SIMILAR PATTERNS OF AMINO ACIDS FOR 1GTF_N_TRPN81_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 HIS A 147
HIS A 167
THR A 168
SER A 643
 None
O  A1100 ( 3.9A)
None
FLC  A 756 (-2.8A)
 0.83A 1gtfN-1b0kA:
undetectable
1gtfO-1b0kA:
undetectable		 1gtfN-1b0kA:
8.16
1gtfO-1b0kA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 GLY A 118
ALA A  25
THR A 125
THR A  82
 None
 0.69A 1gtfN-1c3xA:
undetectable
1gtfO-1c3xA:
undetectable		 1gtfN-1c3xA:
14.98
1gtfO-1c3xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f26 NITRIC OXIDE
REDUCTASE

(Fusarium
oxysporum) 		PF00067
(p450) 		4 GLY A 344
ALA A 318
HIS A 283
THR A 284
 None
 0.73A 1gtfN-1f26A:
undetectable
1gtfO-1f26A:
undetectable		 1gtfN-1f26A:
11.72
1gtfO-1f26A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		4 ALA A  60
HIS A  34
THR A  35
SER A  57
 None
 0.88A 1gtfN-1i9gA:
1.2
1gtfO-1i9gA:
1.2		 1gtfN-1i9gA:
15.33
1gtfO-1i9gA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLY A  46
HIS A  38
ALA A  51
THR A 299
 None
 0.88A 1gtfN-1iduA:
undetectable
1gtfO-1iduA:
undetectable		 1gtfN-1iduA:
8.08
1gtfO-1iduA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 412
ALA A 510
THR A 500
THR A 417
SER A 245
 None
None
None
TRA  A 866 (-4.0A)
TRA  A 866 (-2.6A)
 1.08A 1gtfN-1l5jA:
undetectable
1gtfO-1l5jA:
undetectable		 1gtfN-1l5jA:
7.07
1gtfO-1l5jA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lw3 MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PO4  A 655 (-3.6A)
None
None
None
 0.78A 1gtfN-1lw3A:
undetectable
1gtfO-1lw3A:
undetectable		 1gtfN-1lw3A:
7.46
1gtfO-1lw3A:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 GLY A  11
THR A 156
THR A 389
SER A 384
 None
 0.82A 1gtfN-1mb9A:
0.0
1gtfO-1mb9A:
undetectable		 1gtfN-1mb9A:
9.16
1gtfO-1mb9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mf1 ADENYLOSUCCINATE
SYNTHETASE

(Mus musculus) 		PF00709
(Adenylsucc_synt) 		4 GLY A  66
ALA A 134
HIS A 105
THR A 170
 None
 0.88A 1gtfN-1mf1A:
undetectable
1gtfO-1mf1A:
0.0		 1gtfN-1mf1A:
12.81
1gtfO-1mf1A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		5 GLY B 156
ALA B 151
THR B 139
HIS B 103
THR B 137
 None
 1.28A 1gtfN-1mioB:
undetectable
1gtfO-1mioB:
undetectable		 1gtfN-1mioB:
9.76
1gtfO-1mioB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 GLY Q 105
ALA Q  96
THR Q  99
THR Q 376
 None
 0.72A 1gtfN-1oh2Q:
undetectable
1gtfO-1oh2Q:
undetectable		 1gtfN-1oh2Q:
12.04
1gtfO-1oh2Q:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh5 PROTEIN
(HYDROXYACYLGLUTATHI
ONE HYDROLASE)

(Homo sapiens) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		4 GLY A  61
ALA A  84
HIS A  55
THR A  52
 None
 0.87A 1gtfN-1qh5A:
undetectable
1gtfO-1qh5A:
undetectable		 1gtfN-1qh5A:
14.90
1gtfO-1qh5A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 284
HIS A 282
ALA A 312
THR A 351
THR A 679
 None
 1.46A 1gtfN-1sb3A:
undetectable
1gtfO-1sb3A:
undetectable		 1gtfN-1sb3A:
7.84
1gtfO-1sb3A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 THR A 313
HIS A 315
THR A 317
THR A  32
 None
 0.89A 1gtfN-1uzgA:
undetectable
1gtfO-1uzgA:
undetectable		 1gtfN-1uzgA:
11.48
1gtfO-1uzgA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 188
ALA A 196
THR A  49
THR A 183
THR A  40
 None
 1.14A 1gtfN-1v9cA:
undetectable
1gtfO-1v9cA:
undetectable		 1gtfN-1v9cA:
19.25
1gtfO-1v9cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybd URIDYLATE KINASE

(Neisseria
meningitidis) 		PF00696
(AA_kinase) 		4 GLY A  23
ALA A 221
THR A  37
THR A  33
 None
 0.89A 1gtfN-1ybdA:
undetectable
1gtfO-1ybdA:
undetectable		 1gtfN-1ybdA:
16.53
1gtfO-1ybdA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 420
THR A 428
THR A 424
SER A 271
 PIB  A3632 (-3.7A)
None
None
None
 0.72A 1gtfN-1zsqA:
undetectable
1gtfO-1zsqA:
undetectable		 1gtfN-1zsqA:
12.02
1gtfO-1zsqA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 182
ALA A 208
THR A 185
THR A 319
 NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
 0.78A 1gtfN-2eerA:
undetectable
1gtfO-2eerA:
undetectable		 1gtfN-2eerA:
13.02
1gtfO-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus;
Lupinus luteus) 		PF01112
(Asparaginase_2)
PF01112
(Asparaginase_2) 		5 GLY B 195
HIS A   9
ALA A  67
THR B 225
THR B 209
 None
None
NA  A 401 (-4.6A)
None
None
 1.41A 1gtfN-2gezB:
undetectable
1gtfO-2gezB:
undetectable		 1gtfN-2gezB:
20.15
1gtfO-2gezB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 GLY A 577
HIS A 496
ALA A 580
SER A 492
 EDO  A 619 (-3.2A)
None
EDO  A 624 (-3.5A)
EDO  A 621 ( 4.6A)
 0.83A 1gtfN-2gmhA:
undetectable
1gtfO-2gmhA:
undetectable		 1gtfN-2gmhA:
8.82
1gtfO-2gmhA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 GLY A  23
HIS A  59
ALA A  87
HIS A  58
 None
 0.79A 1gtfN-2i3aA:
undetectable
1gtfO-2i3aA:
undetectable		 1gtfN-2i3aA:
12.78
1gtfO-2i3aA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		4 GLY A  87
THR A 143
HIS A 140
THR A 139
 UPG  A 901 (-3.9A)
None
None
None
 0.87A 1gtfN-2icyA:
undetectable
1gtfO-2icyA:
undetectable		 1gtfN-2icyA:
12.69
1gtfO-2icyA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 GLY A 373
ALA A 176
HIS A 200
THR A 205
 None
 0.86A 1gtfN-2iouA:
undetectable
1gtfO-2iouA:
undetectable		 1gtfN-2iouA:
12.77
1gtfO-2iouA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 GLY A 276
THR A 107
HIS A 134
SER A 198
 None
 0.88A 1gtfN-2qfvA:
0.0
1gtfO-2qfvA:
0.0		 1gtfN-2qfvA:
11.53
1gtfO-2qfvA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzn VENOM ALLERGEN 3

(Solenopsis
invicta) 		PF00188
(CAP) 		4 GLY A 122
HIS A 190
THR A 188
SER A  34
 None
 0.89A 1gtfN-2vznA:
undetectable
1gtfO-2vznA:
undetectable		 1gtfN-2vznA:
18.46
1gtfO-2vznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 232
HIS A 244
THR A 245
THR A 191
 PEG  A1779 (-4.4A)
FMT  A1766 (-3.9A)
None
None
 0.85A 1gtfN-2wdaA:
undetectable
1gtfO-2wdaA:
undetectable		 1gtfN-2wdaA:
6.68
1gtfO-2wdaA:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 435
ALA A 407
THR A 442
THR A 439
SER A 402
 ADP  A1854 (-3.1A)
ADP  A1854 ( 4.5A)
None
None
None
 1.27A 1gtfN-2xzlA:
undetectable
1gtfO-2xzlA:
undetectable		 1gtfN-2xzlA:
7.24
1gtfO-2xzlA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ALA A  60
HIS A  83
THR A  84
SER A  62
 None
 0.76A 1gtfN-2yk0A:
undetectable
1gtfO-2yk0A:
undetectable		 1gtfN-2yk0A:
6.32
1gtfO-2yk0A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium) 		PF01370
(Epimerase) 		5 GLY A 166
THR A 178
THR A 179
THR A 112
SER A  74
 NAD  A3001 ( 4.6A)
None
NAD  A3001 ( 4.7A)
NAD  A3001 ( 4.5A)
None
 1.34A 1gtfN-3a1nA:
undetectable
1gtfO-3a1nA:
undetectable		 1gtfN-3a1nA:
13.02
1gtfO-3a1nA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afg SUBTILISIN-LIKE
SERINE PROTEASE

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8)
PF04151
(PPC) 		4 GLY A 301
ALA A 292
THR A 358
SER A 251
 None
 0.86A 1gtfN-3afgA:
3.0
1gtfO-3afgA:
3.0		 1gtfN-3afgA:
11.86
1gtfO-3afgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4w ALDEHYDE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 GLY A 417
ALA A 408
THR A 436
SER A 411
 None
 0.87A 1gtfN-3b4wA:
undetectable
1gtfO-3b4wA:
undetectable		 1gtfN-3b4wA:
10.29
1gtfO-3b4wA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 GLY A 160
ALA A 165
THR A 147
SER A 167
 None
None
None
ZN  A 302 ( 4.8A)
 0.80A 1gtfN-3dbkA:
undetectable
1gtfO-3dbkA:
undetectable		 1gtfN-3dbkA:
12.75
1gtfO-3dbkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		4 GLY A 115
ALA A 119
THR A 143
THR A 100
 None
CL  A 374 ( 4.1A)
None
None
 0.83A 1gtfN-3dzcA:
undetectable
1gtfO-3dzcA:
undetectable		 1gtfN-3dzcA:
11.11
1gtfO-3dzcA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		5 GLY A 208
ALA A 212
THR A 239
HIS A 204
SER A 214
 None
 1.33A 1gtfN-3eegA:
undetectable
1gtfO-3eegA:
undetectable		 1gtfN-3eegA:
17.23
1gtfO-3eegA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa3 2,3-DIMETHYLMALATE
LYASE

(Aspergillus
niger) 		PF13714
(PEP_mutase) 		4 GLY A  47
ALA A  72
HIS A  55
THR A  50
 OAF  A 501 (-3.3A)
None
None
None
 0.88A 1gtfN-3fa3A:
undetectable
1gtfO-3fa3A:
undetectable		 1gtfN-3fa3A:
12.25
1gtfO-3fa3A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		4 GLY A 149
ALA A  38
THR A 134
THR A 145
 None
 0.63A 1gtfN-3faoA:
undetectable
1gtfO-3faoA:
undetectable		 1gtfN-3faoA:
18.44
1gtfO-3faoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 GLY A  77
ALA A 316
THR A 234
SER A 277
 None
 0.77A 1gtfN-3fpzA:
undetectable
1gtfO-3fpzA:
undetectable		 1gtfN-3fpzA:
16.03
1gtfO-3fpzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gve YFKN PROTEIN

(Bacillus
subtilis) 		PF00149
(Metallophos) 		4 ALA A  72
THR A 332
HIS A 329
THR A 328
 None
 0.85A 1gtfN-3gveA:
undetectable
1gtfO-3gveA:
undetectable		 1gtfN-3gveA:
12.61
1gtfO-3gveA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 GLY A 116
THR A  70
HIS A 121
SER A  66
 None
 0.64A 1gtfN-3ihaA:
undetectable
1gtfO-3ihaA:
undetectable		 1gtfN-3ihaA:
7.68
1gtfO-3ihaA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		4 GLY A  90
ALA A 124
THR A 185
THR A  71
 None
None
None
LYS  A 501 (-4.2A)
 0.82A 1gtfN-3k4uA:
undetectable
1gtfO-3k4uA:
undetectable		 1gtfN-3k4uA:
19.60
1gtfO-3k4uA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 GLY A 184
ALA A 155
THR A 236
SER A 153
 None
 0.88A 1gtfN-3k96A:
undetectable
1gtfO-3k96A:
undetectable		 1gtfN-3k96A:
13.90
1gtfO-3k96A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 HIS A 311
ALA A 214
THR A 315
THR A 313
 None
 0.88A 1gtfN-3kzuA:
undetectable
1gtfO-3kzuA:
undetectable		 1gtfN-3kzuA:
10.51
1gtfO-3kzuA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 GLY A 365
ALA A 370
THR A 352
SER A 372
 None
None
None
ZN  A   1 ( 4.9A)
 0.82A 1gtfN-3nqxA:
undetectable
1gtfO-3nqxA:
undetectable		 1gtfN-3nqxA:
14.98
1gtfO-3nqxA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		4 GLY A 122
THR A 177
HIS A 174
THR A 173
 None
 0.87A 1gtfN-3ogzA:
undetectable
1gtfO-3ogzA:
undetectable		 1gtfN-3ogzA:
6.79
1gtfO-3ogzA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		4 GLY A 103
THR A 110
HIS A 107
THR A 106
 None
 0.87A 1gtfN-3p3lA:
undetectable
1gtfO-3p3lA:
undetectable		 1gtfN-3p3lA:
10.84
1gtfO-3p3lA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		5 GLY A 160
ALA A 140
THR A 116
THR A 165
SER A 138
 None
 1.19A 1gtfN-3rwbA:
undetectable
1gtfO-3rwbA:
undetectable		 1gtfN-3rwbA:
16.06
1gtfO-3rwbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		4 GLY A  64
ALA A 118
THR A  75
THR A  74
 None
 0.86A 1gtfN-3slkA:
undetectable
1gtfO-3slkA:
undetectable		 1gtfN-3slkA:
6.42
1gtfO-3slkA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		4 GLY A 446
ALA A 468
THR A 480
HIS A 460
 FDA  A 600 (-3.2A)
None
None
None
 0.85A 1gtfN-3ukfA:
undetectable
1gtfO-3ukfA:
undetectable		 1gtfN-3ukfA:
11.33
1gtfO-3ukfA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 GLY A 473
THR A 412
HIS A 411
THR A 425
 None
 0.69A 1gtfN-3vm7A:
undetectable
1gtfO-3vm7A:
undetectable		 1gtfN-3vm7A:
8.13
1gtfO-3vm7A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		4 GLY A 391
ALA A 382
THR A 410
SER A 385
 None
 0.69A 1gtfN-3vz0A:
undetectable
1gtfO-3vz0A:
undetectable		 1gtfN-3vz0A:
10.20
1gtfO-3vz0A:
10.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zte TRYPTOPHAN OPERON
RNA-BINDING
ATTENUATION PROTEIN
(TRAP)

(Bacillus
licheniformis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
THR A  49
HIS A  51
THR A  52
 TRP  A  80 (-3.5A)
None
TRP  A  80 (-2.8A)
None
TRP  A  80 (-3.6A)
 0.30A 1gtfN-3zteA:
14.2
1gtfO-3zteA:
14.2		 1gtfN-3zteA:
78.21
1gtfO-3zteA:
78.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx9 CAPSID PROTEIN

(Turnip crinkle
virus) 		PF00729
(Viral_coat) 		4 GLY A 299
ALA A 295
THR A 337
HIS A 276
 None
 0.89A 1gtfN-3zx9A:
undetectable
1gtfO-3zx9A:
undetectable		 1gtfN-3zx9A:
11.40
1gtfO-3zx9A:
11.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzl TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
halodurans) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A  81 (-3.5A)
None
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
None
TRP  A  81 (-3.7A)
 0.36A 1gtfN-3zzlA:
13.2
1gtfO-3zzlA:
13.1		 1gtfN-3zzlA:
71.43
1gtfO-3zzlA:
71.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzq TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		5 GLY A  23
HIS A  33
ALA A  46
THR A  49
THR A  52
 TRP  A  81 (-3.4A)
TRP  A  81 ( 4.9A)
TRP  A  81 ( 3.7A)
TRP  A  81 ( 2.9A)
TRP  A  81 (-3.8A)
 0.22A 1gtfN-3zzqA:
13.7
1gtfO-3zzqA:
13.6		 1gtfN-3zzqA:
80.00
1gtfO-3zzqA:
80.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zzs TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 TRP  A1072 (-3.5A)
None
TRP  A1072 ( 3.8A)
TRP  A1072 (-2.9A)
None
TRP  A1072 (-3.8A)
 0.23A 1gtfN-3zzsA:
13.5
1gtfO-3zzsA:
13.5		 1gtfN-3zzsA:
100.00
1gtfO-3zzsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0s OCTENOYL-COA
REDUCTASE/CARBOXYLAS
E

(Streptomyces
cinnabarigriseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 228
HIS A 313
THR A 318
THR A 314
SER A 322
 NAP  A1447 (-3.2A)
NAP  A1447 (-4.3A)
None
NAP  A1447 (-4.6A)
None
 1.31A 1gtfN-4a0sA:
undetectable
1gtfO-4a0sA:
undetectable		 1gtfN-4a0sA:
10.76
1gtfO-4a0sA:
10.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b27 TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Bacillus
subtilis) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 GLY  A  23 (-0.0A)
HIS  A  33 ( 1.0A)
ALA  A  46 ( 0.0A)
THR  A  49 (-0.8A)
HIS  A  51 ( 1.0A)
THR  A  52 (-0.8A)
 0.33A 1gtfN-4b27A:
13.1
1gtfO-4b27A:
13.1		 1gtfN-4b27A:
76.32
1gtfO-4b27A:
76.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 GLY A 155
ALA A 160
THR A 142
SER A 162
 None
None
None
ZN  A 401 ( 4.9A)
 0.80A 1gtfN-4b52A:
undetectable
1gtfO-4b52A:
undetectable		 1gtfN-4b52A:
12.83
1gtfO-4b52A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 HIS A  55
HIS A  53
THR A  62
SER A 132
 None
 0.82A 1gtfN-4bc5A:
undetectable
1gtfO-4bc5A:
undetectable		 1gtfN-4bc5A:
9.72
1gtfO-4bc5A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 400
THR A 499
THR A 449
THR A 395
 None
None
None
EDO  A1590 (-4.9A)
 0.74A 1gtfN-4c22A:
undetectable
1gtfO-4c22A:
undetectable		 1gtfN-4c22A:
8.11
1gtfO-4c22A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)

(Streptomyces
himastatinicus) 		PF00067
(p450) 		4 GLY A 340
ALA A  43
HIS A 344
THR A 286
 HEM  A 401 ( 4.1A)
None
HEM  A 401 (-3.9A)
HEM  A 401 (-3.3A)
 0.82A 1gtfN-4e2pA:
undetectable
1gtfO-4e2pA:
undetectable		 1gtfN-4e2pA:
10.50
1gtfO-4e2pA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		4 GLY A  90
ALA A  74
THR A  82
THR A 118
 None
 0.87A 1gtfN-4ee8A:
undetectable
1gtfO-4ee8A:
undetectable		 1gtfN-4ee8A:
15.19
1gtfO-4ee8A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 GLY A 277
THR A 109
HIS A 136
SER A 199
 None
 0.87A 1gtfN-4hcxA:
undetectable
1gtfO-4hcxA:
undetectable		 1gtfN-4hcxA:
11.49
1gtfO-4hcxA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 GLY A 267
THR A 229
THR A 270
THR A 239
 ADP  A 601 (-3.1A)
None
ADP  A 601 (-3.2A)
ADP  A 601 (-2.9A)
 0.77A 1gtfN-4ihqA:
undetectable
1gtfO-4ihqA:
undetectable		 1gtfN-4ihqA:
11.31
1gtfO-4ihqA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jy4 PGT121 LIGHT CHAIN
PGT121 HEAVY CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLY B 137
ALA B 134
HIS B 162
THR A 117
 None
 0.81A 1gtfN-4jy4B:
undetectable
1gtfO-4jy4B:
undetectable		 1gtfN-4jy4B:
14.10
1gtfO-4jy4B:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		4 GLY A 127
ALA A  58
THR A 106
THR A 130
 FMT  A 501 (-3.4A)
None
None
None
 0.87A 1gtfN-4kv7A:
undetectable
1gtfO-4kv7A:
undetectable		 1gtfN-4kv7A:
13.40
1gtfO-4kv7A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6q HASAP

(Pseudomonas
aeruginosa) 		PF06438
(HasA) 		4 GLY A 128
THR A  76
HIS A  83
THR A  84
 None
None
HEM  A 202 ( 3.5A)
None
 0.87A 1gtfN-4o6qA:
undetectable
1gtfO-4o6qA:
undetectable		 1gtfN-4o6qA:
18.72
1gtfO-4o6qA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obm UNCHARACTERIZED
PROTEIN

([Eubacterium]
siraeum) 		no annotation 4 GLY A 113
ALA A 274
THR A 280
THR A  67
 None
 0.68A 1gtfN-4obmA:
undetectable
1gtfO-4obmA:
undetectable		 1gtfN-4obmA:
16.02
1gtfO-4obmA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		5 GLY A 213
ALA A 217
THR A 244
HIS A 209
SER A 219
 None
None
None
ZN  A 401 ( 3.4A)
None
 1.15A 1gtfN-4ov4A:
undetectable
1gtfO-4ov4A:
undetectable		 1gtfN-4ov4A:
11.11
1gtfO-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		4 GLY A 236
ALA A 215
THR A 249
SER A 219
 None
 0.88A 1gtfN-4ov4A:
undetectable
1gtfO-4ov4A:
undetectable		 1gtfN-4ov4A:
11.11
1gtfO-4ov4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 GLY A  84
ALA A  71
HIS A 119
THR A 115
THR A  87
 None
 1.35A 1gtfN-4q0gA:
undetectable
1gtfO-4q0gA:
undetectable		 1gtfN-4q0gA:
9.33
1gtfO-4q0gA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r58 LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 HIS A 176
THR A 133
HIS A 154
THR A 155
 None
 0.87A 1gtfN-4r58A:
undetectable
1gtfO-4r58A:
undetectable		 1gtfN-4r58A:
15.91
1gtfO-4r58A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 GLY A 289
ALA A 589
THR A 583
THR A 442
 BEF  A1732 (-3.0A)
None
BEF  A1732 (-4.2A)
None
 0.78A 1gtfN-4umvA:
undetectable
1gtfO-4umvA:
undetectable		 1gtfN-4umvA:
7.07
1gtfO-4umvA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfj ARGININOSUCCINATE
SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00764
(Arginosuc_synth) 		4 GLY A 225
THR A 291
HIS A 334
SER A 355
 None
 0.75A 1gtfN-4xfjA:
undetectable
1gtfO-4xfjA:
undetectable		 1gtfN-4xfjA:
8.68
1gtfO-4xfjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgn 3-HYDROXYACYL-COA
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00106
(adh_short) 		5 GLY A 164
ALA A 144
THR A 115
THR A 169
SER A 142
 None
 1.13A 1gtfN-4xgnA:
undetectable
1gtfO-4xgnA:
undetectable		 1gtfN-4xgnA:
13.85
1gtfO-4xgnA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLY A 251
ALA A 430
HIS A 453
THR A 405
 None
 0.84A 1gtfN-4yweA:
undetectable
1gtfO-4yweA:
undetectable		 1gtfN-4yweA:
8.54
1gtfO-4yweA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN
LLAMA FAB FRAGMENT
68F2 LIGHT CHAIN

(Lama glama;
Lama glama) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLY H 148
ALA H 145
HIS H 173
THR L 120
 None
 0.89A 1gtfN-4zs7H:
undetectable
1gtfO-4zs7H:
undetectable		 1gtfN-4zs7H:
15.07
1gtfO-4zs7H:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zut CLASSICAL MHC CLASS
I ANTIGEN

(Equus caballus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 GLY A  77
ALA A  11
HIS A  82
SER A  13
 None
 0.89A 1gtfN-4zutA:
undetectable
1gtfO-4zutA:
undetectable		 1gtfN-4zutA:
15.59
1gtfO-4zutA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 GLY A 162
ALA A 167
THR A 149
SER A 169
 None
None
None
ZN  A1317 ( 4.6A)
 0.85A 1gtfN-5a3yA:
undetectable
1gtfO-5a3yA:
undetectable		 1gtfN-5a3yA:
7.66
1gtfO-5a3yA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c16 MYOTUBULARIN-RELATED
PROTEIN 1

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 GLY A 441
THR A 449
THR A 445
SER A 292
 PO4  A 701 (-3.5A)
None
None
None
 0.67A 1gtfN-5c16A:
undetectable
1gtfO-5c16A:
undetectable		 1gtfN-5c16A:
8.93
1gtfO-5c16A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 1gtfN-5dfaA:
1.4
1gtfO-5dfaA:
undetectable		 1gtfN-5dfaA:
6.85
1gtfO-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLY A 758
ALA A 741
HIS A 647
THR A 756
THR A 674
 None
 1.39A 1gtfN-5dmyA:
undetectable
1gtfO-5dmyA:
undetectable		 1gtfN-5dmyA:
6.41
1gtfO-5dmyA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dni PUTATIVE
L(+)-TARTRATE
DEHYDRATASE SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF05683
(Fumerase_C) 		4 GLY A  78
HIS A  60
THR A  80
THR A  30
 GOL  A 201 (-3.4A)
None
None
None
 0.88A 1gtfN-5dniA:
undetectable
1gtfO-5dniA:
undetectable		 1gtfN-5dniA:
19.89
1gtfO-5dniA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eex TRANSCRIPTION
ATTENUATION PROTEIN
MTRB

(Geobacillus
stearothermophilus) 		PF02081
(TrpBP) 		6 GLY A  23
HIS A  33
ALA A  46
THR A  49
HIS A  51
THR A  52
 None
 0.26A 1gtfN-5eexA:
15.3
1gtfO-5eexA:
15.4		 1gtfN-5eexA:
100.00
1gtfO-5eexA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		4 GLY A 127
HIS A 153
THR A 154
SER A 148
 None
None
None
SAH  A 409 ( 4.2A)
 0.78A 1gtfN-5fubA:
undetectable
1gtfO-5fubA:
undetectable		 1gtfN-5fubA:
14.50
1gtfO-5fubA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		4 GLY A 161
HIS A 187
THR A 188
SER A 182
 None
None
None
SAH  A1446 ( 4.4A)
 0.79A 1gtfN-5fulA:
undetectable
1gtfO-5fulA:
undetectable		 1gtfN-5fulA:
10.25
1gtfO-5fulA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 GLY A 162
ALA A 167
THR A 149
SER A 169
 None
None
None
ZN  A1317 ( 4.7A)
 0.86A 1gtfN-5fxnA:
undetectable
1gtfO-5fxnA:
undetectable		 1gtfN-5fxnA:
10.79
1gtfO-5fxnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		4 GLY i  87
ALA i 259
HIS i 264
THR i 266
 None
 0.85A 1gtfN-5gafi:
undetectable
1gtfO-5gafi:
undetectable		 1gtfN-5gafi:
12.30
1gtfO-5gafi:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A  62
ALA A  58
THR A  84
THR A  48
 None
 0.87A 1gtfN-5gkxA:
undetectable
1gtfO-5gkxA:
undetectable		 1gtfN-5gkxA:
16.60
1gtfO-5gkxA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		4 GLY A 274
ALA A 400
THR A 377
THR A 308
 None
 0.78A 1gtfN-5j84A:
undetectable
1gtfO-5j84A:
undetectable		 1gtfN-5j84A:
8.03
1gtfO-5j84A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 635
ALA A 648
THR A 570
HIS A 638
 None
 0.72A 1gtfN-5jxfA:
undetectable
1gtfO-5jxfA:
undetectable		 1gtfN-5jxfA:
7.11
1gtfO-5jxfA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m23 WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 147
HIS A 128
ALA A 169
THR A 166
 None
 0.82A 1gtfN-5m23A:
undetectable
1gtfO-5m23A:
undetectable		 1gtfN-5m23A:
9.88
1gtfO-5m23A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuv AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens) 		PF00400
(WD40) 		4 GLY A 426
HIS A 407
ALA A 448
THR A 445
 None
 0.88A 1gtfN-5nuvA:
undetectable
1gtfO-5nuvA:
undetectable		 1gtfN-5nuvA:
12.58
1gtfO-5nuvA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0s GLUCOSYLCERAMIDASE

(Thermoanaerobacterium
xylanolyticum) 		PF04685
(DUF608)
PF12215
(Glyco_hydr_116N)
PF17168
(DUF5127) 		4 GLY A 317
THR A 286
THR A 285
THR A 311
 None
 0.82A 1gtfN-5o0sA:
undetectable
1gtfO-5o0sA:
undetectable		 1gtfN-5o0sA:
6.51
1gtfO-5o0sA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t65 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
PCTA

(Pseudomonas
aeruginosa) 		PF02743
(dCache_1) 		4 GLY A 171
ALA A 132
THR A 141
THR A 155
 None
 0.89A 1gtfN-5t65A:
undetectable
1gtfO-5t65A:
undetectable		 1gtfN-5t65A:
15.76
1gtfO-5t65A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 ALA A 144
THR A 136
THR A 137
THR A 210
SER A 132
 None
 1.45A 1gtfN-5ujuA:
undetectable
1gtfO-5ujuA:
undetectable		 1gtfN-5ujuA:
8.35
1gtfO-5ujuA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 5 GLY A 294
ALA A 328
THR A 287
THR A 288
SER A 346
 None
 1.46A 1gtfN-5wh8A:
undetectable
1gtfO-5wh8A:
undetectable		 1gtfN-5wh8A:
undetectable
1gtfO-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3x CLEAVAGE STIMULATION
FACTOR SUBUNIT 1

(Homo sapiens) 		no annotation 4 GLY A 280
HIS A 261
ALA A 303
THR A 299
 None
 0.80A 1gtfN-6b3xA:
undetectable
1gtfO-6b3xA:
undetectable		 1gtfN-6b3xA:
15.69
1gtfO-6b3xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WD REPEAT-CONTAINING
PROTEIN 5

(Homo sapiens) 		no annotation 4 GLY W 147
HIS W 128
ALA W 169
THR W 166
 None
 0.83A 1gtfN-6bynW:
undetectable
1gtfO-6bynW:
undetectable		 1gtfN-6bynW:
undetectable
1gtfO-6bynW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc0 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 ALA A 239
HIS A 233
THR A 234
THR A 182
 None
 0.88A 1gtfN-6fc0A:
undetectable
1gtfO-6fc0A:
undetectable		 1gtfN-6fc0A:
undetectable
1gtfO-6fc0A:
undetectable