SIMILAR PATTERNS OF AMINO ACIDS FOR 1GS4_A_ZK5A1918_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 MET A 745
MET A 749
ARG A 752
VAL A 889
 BHM  A   1 (-3.9A)
BHM  A   1 (-4.3A)
BHM  A   1 (-3.8A)
None
 0.45A 1gs4A-2ax9A:
40.8		 1gs4A-2ax9A:
99.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huo INOSITOL OXYGENASE

(Mus musculus) 		PF05153
(MIOX) 		4 HIS A  98
MET A  74
ARG A 268
VAL A  91
 FE  A 301 (-3.2A)
None
None
None
 1.46A 1gs4A-2huoA:
0.0		 1gs4A-2huoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8b COATOMER ALPHA
SUBUNIT

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		4 HIS A 255
MET A   1
MET A   3
VAL A 236
 None
 1.41A 1gs4A-4j8bA:
0.0		 1gs4A-4j8bA:
21.41