SIMILAR PATTERNS OF AMINO ACIDS FOR 1GSE_A_EAAA224_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj4 TROPONIN C

(Gallus gallus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 PHE A  27
ARG A  46
MET A  47
ALA A  23
PHE A  77
 None
 1.14A 1gseA-1aj4A:
undetectable		 1gseA-1aj4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 ARG A 307
GLY A 304
LEU A  45
VAL A  47
PHE A  12
 None
 1.15A 1gseA-1bxcA:
undetectable		 1gseA-1bxcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 LEU A  25
LEU A  21
VAL A  49
ALA A  57
PHE A 331
 None
 1.27A 1gseA-1c4oA:
0.0		 1gseA-1c4oA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 PHE A 176
GLY A 156
LEU A  74
LEU A   7
VAL A  10
 None
 1.26A 1gseA-1f4hA:
0.0		 1gseA-1f4hA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gv3 MANGANESE SUPEROXIDE
DISMUTASE

(Nostoc sp. PCC
7120) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 GLY A 111
LEU A  93
LEU A  96
VAL A  99
ALA A  77
 None
 0.94A 1gseA-1gv3A:
0.0		 1gseA-1gv3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hju BETA-1,4-GALACTANASE

(Thermothelomyces
thermophila) 		PF07745
(Glyco_hydro_53) 		5 GLY A 163
PRO A 173
VAL A 130
ALA A 116
PHE A  80
 None
 1.12A 1gseA-1hjuA:
0.0		 1gseA-1hjuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 ARG A 436
GLY A 437
LEU A 435
PRO A 535
VAL A 534
 None
 1.22A 1gseA-1kspA:
undetectable		 1gseA-1kspA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kv9 TYPE II
QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 ARG A 276
GLY A 280
LEU A 273
VAL A 246
ALA A 182
 None
 1.16A 1gseA-1kv9A:
undetectable		 1gseA-1kv9A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lv7 FTSH

(Escherichia
coli) 		PF00004
(AAA) 		5 GLY A 260
LEU A 278
LEU A 282
ALA A 298
PHE A 316
 None
 0.91A 1gseA-1lv7A:
undetectable		 1gseA-1lv7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		5 PHE A  40
ARG A  74
GLY A  70
LEU A 100
LEU A  97
 None
 1.16A 1gseA-1o9gA:
0.0		 1gseA-1o9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		5 LEU A 273
PRO A 271
VAL A 272
ALA A 246
PHE A 250
 None
 1.15A 1gseA-1ps6A:
undetectable		 1gseA-1ps6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 GLY A 337
LEU A 343
VAL A 346
ALA A 378
PHE A 394
 None
 1.21A 1gseA-1rblA:
undetectable		 1gseA-1rblA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 104
PHE A 102
LEU A 117
VAL A 164
ALA A  74
 None
 1.23A 1gseA-1ub7A:
undetectable		 1gseA-1ub7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4n 271AA LONG
HYPOTHETICAL
5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfurisphaera
tokodaii) 		PF01048
(PNP_UDP_1) 		5 GLY A  16
LEU A  19
LEU A 244
VAL A 240
ALA A  93
 None
 1.09A 1gseA-1v4nA:
undetectable		 1gseA-1v4nA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5j KIAA1355 PROTEIN

(Homo sapiens) 		PF00041
(fn3) 		5 ARG A  45
GLY A  44
LEU A  80
PRO A  91
VAL A  81
 None
 1.25A 1gseA-1v5jA:
undetectable		 1gseA-1v5jA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ARG A  13
GLY A  14
LYS A  15
LEU A 107
PRO A 110
 None
None
GSH  A2457 (-3.6A)
None
None
 1.20A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A   9
ARG A  13
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 0.91A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vf1 GLUTATHIONE
S-TRANSFERASE 3

(Gallus gallus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 TYR A   9
PHE A  10
GLY A  14
LYS A  15
LEU A 107
 None
None
None
GSH  A2457 (-3.6A)
None
 1.25A 1gseA-1vf1A:
32.8		 1gseA-1vf1A:
64.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 GLY A 467
LEU A 424
LEU A 450
VAL A 408
PHE A 470
 None
 1.13A 1gseA-1wkyA:
undetectable		 1gseA-1wkyA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl8 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Pyrococcus
horikoshii) 		PF00117
(GATase) 		5 GLY A 162
LEU A  76
PRO A 167
ALA A 143
PHE A 115
 None
 1.13A 1gseA-1wl8A:
2.0		 1gseA-1wl8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  36
VAL A  11
MET A  33
ALA A 346
PHE A  88
 None
 1.02A 1gseA-1ys4A:
undetectable		 1gseA-1ys4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb3 COBALAMIN
BIOSYNTHESIS
PRECORRIN-6Y
METHYLASE (CBIE)

(Archaeoglobus
fulgidus) 		PF00590
(TP_methylase) 		5 ARG A 153
LEU A 132
LEU A 136
VAL A 191
ALA A 177
 None
 1.15A 1gseA-2bb3A:
undetectable		 1gseA-2bb3A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmx ALKYL
HYDROPEROXIDASE C

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		5 LEU A 111
LEU A  83
VAL A  50
ALA A 122
PHE A  10
 None
 1.05A 1gseA-2bmxA:
undetectable		 1gseA-2bmxA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		5 GLY A 403
LEU A 407
PRO A 484
VAL A 483
PHE A 472
 None
 1.17A 1gseA-2bxyA:
undetectable		 1gseA-2bxyA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		5 GLY A 303
LEU A 218
PRO A 190
VAL A 192
PHE A 248
 None
 1.04A 1gseA-2etvA:
undetectable		 1gseA-2etvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2e PA1607

(Pseudomonas
aeruginosa) 		PF01638
(HxlR) 		5 ARG A  87
GLY A  86
LEU A  89
LEU A  92
PRO A  91
 None
 1.18A 1gseA-2f2eA:
undetectable		 1gseA-2f2eA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		5 PHE A 331
LEU A 385
LEU A 382
VAL A 314
ALA A 344
 None
 1.20A 1gseA-2ivdA:
undetectable		 1gseA-2ivdA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxn GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG] SUBUNIT A

(Methanocaldococcus
jannaschii) 		PF00117
(GATase) 		5 GLY A 159
LEU A  73
PRO A 164
ALA A 140
PHE A 112
 None
 1.19A 1gseA-2lxnA:
2.4		 1gseA-2lxnA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1r LIPID KINASE YEGS

(Salmonella
enterica) 		PF00781
(DAGK_cat) 		5 ARG A 290
GLY A  89
LEU A  88
ALA A 103
PHE A  99
 None
 1.14A 1gseA-2p1rA:
1.8		 1gseA-2p1rA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qty POLY(ADP-RIBOSE)
GLYCOHYDROLASE ARH3

(Mus musculus) 		PF03747
(ADP_ribosyl_GH) 		5 GLY A  17
LEU A 289
LEU A 285
PRO A 320
VAL A 319
 None
 1.25A 1gseA-2qtyA:
1.4		 1gseA-2qtyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ARG A 341
LEU A 403
LEU A 472
VAL A 476
ALA A 410
 None
 1.09A 1gseA-2qykA:
undetectable		 1gseA-2qykA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ARG A 251
LEU A 313
LEU A 382
VAL A 386
ALA A 320
 None
 0.97A 1gseA-2qymA:
undetectable		 1gseA-2qymA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rug CYTOPLASMIC
POLYADENYLATION
ELEMENT-BINDING
PROTEIN 3

(Homo sapiens) 		PF16367
(RRM_7) 		5 GLY A 465
LEU A 467
LEU A 489
VAL A 443
ALA A 499
 None
 1.20A 1gseA-2rugA:
undetectable		 1gseA-2rugA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 LYS A 102
LEU A 110
LEU A 143
VAL A 190
PHE A  97
 None
 1.10A 1gseA-2uuuA:
undetectable		 1gseA-2uuuA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE

(Hedera helix) 		PF03405
(FA_desaturase_2) 		5 GLY B 315
LEU B 311
LEU B 308
VAL B 305
ALA B 251
 None
 1.12A 1gseA-2uw1B:
undetectable		 1gseA-2uw1B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3b RUBREDOXIN REDUCTASE

(Pseudomonas
aeruginosa) 		PF07992
(Pyr_redox_2) 		6 ARG A 147
LEU A 171
LEU A 150
VAL A 236
ALA A 142
PHE A 138
 None
 1.29A 1gseA-2v3bA:
undetectable		 1gseA-2v3bA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		5 GLY A 390
LEU A 382
VAL A 325
ALA A 393
PHE A 316
 None
 1.26A 1gseA-2wokA:
undetectable		 1gseA-2wokA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ypq PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE AROG

(Mycobacterium
tuberculosis) 		PF01474
(DAHP_synth_2) 		6 PHE A  91
GLY A 149
LEU A 250
PRO A  38
VAL A 251
ALA A 172
 None
 1.48A 1gseA-2ypqA:
undetectable		 1gseA-2ypqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 GLY A 160
LEU A  75
PRO A 165
ALA A 141
PHE A 113
 None
 1.17A 1gseA-2ywbA:
undetectable		 1gseA-2ywbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhy ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE,
PUTATIVE

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 GLY A 117
LEU A  49
LEU A  62
VAL A  58
ALA A 169
 None
 1.10A 1gseA-2zhyA:
undetectable		 1gseA-2zhyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		5 GLY A  75
LEU A  77
VAL A 250
ALA A  70
PHE A 271
 None
 1.06A 1gseA-3a3uA:
undetectable		 1gseA-3a3uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		5 PHE A 393
LEU A 316
VAL A 313
MET A 370
ALA A 353
 None
 1.27A 1gseA-3aflA:
4.7		 1gseA-3aflA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjr PUTATIVE
CARBOXYLESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 PHE A 190
GLY A 149
LEU A  53
ALA A 256
PHE A  57
 None
 1.26A 1gseA-3bjrA:
undetectable		 1gseA-3bjrA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2b TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		5 PHE A 156
GLY A 148
LEU A  87
ALA A 162
PHE A 199
 None
 1.17A 1gseA-3c2bA:
undetectable		 1gseA-3c2bA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 ARG A  22
GLY A 271
LEU A 269
PRO A 237
VAL A 236
 None
 1.04A 1gseA-3dr2A:
undetectable		 1gseA-3dr2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ARG A 295
LEU A 357
LEU A 426
VAL A 430
ALA A 364
 None
 1.03A 1gseA-3g4gA:
undetectable		 1gseA-3g4gA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN

(Methylobacillus
flagellatus) 		PF00027
(cNMP_binding) 		5 GLY A  96
LEU A  55
LEU A  54
VAL A  72
ALA A  93
 CMP  A 300 (-3.3A)
CMP  A 300 ( 4.5A)
None
None
None
 1.15A 1gseA-3gydA:
undetectable		 1gseA-3gydA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 TYR A 496
GLY A 494
PRO A 454
VAL A 452
PHE A 520
 None
 1.21A 1gseA-3holA:
undetectable		 1gseA-3holA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Vibrio cholerae) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 GLY A 331
LEU A 280
PRO A 247
VAL A 275
ALA A 253
 None
 1.09A 1gseA-3i99A:
undetectable		 1gseA-3i99A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		5 LEU A1419
LEU A1447
VAL A1448
ALA A1435
PHE A1439
 None
 1.22A 1gseA-3lvgA:
undetectable		 1gseA-3lvgA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxt GLUTATHIONE S
TRANSFERASE

(Pseudomonas
protegens) 		PF13417
(GST_N_3) 		5 GLY A 160
LEU A 150
LEU A 145
VAL A 186
ALA A 166
 GOL  A3969 (-3.4A)
GOL  A3969 (-3.7A)
CL  A 528 (-3.9A)
None
None
 1.19A 1gseA-3lxtA:
13.9		 1gseA-3lxtA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A 366
LEU A 320
LEU A 324
PRO A 323
ALA A 387
 None
 1.19A 1gseA-3m1lA:
undetectable		 1gseA-3m1lA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		5 ARG A 109
GLY A 110
VAL A  27
ALA A 115
PHE A  23
 None
 1.12A 1gseA-3m7gA:
2.2		 1gseA-3m7gA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 225
LEU A 269
MET A 231
ALA A 147
PHE A 297
 None
 1.20A 1gseA-3mvjA:
undetectable		 1gseA-3mvjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 GLY A 178
LEU A 132
LEU A 133
PRO A 135
VAL A 136
 None
 1.04A 1gseA-3mzsA:
undetectable		 1gseA-3mzsA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9o PUTATIVE
UNCHARACTERIZED
PROTEIN

(Caenorhabditis
elegans) 		PF02373
(JmjC) 		5 TYR A 504
GLY A 579
LEU A 484
ALA A 437
PHE A 427
 None
 1.24A 1gseA-3n9oA:
2.7		 1gseA-3n9oA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noj 4-CARBOXY-4-HYDROXY-
2-OXOADIPATE
ALDOLASE/OXALOACETAT
E DECARBOXYLASE

(Pseudomonas
putida) 		PF03737
(RraA-like) 		5 ARG A 138
GLY A 121
PRO A  91
VAL A  66
PHE A  74
 None
 1.23A 1gseA-3nojA:
undetectable		 1gseA-3nojA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ARG A 203
LEU A 265
LEU A 334
VAL A 338
ALA A 272
 None
 0.99A 1gseA-3o57A:
undetectable		 1gseA-3o57A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi6 CYSTATHIONINE
GAMMA-SYNTHASE METB
(CGS)

(Mycobacterium
ulcerans) 		PF01053
(Cys_Met_Meta_PP) 		5 ARG A 149
LEU A 150
LEU A 181
VAL A 201
PHE A 232
 None
 1.21A 1gseA-3qi6A:
undetectable		 1gseA-3qi6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 GLY A 478
LEU A 440
LEU A 442
VAL A 470
ALA A 494
 None
 1.02A 1gseA-3qp9A:
undetectable		 1gseA-3qp9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r97 MALONYL COA-ACP
TRANSACYLASE

(Xanthomonas
oryzae) 		PF00698
(Acyl_transf_1) 		5 ARG A  86
GLY A  84
LEU A  78
VAL A  75
ALA A 275
 None
 1.11A 1gseA-3r97A:
undetectable		 1gseA-3r97A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 ARG A 104
LEU A  89
LEU A  84
VAL A 158
ALA A 212
 None
 1.24A 1gseA-3ue9A:
undetectable		 1gseA-3ue9A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ukf UDP-GALACTOPYRANOSE
MUTASE

(Aspergillus
fumigatus) 		PF13450
(NAD_binding_8) 		5 PHE A 318
GLY A 394
VAL A 300
MET A 400
ALA A 328
 None
 0.89A 1gseA-3ukfA:
undetectable		 1gseA-3ukfA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 TYR A 172
ARG A 134
GLY A 135
ALA A 128
PHE A 113
 None
 1.03A 1gseA-3zokA:
undetectable		 1gseA-3zokA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap5 GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2

(Homo sapiens) 		PF10250
(O-FucT) 		5 GLY A 290
LEU A 289
LEU A 319
MET A 349
PHE A 411
 None
 1.24A 1gseA-4ap5A:
undetectable		 1gseA-4ap5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		5 PHE A 252
LEU A 269
LEU A 275
ALA A 197
PHE A 261
 None
 1.22A 1gseA-4b3kA:
undetectable		 1gseA-4b3kA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep5 CROSSOVER JUNCTION
ENDODEOXYRIBONUCLEAS
E RUVC

(Thermus
thermophilus) 		PF02075
(RuvC) 		5 GLY A  33
LEU A  30
LEU A 133
VAL A 129
ALA A 147
 None
 1.25A 1gseA-4ep5A:
undetectable		 1gseA-4ep5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		5 TYR W 561
LEU W 568
VAL W 589
ALA W 599
PHE W 534
 None
 1.22A 1gseA-4f5xW:
undetectable		 1gseA-4f5xW:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		5 GLY A 460
LEU A 423
LEU A 391
ALA A 162
PHE A 453
 None
 1.22A 1gseA-4ftdA:
undetectable		 1gseA-4ftdA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0p ACETATE KINASE

(Cryptococcus
neoformans) 		PF00871
(Acetate_kinase) 		5 GLY A 355
LEU A 407
LEU A 377
VAL A 373
ALA A 219
 None
 1.19A 1gseA-4h0pA:
undetectable		 1gseA-4h0pA:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 PHE A  10
ARG A  13
PRO A 110
VAL A 111
ALA A 216
 None
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
 0.97A 1gseA-4hj2A:
35.9		 1gseA-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		8 TYR A   9
ARG A  13
GLY A  14
LEU A 107
LEU A 108
PRO A 110
VAL A 111
ALA A 216
 LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.4A)
None
LZ6  A 301 (-3.5A)
None
LZ6  A 301 ( 4.6A)
 0.57A 1gseA-4hj2A:
35.9		 1gseA-4hj2A:
99.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hj2 GLUTATHIONE
S-TRANSFERASE A1

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 TYR A   9
ARG A  13
GLY A  14
MET A 208
ALA A 216
 LZ6  A 301 (-4.6A)
None
LZ6  A 301 ( 3.9A)
LZ6  A 301 (-4.0A)
LZ6  A 301 ( 4.6A)
 0.83A 1gseA-4hj2A:
35.9		 1gseA-4hj2A:
99.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6c CYTOCHROME P450
MONOOXYGENASE

(Nocardia
farcinica) 		PF00067
(p450) 		5 LEU A  60
LEU A  54
VAL A  45
MET A 296
ALA A  42
 None
 1.23A 1gseA-4j6cA:
undetectable		 1gseA-4j6cA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg8 TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
14

(Homo sapiens) 		PF00229
(TNF) 		5 GLY A 204
LEU A 180
LEU A 179
VAL A 215
ALA A 237
 None
 1.13A 1gseA-4kg8A:
undetectable		 1gseA-4kg8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		5 GLY A 217
LEU A 215
LEU A 210
ALA A 246
PHE A 223
 None
 1.17A 1gseA-4p8sA:
undetectable		 1gseA-4p8sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 PHE A2208
ARG A2194
GLY A2195
LEU A2176
ALA A2152
 None
 1.21A 1gseA-4rh7A:
undetectable		 1gseA-4rh7A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A  71
PRO A 390
VAL A 392
ALA A 468
PHE A 394
 None
 1.24A 1gseA-4udrA:
undetectable		 1gseA-4udrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 PHE A 361
GLY A 289
LEU A 375
PRO A 389
ALA A 365
 None
 1.08A 1gseA-4wjsA:
undetectable		 1gseA-4wjsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		5 ARG A 375
LEU A 437
LEU A 506
VAL A 510
ALA A 444
 None
 1.03A 1gseA-4wziA:
undetectable		 1gseA-4wziA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		5 TYR A 649
ARG A 107
GLY A 110
ALA A  78
PHE A  76
 None
 1.16A 1gseA-4xhbA:
undetectable		 1gseA-4xhbA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		5 ARG A 303
PRO A 338
VAL A 337
ALA A 295
PHE A 327
 None
 1.12A 1gseA-4yhsA:
2.0		 1gseA-4yhsA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		5 ARG A 198
GLY A 199
LEU A 246
VAL A 223
ALA A 236
 CYS  A2006 (-3.8A)
None
None
None
None
 1.16A 1gseA-4zu9A:
undetectable		 1gseA-4zu9A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L17

(Deinococcus
radiodurans) 		PF01196
(Ribosomal_L17) 		5 ARG K  33
GLY K  32
LEU K 115
VAL K  48
ALA K  27
 None
None
None
None
G  X1278 ( 3.4A)
 1.23A 1gseA-5dm6K:
undetectable		 1gseA-5dm6K:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 GLY A 212
LEU A 230
LEU A 234
ALA A 250
PHE A 268
 None
 0.96A 1gseA-5eqtA:
undetectable		 1gseA-5eqtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eui HBB PROTEIN

(Ochotona
princeps) 		PF00042
(Globin) 		5 GLY B  74
LEU B  78
LEU B   3
VAL B   1
ALA B 140
 None
 1.22A 1gseA-5euiB:
undetectable		 1gseA-5euiB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 GLY A 128
LEU A  86
VAL A  76
ALA B 164
PHE B 116
 None
 1.18A 1gseA-5gj4A:
undetectable		 1gseA-5gj4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw8 HYPOTHETICAL
SECRETORY LIPASE
(FAMILY 3)

(Malassezia
globosa) 		PF01764
(Lipase_3) 		5 TYR A  54
GLY A 100
LEU A 106
PRO A 201
VAL A 230
 None
 1.24A 1gseA-5gw8A:
undetectable		 1gseA-5gw8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihv BETA-LACTAMASE

(Burkholderia
ambifaria) 		PF13354
(Beta-lactamase2) 		5 ARG A 259
GLY A 201
LEU A 236
VAL A 238
ALA A 251
 None
 1.14A 1gseA-5ihvA:
undetectable		 1gseA-5ihvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil)
no annotation 		5 TYR A 522
PHE A 521
LEU B1183
LEU A 508
VAL A 511
 None
None
None
CL  B1301 ( 4.7A)
None
 1.16A 1gseA-5ikjA:
undetectable		 1gseA-5ikjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im6 DESIGNED
SELF-ASSEMBLING
ICOSAHEDRAL CAGE
I32-28 TRIMERIC
SUBUNIT

(Burkholderia
thailandensis) 		PF01923
(Cob_adeno_trans) 		5 GLY A 117
LEU A  49
LEU A  62
VAL A  58
ALA A 169
 None
 1.12A 1gseA-5im6A:
undetectable		 1gseA-5im6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 ARG A  53
GLY A  52
LEU A  45
LEU A  42
ALA A  59
 None
None
None
6ZL  A 502 (-4.4A)
6ZL  A 504 ( 4.1A)
 1.17A 1gseA-5l26A:
undetectable		 1gseA-5l26A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8b ALPHA-L-ARABINOFURAN
OSIDASE II

(Lactobacillus
brevis) 		PF04616
(Glyco_hydro_43) 		5 ARG A 212
LEU A 215
VAL A 206
ALA A 147
PHE A 145
 None
 1.25A 1gseA-5m8bA:
undetectable		 1gseA-5m8bA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 5 LEU A 112
LEU A 158
VAL A 162
ALA A 192
PHE A 214
 None
 1.26A 1gseA-5o96A:
undetectable		 1gseA-5o96A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofq CYTOCHROME P450

(Bacillus
megaterium) 		PF00067
(p450) 		5 ARG A 255
GLY A 253
LEU A 282
PRO A 287
ALA A 138
 None
None
None
HEM  A 501 ( 4.2A)
None
 1.19A 1gseA-5ofqA:
undetectable		 1gseA-5ofqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 5 ARG A 375
LEU A 437
LEU A 506
VAL A 510
ALA A 444
 None
 1.04A 1gseA-5ohjA:
undetectable		 1gseA-5ohjA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 TYR A 239
ARG A 209
GLY A 205
LEU A 211
PHE A 267
 None
 1.14A 1gseA-5wbfA:
undetectable		 1gseA-5wbfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 5 ARG A 129
LEU A 191
LEU A 260
VAL A 264
ALA A 198
 None
 1.04A 1gseA-5wh6A:
undetectable		 1gseA-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 174
LEU A 376
LEU A 390
VAL A 245
ALA A 180
 None
 1.26A 1gseA-5wx4A:
undetectable		 1gseA-5wx4A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 GLY A  66
LEU A  35
LEU A  24
VAL A  86
ALA A  72
 None
 0.99A 1gseA-5x9wA:
undetectable		 1gseA-5x9wA:
14.90