SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTI_A_CCSA47

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 THR A 114
LEU A 116
GLY A 157
LEU A 170
 None
None
ANP  A 400 (-4.3A)
ANP  A 400 (-4.0A)
 0.93A 1gtiA-1cm8A:
undetectable		 1gtiA-1cm8A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy6 CARBAPENEM-HYDROLYSI
NG BETA-LACTAMASE
SME-1

(Serratia
marcescens) 		PF13354
(Beta-lactamase2) 		4 THR A 135
LEU A 142
GLY A 144
LEU A 162
 None
 0.95A 1gtiA-1dy6A:
undetectable		 1gtiA-1dy6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 LEU A  42
LEU A  79
GLY A  75
LEU A  98
 None
 0.85A 1gtiA-1e4oA:
0.2		 1gtiA-1e4oA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuf CENTROMERE ABP1
PROTEIN

(Schizosaccharomyces
pombe) 		PF03221
(HTH_Tnp_Tc5) 		4 LEU A  33
GLY A  29
LEU A  24
TYR A  20
 None
 0.81A 1gtiA-1iufA:
undetectable		 1gtiA-1iufA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 LEU B  60
LEU B  42
GLY B  40
LEU B  76
 None
None
ATP  B 250 (-3.4A)
None
 0.70A 1gtiA-1jwaB:
undetectable		 1gtiA-1jwaB:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		6 TRP A  38
LEU A  43
LEU A  48
GLY A  50
LEU A  52
TYR A  63
 GSH  A 504 (-3.9A)
None
None
None
GSH  A 504 (-4.7A)
None
 0.66A 1gtiA-1lbkA:
33.4		 1gtiA-1lbkA:
82.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocs SORTING NEXIN GRD19

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		4 LEU A  68
LEU A 143
GLY A 147
LEU A 151
 None
 0.84A 1gtiA-1ocsA:
undetectable		 1gtiA-1ocsA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1r PUTIDAREDOXIN
REDUCTASE

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 THR A 210
LEU A 178
GLY A 156
LEU A 162
 None
 0.94A 1gtiA-1q1rA:
undetectable		 1gtiA-1q1rA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 LEU B 236
LEU B 316
GLY B 482
LEU B 324
 None
 0.82A 1gtiA-1qh1B:
0.1		 1gtiA-1qh1B:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 LEU B 354
LEU B 135
GLY B 136
LEU B 139
 None
 0.95A 1gtiA-1tnuB:
1.8		 1gtiA-1tnuB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 LEU A 256
THR A 260
GLY A 302
LEU A 105
 None
 0.92A 1gtiA-1us4A:
undetectable		 1gtiA-1us4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 LEU A  17
LEU A  36
GLY A  84
LEU A  82
 None
SAH  A 501 ( 4.9A)
SAH  A 501 (-4.9A)
None
 0.93A 1gtiA-1v9aA:
undetectable		 1gtiA-1v9aA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x6d INTERLEUKIN-16

(Homo sapiens) 		PF00595
(PDZ) 		4 LEU A  75
THR A  78
GLY A  35
LEU A  33
 None
 0.95A 1gtiA-1x6dA:
undetectable		 1gtiA-1x6dA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yii ANNEXIN A5

(Gallus gallus) 		PF00191
(Annexin) 		4 LEU A 296
LEU A 314
GLY A 317
LEU A 281
 None
 0.89A 1gtiA-1yiiA:
undetectable		 1gtiA-1yiiA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl9 GLUTATHIONE
S-TRANSFERASE 5

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TRP A  39
LEU A  42
GLY A  51
LEU A  53
 GSH  A 501 (-4.1A)
None
None
GSH  A 501 (-4.5A)
 0.71A 1gtiA-1zl9A:
22.7		 1gtiA-1zl9A:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		4 TRP A  41
LEU A 160
GLY A 162
LEU A  30
 None
 0.89A 1gtiA-2amlA:
undetectable		 1gtiA-2amlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		4 LEU H 138
THR H 129
GLY H 150
LEU H 114
 None
 0.95A 1gtiA-2bbkH:
undetectable		 1gtiA-2bbkH:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 LEU A 114
THR A 228
GLY A 111
LEU A 254
 None
 0.93A 1gtiA-2cxiA:
undetectable		 1gtiA-2cxiA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7

(Homo sapiens) 		PF04857
(CAF1) 		4 TRP A 153
LEU A 165
LEU A 139
LEU A  79
 None
 0.86A 1gtiA-2d5rA:
undetectable		 1gtiA-2d5rA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		5 LEU A 183
THR A 209
LEU A 215
GLY A 214
LEU A 179
 None
 1.39A 1gtiA-2e6mA:
undetectable		 1gtiA-2e6mA:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE

(Sus scrofa) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  41
LEU A  46
LEU A  50
TYR A  61
 GTS  A 208 (-3.9A)
None
None
GTS  A 208 (-4.8A)
None
 0.71A 1gtiA-2gsrA:
34.7		 1gtiA-2gsrA:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5v DNA REPLICATION AND
REPAIR PROTEIN RECF

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 LEU A   9
LEU A  12
GLY A  20
LEU A  17
 None
 0.95A 1gtiA-2o5vA:
undetectable		 1gtiA-2o5vA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2puz IMIDAZOLONEPROPIONAS
E

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1) 		4 LEU A 361
THR A  79
LEU A  26
GLY A  37
 None
 0.94A 1gtiA-2puzA:
undetectable		 1gtiA-2puzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2v BETA-D-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
putida) 		PF00106
(adh_short) 		4 LEU A  61
THR A  11
LEU A  34
GLY A  36
 None
 0.95A 1gtiA-2q2vA:
undetectable		 1gtiA-2q2vA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 THR A 472
GLY A 432
LEU A 435
TYR A 485
 None
 0.94A 1gtiA-2quaA:
undetectable		 1gtiA-2quaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 THR A 128
LEU A  34
GLY A  11
LEU A  17
 None
None
FAD  A 403 (-3.2A)
None
 0.86A 1gtiA-2rgjA:
undetectable		 1gtiA-2rgjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		4 LEU A  71
THR A   6
GLY A  14
LEU A  12
 None
 0.95A 1gtiA-2vrcA:
undetectable		 1gtiA-2vrcA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		4 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 0.79A 1gtiA-2ww9A:
undetectable		 1gtiA-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4l MANNOSYLGLYCERATE
SYNTHASE

(Rhodothermus
marinus) 		no annotation 5 TRP A 282
LEU A 278
THR A 345
LEU A 340
LEU A 301
 None
 1.37A 1gtiA-2y4lA:
undetectable		 1gtiA-2y4lA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqu 2-OXOGLUTARATE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 227
LEU A 196
GLY A 174
LEU A 180
 None
 0.86A 1gtiA-2yquA:
undetectable		 1gtiA-2yquA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1u HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Desulfovibrio
vulgaris) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 337
LEU A 264
GLY A 223
LEU A 332
 None
 0.86A 1gtiA-2z1uA:
undetectable		 1gtiA-2z1uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 TRP A 359
LEU A 385
LEU A 372
LEU A 367
 None
 0.86A 1gtiA-2zpaA:
undetectable		 1gtiA-2zpaA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		4 LEU A 277
THR A 489
LEU A 491
GLY A 494
 None
 0.87A 1gtiA-3a1iA:
undetectable		 1gtiA-3a1iA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE

(Geobacillus
stearothermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 188
GLY A 192
LEU A 194
TYR A 246
 None
 0.90A 1gtiA-3a74A:
undetectable		 1gtiA-3a74A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agk PEPTIDE CHAIN
RELEASE FACTOR
SUBUNIT 1

(Aeropyrum
pernix) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 LEU A 213
LEU A 158
GLY A 144
LEU A 166
 None
 0.89A 1gtiA-3agkA:
undetectable		 1gtiA-3agkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 286
LEU A  84
GLY A 282
LEU A 293
 None
 0.71A 1gtiA-3bt6A:
undetectable		 1gtiA-3bt6A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 LEU A 479
LEU A 444
GLY A 441
LEU A 308
 None
 0.90A 1gtiA-3e1sA:
undetectable		 1gtiA-3e1sA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A

(Homo sapiens) 		PF00620
(RhoGAP) 		4 LEU A 231
THR A 156
LEU A 158
LEU A 163
 None
 0.91A 1gtiA-3eapA:
undetectable		 1gtiA-3eapA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy7 CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 3

(Homo sapiens) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		4 LEU A   6
LEU A  34
GLY A  36
LEU A  86
 None
 0.84A 1gtiA-3fy7A:
13.1		 1gtiA-3fy7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g10 CCR4-NOT COMPLEX
SUBUNIT CAF1

(Schizosaccharomyces
pombe) 		PF04857
(CAF1) 		4 TRP A 163
LEU A 175
LEU A 149
LEU A  89
 None
 0.81A 1gtiA-3g10A:
undetectable		 1gtiA-3g10A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhe RIBOSE-5-PHOSPHATE
ISOMERASE A

(Bartonella
henselae) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A  45
LEU A  59
GLY A  61
LEU A  68
 None
None
None
CL  A 499 ( 4.7A)
 0.80A 1gtiA-3hheA:
undetectable		 1gtiA-3hheA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		4 LEU A2174
GLY A2142
LEU A2236
TYR A1974
 None
 0.84A 1gtiA-3jbzA:
2.8		 1gtiA-3jbzA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9r CD1B3

(Bos taurus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 LEU A 161
THR A 165
LEU A 170
GLY A 101
LEU A  12
 None
None
None
None
L9R  A 284 ( 4.1A)
 1.16A 1gtiA-3l9rA:
undetectable		 1gtiA-3l9rA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE

(Novosphingobium
aromaticivorans) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 THR A 213
LEU A 181
GLY A 159
LEU A 165
 None
 0.85A 1gtiA-3lxdA:
undetectable		 1gtiA-3lxdA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 TRP A  23
LEU A 183
GLY A 209
LEU A 281
 None
 0.68A 1gtiA-3n2tA:
undetectable		 1gtiA-3n2tA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		5 LEU A  68
THR A  66
LEU A  42
GLY A  46
LEU A  48
 None
None
GOL  A 277 ( 4.4A)
None
None
 1.49A 1gtiA-3nibA:
undetectable		 1gtiA-3nibA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnd POSSIBLE SUBSTRATE
BINDING PROTEIN OF
ABC TRANSPORTER
SYSTEM

(Rhodopseudomonas
palustris) 		no annotation 5 TRP B 278
LEU B 279
THR B 295
LEU B  38
GLY B  41
 None
 1.24A 1gtiA-3nndB:
undetectable		 1gtiA-3nndB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		4 THR A 208
LEU A  29
GLY A   7
LEU A  13
 None
None
AMP  A 422 (-3.2A)
None
 0.78A 1gtiA-3nrnA:
undetectable		 1gtiA-3nrnA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  43
THR A  46
LEU A  48
GLY A  50
LEU A  52
 None
None
None
None
GTB  A 210 (-4.9A)
 1.17A 1gtiA-3o76A:
35.1		 1gtiA-3o76A:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 THR A  46
LEU A  48
GLY A  50
LEU A  52
TYR A  63
 None
None
None
GTB  A 210 (-4.9A)
None
 0.59A 1gtiA-3o76A:
35.1		 1gtiA-3o76A:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  43
LEU A  48
GLY A  50
LEU A  52
 GTB  A 210 (-4.0A)
None
None
None
GTB  A 210 (-4.9A)
 0.64A 1gtiA-3o76A:
35.1		 1gtiA-3o76A:
99.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TRP A  38
LEU A  48
GLY A  50
LEU A  52
TYR A  63
 GTB  A 210 (-4.0A)
None
None
GTB  A 210 (-4.9A)
None
 0.41A 1gtiA-3o76A:
35.1		 1gtiA-3o76A:
99.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 LEU A 187
THR A 139
LEU A 179
GLY A 182
 NAD  A1385 (-4.2A)
NAD  A1385 (-2.8A)
None
NAD  A1385 (-4.1A)
 0.90A 1gtiA-3ox4A:
undetectable		 1gtiA-3ox4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2y ALANINE
DEHYDROGENASE/PYRIDI
NE NUCLEOTIDE
TRANSHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 334
THR A   2
GLY A  31
LEU A  27
 None
 0.93A 1gtiA-3p2yA:
undetectable		 1gtiA-3p2yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p54 ENVELOPE
GLYCOPROTEIN

(Japanese
encephalitis
virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LEU A 285
GLY A 283
LEU A 280
TYR A 137
 None
 0.94A 1gtiA-3p54A:
undetectable		 1gtiA-3p54A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.87A 1gtiA-3pblA:
undetectable		 1gtiA-3pblA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.82A 1gtiA-3pdsA:
undetectable		 1gtiA-3pdsA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 LEU A 174
LEU A 163
GLY A 166
LEU A 190
 None
 0.92A 1gtiA-3q1tA:
undetectable		 1gtiA-3q1tA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 LEU A 168
LEU A 157
GLY A 160
LEU A 184
 None
 0.90A 1gtiA-3qk8A:
undetectable		 1gtiA-3qk8A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		4 THR A 276
LEU A 278
GLY A 281
LEU A 354
 None
 0.91A 1gtiA-3qtgA:
undetectable		 1gtiA-3qtgA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6a BREAST CANCER
ANTI-ESTROGEN
RESISTANCE PROTEIN 3

(Homo sapiens) 		PF00617
(RasGEF) 		4 TRP A 666
LEU A 669
THR A 676
LEU A 654
 None
 0.95A 1gtiA-3t6aA:
1.6		 1gtiA-3t6aA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 LEU A 304
LEU A 515
GLY A 519
LEU A 428
 None
 0.83A 1gtiA-3tv2A:
undetectable		 1gtiA-3tv2A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.81A 1gtiA-3v2yA:
undetectable		 1gtiA-3v2yA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		4 LEU A 296
THR A 299
GLY A 271
LEU A 320
 None
 0.88A 1gtiA-3zidA:
undetectable		 1gtiA-3zidA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 155
LEU A 215
GLY A 211
LEU A 209
 None
 0.77A 1gtiA-4arvA:
undetectable		 1gtiA-4arvA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		4 TRP A 359
LEU A 306
LEU A 270
LEU A 267
 None
 0.92A 1gtiA-4au2A:
undetectable		 1gtiA-4au2A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayj BOGT -
METAL-INDEPENDENT
GLYCOSYLTRANSFERASE

(Bacteroides
ovatus) 		PF03414
(Glyco_transf_6) 		4 LEU A 167
THR A 163
GLY A 160
LEU A   6
 None
 0.95A 1gtiA-4ayjA:
undetectable		 1gtiA-4ayjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2z OXYSTEROL-BINDING
PROTEIN HOMOLOG 6

(Saccharomyces
cerevisiae) 		PF01237
(Oxysterol_BP) 		4 LEU A 339
THR A  71
LEU A  69
LEU A 128
 None
None
P5S  A1436 (-3.6A)
None
 0.81A 1gtiA-4b2zA:
undetectable		 1gtiA-4b2zA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A  16
LEU A  23
GLY A  21
LEU A  47
 None
 0.82A 1gtiA-4bkmA:
undetectable		 1gtiA-4bkmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A  16
LEU A  23
GLY A  21
LEU A  47
 None
 0.89A 1gtiA-4bx0A:
undetectable		 1gtiA-4bx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bz7 HISTONE DEACETYLASE
8

(Schistosoma
mansoni) 		PF00850
(Hist_deacetyl) 		4 LEU A 266
LEU A 320
GLY A 318
LEU A 185
 None
 0.88A 1gtiA-4bz7A:
undetectable		 1gtiA-4bz7A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3y 3-KETOSTEROID
DEHYDROGENASE

(Rhodococcus
erythropolis) 		PF00890
(FAD_binding_2) 		4 THR A 191
LEU A  36
GLY A  14
LEU A  20
 None
None
FAD  A 551 (-3.3A)
None
 0.87A 1gtiA-4c3yA:
undetectable		 1gtiA-4c3yA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 TRP A1581
THR A1547
GLY A1550
LEU A1535
 None
 0.83A 1gtiA-4c6oA:
undetectable		 1gtiA-4c6oA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dpg LYSINE--TRNA LIGASE

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.94A 1gtiA-4dpgA:
undetectable		 1gtiA-4dpgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e22 CYTIDYLATE KINASE

(Yersinia
pseudotuberculosis) 		PF02224
(Cytidylate_kin) 		4 LEU A 224
LEU A 126
GLY A 125
LEU A  29
 None
 0.90A 1gtiA-4e22A:
undetectable		 1gtiA-4e22A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		4 LEU A 108
THR A 111
LEU A  28
GLY A  86
 None
 0.94A 1gtiA-4e84A:
undetectable		 1gtiA-4e84A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emi TODA

(Pseudomonas
putida) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		4 LEU A 195
THR A 160
GLY A 155
LEU A 179
 None
 0.91A 1gtiA-4emiA:
undetectable		 1gtiA-4emiA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqj HEMAGGLUTININ

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 LEU A 286
LEU A  84
GLY A 282
LEU A 293
 None
 0.72A 1gtiA-4fqjA:
undetectable		 1gtiA-4fqjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fsp PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 THR A 135
LEU A 146
GLY A 185
LEU A 114
 None
None
C8E  A 406 ( 4.0A)
None
 0.81A 1gtiA-4fspA:
undetectable		 1gtiA-4fspA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		4 LEU A 318
THR A 313
LEU A 311
LEU A 277
 None
 0.81A 1gtiA-4jzxA:
undetectable		 1gtiA-4jzxA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.89A 1gtiA-4k5yA:
undetectable		 1gtiA-4k5yA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 LEU A 208
LEU A 182
GLY A 184
LEU A  47
 None
 0.92A 1gtiA-4llsA:
undetectable		 1gtiA-4llsA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		4 LEU A  10
LEU A  53
GLY A  52
LEU A  47
 PG4  A 211 (-4.4A)
None
None
None
 0.94A 1gtiA-4mesA:
undetectable		 1gtiA-4mesA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 LEU A  24
THR A  16
GLY A  28
LEU A  68
 None
 0.92A 1gtiA-4n4pA:
undetectable		 1gtiA-4n4pA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q5f GLUTATHIONE
S-TRANSFERASE 1

(Ascaris suum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TRP A  39
LEU A  42
GLY A  49
LEU A  51
 GSH  A 301 (-4.0A)
None
None
GSH  A 301 (-4.8A)
 0.72A 1gtiA-4q5fA:
24.3		 1gtiA-4q5fA:
31.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 LEU A 362
LEU A 386
GLY A 281
LEU A  97
 None
 0.73A 1gtiA-4r04A:
undetectable		 1gtiA-4r04A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 THR A 174
GLY A 189
LEU A 191
TYR A 192
 None
 0.83A 1gtiA-4rewA:
undetectable		 1gtiA-4rewA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF12109
(CXCR4_N) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.90A 1gtiA-4rwsA:
undetectable		 1gtiA-4rwsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn3 TRIM5/CYCLOPHILIN A
FUSION PROTEIN/T4
LYSOZYME CHIMERA

(Macaca mulatta;
Escherichia
virus T4) 		PF00643
(zf-B_box)
PF00959
(Phage_lysozyme) 		4 LEU A 336
LEU A 318
GLY A 331
LEU A 369
 None
 0.92A 1gtiA-4tn3A:
undetectable		 1gtiA-4tn3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		4 LEU A 142
LEU A 192
GLY A 190
LEU A 186
 None
None
CA  A 802 (-3.5A)
None
 0.93A 1gtiA-4tr2A:
undetectable		 1gtiA-4tr2A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.95A 1gtiA-4u14A:
undetectable		 1gtiA-4u14A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 LEU A 147
LEU A 193
GLY A 196
LEU A 407
 None
 0.90A 1gtiA-4xciA:
undetectable		 1gtiA-4xciA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.88A 1gtiA-4xeeA:
undetectable		 1gtiA-4xeeA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF01946
(Thi4) 		4 THR A 134
LEU A  65
GLY A  43
LEU A  49
 None
None
48F  A 301 (-3.4A)
None
 0.82A 1gtiA-4y4mA:
undetectable		 1gtiA-4y4mA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		4 THR A 129
LEU A  58
GLY A  36
LEU A  42
 None
None
48H  A 302 (-3.2A)
None
 0.74A 1gtiA-4y4nA:
undetectable		 1gtiA-4y4nA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8z UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 LEU A  98
LEU A 108
GLY A 111
LEU A 306
 None
 0.83A 1gtiA-4z8zA:
undetectable		 1gtiA-4z8zA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 LEU A1033
LEU A1015
GLY A1028
LEU A1066
 None
 0.89A 1gtiA-4zwjA:
undetectable		 1gtiA-4zwjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao5 C-TYPE MANNOSE
RECEPTOR 2

(Homo sapiens) 		PF00040
(fn2)
PF00059
(Lectin_C) 		4 TRP A 158
LEU A 134
GLY A  53
LEU A  55
 None
 0.90A 1gtiA-5ao5A:
undetectable		 1gtiA-5ao5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Homo sapiens) 		PF04189
(Gcd10p) 		4 LEU B 388
THR B 458
GLY B 418
LEU B 414
 None
 0.94A 1gtiA-5ccxB:
undetectable		 1gtiA-5ccxB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 TRP A  91
THR A 224
LEU A 226
LEU A 231
 None
 0.92A 1gtiA-5d1rA:
undetectable		 1gtiA-5d1rA:
22.39