SIMILAR PATTERNS OF AMINO ACIDS FOR 1GSF_D_EAAD223_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 PHE A 357
GLY A 272
LEU A 270
VAL A 150
 None
 0.97A 1gsfD-1fbaA:
0.0		 1gsfD-1fbaA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gae D-GLYCERALDEHYDE-3-P
HOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 TYR O 317
GLY O 120
LEU O 100
MET O 127
 NAD  O 336 ( 3.9A)
NAD  O 336 ( 3.8A)
None
None
 1.24A 1gsfD-1gaeO:
0.3		 1gsfD-1gaeO:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlm HEMOGLOBIN (CYANO
MET)

(Molpadia
arenicola) 		PF00042
(Globin) 		4 TYR A 114
GLY A 150
LEU A  97
PHE A 145
 HEM  A 159 ( 4.9A)
None
None
None
 1.09A 1gsfD-1hlmA:
undetectable		 1gsfD-1hlmA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		4 TYR A 112
GLY A  92
VAL A 183
PHE A 162
 None
PYR  A1444 (-3.7A)
None
None
 1.20A 1gsfD-1igwA:
0.0		 1gsfD-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		4 TYR A 112
LEU A  90
VAL A 183
PHE A 162
 None
 1.09A 1gsfD-1igwA:
0.0		 1gsfD-1igwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll2 GLYCOGENIN-1

(Oryctolagus
cuniculus) 		PF01501
(Glyco_transf_8) 		4 GLY A 162
LEU A  80
VAL A 152
PHE A 159
 None
 1.21A 1gsfD-1ll2A:
0.0		 1gsfD-1ll2A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 PHE A 479
GLY A 475
LEU A 513
VAL A 502
 None
 0.87A 1gsfD-1mhsA:
1.5		 1gsfD-1mhsA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 PHE A2397
GLY A2395
VAL A2186
PHE A2389
 None
 1.02A 1gsfD-1mi1A:
0.0		 1gsfD-1mi1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1np7 DNA PHOTOLYASE

(Synechocystis
sp. PCC 6803) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 PHE A 295
ARG A 293
VAL A 110
PHE A 296
 None
None
None
FAD  A 500 (-4.7A)
 1.20A 1gsfD-1np7A:
0.0		 1gsfD-1np7A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od3 PUTATIVE XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 TYR A  65
LEU A  42
VAL A 139
PHE A 144
 None
 0.98A 1gsfD-1od3A:
undetectable		 1gsfD-1od3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1

(Bos taurus) 		PF00153
(Mito_carr) 		4 TYR A 131
PHE A 135
GLY A 175
VAL A  37
 None
 1.08A 1gsfD-1okcA:
0.5		 1gsfD-1okcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A  87
GLY A 121
LEU A  66
VAL A 149
 None
 1.20A 1gsfD-1pieA:
undetectable		 1gsfD-1pieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfD-1r4nA:
undetectable		 1gsfD-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		4 GLY A   9
LEU A  33
VAL A  24
PHE A 275
 None
 1.09A 1gsfD-1tltA:
undetectable		 1gsfD-1tltA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR X 197
GLY X 204
LEU X 266
MET X 385
 None
 1.23A 1gsfD-1u8xX:
undetectable		 1gsfD-1u8xX:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue8 367AA LONG
HYPOTHETICAL
CYTOCHROME P450

(Sulfurisphaera
tokodaii) 		PF00067
(p450) 		4 PHE A 118
GLY A 220
VAL A 244
PHE A 334
 None
 1.23A 1gsfD-1ue8A:
undetectable		 1gsfD-1ue8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfD-1z3zA:
undetectable		 1gsfD-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		4 PHE A 113
GLY A 143
LEU A 184
PHE A  19
 None
 1.06A 1gsfD-2a33A:
undetectable		 1gsfD-2a33A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		4 TYR 2 121
GLY 2 114
VAL 2 127
PHE 2 144
 None
 1.01A 1gsfD-2bpa2:
undetectable		 1gsfD-2bpa2:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqk C-MPL BINDING
PROTEIN

(Homo sapiens) 		PF05383
(La) 		4 GLY A 119
LEU A 104
VAL A  87
PHE A  81
 None
 1.21A 1gsfD-2cqkA:
undetectable		 1gsfD-2cqkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.89A 1gsfD-2ftzA:
2.4		 1gsfD-2ftzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lwy BACTERIAL
INTEIN-LIKE DOMAIN

(Ruminiclostridium
thermocellum) 		PF07591
(PT-HINT) 		4 GLY A 127
LEU A  14
VAL A  26
PHE A   2
 None
 1.23A 1gsfD-2lwyA:
undetectable		 1gsfD-2lwyA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjj MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Novosphingobium
aromaticivorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A 215
GLY A 211
ARG A 214
VAL A 161
 None
 1.17A 1gsfD-2qjjA:
undetectable		 1gsfD-2qjjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 PHE A 565
GLY A 567
LEU A 407
PHE A 549
 None
 1.06A 1gsfD-2quaA:
undetectable		 1gsfD-2quaA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd9 ALANINE RACEMASE

(Bacillus
anthracis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PHE A  68
GLY A  88
ARG A 138
VAL A  39
 None
None
IN5  A1394 (-3.1A)
IN5  A1394 (-4.6A)
 1.24A 1gsfD-2vd9A:
undetectable		 1gsfD-2vd9A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wd5 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
1A

(Mus musculus) 		PF06470
(SMC_hinge) 		4 GLY A 654
LEU A 659
VAL A 537
PHE A 646
 None
 1.13A 1gsfD-2wd5A:
undetectable		 1gsfD-2wd5A:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE

(Thermus
thermophilus) 		no annotation 4 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfD-2yvsA:
undetectable		 1gsfD-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		4 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfD-3akkA:
undetectable		 1gsfD-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cez METHIONINE-R-SULFOXI
DE REDUCTASE

(Burkholderia
pseudomallei) 		PF01641
(SelR) 		4 TYR A  69
PHE A  79
GLY A 118
ARG A 126
 None
 1.18A 1gsfD-3cezA:
undetectable		 1gsfD-3cezA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 PHE B  96
GLY B  66
LEU B  75
VAL B 213
 None
None
FES  B 244 ( 4.4A)
None
 1.23A 1gsfD-3cirB:
undetectable		 1gsfD-3cirB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		4 PHE A 111
GLY A 118
LEU A 294
VAL A  81
 None
 0.98A 1gsfD-3e61A:
undetectable		 1gsfD-3e61A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		4 PHE A 164
GLY A 170
LEU A 100
VAL A 310
 None
 1.17A 1gsfD-3e9mA:
undetectable		 1gsfD-3e9mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.89A 1gsfD-3egcA:
undetectable		 1gsfD-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 PHE A 273
GLY A 267
ARG A 268
LEU A 434
 None
 0.87A 1gsfD-3gjuA:
undetectable		 1gsfD-3gjuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 252
GLY A 638
VAL A 510
PHE A 630
 None
 1.01A 1gsfD-3gwjA:
undetectable		 1gsfD-3gwjA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		4 PHE A  95
ARG A  89
MET A 205
PHE A  23
 None
 1.14A 1gsfD-3hbjA:
undetectable		 1gsfD-3hbjA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		4 PHE A 274
GLY A 268
ARG A 269
LEU A 429
 None
 0.73A 1gsfD-3hmuA:
undetectable		 1gsfD-3hmuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqg TYPE-2 RESTRICTION
ENZYME ECORII

(Escherichia
coli) 		PF09019
(EcoRII-C) 		4 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.83A 1gsfD-3hqgA:
2.3		 1gsfD-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 TYR A 109
PHE A 105
GLY A  70
VAL A 299
 None
 1.10A 1gsfD-3i4gA:
2.9		 1gsfD-3i4gA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		4 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfD-3i5tA:
undetectable		 1gsfD-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		4 GLY A 164
ARG A 195
LEU A 296
VAL A 323
 None
ACT  A   1 (-2.7A)
None
None
 1.24A 1gsfD-3kkeA:
undetectable		 1gsfD-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loo ANOPHELES GAMBIAE
ADENOSINE KINASE

(Anopheles
gambiae) 		PF00294
(PfkB) 		4 GLY A  11
LEU A  70
VAL A 303
PHE A 191
 None
 1.10A 1gsfD-3looA:
undetectable		 1gsfD-3looA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE

(Nostoc sp. PCC
7120) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 TYR A  68
PHE A 127
GLY A 129
PHE A  15
 None
 1.17A 1gsfD-3netA:
undetectable		 1gsfD-3netA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		no annotation 4 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfD-3nr8B:
undetectable		 1gsfD-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.87A 1gsfD-3ruyA:
undetectable		 1gsfD-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 PHE A  30
GLY A  98
LEU A 129
VAL A 122
 None
None
None
EPZ  A 501 (-4.2A)
 1.07A 1gsfD-3swdA:
undetectable		 1gsfD-3swdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 PHE A  31
GLY A  99
LEU A 130
VAL A 123
 None
None
None
UD1  A 501 (-4.2A)
 0.98A 1gsfD-3vcyA:
undetectable		 1gsfD-3vcyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfD-3w15A:
undetectable		 1gsfD-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		4 GLY A 191
LEU A 214
VAL A 346
PHE A 324
 None
 1.22A 1gsfD-3zpxA:
undetectable		 1gsfD-3zpxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 PHE A 314
GLY A 329
VAL A 379
PHE A 364
 None
 1.05A 1gsfD-4a05A:
1.3		 1gsfD-4a05A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		4 PHE A  58
GLY A 104
VAL A 138
PHE A  29
 None
 0.97A 1gsfD-4aa9A:
undetectable		 1gsfD-4aa9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfD-4adeA:
undetectable		 1gsfD-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		4 PHE A 423
GLY A 418
LEU A 332
VAL A 327
 None
 1.04A 1gsfD-4ainA:
undetectable		 1gsfD-4ainA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atb INTERLEUKIN
ENHANCER-BINDING
FACTOR 3

(Mus musculus) 		PF07528
(DZF) 		4 GLY B 260
LEU B 223
VAL B 229
MET B 266
 None
 1.21A 1gsfD-4atbB:
undetectable		 1gsfD-4atbB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		4 PHE A 456
GLY A 434
LEU A 438
PHE A 458
 None
 1.23A 1gsfD-4blaA:
undetectable		 1gsfD-4blaA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cd8 ENDO-BETA-1,4-MANNAN
ASE

(Alicyclobacillus
acidocaldarius) 		no annotation 4 PHE A 229
GLY A 233
VAL A 310
MET A 265
 None
 1.19A 1gsfD-4cd8A:
undetectable		 1gsfD-4cd8A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 254
ARG A 279
LEU A 281
VAL A 234
 None
EDO  A 409 ( 3.7A)
None
None
 1.19A 1gsfD-4ej6A:
undetectable		 1gsfD-4ej6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00188
(CAP)
PF14504
(CAP_assoc_N) 		4 PHE A 342
GLY A 331
LEU A 228
VAL A 304
 None
 1.07A 1gsfD-4h0aA:
undetectable		 1gsfD-4h0aA:
22.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 TYR A   9
GLY A  14
ARG A  15
LEU A 107
MET A 208
PHE A 220
 LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
 0.45A 1gsfD-4hj2A:
36.3		 1gsfD-4hj2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
 LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
 0.55A 1gsfD-4hj2A:
36.3		 1gsfD-4hj2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PHE A 482
GLY A 486
VAL A1017
PHE A 901
 None
 1.15A 1gsfD-4hpfA:
undetectable		 1gsfD-4hpfA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfD-4hppA:
undetectable		 1gsfD-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3h TOPOISOMERASE IV
SUBUNIT B, DNA
TOPOISOMERASE 4
SUBUNIT A CHIMERA

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim)
PF02518
(HATPase_c) 		4 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.10A 1gsfD-4i3hA:
undetectable		 1gsfD-4i3hA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN

(Streptococcus
pneumoniae) 		PF01497
(Peripla_BP_2) 		4 PHE A 244
LEU A 199
VAL A 257
MET A 208
 None
 1.10A 1gsfD-4jccA:
undetectable		 1gsfD-4jccA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		4 GLY A 413
LEU A 433
VAL A 277
PHE A 416
 None
None
None
PG4  A 501 (-4.6A)
 1.16A 1gsfD-4ke4A:
undetectable		 1gsfD-4ke4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		4 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.85A 1gsfD-4kg8A:
undetectable		 1gsfD-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opu CONSERVED ARCHAEAL
PROTEIN

(Sulfolobus
acidocaldarius) 		PF01266
(DAO) 		4 PHE A 319
GLY A  28
ARG A  27
VAL A 114
 None
 1.16A 1gsfD-4opuA:
undetectable		 1gsfD-4opuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.84A 1gsfD-4ppmA:
undetectable		 1gsfD-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 TYR A 539
GLY A 280
VAL A 261
PHE A  53
 None
 1.05A 1gsfD-4r1dA:
undetectable		 1gsfD-4r1dA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		4 GLY A 631
LEU A 626
VAL A 634
PHE A 904
 None
 1.22A 1gsfD-4ra7A:
undetectable		 1gsfD-4ra7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		4 PHE A 299
GLY A 308
LEU A 363
PHE A 288
 None
 1.19A 1gsfD-4rmlA:
undetectable		 1gsfD-4rmlA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzc FV M6P-1 HEAVY CHAIN
FV M6P-1 LIGHT CHAIN

(Oryctolagus
cuniculus) 		no annotation 4 TYR H 100
GLY H  99
VAL L  28
PHE L  98
 None
 1.12A 1gsfD-4rzcH:
undetectable		 1gsfD-4rzcH:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5k ASPARTATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF00155
(Aminotran_1_2) 		4 PHE A 235
GLY A  92
LEU A  96
VAL A 200
 None
PLP  A 500 (-3.6A)
None
None
 1.05A 1gsfD-4w5kA:
undetectable		 1gsfD-4w5kA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3o DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE

(Streptococcus
pneumoniae) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 TYR A1229
GLY A1210
LEU A1482
VAL A1238
 None
 1.18A 1gsfD-4z3oA:
undetectable		 1gsfD-4z3oA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PHE A 301
GLY A 298
ARG A 115
PHE A 302
 None
 1.22A 1gsfD-4zgsA:
undetectable		 1gsfD-4zgsA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfD-4zv1A:
undetectable		 1gsfD-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf PROBABLE
ATP-DEPENDENT
TRANSPORTER SUFC

(Escherichia
coli) 		PF00005
(ABC_tran) 		4 PHE C 146
GLY C 149
LEU C 176
VAL C 183
 None
 1.20A 1gsfD-5awfC:
undetectable		 1gsfD-5awfC:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		4 PHE A 161
GLY A  23
LEU A  78
VAL A  82
 None
 1.05A 1gsfD-5cgzA:
undetectable		 1gsfD-5cgzA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.91A 1gsfD-5dkuA:
undetectable		 1gsfD-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 GLY A 695
ARG A 602
MET A 528
PHE A 661
 None
 1.07A 1gsfD-5ed8A:
undetectable		 1gsfD-5ed8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g26 INTIMIN

(Escherichia
coli) 		PF11924
(IAT_beta) 		4 TYR A 350
GLY A 371
LEU A 360
PHE A 330
 None
None
None
97N  A1451 ( 4.8A)
 1.22A 1gsfD-5g26A:
undetectable		 1gsfD-5g26A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 TYR A 335
PHE A 334
VAL A 471
PHE A 414
 None
 1.15A 1gsfD-5gr1A:
undetectable		 1gsfD-5gr1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 240
GLY A 460
LEU A  41
PHE A 169
 None
 0.86A 1gsfD-5huuA:
1.9		 1gsfD-5huuA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 PHE A 347
GLY A 342
ARG A 344
VAL A 320
 None
 1.19A 1gsfD-5ic7A:
undetectable		 1gsfD-5ic7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j68 ASTROTACTIN-2

(Homo sapiens) 		PF01823
(MACPF) 		4 TYR A1260
GLY A1125
ARG A1124
LEU A1008
 None
 1.06A 1gsfD-5j68A:
2.7		 1gsfD-5j68A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A  35
GLY A  60
LEU A 344
VAL A 349
 None
 1.20A 1gsfD-5karA:
undetectable		 1gsfD-5karA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kr6 4-AMINOBUTYRATE
TRANSAMINASE

(Pseudomonas) 		PF00202
(Aminotran_3) 		4 PHE A 272
GLY A 266
ARG A 267
LEU A 433
 None
 0.76A 1gsfD-5kr6A:
undetectable		 1gsfD-5kr6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL

(Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 TYR C 124
GLY D 254
LEU D 260
VAL D 245
 None
 1.07A 1gsfD-5lc5C:
undetectable		 1gsfD-5lc5C:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liq NICKING ENDONUCLEASE
N.BSPD6I

(Bacillus sp.
(in: Bacteria)) 		PF09491
(RE_AlwI) 		4 GLY A  96
LEU A  23
VAL A  73
PHE A  83
 None
 1.14A 1gsfD-5liqA:
undetectable		 1gsfD-5liqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 4 PHE A 155
GLY A 152
ARG A 153
LEU A 463
 None
 1.17A 1gsfD-5mhfA:
undetectable		 1gsfD-5mhfA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nb3 PHYCOERYTHRIN BETA
SUBUNIT,PHYCOERYTHRI
N BETA SUBUNIT

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		4 PHE M  28
GLY M  32
LEU M  36
PHE M   5
 None
MPD  M 204 ( 4.0A)
PEB  M 187 (-4.2A)
None
 0.83A 1gsfD-5nb3M:
undetectable		 1gsfD-5nb3M:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLY A 378
LEU A 383
VAL A 386
PHE A   1
 None
 1.18A 1gsfD-5neuA:
undetectable		 1gsfD-5neuA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A 282
PHE A 201
LEU A 182
VAL A 165
 None
 1.11A 1gsfD-5nz7A:
3.9		 1gsfD-5nz7A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oko PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 557
GLY A 545
LEU A 583
PHE A 605
 None
 0.92A 1gsfD-5okoA:
undetectable		 1gsfD-5okoA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDG

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF12838
(Fer4_7) 		4 PHE B 166
GLY G  35
ARG B 163
VAL G  48
 None
 1.05A 1gsfD-5t5iB:
undetectable		 1gsfD-5t5iB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xon PROTEIN THAT FORMS A
COMPLEX WITH SPT4P
RNA POLYMERASE II
SUBUNIT

(Komagataella
phaffii) 		PF00467
(KOW)
PF00575
(S1)
PF03439
(Spt5-NGN)
PF03876
(SHS2_Rpb7-N) 		4 GLY W 669
ARG G 113
VAL G 148
PHE G 109
 None
 1.19A 1gsfD-5xonW:
undetectable		 1gsfD-5xonW:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbk PUTATIVE CYTOKININ
RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 103
GLY A 133
LEU A 174
PHE A   9
 None
 1.13A 1gsfD-5zbkA:
undetectable		 1gsfD-5zbkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 PHE A 493
GLY A 488
LEU A 459
VAL A 323
 None
 1.01A 1gsfD-6cc4A:
0.8		 1gsfD-6cc4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 4 TYR A 195
GLY A 202
LEU A 264
MET A 383
 None
 1.22A 1gsfD-6duxA:
undetectable		 1gsfD-6duxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 4 GLY J 765
LEU J 225
VAL J 218
PHE J 193
 None
 0.70A 1gsfD-6fhsJ:
undetectable		 1gsfD-6fhsJ:
15.38