SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_D_DVAD8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		3 TRP A 197
VAL A 199
TRP A 200
 None
 1.32A 1gmkC-1azwA:
undetectable
1gmkD-1azwA:
undetectable		 1gmkC-1azwA:
6.85
1gmkD-1azwA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhe POLYGALACTURONASE

(Pectobacterium
carotovorum) 		PF00295
(Glyco_hydro_28) 		3 TRP A 135
VAL A 132
TRP A 134
 None
 0.99A 1gmkC-1bheA:
undetectable
1gmkD-1bheA:
undetectable		 1gmkC-1bheA:
3.31
1gmkD-1bheA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		3 TRP A1342
VAL A1079
TRP A1078
 None
 0.92A 1gmkC-1c0iA:
undetectable
1gmkD-1c0iA:
undetectable		 1gmkC-1c0iA:
3.56
1gmkD-1c0iA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 TRP A  98
VAL A 190
TRP A 227
 None
 1.19A 1gmkC-1cn3A:
undetectable
1gmkD-1cn3A:
undetectable		 1gmkC-1cn3A:
4.64
1gmkD-1cn3A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 TRP A 316
VAL A 278
TRP A 279
 None
 1.29A 1gmkC-1eceA:
undetectable
1gmkD-1eceA:
undetectable		 1gmkC-1eceA:
4.04
1gmkD-1eceA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 TRP A 193
VAL A 158
TRP A 157
 None
 1.40A 1gmkC-1ehkA:
undetectable
1gmkD-1ehkA:
undetectable		 1gmkC-1ehkA:
3.54
1gmkD-1ehkA:
3.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1r VIRAL IL-6

(Human
gammaherpesvirus
8) 		PF00489
(IL6) 		3 TRP B  21
VAL B  99
TRP B  18
 None
 1.27A 1gmkC-1i1rB:
undetectable
1gmkD-1i1rB:
undetectable		 1gmkC-1i1rB:
8.87
1gmkD-1i1rB:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		3 TRP A 767
VAL A 784
TRP A 785
 None
 1.12A 1gmkC-1lufA:
undetectable
1gmkD-1lufA:
undetectable		 1gmkC-1lufA:
4.56
1gmkD-1lufA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 TRP A 196
VAL A 106
TRP A 104
 None
 1.49A 1gmkC-1otkA:
undetectable
1gmkD-1otkA:
undetectable		 1gmkC-1otkA:
6.67
1gmkD-1otkA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r76 PECTATE LYASE

(Niveispirillum
irakense) 		PF09492
(Pec_lyase) 		3 TRP A 218
VAL A 221
TRP A 222
 None
 1.48A 1gmkC-1r76A:
undetectable
1gmkD-1r76A:
undetectable		 1gmkC-1r76A:
4.26
1gmkD-1r76A:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE

(Acetobacter
pasteurianus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 TRP A 332
VAL A 364
TRP A 349
 None
 1.31A 1gmkC-1ryyA:
undetectable
1gmkD-1ryyA:
undetectable		 1gmkC-1ryyA:
7.02
1gmkD-1ryyA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		3 TRP B1841
VAL B1862
TRP B1840
 None
 1.35A 1gmkC-1sddB:
undetectable
1gmkD-1sddB:
undetectable		 1gmkC-1sddB:
2.65
1gmkD-1sddB:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sie POLYOMAVIRUS COAT
PROTEIN VP1

(Mus musculus
polyomavirus 1) 		PF00718
(Polyoma_coat) 		3 TRP A  98
VAL A 190
TRP A 227
 None
 1.29A 1gmkC-1sieA:
undetectable
1gmkD-1sieA:
undetectable		 1gmkC-1sieA:
4.22
1gmkD-1sieA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		3 TRP A 131
VAL A 178
TRP A 172
 None
 1.47A 1gmkC-1t0bA:
undetectable
1gmkD-1t0bA:
undetectable		 1gmkC-1t0bA:
6.67
1gmkD-1t0bA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 TRP B 274
VAL B 265
TRP B 266
 None
 1.34A 1gmkC-1ta3B:
undetectable
1gmkD-1ta3B:
undetectable		 1gmkC-1ta3B:
4.09
1gmkD-1ta3B:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		3 TRP A 135
VAL A 364
TRP A 365
 None
 0.96A 1gmkC-1u7gA:
undetectable
1gmkD-1u7gA:
undetectable		 1gmkC-1u7gA:
5.19
1gmkD-1u7gA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		3 TRP A 135
VAL A 368
TRP A 365
 None
 1.19A 1gmkC-1u7gA:
undetectable
1gmkD-1u7gA:
undetectable		 1gmkC-1u7gA:
5.19
1gmkD-1u7gA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		3 TRP A 200
VAL A 202
TRP A 203
 None
 1.31A 1gmkC-1x2bA:
undetectable
1gmkD-1x2bA:
undetectable		 1gmkC-1x2bA:
5.47
1gmkD-1x2bA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus;
Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B)
PF02461
(AMO) 		3 TRP A 206
VAL A 200
TRP B  87
 None
 1.26A 1gmkC-1yewA:
undetectable
1gmkD-1yewA:
undetectable		 1gmkC-1yewA:
3.53
1gmkD-1yewA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zb1 BRO1 PROTEIN

(Saccharomyces
cerevisiae) 		PF03097
(BRO1) 		3 TRP A 291
VAL A 243
TRP A 239
 None
 1.30A 1gmkC-1zb1A:
undetectable
1gmkD-1zb1A:
undetectable		 1gmkC-1zb1A:
2.55
1gmkD-1zb1A:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B

(Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		3 TRP C 348
VAL C 342
TRP C 129
 None
 1.39A 1gmkC-1zrtC:
undetectable
1gmkD-1zrtC:
undetectable		 1gmkC-1zrtC:
4.07
1gmkD-1zrtC:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eqk TUDOR
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		PF00567
(TUDOR) 		3 TRP A  17
VAL A  65
TRP A  22
 None
 1.26A 1gmkC-2eqkA:
undetectable
1gmkD-2eqkA:
undetectable		 1gmkC-2eqkA:
22.22
1gmkD-2eqkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsx COG0607:
RHODANESE-RELATED
SULFURTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		3 TRP A 137
VAL A 133
TRP A 130
 None
 1.14A 1gmkC-2fsxA:
undetectable
1gmkD-2fsxA:
undetectable		 1gmkC-2fsxA:
7.97
1gmkD-2fsxA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		3 TRP A 209
VAL A 213
TRP A 220
 None
None
EDO  A1263 (-4.1A)
 1.44A 1gmkC-2ivxA:
undetectable
1gmkD-2ivxA:
undetectable		 1gmkC-2ivxA:
4.76
1gmkD-2ivxA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		3 TRP A  75
VAL A 161
TRP A  72
 None
 1.49A 1gmkC-2j6lA:
undetectable
1gmkD-2j6lA:
undetectable		 1gmkC-2j6lA:
3.50
1gmkD-2j6lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ofk 3-METHYLADENINE DNA
GLYCOSYLASE I,
CONSTITUTIVE

(Salmonella
enterica) 		PF03352
(Adenine_glyco) 		3 TRP A  46
VAL A   7
TRP A  21
 PGE  A 701 (-3.6A)
None
PGE  A 701 ( 4.6A)
 1.48A 1gmkC-2ofkA:
undetectable
1gmkD-2ofkA:
undetectable		 1gmkC-2ofkA:
9.21
1gmkD-2ofkA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 TRP A 196
VAL A 137
TRP A 136
 EDO  A 336 ( 3.7A)
None
EDO  A 341 ( 3.8A)
 1.36A 1gmkC-2r3sA:
undetectable
1gmkD-2r3sA:
undetectable		 1gmkC-2r3sA:
4.74
1gmkD-2r3sA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 TRP A 144
VAL A 200
TRP A 203
 GOL  A1449 (-4.2A)
None
GOL  A1449 (-4.3A)
 1.26A 1gmkC-2wnwA:
undetectable
1gmkD-2wnwA:
undetectable		 1gmkC-2wnwA:
3.04
1gmkD-2wnwA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beh MLL3241 PROTEIN

(Mesorhizobium
loti) 		PF07885
(Ion_trans_2) 		3 TRP A 104
VAL A  79
TRP A  49
 None
 1.35A 1gmkC-3behA:
undetectable
1gmkD-3behA:
undetectable		 1gmkC-3behA:
6.34
1gmkD-3behA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg1 PROTEIN SEC13
HOMOLOG

(Homo sapiens) 		PF00400
(WD40) 		3 TRP A 158
VAL A 218
TRP A 220
 None
 1.36A 1gmkC-3bg1A:
undetectable
1gmkD-3bg1A:
undetectable		 1gmkC-3bg1A:
4.15
1gmkD-3bg1A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dn7 CYCLIC NUCLEOTIDE
BINDING REGULATORY
PROTEIN

(Cytophaga
hutchinsonii) 		PF00027
(cNMP_binding) 		3 TRP A  77
VAL A  52
TRP A  78
 None
 1.44A 1gmkC-3dn7A:
undetectable
1gmkD-3dn7A:
undetectable		 1gmkC-3dn7A:
11.90
1gmkD-3dn7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzj POLYNEURIDINE-ALDEHY
DE ESTERASE

(Rauvolfia
serpentina) 		PF00561
(Abhydrolase_1) 		3 TRP A  24
VAL A  43
TRP A  26
 None
 1.36A 1gmkC-3gzjA:
undetectable
1gmkD-3gzjA:
undetectable		 1gmkC-3gzjA:
5.61
1gmkD-3gzjA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hlz UNCHARACTERIZED
PROTEIN BT_1490

(Bacteroides
thetaiotaomicron) 		PF12712
(DUF3805)
PF12713
(DUF3806) 		3 TRP A  21
VAL A  38
TRP A  39
 None
 1.47A 1gmkC-3hlzA:
undetectable
1gmkD-3hlzA:
undetectable		 1gmkC-3hlzA:
4.84
1gmkD-3hlzA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hup EARLY ACTIVATION
ANTIGEN CD69

(Homo sapiens) 		PF00059
(Lectin_C) 		3 TRP A 192
VAL A 143
TRP A 142
 None
 1.43A 1gmkC-3hupA:
undetectable
1gmkD-3hupA:
undetectable		 1gmkC-3hupA:
10.71
1gmkD-3hupA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 TRP A 138
VAL A 178
TRP A 177
 None
 1.16A 1gmkC-3ib3A:
undetectable
1gmkD-3ib3A:
undetectable		 1gmkC-3ib3A:
3.23
1gmkD-3ib3A:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF4

(Schizosaccharomyces
pombe) 		PF02184
(HAT) 		3 TRP R 167
VAL R 160
TRP R 164
 None
 1.36A 1gmkC-3jb9R:
undetectable
1gmkD-3jb9R:
undetectable		 1gmkC-3jb9R:
1.93
1gmkD-3jb9R:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		3 TRP A 359
VAL A 268
TRP A 249
 None
 1.47A 1gmkC-3lq1A:
undetectable
1gmkD-3lq1A:
undetectable		 1gmkC-3lq1A:
5.20
1gmkD-3lq1A:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		3 TRP A 216
VAL A 151
TRP A 152
 None
 1.32A 1gmkC-3nfvA:
undetectable
1gmkD-3nfvA:
undetectable		 1gmkC-3nfvA:
3.06
1gmkD-3nfvA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrb FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Pseudomonas
putida) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 TRP A  79
VAL A   8
TRP A  80
 None
EDO  A 290 ( 4.6A)
None
 1.30A 1gmkC-3nrbA:
undetectable
1gmkD-3nrbA:
undetectable		 1gmkC-3nrbA:
5.92
1gmkD-3nrbA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 3 TRP J 157
VAL J 151
TRP J 135
 None
 0.90A 1gmkC-3rfrJ:
undetectable
1gmkD-3rfrJ:
undetectable		 1gmkC-3rfrJ:
6.14
1gmkD-3rfrJ:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjv PUTATIVE SEL1 REPEAT
PROTEIN

(Klebsiella
pneumoniae) 		PF08238
(Sel1) 		3 TRP A  56
VAL A  45
TRP A  44
 None
 1.38A 1gmkC-3rjvA:
undetectable
1gmkD-3rjvA:
undetectable		 1gmkC-3rjvA:
5.98
1gmkD-3rjvA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		3 TRP A1202
VAL A1184
TRP A1203
 None
 1.18A 1gmkC-3sfzA:
undetectable
1gmkD-3sfzA:
undetectable		 1gmkC-3sfzA:
1.80
1gmkD-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		3 TRP A 100
VAL A 102
TRP A  99
 None
 1.50A 1gmkC-3smaA:
undetectable
1gmkD-3smaA:
undetectable		 1gmkC-3smaA:
5.47
1gmkD-3smaA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TRP A 666
VAL A 683
TRP A 684
 None
 1.19A 1gmkC-3tt0A:
undetectable
1gmkD-3tt0A:
undetectable		 1gmkC-3tt0A:
2.62
1gmkD-3tt0A:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		3 TRP A 479
VAL A 488
TRP A 482
 None
 1.49A 1gmkC-3ttbA:
undetectable
1gmkD-3ttbA:
undetectable		 1gmkC-3ttbA:
2.85
1gmkD-3ttbA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb FLAVOPROTEIN SUBUNIT
OF COMPLEX II

(Ascaris suum) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 TRP A 637
VAL A 625
TRP A 112
 None
 1.43A 1gmkC-3vrbA:
undetectable
1gmkD-3vrbA:
undetectable		 1gmkC-3vrbA:
1.89
1gmkD-3vrbA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		3 TRP A  37
VAL A 153
TRP A  41
 None
 1.46A 1gmkC-3vz0A:
undetectable
1gmkD-3vz0A:
undetectable		 1gmkC-3vz0A:
7.86
1gmkD-3vz0A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 TRP A 142
VAL A 283
TRP A 236
 None
 1.20A 1gmkC-3w5nA:
undetectable
1gmkD-3w5nA:
undetectable		 1gmkC-3w5nA:
2.27
1gmkD-3w5nA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsb FARNESYLTRANSFERASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF00494
(SQS_PSY) 		3 TRP A 225
VAL A 154
TRP A 230
 None
 1.29A 1gmkC-3wsbA:
undetectable
1gmkD-3wsbA:
undetectable		 1gmkC-3wsbA:
4.93
1gmkD-3wsbA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze6 PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 TRP A 258
VAL A 256
TRP A 252
 None
None
SF4  A 285 (-4.0A)
 0.94A 1gmkC-3ze6A:
undetectable
1gmkD-3ze6A:
undetectable		 1gmkC-3ze6A:
4.92
1gmkD-3ze6A:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 TRP A 286
VAL A 203
TRP A 289
 None
 1.06A 1gmkC-3zukA:
undetectable
1gmkD-3zukA:
undetectable		 1gmkC-3zukA:
2.54
1gmkD-3zukA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TRP A1071
VAL A1088
TRP A1089
 None
 1.21A 1gmkC-4agdA:
undetectable
1gmkD-4agdA:
undetectable		 1gmkC-4agdA:
4.14
1gmkD-4agdA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		3 TRP A 141
VAL A 162
TRP A 140
 None
 1.32A 1gmkC-4ao7A:
undetectable
1gmkD-4ao7A:
undetectable		 1gmkC-4ao7A:
9.45
1gmkD-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		3 TRP A 141
VAL A 189
TRP A 140
 None
 1.37A 1gmkC-4ao7A:
undetectable
1gmkD-4ao7A:
undetectable		 1gmkC-4ao7A:
9.45
1gmkD-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 TRP A 435
VAL A 478
TRP A 479
 None
 1.06A 1gmkC-4bh6A:
undetectable
1gmkD-4bh6A:
undetectable		 1gmkC-4bh6A:
5.56
1gmkD-4bh6A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		3 TRP A 234
VAL A 224
TRP A 231
 None
None
EDO  A 304 ( 4.3A)
 1.42A 1gmkC-4ecfA:
undetectable
1gmkD-4ecfA:
undetectable		 1gmkC-4ecfA:
6.67
1gmkD-4ecfA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		3 TRP A 237
VAL A  61
TRP A  62
 None
 1.45A 1gmkC-4el8A:
undetectable
1gmkD-4el8A:
undetectable		 1gmkC-4el8A:
2.45
1gmkD-4el8A:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g25 PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		3 TRP A 547
VAL A 333
TRP A 290
 None
 1.32A 1gmkC-4g25A:
undetectable
1gmkD-4g25A:
undetectable		 1gmkC-4g25A:
3.75
1gmkD-4g25A:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TRP A 115
VAL A 110
TRP A  85
 None
 1.39A 1gmkC-4h19A:
undetectable
1gmkD-4h19A:
undetectable		 1gmkC-4h19A:
6.44
1gmkD-4h19A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iit PHENYLACETATE-COA
OXYGENASE SUBUNIT
PAAC

(Klebsiella
pneumoniae) 		PF05138
(PaaA_PaaC) 		3 TRP C 198
VAL C 108
TRP C 106
 None
 1.49A 1gmkC-4iitC:
undetectable
1gmkD-4iitC:
undetectable		 1gmkC-4iitC:
4.08
1gmkD-4iitC:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 3 TRP E 411
VAL E 413
TRP E 407
 None
 1.39A 1gmkC-4kprE:
undetectable
1gmkD-4kprE:
undetectable		 1gmkC-4kprE:
3.75
1gmkD-4kprE:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Xylanimonas
cellulosilytica) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		3 TRP A 274
VAL A 285
TRP A 312
 None
 1.40A 1gmkC-4lpqA:
undetectable
1gmkD-4lpqA:
undetectable		 1gmkC-4lpqA:
9.03
1gmkD-4lpqA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 3 TRP A 280
VAL A 335
TRP A 396
 None
 1.38A 1gmkC-4ofzA:
undetectable
1gmkD-4ofzA:
undetectable		 1gmkC-4ofzA:
3.75
1gmkD-4ofzA:
3.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 TRP A 249
VAL A 170
TRP A 168
 None
 1.38A 1gmkC-4ptxA:
undetectable
1gmkD-4ptxA:
undetectable		 1gmkC-4ptxA:
2.50
1gmkD-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		3 TRP A 447
VAL A 435
TRP A 226
 None
 0.71A 1gmkC-4rmlA:
undetectable
1gmkD-4rmlA:
undetectable		 1gmkC-4rmlA:
3.64
1gmkD-4rmlA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u2x IMPORTIN SUBUNIT
ALPHA-6

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 TRP D 403
VAL D 363
TRP D 361
 None
 1.40A 1gmkC-4u2xD:
undetectable
1gmkD-4u2xD:
undetectable		 1gmkC-4u2xD:
8.13
1gmkD-4u2xD:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		3 TRP A 171
VAL A 188
TRP A 189
 None
 1.16A 1gmkC-4ueuA:
undetectable
1gmkD-4ueuA:
undetectable		 1gmkC-4ueuA:
9.09
1gmkD-4ueuA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		3 TRP A 666
VAL A 671
TRP A 670
 None
 1.43A 1gmkC-4wiwA:
undetectable
1gmkD-4wiwA:
undetectable		 1gmkC-4wiwA:
5.05
1gmkD-4wiwA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 TRP A 302
VAL A 291
TRP A 305
 None
 1.21A 1gmkC-4wv3A:
undetectable
1gmkD-4wv3A:
undetectable		 1gmkC-4wv3A:
5.86
1gmkD-4wv3A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmv AMINOPEPTIDASE N

(Escherichia
coli) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		3 TRP A  71
VAL A  82
TRP A  74
 GOL  A 914 ( 3.8A)
None
None
 1.29A 1gmkC-4xmvA:
undetectable
1gmkD-4xmvA:
undetectable		 1gmkC-4xmvA:
1.84
1gmkD-4xmvA:
1.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		3 TRP A 223
VAL A 229
TRP A 224
 None
TMP  A 503 (-4.4A)
None
 1.42A 1gmkC-4xr9A:
undetectable
1gmkD-4xr9A:
undetectable		 1gmkC-4xr9A:
5.36
1gmkD-4xr9A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 TRP R 359
VAL R 402
TRP R 403
 None
 1.09A 1gmkC-5a31R:
undetectable
1gmkD-5a31R:
undetectable		 1gmkC-5a31R:
4.15
1gmkD-5a31R:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmn LATROPHILIN-3

(Homo sapiens) 		PF02191
(OLF) 		3 TRP E 379
VAL E 367
TRP E 158
 None
CA  E 401 (-4.8A)
None
 0.77A 1gmkC-5cmnE:
undetectable
1gmkD-5cmnE:
undetectable		 1gmkC-5cmnE:
4.23
1gmkD-5cmnE:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 3 TRP A  93
VAL A  91
TRP A  96
 None
 1.16A 1gmkC-5fkrA:
undetectable
1gmkD-5fkrA:
undetectable		 1gmkC-5fkrA:
2.40
1gmkD-5fkrA:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftt ADHESION G
PROTEIN-COUPLED
RECEPTOR L3

(Mus musculus) 		PF02140
(Gal_Lectin)
PF02191
(OLF) 		3 TRP C 447
VAL C 435
TRP C 226
 None
CA  C1467 (-4.8A)
None
 0.80A 1gmkC-5fttC:
undetectable
1gmkD-5fttC:
undetectable		 1gmkC-5fttC:
5.14
1gmkD-5fttC:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hk8 PROBABLE
PHEOPHORBIDASE

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		3 TRP A  24
VAL A  43
TRP A  26
 None
 1.34A 1gmkC-5hk8A:
undetectable
1gmkD-5hk8A:
undetectable		 1gmkC-5hk8A:
4.23
1gmkD-5hk8A:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8k HHH1 FAB HEAVY CHAIN
HHH1 FAB LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 TRP H 100
VAL L  29
TRP L  30
 None
 1.38A 1gmkC-5i8kH:
undetectable
1gmkD-5i8kH:
undetectable		 1gmkC-5i8kH:
5.62
1gmkD-5i8kH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixu UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF07978
(NIPSNAP) 		3 TRP A  60
VAL A  98
TRP A  59
 None
 1.35A 1gmkC-5ixuA:
undetectable
1gmkD-5ixuA:
undetectable		 1gmkC-5ixuA:
9.57
1gmkD-5ixuA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		3 TRP A 780
VAL A 755
TRP A 757
 None
 1.22A 1gmkC-5ja1A:
undetectable
1gmkD-5ja1A:
undetectable		 1gmkC-5ja1A:
2.26
1gmkD-5ja1A:
2.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		3 TRP A 258
VAL A 256
TRP A 252
 None
None
SF4  A 302 (-3.9A)
 0.93A 1gmkC-5jsyA:
undetectable
1gmkD-5jsyA:
undetectable		 1gmkC-5jsyA:
4.30
1gmkD-5jsyA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		3 TRP A  64
VAL A  62
TRP A  67
 None
 1.06A 1gmkC-5jwzA:
undetectable
1gmkD-5jwzA:
undetectable		 1gmkC-5jwzA:
2.12
1gmkD-5jwzA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		3 TRP A  17
VAL A 159
TRP A 205
 None
 1.27A 1gmkC-5k9hA:
undetectable
1gmkD-5k9hA:
undetectable		 1gmkC-5k9hA:
1.79
1gmkD-5k9hA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kj2 HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF08214
(HAT_KAT11) 		3 TRP A1436
VAL A1597
TRP A1509
 None
 1.36A 1gmkC-5kj2A:
undetectable
1gmkD-5kj2A:
undetectable		 1gmkC-5kj2A:
3.83
1gmkD-5kj2A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n05 AUXILIARY ACTIVITY 9

(Lentinus
similis) 		PF03443
(Glyco_hydro_61) 		3 TRP A   8
VAL A   4
TRP A   5
 None
None
CL  A 314 (-4.7A)
 1.37A 1gmkC-5n05A:
undetectable
1gmkD-5n05A:
undetectable		 1gmkC-5n05A:
6.63
1gmkD-5n05A:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol8 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 TRP A 182
VAL A 174
TRP A 194
 None
 1.26A 1gmkC-5ol8A:
undetectable
1gmkD-5ol8A:
undetectable		 1gmkC-5ol8A:
3.07
1gmkD-5ol8A:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbk IMPORTIN SUBUNIT
ALPHA-3

(Homo sapiens) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		3 TRP A 390
VAL A 347
TRP A 348
 None
 1.31A 1gmkC-5tbkA:
undetectable
1gmkD-5tbkA:
undetectable		 1gmkC-5tbkA:
8.05
1gmkD-5tbkA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 TRP A 766
VAL A 783
TRP A 784
 None
 1.15A 1gmkC-5td2A:
undetectable
1gmkD-5td2A:
undetectable		 1gmkC-5td2A:
3.97
1gmkD-5td2A:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		3 TRP A 413
VAL A 410
TRP A 414
 None
 1.00A 1gmkC-5uamA:
undetectable
1gmkD-5uamA:
undetectable		 1gmkC-5uamA:
4.30
1gmkD-5uamA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 TRP A 606
VAL A 611
TRP A 609
 None
 1.48A 1gmkC-5uowA:
undetectable
1gmkD-5uowA:
undetectable		 1gmkC-5uowA:
3.90
1gmkD-5uowA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 3 TRP A1053
VAL A1070
TRP A1071
 None
 1.09A 1gmkC-5wnoA:
undetectable
1gmkD-5wnoA:
undetectable		 1gmkC-5wnoA:
undetectable
1gmkD-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y83 MEMBRANE PROTEIN
INSERTASE YIDC

(Thermotoga
maritima) 		no annotation 3 TRP A 240
VAL A 235
TRP A 239
 None
 1.34A 1gmkC-5y83A:
undetectable
1gmkD-5y83A:
undetectable		 1gmkC-5y83A:
undetectable
1gmkD-5y83A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 3 TRP A 414
VAL A 352
TRP A 417
 None
 0.94A 1gmkC-5ybbA:
undetectable
1gmkD-5ybbA:
undetectable		 1gmkC-5ybbA:
4.08
1gmkD-5ybbA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 3 TRP A  94
VAL A 264
TRP A 266
 None
 1.20A 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable		 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 3 TRP A 266
VAL A  93
TRP A  94
 None
 1.43A 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable		 1gmkC-5yj6A:
undetectable
1gmkD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		no annotation
no annotation 		3 TRP A 202
VAL A 200
TRP B  87
 None
CM5  A 502 ( 4.9A)
None
 1.30A 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable		 1gmkC-6cxhA:
undetectable
1gmkD-6cxhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 3 TRP F 361
VAL F 315
TRP F 313
 None
 1.44A 1gmkC-6f0kF:
undetectable
1gmkD-6f0kF:
undetectable		 1gmkC-6f0kF:
undetectable
1gmkD-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 3 TRP A 251
VAL A 243
TRP A 250
 None
 1.38A 1gmkC-6f2tA:
undetectable
1gmkD-6f2tA:
undetectable		 1gmkC-6f2tA:
undetectable
1gmkD-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 3 TRP A 275
VAL A 270
TRP A 272
 None
 1.46A 1gmkC-6gctA:
undetectable
1gmkD-6gctA:
undetectable		 1gmkC-6gctA:
undetectable
1gmkD-6gctA:
undetectable