYR B  20
 None
None
HEM  B 160 ( 4.5A)
None
 1.15A 1gtiC-1yhuB:
undetectable		 1gtiC-1yhuB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2agk 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Saccharomyces
cerevisiae) 		PF00977
(His_biosynth) 		4 THR A 172
LEU A 122
GLY A 127
LYS A 100
 None
 1.25A 1gtiC-2agkA:
undetectable		 1gtiC-2agkA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahq RNA POLYMERASE SIGMA
FACTOR RPON

(Aquifex
aeolicus) 		PF04552
(Sigma54_DBD) 		4 LEU A  21
GLY A  19
LYS A  61
TYR A  62
 None
 1.26A 1gtiC-2ahqA:
undetectable		 1gtiC-2ahqA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfu COWPEA MOSAIC VIRUS,
LARGE (L) SUBUNIT

(Cowpea mosaic
virus) 		PF02247
(Como_LCP) 		4 TRP L 196
THR L 251
LEU L 344
GLY L 198
 None
 1.33A 1gtiC-2bfuL:
undetectable		 1gtiC-2bfuL:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2z CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 4

(Homo sapiens) 		PF13410
(GST_C_2) 		4 LEU A  99
GLY A  49
LYS A 103
TYR A 104
 None
 1.18A 1gtiC-2d2zA:
13.8		 1gtiC-2d2zA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 THR A 615
LEU A 609
GLY A 613
LYS A 466
 None
 1.21A 1gtiC-2db3A:
undetectable		 1gtiC-2db3A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 LEU A 128
GLY A 133
LYS A  54
TYR A  55
 None
 1.03A 1gtiC-2dj0A:
undetectable		 1gtiC-2dj0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT

(Gallus gallus) 		PF00079
(Serpin) 		4 THR A  42
LEU A  44
GLY A 333
TYR A 132
 None
 1.21A 1gtiC-2dutA:
undetectable		 1gtiC-2dutA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9r SPHINGOMYELINASE D 1

(Loxosceles
laeta) 		no annotation 4 LEU A 242
GLY A 245
LYS A 269
TYR A 270
 None
 0.95A 1gtiC-2f9rA:
undetectable		 1gtiC-2f9rA:
22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TRP A  38
LEU A  46
LYS A  52
TYR A  61
 GTS  A 208 (-3.9A)
None
None
None
 0.56A 1gtiC-2gsrA:
34.6		 1gtiC-2gsrA:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF03054
(tRNA_Me_trans) 		4 THR A 153
GLY A 356
LYS A 310
TYR A 349
 None
 1.05A 1gtiC-2hmaA:
undetectable		 1gtiC-2hmaA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		4 THR A 131
LEU A 122
GLY A 124
LYS A  30
 None
 1.29A 1gtiC-2nq3A:
undetectable		 1gtiC-2nq3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrj HBL B PROTEIN

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		4 THR A 341
GLY A 222
LYS A  45
TYR A  41
 None
 1.18A 1gtiC-2nrjA:
undetectable		 1gtiC-2nrjA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 THR A 165
LEU A 162
GLY A 160
TYR A 158
 None
 1.35A 1gtiC-2optA:
undetectable		 1gtiC-2optA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 LEU A 160
GLY A 162
LYS A   1
TYR A 159
 None
 1.22A 1gtiC-2qriA:
undetectable		 1gtiC-2qriA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r51 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26B

(Mus musculus) 		PF03643
(Vps26) 		4 THR A 256
LEU A 292
LYS A 211
TYR A 270
 None
 1.34A 1gtiC-2r51A:
undetectable		 1gtiC-2r51A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 LEU A 344
GLY A 324
LYS A 331
TYR A 327
 None
 1.27A 1gtiC-2v1uA:
undetectable		 1gtiC-2v1uA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 LEU A  84
GLY A 148
LYS A 105
TYR A 118
 None
 1.25A 1gtiC-2vy0A:
undetectable		 1gtiC-2vy0A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xc8 GENE 22 PRODUCT

(Bacillus phage
SPP1) 		no annotation 4 THR A  49
LEU A  48
LYS A  77
TYR A  58
 None
 1.34A 1gtiC-2xc8A:
undetectable		 1gtiC-2xc8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 THR A  22
GLY A  91
LYS A 179
TYR A 180
 None
 1.34A 1gtiC-2yokA:
undetectable		 1gtiC-2yokA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		4 TRP C 187
THR A  80
LEU A 106
GLY A  90
 None
 1.33A 1gtiC-3cjiC:
undetectable		 1gtiC-3cjiC:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TRP A 384
THR A  87
GLY A  89
TYR A 546
 None
NAG  A 710 (-4.5A)
None
None
 1.33A 1gtiC-3dkhA:
undetectable		 1gtiC-3dkhA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TRP A 543
THR A  87
LEU A  85
GLY A  89
 None
NAG  A 710 (-4.5A)
None
None
 1.19A 1gtiC-3dkhA:
undetectable		 1gtiC-3dkhA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 THR A1195
LEU A1204
GLY A1199
TYR A1211
 None
 1.35A 1gtiC-3egwA:
undetectable		 1gtiC-3egwA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdw SYNAPTOTAGMIN-LIKE
PROTEIN 4

(Homo sapiens) 		PF00168
(C2) 		4 THR A 399
LEU A 401
GLY A 409
TYR A 430
 None
 1.18A 1gtiC-3fdwA:
undetectable		 1gtiC-3fdwA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		4 TRP A 171
THR A 147
GLY A 101
TYR A 103
 None
 1.05A 1gtiC-3gt5A:
2.8		 1gtiC-3gt5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 THR A 101
LEU A  98
GLY A  96
TYR A  89
 None
 0.96A 1gtiC-3iv0A:
2.9		 1gtiC-3iv0A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES1
40S RIBOSOMAL
PROTEIN US11

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF01015
(Ribosomal_S3Ae)
PF00411
(Ribosomal_S11) 		4 THR B  46
LEU P  47
GLY P  49
TYR B  66
 None
None
U  A 987 ( 3.2A)
None
 1.11A 1gtiC-3j7aB:
undetectable		 1gtiC-3j7aB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kux PUTATIVE
OXIDOREDUCTASE

(Yersinia pestis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 THR A 132
LEU A 136
LYS A 249
TYR A 247
 None
 1.04A 1gtiC-3kuxA:
undetectable		 1gtiC-3kuxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA
COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF06957
(COPI_C)
PF04733
(Coatomer_E) 		4 THR A 957
GLY B  13
LYS B  39
TYR B  10
 None
 1.20A 1gtiC-3mv3A:
undetectable		 1gtiC-3mv3A:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  48
GLY A  50
LYS A  54
TYR A  63
 GTB  A 210 (-4.0A)
None
None
None
None
 0.56A 1gtiC-3o76A:
34.8		 1gtiC-3o76A:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
THR A  46
GLY A  50
LYS A  54
TYR A  63
 GTB  A 210 (-4.0A)
None
None
None
None
 1.08A 1gtiC-3o76A:
34.8		 1gtiC-3o76A:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oix PUTATIVE
DIHYDROOROTATE
DEHYDROGENASE
DIHYDROOROTATE
OXIDASE

(Streptococcus
mutans) 		PF01180
(DHO_dh) 		4 THR A  63
LEU A  65
GLY A 220
TYR A 222
 None
None
FMN  A 400 (-3.4A)
None
 1.11A 1gtiC-3oixA:
undetectable		 1gtiC-3oixA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqu TRANSFERRIN BINDING
PROTEIN B

(Actinobacillus
suis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 THR A  48
GLY A 305
LYS A 317
TYR A 162
 None
 0.81A 1gtiC-3pquA:
undetectable		 1gtiC-3pquA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 THR A 204
LEU A 201
GLY A 199
TYR A 178
 None
 1.13A 1gtiC-3ro2A:
1.4		 1gtiC-3ro2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujm RASPUTIN

(Drosophila
melanogaster) 		PF02136
(NTF2) 		4 LEU A 112
GLY A  87
LYS A 118
TYR A 120
 None
 1.28A 1gtiC-3ujmA:
undetectable		 1gtiC-3ujmA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vf1 11R-LIPOXYGENASE

(Gersemia
fruticosa) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 TRP A 148
THR A 384
GLY A 160
TYR A 520
 None
 1.15A 1gtiC-3vf1A:
undetectable		 1gtiC-3vf1A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu A2 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 THR B  65
LEU B  68
GLY B  70
TYR B  19
 None
None
HEM  B 201 ( 4.1A)
None
 1.04A 1gtiC-3wcuB:
undetectable		 1gtiC-3wcuB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 THR A 205
LEU A 203
GLY A 200
LYS A 294
 None
 1.26A 1gtiC-3wjoA:
undetectable		 1gtiC-3wjoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		4 LEU A 745
GLY A 747
LYS A 730
TYR A 682
 None
 0.99A 1gtiC-3wsyA:
undetectable		 1gtiC-3wsyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 THR A1269
LEU A1210
GLY A1209
TYR A1211
 None
 1.32A 1gtiC-3zyvA:
undetectable		 1gtiC-3zyvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1s PARTNER OF
INSCUTEABLE

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 THR A 227
LEU A 224
GLY A 222
TYR A 201
 None
 1.17A 1gtiC-4a1sA:
1.4		 1gtiC-4a1sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dje CORRINOID/IRON-SULFU
R PROTEIN SMALL
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD) 		4 LEU D 300
GLY D 254
LYS D 101
TYR D  99
 None
 0.97A 1gtiC-4djeD:
undetectable		 1gtiC-4djeD:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 LEU A 167
GLY A 169
LYS A 107
TYR A 108
 None
 1.10A 1gtiC-4dwsA:
undetectable		 1gtiC-4dwsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eog PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09455
(Cas_DxTHG) 		4 TRP A  16
THR A   8
LEU A 165
GLY A 168
 None
 1.28A 1gtiC-4eogA:
undetectable		 1gtiC-4eogA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		4 LEU A 234
GLY A 140
LYS A   7
TYR A   9
 None
 1.19A 1gtiC-4fs3A:
undetectable		 1gtiC-4fs3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ged ASCORBATE PEROXIDASE

(Leishmania
major) 		PF00141
(peroxidase) 		4 LEU A 290
GLY A 179
LYS A  78
TYR A  73
 None
 1.17A 1gtiC-4gedA:
undetectable		 1gtiC-4gedA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn8 REGUCALCIN

(Mus musculus) 		PF08450
(SGL) 		4 THR A  44
LEU A  29
LYS A 283
TYR A 259
 None
 1.16A 1gtiC-4gn8A:
undetectable		 1gtiC-4gn8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gu7 PUTATIVE
UNCHARACTERIZED
PROTEIN SCO7193

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		4 TRP A  71
THR A 303
LEU A 104
GLY A  67
 None
 1.21A 1gtiC-4gu7A:
undetectable		 1gtiC-4gu7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhr G-PROTEIN-SIGNALING
MODULATOR 2

(Mus musculus) 		PF02188
(GoLoco)
PF13176
(TPR_7)
PF13424
(TPR_12) 		4 THR A 204
LEU A 201
GLY A 199
TYR A 178
 None
 1.21A 1gtiC-4jhrA:
undetectable		 1gtiC-4jhrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		4 LEU A 209
GLY A 212
LYS A 144
TYR A 146
 None
 1.01A 1gtiC-4kk2A:
undetectable		 1gtiC-4kk2A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leo RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 THR C  13
LEU C  44
GLY C  42
TYR C  34
 None
 1.28A 1gtiC-4leoC:
undetectable		 1gtiC-4leoC:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 4 LEU A 183
GLY A  87
LYS A  90
TYR A  89
 None
 1.26A 1gtiC-4mfzA:
undetectable		 1gtiC-4mfzA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		4 THR A 184
LEU A 181
GLY A 179
TYR A 104
 None
 1.09A 1gtiC-4mhlA:
undetectable		 1gtiC-4mhlA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		4 THR A 139
LEU A 111
GLY A 137
LYS A  79
 None
 1.18A 1gtiC-4mjzA:
undetectable		 1gtiC-4mjzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		4 LEU A 204
GLY A 332
LYS A 369
TYR A 374
 None
 1.34A 1gtiC-4nz6A:
undetectable		 1gtiC-4nz6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 329
LEU A 331
GLY A 185
LYS A 150
 None
 1.22A 1gtiC-4o38A:
undetectable		 1gtiC-4o38A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqq DEOXYRIBONUCLEOSIDE
REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		4 LEU A 291
GLY A 293
LYS A  71
TYR A  72
 None
 1.25A 1gtiC-4oqqA:
undetectable		 1gtiC-4oqqA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1b TOLUENE-4-MONOOXYGEN
ASE SYSTEM
FERREDOXIN SUBUNIT

(Pseudomonas
mendocina) 		PF00355
(Rieske) 		4 THR H  75
LEU H  86
LYS H  39
TYR H  41
 None
 1.18A 1gtiC-4p1bH:
undetectable		 1gtiC-4p1bH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 LEU A  50
GLY A  46
LYS A 220
TYR A  41
 None
 1.06A 1gtiC-4qtsA:
undetectable		 1gtiC-4qtsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6w PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF13649
(Methyltransf_25) 		4 THR A  44
LEU A  41
GLY A  39
TYR A  35
 None
 1.27A 1gtiC-4r6wA:
undetectable		 1gtiC-4r6wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9x COPPER HOMEOSTASIS
PROTEIN CUTC

(Bacillus
anthracis) 		PF03932
(CutC) 		4 THR A  64
LEU A  93
GLY A  91
LYS A 103
 None
 1.27A 1gtiC-4r9xA:
undetectable		 1gtiC-4r9xA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 TRP A3546
LEU A3558
GLY A3556
LYS A3507
 None
 1.33A 1gtiC-4tktA:
undetectable		 1gtiC-4tktA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufc GH95

(Bacteroides
ovatus) 		PF14498
(Glyco_hyd_65N_2) 		4 LEU A 457
GLY A 713
LYS A 462
TYR A 456
 None
 1.12A 1gtiC-4ufcA:
1.7		 1gtiC-4ufcA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xup ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		4 THR A 248
LEU A 276
GLY A 279
TYR A 242
 None
 1.30A 1gtiC-4xupA:
undetectable		 1gtiC-4xupA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xut ENDO-1,4-BETA-XYLANA
SE C

(Paenibacillus
barcinonensis) 		PF02018
(CBM_4_9) 		4 THR A 248
LEU A 276
GLY A 279
TYR A 242
 None
 1.28A 1gtiC-4xutA:
undetectable		 1gtiC-4xutA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 THR A 229
LEU A 226
GLY A 224
TYR A 136
 None
 1.07A 1gtiC-4zwjA:
undetectable		 1gtiC-4zwjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 THR A 204
LEU A 201
GLY A 199
TYR A 178
 None
 1.10A 1gtiC-5a6cA:
undetectable		 1gtiC-5a6cA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12) 		4 THR B 227
LEU B 224
GLY B 222
TYR B 201
 None
 1.22A 1gtiC-5a7dB:
1.2		 1gtiC-5a7dB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afo FIMBRIAE

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 THR A  18
LEU A 133
GLY A 131
TYR A  40
 None
 1.32A 1gtiC-5afoA:
undetectable		 1gtiC-5afoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d66 UNCHARACTERIZED
PROTEIN

(Acinetobacter
baumannii) 		PF12796
(Ank_2) 		4 THR A 142
LEU A 112
GLY A 115
TYR A 111
 None
 1.23A 1gtiC-5d66A:
undetectable		 1gtiC-5d66A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgg UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 THR A 240
GLY A 186
LYS A 263
TYR A 259
 None
 1.18A 1gtiC-5dggA:
undetectable		 1gtiC-5dggA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 LEU A  52
GLY A  50
LYS A 221
TYR A 223
 None
 1.19A 1gtiC-5fjnA:
undetectable		 1gtiC-5fjnA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gv1 ENDO-1,4-BETA-XYLANA
SE

(termite gut
metagenome) 		PF00457
(Glyco_hydro_11) 		4 LEU A  23
GLY A  25
LYS A  73
TYR A  62
 None
 1.05A 1gtiC-5gv1A:
undetectable		 1gtiC-5gv1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h20 PUTATIVE PADR-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Bacteroides
fragilis) 		PF03551
(PadR) 		4 THR A  54
LEU A  62
LYS A  76
TYR A  78
 None
 1.31A 1gtiC-5h20A:
undetectable		 1gtiC-5h20A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6r SLIT-ROBO RHO
GTPASE-ACTIVATING
PROTEIN 2

(Homo sapiens) 		PF00611
(FCH) 		4 LEU A 458
GLY A 460
LYS A 388
TYR A 457
 None
 1.10A 1gtiC-5i6rA:
undetectable		 1gtiC-5i6rA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 LEU A 220
GLY A 140
LYS A 469
TYR A 139
 None
 1.33A 1gtiC-5izdA:
undetectable		 1gtiC-5izdA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf2 PREDICTED
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00583
(Acetyltransf_1) 		4 TRP A 288
THR A 118
GLY A 115
TYR A  77
 None
None
ACO  A 402 ( 4.7A)
None
 1.30A 1gtiC-5kf2A:
undetectable		 1gtiC-5kf2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		4 LEU A  16
GLY A  14
LYS A 370
TYR A 403
 None
 1.17A 1gtiC-5ldtA:
undetectable		 1gtiC-5ldtA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		4 THR A 301
GLY A 304
LYS A 425
TYR A 420
 NDP  A 701 (-3.5A)
GOL  A 702 ( 4.0A)
NDP  A 701 (-2.7A)
GOL  A 702 (-4.9A)
 1.33A 1gtiC-5mq6A:
undetectable		 1gtiC-5mq6A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 TRP A1062
THR A1004
LEU A1000
TYR A1165
 None
 1.23A 1gtiC-5mzaA:
undetectable		 1gtiC-5mzaA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nt7 ATP-DEPENDENT RNA
HELICASE VASA,
ISOFORM A

(Drosophila
melanogaster) 		PF00271
(Helicase_C) 		4 THR B 615
LEU B 609
GLY B 613
LYS B 466
 None
 1.16A 1gtiC-5nt7B:
undetectable		 1gtiC-5nt7B:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 467
GLY A 470
LYS A 520
TYR A 466
 None
 1.27A 1gtiC-5tc3A:
undetectable		 1gtiC-5tc3A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		4 THR A 288
LEU A 262
GLY A 223
TYR A 231
 None
 1.27A 1gtiC-5tcbA:
undetectable		 1gtiC-5tcbA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5usx THIOREDOXIN
REDUCTASE

(Vibrio
vulnificus) 		PF07992
(Pyr_redox_2) 		4 THR A  36
GLY A  42
LYS A  70
TYR A  19
 None
FAD  A 402 (-3.4A)
None
None
 1.23A 1gtiC-5usxA:
undetectable		 1gtiC-5usxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w11 GLUCANASE

(Thermothelomyces
thermophila) 		no annotation 4 THR A   5
GLY A  75
LYS A 167
TYR A 168
 None
 1.22A 1gtiC-5w11A:
undetectable		 1gtiC-5w11A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE

(Marinomonas
mediterranea) 		no annotation 4 TRP A 164
THR A 140
GLY A  94
TYR A  96
 None
 1.15A 1gtiC-5x32A:
3.1		 1gtiC-5x32A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES1
RIBOSOMAL PROTEIN
US11

(Toxoplasma
gondii;
Toxoplasma
gondii) 		PF01015
(Ribosomal_S3Ae)
PF00411
(Ribosomal_S11) 		4 THR B  46
LEU O  52
GLY O  54
TYR B  66
 None
None
U  2 915 ( 4.2A)
None
 1.10A 1gtiC-5xxuB:
undetectable		 1gtiC-5xxuB:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yuh B3 DOMAIN-CONTAINING
TRANSCRIPTION
REPRESSOR VAL1

(Arabidopsis
thaliana) 		no annotation 4 THR A  95
LEU A  67
GLY A  92
LYS A  70
 None
 1.20A 1gtiC-5yuhA:
undetectable		 1gtiC-5yuhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 4 THR A 952
LEU A 904
GLY A 906
LYS A 899
 None
 1.05A 1gtiC-6cnhA:
undetectable		 1gtiC-6cnhA:
undetectable