SIMILAR PATTERNS OF AMINO ACIDS FOR 1GSF_C_EAAC223_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0a ASPARTYL TRNA
SYNTHETASE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLY A 407
LEU A 292
VAL A 323
PHE A 340
 None
 0.99A 1gsfC-1c0aA:
0.0		 1gsfC-1c0aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czi CHYMOSIN

(Bos taurus) 		PF00026
(Asp) 		4 PHE E  56
GLY E 102
VAL E 136
PHE E  27
 None
 1.02A 1gsfC-1cziE:
0.0		 1gsfC-1cziE:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 PHE A 357
GLY A 272
LEU A 270
VAL A 150
 None
 0.97A 1gsfC-1fbaA:
0.0		 1gsfC-1fbaA:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gul GLUTATHIONE
TRANSFERASE A4-4

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A   9
GLY A  14
ARG A  15
PHE A 220
 None
 0.63A 1gsfC-1gulA:
32.8		 1gsfC-1gulA:
53.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 GLY A 201
LEU A 155
VAL A 134
MET A 183
 None
 1.01A 1gsfC-1imjA:
0.0		 1gsfC-1imjA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		4 TYR A 323
LEU A 300
VAL A 293
PHE A 274
 None
 0.99A 1gsfC-1j1wA:
0.0		 1gsfC-1j1wA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 GLY A 437
LEU A 435
VAL A 534
PHE A 440
 None
 1.01A 1gsfC-1kspA:
undetectable		 1gsfC-1kspA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 PHE A 479
GLY A 475
LEU A 513
VAL A 502
 None
 0.87A 1gsfC-1mhsA:
1.5		 1gsfC-1mhsA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhs PLASMA MEMBRANE
ATPASE

(Neurospora
crassa) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		4 PHE A 810
LEU A 698
VAL A 693
PHE A 868
 None
 1.02A 1gsfC-1mhsA:
1.5		 1gsfC-1mhsA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mi1 NEUROBEACHIN

(Homo sapiens) 		PF02138
(Beach)
PF14844
(PH_BEACH) 		4 PHE A2397
GLY A2395
VAL A2186
PHE A2389
 None
 1.02A 1gsfC-1mi1A:
0.0		 1gsfC-1mi1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PHE A 815
GLY A 811
LEU A 789
MET A 648
 None
 0.94A 1gsfC-1nl3A:
undetectable		 1gsfC-1nl3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od3 PUTATIVE XYLANASE

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 TYR A  65
LEU A  42
VAL A 139
PHE A 144
 None
 0.97A 1gsfC-1od3A:
undetectable		 1gsfC-1od3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p5q FK506-BINDING
PROTEIN 4

(Homo sapiens) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF07719
(TPR_2) 		4 GLY A 355
ARG A 359
LEU A 346
PHE A 376
 None
 1.03A 1gsfC-1p5qA:
0.0		 1gsfC-1p5qA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrp PEPSIN 3A

(Homo sapiens) 		PF00026
(Asp) 		4 PHE E  56
GLY E 102
VAL E 136
PHE E  27
 None
 1.00A 1gsfC-1qrpE:
undetectable		 1gsfC-1qrpE:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		4 GLY A  53
LEU A  28
VAL A 505
PHE A  57
 None
 1.00A 1gsfC-1r4nA:
undetectable		 1gsfC-1r4nA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		4 PHE A 101
GLY A 131
LEU A 172
PHE A   7
 None
 0.87A 1gsfC-1t35A:
undetectable		 1gsfC-1t35A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzs CATHEPSIN E

(Homo sapiens) 		PF00026
(Asp) 		4 PHE A  67
GLY A 113
VAL A 147
PHE A  38
 None
 0.93A 1gsfC-1tzsA:
undetectable		 1gsfC-1tzsA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT
DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU)
PF02288
(Dehydratase_MU) 		4 TYR A 226
GLY A 235
LEU B 148
VAL B 113
 None
CNC  B2601 ( 3.7A)
CNC  B2601 (-4.1A)
CNC  B2601 (-4.9A)
 1.02A 1gsfC-1uc4A:
undetectable		 1gsfC-1uc4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uy4 ENDO-1,4-BETA-XYLANA
SE A

([Clostridium]
stercorarium) 		PF03422
(CBM_6) 		4 TYR A  60
LEU A  37
VAL A 134
PHE A 139
 None
 1.00A 1gsfC-1uy4A:
undetectable		 1gsfC-1uy4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vax URIC ACID OXIDASE

(Arthrobacter
globiformis) 		PF01014
(Uricase) 		4 GLY A  93
LEU A 137
VAL A  44
PHE A  77
 None
 1.02A 1gsfC-1vaxA:
undetectable		 1gsfC-1vaxA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 TYR A 205
PHE A 209
GLY A 240
PHE A 304
 None
 0.88A 1gsfC-1x9eA:
undetectable		 1gsfC-1x9eA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		4 GLY A 160
LEU A 120
VAL A 105
PHE A 102
 None
 1.03A 1gsfC-1yghA:
undetectable		 1gsfC-1yghA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 GLY A 250
ARG A 251
LEU A 411
VAL A 317
 None
 0.82A 1gsfC-1z3zA:
undetectable		 1gsfC-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 PHE A 256
ARG A 251
LEU A 411
VAL A 317
 None
 0.91A 1gsfC-1z3zA:
undetectable		 1gsfC-1z3zA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bpa PROTEIN (SUBUNIT OF
BACTERIOPHAGE
PHIX174)

(Escherichia
virus phiX174) 		PF02306
(Phage_G) 		4 TYR 2 121
GLY 2 114
VAL 2 127
PHE 2 144
 None
 1.01A 1gsfC-2bpa2:
undetectable		 1gsfC-2bpa2:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpk SODIUM/CALCIUM
EXCHANGER 1

(Canis lupus) 		PF03160
(Calx-beta) 		4 GLY A 398
LEU A 401
VAL A 405
PHE A 375
 None
 1.01A 1gsfC-2dpkA:
undetectable		 1gsfC-2dpkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo5 419AA LONG
HYPOTHETICAL
AMINOTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00202
(Aminotran_3) 		4 PHE A 265
GLY A 259
ARG A 260
LEU A 397
 None
 0.86A 1gsfC-2eo5A:
undetectable		 1gsfC-2eo5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 PHE A 193
GLY A 165
VAL A  63
PHE A 172
 None
 0.89A 1gsfC-2ftzA:
2.6		 1gsfC-2ftzA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 TYR A 608
GLY A 618
ARG A 634
VAL A 118
 None
None
None
COA  A 800 (-3.9A)
 0.93A 1gsfC-2gq3A:
2.1		 1gsfC-2gq3A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 PHE A 429
GLY A 427
ARG A 472
VAL A 420
 None
 0.97A 1gsfC-2ipcA:
2.5		 1gsfC-2ipcA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5g ALR4455 PROTEIN

(Nostoc sp. PCC
7120) 		PF00378
(ECH_1) 		4 GLY D  96
LEU D 240
VAL D 155
PHE D  38
 None
 1.00A 1gsfC-2j5gD:
undetectable		 1gsfC-2j5gD:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER PERMEASE
PROTEIN HI1471

(Haemophilus
influenzae) 		PF01032
(FecCD) 		4 GLY A 276
ARG A 272
LEU A 282
VAL A 289
 None
 1.02A 1gsfC-2nq2A:
undetectable		 1gsfC-2nq2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppy ENOYL-COA HYDRATASE

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		4 TYR A  32
GLY A  69
VAL A 144
PHE A  86
 None
 1.01A 1gsfC-2ppyA:
undetectable		 1gsfC-2ppyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvu ARTJ

(Geobacillus
stearothermophilus) 		PF00497
(SBP_bac_3) 		4 TYR A 103
PHE A 104
GLY A  86
PHE A  45
 None
SO4  A 253 ( 4.2A)
LYS  A 301 (-4.9A)
None
 0.94A 1gsfC-2pvuA:
undetectable		 1gsfC-2pvuA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra9 UNCHARACTERIZED
PROTEIN DUF1285

(Shewanella
baltica) 		PF06938
(DUF1285) 		4 PHE A 145
GLY A 138
LEU A  87
PHE A  91
 None
EDO  A 161 (-3.6A)
None
EDO  A 160 ( 3.9A)
 0.82A 1gsfC-2ra9A:
undetectable		 1gsfC-2ra9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A1334
LEU A1300
VAL A1327
PHE A1337
 None
 1.01A 1gsfC-2vdcA:
undetectable		 1gsfC-2vdcA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 PHE A 323
GLY A 319
ARG A 322
VAL A 294
 None
 0.91A 1gsfC-2vgiA:
undetectable		 1gsfC-2vgiA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsw 72 KDA INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 PHE A 420
GLY A 408
LEU A 446
PHE A 475
 None
 0.82A 1gsfC-2xswA:
undetectable		 1gsfC-2xswA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 TYR A 785
GLY A 789
LEU A 645
PHE A 739
 None
 0.87A 1gsfC-2y35A:
undetectable		 1gsfC-2y35A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvs GLYCOLATE OXIDASE
SUBUNIT GLCE

(Thermus
thermophilus) 		no annotation 4 GLY A  51
ARG A  49
LEU A  46
VAL A  37
 None
 1.01A 1gsfC-2yvsA:
undetectable		 1gsfC-2yvsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		4 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfC-3akkA:
undetectable		 1gsfC-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 PHE A 275
GLY A 241
LEU A 206
VAL A 199
 None
 0.96A 1gsfC-3anyA:
undetectable		 1gsfC-3anyA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		4 PHE A  56
GLY A  50
LEU A  97
VAL A 129
 None
 0.91A 1gsfC-3bkwA:
undetectable		 1gsfC-3bkwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du4 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 PHE A 264
GLY A 258
ARG A 259
LEU A 422
 None
 0.70A 1gsfC-3du4A:
undetectable		 1gsfC-3du4A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 PHE A  43
GLY A 111
LEU A 128
PHE A 154
 None
 0.98A 1gsfC-3e38A:
undetectable		 1gsfC-3e38A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		4 PHE A 111
GLY A 118
LEU A 294
VAL A  81
 None
 0.98A 1gsfC-3e61A:
undetectable		 1gsfC-3e61A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egc PUTATIVE RIBOSE
OPERON REPRESSOR

(Burkholderia
thailandensis) 		PF00532
(Peripla_BP_1) 		4 PHE A 119
GLY A 126
LEU A 311
VAL A  89
 None
 0.89A 1gsfC-3egcA:
undetectable		 1gsfC-3egcA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 PHE A 273
GLY A 267
ARG A 268
LEU A 434
 None
 0.87A 1gsfC-3gjuA:
undetectable		 1gsfC-3gjuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwj ARYLPHORIN

(Antheraea
pernyi) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 TYR A 252
GLY A 638
VAL A 510
PHE A 630
 None
 1.01A 1gsfC-3gwjA:
undetectable		 1gsfC-3gwjA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		4 PHE A 274
GLY A 268
ARG A 269
LEU A 429
 None
 0.73A 1gsfC-3hmuA:
undetectable		 1gsfC-3hmuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hqg TYPE-2 RESTRICTION
ENZYME ECORII

(Escherichia
coli) 		PF09019
(EcoRII-C) 		4 PHE A 278
GLY A 282
ARG A 284
PHE A 286
 None
 0.82A 1gsfC-3hqgA:
2.3		 1gsfC-3hqgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyi PROTEIN DUF199/WHIA

(Thermotoga
maritima) 		PF02650
(HTH_WhiA)
PF10298
(WhiA_N)
PF14527
(LAGLIDADG_WhiA) 		4 PHE A 119
GLY A 117
VAL A  20
PHE A 181
 None
 0.95A 1gsfC-3hyiA:
undetectable		 1gsfC-3hyiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		4 GLY A 238
ARG A 239
LEU A 407
VAL A 309
 None
 0.99A 1gsfC-3i4jA:
undetectable		 1gsfC-3i4jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		4 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfC-3i5tA:
undetectable		 1gsfC-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 15
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF11497
(NADH_Oxid_Nqo15)
PF13510
(Fer2_4) 		4 PHE 3 202
GLY 3 212
ARG 7  88
VAL 3 164
 SF4  3 785 ( 4.8A)
None
None
None
 0.99A 1gsfC-3i9v3:
undetectable		 1gsfC-3i9v3:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kke LACI FAMILY
TRANSCRIPTIONAL
REGULATOR

(Mycolicibacterium
smegmatis) 		PF13377
(Peripla_BP_3) 		4 GLY A 164
ARG A 195
LEU A 296
VAL A 322
 None
ACT  A   1 (-2.7A)
None
None
 0.79A 1gsfC-3kkeA:
undetectable		 1gsfC-3kkeA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 PHE A 265
GLY A 259
ARG A 260
LEU A 428
 None
 0.74A 1gsfC-3n5mA:
undetectable		 1gsfC-3n5mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr8 PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		no annotation 4 PHE B 557
GLY B 545
LEU B 583
PHE B 605
 None
 0.91A 1gsfC-3nr8B:
undetectable		 1gsfC-3nr8B:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		4 PHE A  56
GLY A 102
VAL A 136
PHE A  27
 None
 1.02A 1gsfC-3psgA:
undetectable		 1gsfC-3psgA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2u METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		4 PHE A   3
GLY A  19
LEU A  47
VAL A  41
 None
 0.99A 1gsfC-3r2uA:
undetectable		 1gsfC-3r2uA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.88A 1gsfC-3ruyA:
undetectable		 1gsfC-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE

(Mycolicibacterium
smegmatis) 		PF01522
(Polysacc_deac_1) 		4 GLY A  75
LEU A  68
VAL A  61
PHE A  78
 None
 1.01A 1gsfC-3rxzA:
undetectable		 1gsfC-3rxzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vaa SHIKIMATE KINASE

(Bacteroides
thetaiotaomicron) 		PF01202
(SKI) 		4 GLY A  13
LEU A 156
VAL A 166
PHE A  29
 PEG  A 178 (-3.2A)
None
None
None
 1.00A 1gsfC-3vaaA:
undetectable		 1gsfC-3vaaA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 PHE A  31
GLY A  99
LEU A 130
VAL A 123
 None
None
None
UD1  A 501 (-4.2A)
 0.97A 1gsfC-3vcyA:
undetectable		 1gsfC-3vcyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 PHE A   9
GLY A  11
VAL A  78
PHE A  41
 None
 1.00A 1gsfC-3w15A:
undetectable		 1gsfC-3w15A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 PHE A 251
ARG A 633
LEU A  32
VAL A  23
 None
 0.93A 1gsfC-3wevA:
undetectable		 1gsfC-3wevA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zj0 ACETYLTRANSFERASE

(Oceanicola
granulosus) 		PF00583
(Acetyltransf_1) 		4 GLY A 200
ARG A 188
LEU A 190
VAL A 197
 None
 1.01A 1gsfC-3zj0A:
undetectable		 1gsfC-3zj0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius) 		PF00026
(Asp) 		4 PHE A  58
GLY A 104
VAL A 138
PHE A  29
 None
 0.97A 1gsfC-4aa9A:
undetectable		 1gsfC-4aa9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLY A 230
ARG A 231
LEU A 379
VAL A 295
 None
 1.03A 1gsfC-4adeA:
undetectable		 1gsfC-4adeA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 PHE A 280
GLY A 278
LEU A  76
VAL A 187
 None
None
GDP  A 901 (-3.8A)
GDP  A 901 (-3.6A)
 1.03A 1gsfC-4b8wA:
undetectable		 1gsfC-4b8wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc7 ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE,
PEROXISOMAL

(Cavia porcellus) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 GLY A 504
ARG A 503
VAL A 465
PHE A 428
 None
 0.96A 1gsfC-4bc7A:
undetectable		 1gsfC-4bc7A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ce5 AT-OMEGATA

(Aspergillus
terreus) 		PF01063
(Aminotran_4) 		4 TYR A 146
PHE A 115
GLY A 277
VAL A 238
 None
None
None
PLP  A1180 ( 3.7A)
 1.01A 1gsfC-4ce5A:
undetectable		 1gsfC-4ce5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 TYR A 613
GLY A 623
ARG A 639
VAL A 118
 None
 0.99A 1gsfC-4ex4A:
undetectable		 1gsfC-4ex4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 PHE A 814
GLY A 816
VAL A 828
PHE A 853
 None
 0.94A 1gsfC-4fddA:
3.9		 1gsfC-4fddA:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		7 TYR A   9
GLY A  14
ARG A  15
LEU A 107
VAL A 111
MET A 208
PHE A 220
 LZ6  A 301 (-4.6A)
LZ6  A 301 ( 3.9A)
None
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-4.0A)
LZ6  A 301 (-3.7A)
 0.65A 1gsfC-4hj2A:
36.3		 1gsfC-4hj2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 PHE A 159
GLY A 157
ARG A 154
PHE A 177
 None
 1.00A 1gsfC-4hppA:
undetectable		 1gsfC-4hppA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6o METALLOPHOSPHOESTERA
SE

(Ruminiclostridium
thermocellum) 		PF00149
(Metallophos) 		4 GLY A 334
LEU A 171
VAL A 313
PHE A 330
 None
None
PGE  A 502 (-4.2A)
None
 1.00A 1gsfC-4j6oA:
undetectable		 1gsfC-4j6oA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		4 GLY A 204
LEU A 180
VAL A 215
PHE A 238
 None
 0.86A 1gsfC-4kg8A:
undetectable		 1gsfC-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		4 GLY A  29
LEU A 215
VAL A 168
PHE A  86
 F6R  A 304 ( 3.7A)
None
F6R  A 304 (-3.6A)
None
 0.96A 1gsfC-4n6fA:
undetectable		 1gsfC-4n6fA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nru RNA DEPENDENT RNA
POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 GLY A 259
LEU A 280
VAL A 275
PHE A 202
 None
 1.02A 1gsfC-4nruA:
undetectable		 1gsfC-4nruA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf6 C4-DICARBOXYLATE-BIN
DING PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 PHE A 182
LEU A 236
VAL A 108
PHE A 314
 None
None
PGE  A 402 ( 4.1A)
None
 1.02A 1gsfC-4pf6A:
undetectable		 1gsfC-4pf6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 4 GLY A 140
ARG A 124
LEU B 492
PHE A 459
 None
 0.91A 1gsfC-4po6A:
2.2		 1gsfC-4po6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 PHE A 629
GLY A 623
ARG A 624
LEU A 827
 None
 0.84A 1gsfC-4ppmA:
undetectable		 1gsfC-4ppmA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		4 PHE A  31
GLY A  99
LEU A 130
VAL A 123
 None
None
None
UD1  A 503 (-4.2A)
 1.03A 1gsfC-4r7uA:
undetectable		 1gsfC-4r7uA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxv HYPOTHETICAL PROTEIN
LPG0944

(Legionella
pneumophila) 		no annotation 4 TYR A  17
LEU A 112
VAL A 126
PHE A 104
 None
 1.02A 1gsfC-4rxvA:
undetectable		 1gsfC-4rxvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Pseudomonas
aeruginosa) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 GLY M 410
LEU M 295
VAL M 326
PHE M 343
 None
 1.00A 1gsfC-4wj3M:
undetectable		 1gsfC-4wj3M:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 TYR A 401
GLY A 376
VAL A 363
MET A 394
 None
 1.03A 1gsfC-4wzbA:
undetectable		 1gsfC-4wzbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf7 CARBOHYDRATE/PYRIMID
INE KINASE, PFKB
FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 PHE A 180
GLY A 159
LEU A 125
PHE A 176
 None
 0.99A 1gsfC-4xf7A:
undetectable		 1gsfC-4xf7A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 PHE A 280
GLY A 276
ARG A 279
VAL A 251
 None
 0.99A 1gsfC-4yj5A:
undetectable		 1gsfC-4yj5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv1 ANCQR

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 TYR A  93
PHE A  94
GLY A  76
PHE A  35
 None
None
ARG  A 301 (-4.5A)
None
 0.73A 1gsfC-4zv1A:
undetectable		 1gsfC-4zv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 GLY A 149
ARG A 153
MET A 147
PHE A 157
 None
 0.96A 1gsfC-5aq1A:
undetectable		 1gsfC-5aq1A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7c S-CRYSTALLIN OCTVUS4

(Octopus
vulgaris) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A   8
GLY A  13
ARG A  14
LEU A 100
 None
None
GSH  A 301 (-4.1A)
None
 0.75A 1gsfC-5b7cA:
21.4		 1gsfC-5b7cA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 LEU A 208
VAL A 383
MET A 275
PHE A  83
 None
 0.98A 1gsfC-5cd2A:
undetectable		 1gsfC-5cd2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 TYR A 545
GLY A 549
ARG A 530
PHE A 374
 None
 0.91A 1gsfC-5dkuA:
3.4		 1gsfC-5dkuA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0a TRANSAMINASE

(Bacillus
megaterium) 		PF00202
(Aminotran_3) 		4 PHE A 282
GLY A 276
ARG A 277
LEU A 447
 None
 0.85A 1gsfC-5g0aA:
undetectable		 1gsfC-5g0aA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		4 PHE A 271
GLY A 265
ARG A 266
LEU A 429
 None
 0.72A 1gsfC-5ghfA:
undetectable		 1gsfC-5ghfA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 PHE A 379
GLY A 528
LEU A 549
PHE A 530
 PHE  A 379 ( 1.3A)
GLY  A 528 ( 0.0A)
LEU  A 549 ( 0.6A)
PHE  A 530 ( 1.3A)
 1.02A 1gsfC-5gprA:
undetectable		 1gsfC-5gprA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A

(Escherichia
coli;
Staphylococcus
aureus) 		PF00202
(Aminotran_3)
PF02216
(B) 		4 PHE A 284
GLY A 278
ARG A 279
LEU A 431
 None
 0.77A 1gsfC-5h7dA:
undetectable		 1gsfC-5h7dA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huu ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
[UDP-FORMING]

(Candida
albicans) 		PF00982
(Glyco_transf_20) 		4 PHE A 240
GLY A 460
LEU A  41
PHE A 169
 None
 0.86A 1gsfC-5huuA:
undetectable		 1gsfC-5huuA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 PHE A  96
GLY A  90
LEU A 265
VAL A 232
 None
 1.03A 1gsfC-5icqA:
2.3		 1gsfC-5icqA:
16.89