SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_D_DVAD6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 VAL A1358
TRP A1368
ALA A1370
VAL A1360
 None
 1.12A 1gmkC-2bruA:
undetectable
1gmkD-2bruA:
undetectable		 1gmkC-2bruA:
3.11
1gmkD-2bruA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 398
TRP A 358
ALA A 359
VAL A 415
 None
 1.41A 1gmkC-2eq9A:
undetectable
1gmkD-2eq9A:
undetectable		 1gmkC-2eq9A:
3.06
1gmkD-2eq9A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 VAL A 324
TRP A 372
ALA A 371
VAL A 350
 None
 1.49A 1gmkC-2et6A:
undetectable
1gmkD-2et6A:
undetectable		 1gmkC-2et6A:
5.28
1gmkD-2et6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv5 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF10052
(DUF2288) 		4 VAL A  91
TRP A  95
ALA A  35
VAL A  97
 None
 1.42A 1gmkC-2lv5A:
undetectable
1gmkD-2lv5A:
undetectable		 1gmkC-2lv5A:
14.49
1gmkD-2lv5A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izy TRANSLATION
INITIATION FACTOR
IF-2, MITOCHONDRIAL

(Bos taurus) 		PF00009
(GTP_EFTU)
PF11987
(IF-2) 		4 VAL P 434
TRP P 393
ALA P 394
VAL P 388
 None
 1.16A 1gmkC-3izyP:
undetectable
1gmkD-3izyP:
undetectable		 1gmkC-3izyP:
2.66
1gmkD-3izyP:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 VAL A 177
TRP A 152
ALA A 153
VAL A 183
 None
 1.15A 1gmkC-3k1dA:
undetectable
1gmkD-3k1dA:
undetectable		 1gmkC-3k1dA:
2.24
1gmkD-3k1dA:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r64 NAD DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF00171
(Aldedh) 		4 VAL A 300
TRP A 421
ALA A 419
VAL A 269
 VAL  A 300 ( 0.6A)
TRP  A 421 ( 0.5A)
ALA  A 419 ( 0.0A)
VAL  A 269 ( 0.6A)
 1.13A 1gmkC-3r64A:
undetectable
1gmkD-3r64A:
undetectable		 1gmkC-3r64A:
3.70
1gmkD-3r64A:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pgh CAFFEIC ACID
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		4 VAL A 312
TRP A 356
ALA A 355
VAL A 298
 None
 1.49A 1gmkC-4pghA:
undetectable
1gmkD-4pghA:
undetectable		 1gmkC-4pghA:
4.94
1gmkD-4pghA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 VAL A 128
TRP A 301
ALA A 302
VAL A 137
 None
 1.38A 1gmkC-4rjzA:
undetectable
1gmkD-4rjzA:
undetectable		 1gmkC-4rjzA:
5.73
1gmkD-4rjzA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 VAL A 488
TRP A 557
ALA A 554
VAL A 484
 None
 1.41A 1gmkC-5ejjA:
undetectable
1gmkD-5ejjA:
undetectable		 1gmkC-5ejjA:
5.08
1gmkD-5ejjA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 VAL A 484
TRP A 481
ALA A 418
VAL A 471
 None
 1.41A 1gmkC-5imyA:
undetectable
1gmkD-5imyA:
undetectable		 1gmkC-5imyA:
3.34
1gmkD-5imyA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2m RIMK-RELATED LYSINE
BIOSYNTHESIS PROTEIN

(Thermococcus
kodakarensis) 		PF08443
(RimK) 		4 VAL A 182
TRP A 218
ALA A 225
VAL A 176
 None
 1.25A 1gmkC-5k2mA:
undetectable
1gmkD-5k2mA:
undetectable		 1gmkC-5k2mA:
6.29
1gmkD-5k2mA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpe KALLIKREIN-10

(Homo sapiens) 		PF00089
(Trypsin) 		4 VAL A  52
TRP A  29
ALA A 120
VAL A  45
 None
 1.41A 1gmkC-5lpeA:
undetectable
1gmkD-5lpeA:
undetectable		 1gmkC-5lpeA:
11.25
1gmkD-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 VAL A  80
TRP A  86
ALA A  83
VAL A  81
 None
 1.48A 1gmkC-5olpA:
undetectable
1gmkD-5olpA:
undetectable		 1gmkC-5olpA:
8.80
1gmkD-5olpA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 VAL A 190
TRP A 173
ALA A 196
VAL A 191
 None
 1.36A 1gmkC-5z5kA:
undetectable
1gmkD-5z5kA:
undetectable		 1gmkC-5z5kA:
undetectable
1gmkD-5z5kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 4 VAL A  36
TRP A  38
ALA A  41
VAL A  39
 None
 1.44A 1gmkC-5zkpA:
undetectable
1gmkD-5zkpA:
undetectable		 1gmkC-5zkpA:
undetectable
1gmkD-5zkpA:
undetectable