SIMILAR PATTERNS OF AMINO ACIDS FOR 1GSE_B_EAAB224_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avb ARCELIN-1

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 GLY A  44
LEU A  30
VAL A 216
LEU A  85
ALA A  86
 None
 1.07A 1gseB-1avbA:
undetectable		 1gseB-1avbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 ARG A 307
GLY A 304
LEU A  45
VAL A  47
PHE A  12
 None
 1.10A 1gseB-1bxcA:
0.0		 1gseB-1bxcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnz BARK AGGLUTININ I,
POLYPEPTIDE A

(Robinia
pseudoacacia) 		PF00139
(Lectin_legB) 		5 GLY A  48
LEU A  32
VAL A 226
LEU A  89
ALA A  90
 None
 1.07A 1gseB-1fnzA:
undetectable		 1gseB-1fnzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8w LEUCOAGGLUTINATING
PHYTOHEMAGGLUTININ

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 GLY A  47
LEU A  30
VAL A 223
LEU A  88
ALA A  89
 None
 1.07A 1gseB-1g8wA:
undetectable		 1gseB-1g8wA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 111
LEU A  93
LEU A  96
VAL A  99
ALA A  77
 None
 0.98A 1gseB-1gv3A:
0.0		 1gseB-1gv3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvl KALLIKREIN 6

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A  44
LEU A  33
LEU A  64
VAL A  85
LEU A 108
 None
 0.88A 1gseB-1gvlA:
undetectable		 1gseB-1gvlA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxn PECTATE LYASE

(Cellvibrio
japonicus) 		PF09492
(Pec_lyase) 		5 GLY A 491
LEU A 458
VAL A 539
ALA A 498
PHE A 449
 None
 0.92A 1gseB-1gxnA:
3.0		 1gseB-1gxnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
aquaticus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 GLY A  37
LEU A 194
LEU A  25
LEU A 210
ALA A 213
 None
 1.02A 1gseB-1hqmA:
undetectable		 1gseB-1hqmA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 TYR A 120
GLY A 189
PRO A 131
VAL A 130
LEU A 210
 None
 1.08A 1gseB-1iirA:
1.7		 1gseB-1iirA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioa ARCELIN-5A

(Phaseolus
vulgaris) 		PF00139
(Lectin_legB) 		5 GLY A  48
LEU A  31
VAL A 218
LEU A  87
ALA A  88
 None
 1.01A 1gseB-1ioaA:
undetectable		 1gseB-1ioaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 GLY A 261
LEU A 279
LEU A 283
ALA A 299
PHE A 317
 None
 1.07A 1gseB-1iy1A:
undetectable		 1gseB-1iy1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 284
PRO A 286
VAL A 287
LEU A 127
PHE A 277
 None
 0.97A 1gseB-1j6uA:
undetectable		 1gseB-1j6uA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 ARG A 436
GLY A 437
LEU A 408
LEU A 428
PHE A 354
 None
 0.97A 1gseB-1kspA:
undetectable		 1gseB-1kspA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		5 GLY A 260
LEU A 278
LEU A 282
ALA A 298
PHE A 316
 None
 0.93A 1gseB-1lv7A:
undetectable		 1gseB-1lv7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV

(Thermotoga
maritima) 		PF00227
(Proteasome) 		5 GLY A  38
VAL A  97
LEU A  71
ALA A  74
PHE A  60
 None
 0.92A 1gseB-1m4yA:
undetectable		 1gseB-1m4yA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		5 LEU A 273
PRO A 271
VAL A 272
ALA A 246
PHE A 250
 None
 1.06A 1gseB-1ps6A:
undetectable		 1gseB-1ps6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmo MANNOSE BINDING
LECTIN, FRIL

(Lablab
purpureus) 		PF00139
(Lectin_legB) 		5 GLY A  48
LEU A  31
VAL E 236
LEU A  88
ALA A  89
 None
 0.96A 1gseB-1qmoA:
undetectable		 1gseB-1qmoA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usw FERULOYL ESTERASE A

(Aspergillus
niger) 		PF01764
(Lipase_3) 		5 TYR A 186
VAL A  96
LEU A 141
ALA A 144
PHE A 168
 None
 1.08A 1gseB-1uswA:
undetectable		 1gseB-1uswA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A   9
ARG A  13
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 0.94A 1gseB-1vf1A:
32.8		 1gseB-1vf1A:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00797
(Acetyltransf_2) 		5 LEU A  91
LEU A 116
VAL A 127
LEU A  29
PHE A  80
 None
 1.10A 1gseB-1w4tA:
undetectable		 1gseB-1w4tA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  36
VAL A  11
MET A  33
ALA A 346
PHE A  88
 None
 0.97A 1gseB-1ys4A:
undetectable		 1gseB-1ys4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A 196
LEU A  39
LEU A 106
ALA A 104
PHE A  59
 None
 1.01A 1gseB-1zlrA:
undetectable		 1gseB-1zlrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmx ALKYL
HYDROPEROXIDASE C

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A 111
LEU A  83
VAL A  50
ALA A 122
PHE A  10
 None
 1.05A 1gseB-2bmxA:
undetectable		 1gseB-2bmxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 GLY A 160
LEU A 179
LEU A 175
VAL A 171
LEU A 163
 None
 1.04A 1gseB-2d0oA:
undetectable		 1gseB-2d0oA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 GLY A 446
LEU A 180
PRO A 471
LEU A 426
ALA A  65
 None
 0.95A 1gseB-2hgsA:
undetectable		 1gseB-2hgsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A 319
LEU A 326
VAL A 325
LEU A  20
ALA A  19
 None
DIO  A 408 ( 4.8A)
None
None
None
 0.95A 1gseB-2hjsA:
2.5		 1gseB-2hjsA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it1 362AA LONG
HYPOTHETICAL
MALTOSE/MALTODEXTRIN
TRANSPORT
ATP-BINDING PROTEIN

(Pyrococcus
horikoshii) 		PF00005
(ABC_tran) 		5 GLY A 137
LEU A 126
VAL A  92
LEU A  86
ALA A 143
 None
 1.08A 1gseB-2it1A:
undetectable		 1gseB-2it1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		5 GLY A 100
LEU A 126
LEU A 149
LEU A 143
ALA A 107
 SAH  A 301 ( 4.6A)
None
None
None
None
 1.09A 1gseB-2oyrA:
undetectable		 1gseB-2oyrA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		5 GLY A 336
LEU A 343
VAL A 342
LEU A 306
ALA A 309
 None
 0.99A 1gseB-2pgsA:
undetectable		 1gseB-2pgsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE

(Hedera helix) 		PF03405
(FA_desaturase_2) 		5 GLY B 315
LEU B 311
LEU B 308
VAL B 305
ALA B 251
 None
 1.09A 1gseB-2uw1B:
undetectable		 1gseB-2uw1B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		6 ARG A 147
LEU A 171
LEU A 150
VAL A 236
ALA A 142
PHE A 138
 None
 1.27A 1gseB-2v3bA:
undetectable		 1gseB-2v3bA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		6 ARG A 147
LEU A 171
LEU A 150
VAL A 236
LEU A 234
PHE A 138
 None
 1.39A 1gseB-2v3bA:
undetectable		 1gseB-2v3bA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ARG A 134
PRO A 159
VAL A  93
LEU A  83
ALA A  79
PHE A  68
 ARG  A 134 ( 0.6A)
PRO  A 159 ( 1.1A)
VAL  A  93 ( 0.6A)
LEU  A  83 ( 0.6A)
ALA  A  79 ( 0.0A)
PHE  A  68 ( 1.3A)
 1.44A 1gseB-2vbfA:
undetectable		 1gseB-2vbfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x30 PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
coelicolor) 		PF00977
(His_biosynth) 		5 GLY A 222
LEU A 225
LEU A 232
LEU A 205
ALA A 219
 SO4  A1242 (-3.6A)
None
None
None
None
 1.10A 1gseB-2x30A:
undetectable		 1gseB-2x30A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xut PROTON/PEPTIDE
SYMPORTER FAMILY
PROTEIN

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 GLY A  30
LEU A  35
PRO A  37
LEU A 172
ALA A 180
 None
 0.91A 1gseB-2xutA:
undetectable		 1gseB-2xutA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		5 GLY D 621
LEU D 583
VAL D 150
LEU D 127
ALA D 630
 None
 1.10A 1gseB-2yibD:
2.0		 1gseB-2yibD:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 GLY A  14
LEU A  53
VAL A  92
LEU A 110
ALA A 114
 None
 1.07A 1gseB-2yxlA:
undetectable		 1gseB-2yxlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ARG A 163
GLY A 162
LEU A 232
LEU A 239
ALA A 242
 None
 1.05A 1gseB-2yxzA:
undetectable		 1gseB-2yxzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 GLY A 117
LEU A  49
LEU A  62
VAL A  58
ALA A 169
 None
 1.04A 1gseB-2zhyA:
undetectable		 1gseB-2zhyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccq 50S RIBOSOMAL
PROTEIN L4P

(Haloarcula
marismortui) 		PF00573
(Ribosomal_L4) 		5 LEU C 156
VAL C 153
LEU C 207
ALA C 210
PHE C 194
 None
 1.05A 1gseB-3ccqC:
undetectable		 1gseB-3ccqC:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 ARG A  22
GLY A 271
LEU A 269
PRO A 237
VAL A 236
 None
 0.95A 1gseB-3dr2A:
undetectable		 1gseB-3dr2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e29 UNCHARACTERIZED
PROTEIN Q7WE92_BORBR

(Bordetella
bronchiseptica) 		PF03061
(4HBT) 		5 GLY A  33
LEU A  36
VAL A  26
LEU A   6
ALA A   5
 None
 0.98A 1gseB-3e29A:
undetectable		 1gseB-3e29A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		5 GLY A 101
LEU A 139
LEU A 140
LEU A 108
ALA A 107
 None
 0.98A 1gseB-3ez1A:
undetectable		 1gseB-3ez1A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 GLY E 266
LEU E 284
LEU E 288
ALA E 304
PHE E 322
 None
 0.94A 1gseB-3kdsE:
undetectable		 1gseB-3kdsE:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyq SYNAPTOBREVIN
HOMOLOG YKT6

(Rattus
norvegicus) 		PF00957
(Synaptobrevin)
PF13774
(Longin) 		5 ARG A 129
LEU A  93
LEU A  94
LEU A 123
ALA A  22
 None
 1.06A 1gseB-3kyqA:
undetectable		 1gseB-3kyqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l09 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Jannaschia sp.
CCS1) 		PF07848
(PaaX) 		6 GLY A  55
LEU A  56
LEU A  23
VAL A  26
LEU A 208
PHE A  50
 None
 1.44A 1gseB-3l09A:
2.8		 1gseB-3l09A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 GLY A 303
LEU A  59
LEU A  23
LEU A 310
ALA A 253
 None
 0.92A 1gseB-3myoA:
undetectable		 1gseB-3myoA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 GLY A 178
LEU A 132
LEU A 133
PRO A 135
VAL A 136
 None
 1.03A 1gseB-3mzsA:
undetectable		 1gseB-3mzsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		5 GLY A 274
VAL A 523
LEU A 150
ALA A 280
PHE A 342
 None
 0.99A 1gseB-3odnA:
undetectable		 1gseB-3odnA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE

(Leishmania
major) 		PF01704
(UDPGP) 		5 GLY A 456
VAL A 485
LEU A 437
ALA A 440
PHE A 490
 None
 0.91A 1gseB-3ogzA:
undetectable		 1gseB-3ogzA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2k OXIDOREDUCTASE

(Bordetella
pertussis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 112
LEU A 329
VAL A 128
LEU A 126
ALA A  89
 None
 1.07A 1gseB-3q2kA:
undetectable		 1gseB-3q2kA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		5 GLY A 289
VAL A 233
LEU A 285
ALA A 310
PHE A 258
 None
 1.09A 1gseB-3qc2A:
undetectable		 1gseB-3qc2A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 GLY A 478
LEU A 440
LEU A 442
VAL A 470
ALA A 494
 None
 0.96A 1gseB-3qp9A:
undetectable		 1gseB-3qp9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		5 ARG A  86
GLY A  84
LEU A  78
VAL A  75
ALA A 275
 None
 1.02A 1gseB-3r97A:
undetectable		 1gseB-3r97A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 305
LEU A 302
LEU A 290
ALA A 289
PHE A 265
 None
 1.08A 1gseB-3rg2A:
undetectable		 1gseB-3rg2A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rk6 POLYADENYLATE-BINDIN
G
PROTEIN-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF02854
(MIF4G) 		6 ARG A 222
LEU A 195
VAL A 192
LEU A 228
ALA A 178
PHE A 188
 None
 1.42A 1gseB-3rk6A:
3.1		 1gseB-3rk6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 GLY A 569
LEU A 601
LEU A 582
VAL A 537
LEU A 507
 None
 1.04A 1gseB-3syjA:
undetectable		 1gseB-3syjA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		5 GLY A 693
LEU A 731
LEU A 714
LEU A 701
ALA A 700
 None
 1.09A 1gseB-3tsyA:
undetectable		 1gseB-3tsyA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 ARG A 788
VAL A 744
LEU A 816
ALA A 819
PHE A 777
 None
 0.87A 1gseB-3tzwA:
undetectable		 1gseB-3tzwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 GLY A 449
LEU A 452
LEU A 432
LEU A 443
ALA A 399
 None
 0.96A 1gseB-3ue3A:
undetectable		 1gseB-3ue3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 265
LEU A 291
VAL A 295
LEU A 273
ALA A 279
 None
 1.06A 1gseB-3uw2A:
undetectable		 1gseB-3uw2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w25 GLYCOSIDE HYDROLASE
FAMILY 10

(Thermoanaerobacterium
saccharolyticum) 		PF00331
(Glyco_hydro_10) 		6 GLY A  84
LEU A 125
VAL A 124
LEU A  56
ALA A  68
PHE A 128
 None
 1.37A 1gseB-3w25A:
undetectable		 1gseB-3w25A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 TYR A 172
ARG A 134
GLY A 135
ALA A 128
PHE A 113
 None
 1.10A 1gseB-3zokA:
undetectable		 1gseB-3zokA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  25
LEU A  88
VAL A 123
LEU A  96
ALA A  97
 None
 1.03A 1gseB-4a73A:
undetectable		 1gseB-4a73A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 LEU A 487
LEU A 491
LEU A 509
ALA A 393
PHE A 453
 None
 0.95A 1gseB-4bwkA:
undetectable		 1gseB-4bwkA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4u MANDALATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(unidentified) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 288
LEU A 117
VAL A 113
LEU A 366
ALA A 100
 None
 1.09A 1gseB-4e4uA:
undetectable		 1gseB-4e4uA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 PRO A 185
MET A 277
LEU A 187
ALA A  50
PHE A 163
 None
 1.07A 1gseB-4f3eA:
3.2		 1gseB-4f3eA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1s 5'-NUCLEOTIDASE

(Homo sapiens) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 LEU A 132
LEU A 127
VAL A 124
LEU A 150
ALA A 146
 None
 0.95A 1gseB-4h1sA:
undetectable		 1gseB-4h1sA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		9 TYR A   9
ARG A  13
GLY A  14
LEU A 107
LEU A 108
PRO A 110
VAL A 111
LEU A 213
ALA A 216
 LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
None
LZ6  A 301 ( 4.6A)
 0.56A 1gseB-4hj2A:
36.0		 1gseB-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 TYR A   9
ARG A  13
GLY A  14
MET A 208
LEU A 213
ALA A 216
 LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.0A)
None
LZ6  A 301 ( 4.6A)
 1.00A 1gseB-4hj2A:
36.0		 1gseB-4hj2A:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqe TRANSCRIPTIONAL
REGULATOR QSRR

(Staphylococcus
aureus) 		PF01638
(HxlR) 		5 GLY A  85
LYS A  84
LEU A  64
LEU A  92
ALA A  91
 None
 0.99A 1gseB-4hqeA:
undetectable		 1gseB-4hqeA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itc LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF07675
(Cleaved_Adhesin) 		5 GLY A1056
LEU A1052
LEU A1050
VAL A1130
LEU A1092
 None
 1.07A 1gseB-4itcA:
undetectable		 1gseB-4itcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		5 LEU A 103
LEU A 107
VAL A 110
LEU A 230
ALA A 127
 None
 0.97A 1gseB-4j7mA:
undetectable		 1gseB-4j7mA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jga 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Rickettsia
rickettsii) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 270
LEU A  15
VAL A 253
LEU A 255
PHE A 365
 None
 0.87A 1gseB-4jgaA:
undetectable		 1gseB-4jgaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		5 ARG B 534
GLY B 533
LEU B 560
VAL B 564
LEU B 540
 None
 1.08A 1gseB-4kmoB:
2.0		 1gseB-4kmoB:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Burkholderia
cenocepacia) 		PF01041
(DegT_DnrJ_EryC1) 		5 ARG A 171
LEU A 250
LEU A  46
ALA A 196
PHE A 183
 None
 1.08A 1gseB-4lc3A:
undetectable		 1gseB-4lc3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 TYR A 624
LEU A 464
VAL A 467
MET A 486
LEU A 482
 PG4  A 803 (-4.1A)
None
None
None
None
 1.05A 1gseB-4m0mA:
undetectable		 1gseB-4m0mA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnq PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
atroolivaceus) 		PF00378
(ECH_1) 		5 GLY A 119
LEU A  33
LEU A  38
LEU A  59
ALA A 126
 None
 1.08A 1gseB-4nnqA:
undetectable		 1gseB-4nnqA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oir DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Thermus
thermophilus) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		5 GLY A  37
LEU A 195
LEU A  25
LEU A 211
ALA A 214
 None
 1.09A 1gseB-4oirA:
undetectable		 1gseB-4oirA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 ARG A 389
VAL A 430
LEU A 402
ALA A 403
PHE A 428
 None
 1.00A 1gseB-4rcnA:
undetectable		 1gseB-4rcnA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C 454
LEU C 404
VAL C 400
ALA C 435
PHE C 395
 None
 0.97A 1gseB-4u1dC:
4.0		 1gseB-4u1dC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		5 LEU A 176
LEU A 196
VAL A 303
LEU A 258
ALA A 261
 None
 0.92A 1gseB-4woyA:
undetectable		 1gseB-4woyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A 283
LEU A 304
LEU A 299
LEU A 310
ALA A 289
 None
 1.00A 1gseB-4z64A:
undetectable		 1gseB-4z64A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 GLY A1109
LEU A1146
VAL A1143
LEU A1115
ALA A1114
 None
 1.09A 1gseB-5aorA:
undetectable		 1gseB-5aorA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eod COAGULATION FACTOR
XI

(Homo sapiens) 		PF00024
(PAN_1)
PF00089
(Trypsin) 		5 GLY A 558
LEU A 397
LEU A 466
ALA A 464
PHE A 415
 None
 1.09A 1gseB-5eodA:
undetectable		 1gseB-5eodA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 GLY A 212
LEU A 230
LEU A 234
ALA A 250
PHE A 268
 None
 0.97A 1gseB-5eqtA:
undetectable		 1gseB-5eqtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU B 472
LEU B 448
VAL B 446
LEU B 467
ALA B 464
 None
 1.07A 1gseB-5gqrB:
undetectable		 1gseB-5gqrB:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 GLY B 935
LEU B 958
VAL B 997
LEU B 965
ALA B1024
 None
 0.95A 1gseB-5gztB:
undetectable		 1gseB-5gztB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 GLY A 935
LEU A 958
VAL A 997
LEU A 965
ALA A1024
 None
 1.01A 1gseB-5gzuA:
undetectable		 1gseB-5gzuA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i45 GLYCOSYL
TRANSFERASES GROUP 1
FAMILY PROTEIN

(Francisella
tularensis) 		PF00534
(Glycos_transf_1) 		6 GLY A 167
LEU A 248
VAL A 252
LEU A 307
ALA A 187
PHE A 183
 None
 1.30A 1gseB-5i45A:
undetectable		 1gseB-5i45A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im6 DESIGNED
SELF-ASSEMBLING
ICOSAHEDRAL CAGE
I32-28 TRIMERIC
SUBUNIT

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 GLY A 117
LEU A  49
LEU A  62
VAL A  58
ALA A 169
 None
 1.06A 1gseB-5im6A:
undetectable		 1gseB-5im6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npu ANC27

(synthetic
construct) 		no annotation 6 ARG A  12
LEU A  13
LEU A  18
VAL A  66
LEU A 156
ALA A 155
 None
 1.30A 1gseB-5npuA:
undetectable		 1gseB-5npuA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue2 MATRILYSIN

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		5 ARG A 177
GLY A 185
PRO A  65
LEU A 156
ALA A 191
 None
 1.03A 1gseB-5ue2A:
undetectable		 1gseB-5ue2A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		5 LEU A 384
LEU A 385
PRO A 387
VAL A 388
LEU A 336
 None
 1.01A 1gseB-5uldA:
0.7		 1gseB-5uldA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 GLY A1712
LEU A1487
VAL A1471
LEU A1719
ALA A1718
 None
 1.06A 1gseB-5v41A:
undetectable		 1gseB-5v41A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 GLY A  66
LEU A  35
LEU A  24
VAL A  86
ALA A  72
 None
 1.04A 1gseB-5x9wA:
undetectable		 1gseB-5x9wA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		5 GLY A 157
LEU A 119
VAL A  77
LEU A 194
ALA A 197
 None
 0.98A 1gseB-5xn6A:
undetectable		 1gseB-5xn6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yge AMINO-ACID
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		no annotation 6 GLY A  76
LEU A 109
LEU A 107
VAL A 103
LEU A 100
ALA A  67
 None
None
None
None
None
GLU  A 202 ( 3.7A)
 1.37A 1gseB-5ygeA:
undetectable		 1gseB-5ygeA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ch3 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		no annotation 5 ARG A 555
LEU A 558
LEU A 561
VAL A 578
LEU A 582
 None
 0.98A 1gseB-6ch3A:
1.8		 1gseB-6ch3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chk TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Lactobacillus
paracasei) 		no annotation 5 LEU A 323
LEU A 156
VAL A 144
LEU A  77
ALA A  80
 None
 0.93A 1gseB-6chkA:
3.1		 1gseB-6chkA:
18.35