SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_C_DVAC8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 VAL A 401
TRP A 236
TRP A 532
 None
 1.43A 1gmkC-1b41A:
undetectable
1gmkD-1b41A:
undetectable		 1gmkC-1b41A:
4.81
1gmkD-1b41A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo6 ESTROGEN
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 VAL A 135
TRP A 264
TRP A 172
 None
 1.35A 1gmkC-1bo6A:
undetectable
1gmkD-1bo6A:
undetectable		 1gmkC-1bo6A:
3.92
1gmkD-1bo6A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 VAL L 332
TRP L 245
TRP L 450
 None
 1.33A 1gmkC-1cc1L:
undetectable
1gmkD-1cc1L:
undetectable		 1gmkC-1cc1L:
8.33
1gmkD-1cc1L:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clx XYLANASE A

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10) 		3 VAL A 124
TRP A  83
TRP A 122
 None
 1.28A 1gmkC-1clxA:
undetectable
1gmkD-1clxA:
undetectable		 1gmkC-1clxA:
8.70
1gmkD-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1deu PROCATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 VAL A 184
TRP A   5
TRP A 196
 None
 1.33A 1gmkC-1deuA:
undetectable
1gmkD-1deuA:
undetectable		 1gmkC-1deuA:
6.34
1gmkD-1deuA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 VAL A 278
TRP A 316
TRP A 267
 None
 0.99A 1gmkC-1eceA:
undetectable
1gmkD-1eceA:
undetectable		 1gmkC-1eceA:
4.04
1gmkD-1eceA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef7 CATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		3 VAL A 184
TRP A   5
TRP A 196
 None
 1.35A 1gmkC-1ef7A:
undetectable
1gmkD-1ef7A:
undetectable		 1gmkC-1ef7A:
6.34
1gmkD-1ef7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		3 VAL A  14
TRP A 131
TRP A 360
 None
 1.23A 1gmkC-1eqcA:
undetectable
1gmkD-1eqcA:
undetectable		 1gmkC-1eqcA:
4.33
1gmkD-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3m ESTROGEN
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 134
TRP A 263
TRP A 171
 None
 1.34A 1gmkC-1g3mA:
undetectable
1gmkD-1g3mA:
undetectable		 1gmkC-1g3mA:
4.38
1gmkD-1g3mA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		3 VAL A  94
TRP A 236
TRP A  89
 None
 1.43A 1gmkC-1g5iA:
undetectable
1gmkD-1g5iA:
undetectable		 1gmkC-1g5iA:
5.37
1gmkD-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		3 VAL A 102
TRP A  99
TRP A 311
 None
 0.77A 1gmkC-1pz3A:
undetectable
1gmkD-1pz3A:
undetectable		 1gmkC-1pz3A:
3.71
1gmkD-1pz3A:
3.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		3 VAL A 310
TRP A 296
TRP A 309
 None
 1.12A 1gmkC-1q0pA:
undetectable
1gmkD-1q0pA:
undetectable		 1gmkC-1q0pA:
17.02
1gmkD-1q0pA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 137
TRP A 266
TRP A 174
 None
 1.27A 1gmkC-1q1qA:
undetectable
1gmkD-1q1qA:
undetectable		 1gmkC-1q1qA:
7.43
1gmkD-1q1qA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		3 VAL A 140
TRP A 173
TRP A 113
 None
 1.02A 1gmkC-1tisA:
undetectable
1gmkD-1tisA:
undetectable		 1gmkC-1tisA:
7.47
1gmkD-1tisA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A 399
TRP A 391
TRP A 395
 None
 1.29A 1gmkC-1ulzA:
undetectable
1gmkD-1ulzA:
undetectable		 1gmkC-1ulzA:
5.00
1gmkD-1ulzA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		3 VAL A 293
TRP A 210
TRP A 294
 None
 1.38A 1gmkC-1umiA:
undetectable
1gmkD-1umiA:
undetectable		 1gmkC-1umiA:
5.48
1gmkD-1umiA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 VAL A 359
TRP A 364
TRP A 358
 None
 1.38A 1gmkC-1v9lA:
undetectable
1gmkD-1v9lA:
undetectable		 1gmkC-1v9lA:
3.64
1gmkD-1v9lA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		3 VAL A 189
TRP A 192
TRP A 182
 None
GOL  A 300 (-4.0A)
None
 1.21A 1gmkC-1vd6A:
undetectable
1gmkD-1vd6A:
undetectable		 1gmkC-1vd6A:
8.57
1gmkD-1vd6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		3 VAL A 679
TRP A 649
TRP A 744
 None
 1.26A 1gmkC-1vs0A:
undetectable
1gmkD-1vs0A:
undetectable		 1gmkC-1vs0A:
7.10
1gmkD-1vs0A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 3 VAL B 387
TRP B 274
TRP B 389
 None
 1.38A 1gmkC-1xnjB:
undetectable
1gmkD-1xnjB:
undetectable		 1gmkC-1xnjB:
3.02
1gmkD-1xnjB:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO) 		3 VAL B  61
TRP B 152
TRP B  60
 None
 1.21A 1gmkC-1yewB:
undetectable
1gmkD-1yewB:
undetectable		 1gmkC-1yewB:
16.05
1gmkD-1yewB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		3 VAL A 577
TRP A 388
TRP A 488
 None
 1.45A 1gmkC-1zsqA:
undetectable
1gmkD-1zsqA:
undetectable		 1gmkC-1zsqA:
3.08
1gmkD-1zsqA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cum TENASCIN-X

(Homo sapiens) 		PF00041
(fn3) 		3 VAL A  33
TRP A  28
TRP A  80
 None
 1.12A 1gmkC-2cumA:
undetectable
1gmkD-2cumA:
undetectable		 1gmkC-2cumA:
17.24
1gmkD-2cumA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2x HYPOTHETICAL PROTEIN
PP5205

(Pseudomonas
putida) 		PF01878
(EVE) 		3 VAL A  99
TRP A   4
TRP A  26
 None
None
SO4  A 301 (-3.4A)
 1.19A 1gmkC-2g2xA:
undetectable
1gmkD-2g2xA:
undetectable		 1gmkC-2g2xA:
8.04
1gmkD-2g2xA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		3 VAL A 454
TRP A 340
TRP A 346
 None
None
SF4  A 650 (-4.6A)
 1.43A 1gmkC-2jh3A:
undetectable
1gmkD-2jh3A:
undetectable		 1gmkC-2jh3A:
7.37
1gmkD-2jh3A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 VAL A 512
TRP A 571
TRP A 578
 None
 1.09A 1gmkC-2jh9A:
undetectable
1gmkD-2jh9A:
undetectable		 1gmkC-2jh9A:
5.85
1gmkD-2jh9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbn CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 3 VAL A  72
TRP A  53
TRP A  17
 None
 1.42A 1gmkC-2kbnA:
undetectable
1gmkD-2kbnA:
undetectable		 1gmkC-2kbnA:
18.52
1gmkD-2kbnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6x SECRETED CATHEPSIN L
1

(Fasciola
hepatica) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 VAL A 278
TRP A 105
TRP A 276
 None
 1.36A 1gmkC-2o6xA:
undetectable
1gmkD-2o6xA:
undetectable		 1gmkC-2o6xA:
14.06
1gmkD-2o6xA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opk HYPOTHETICAL PROTEIN

(Cupriavidus
pinatubonensis) 		PF07883
(Cupin_2) 		3 VAL A 106
TRP A 103
TRP A  55
 None
UNL  A 112 (-3.5A)
None
 0.81A 1gmkC-2opkA:
undetectable
1gmkD-2opkA:
undetectable		 1gmkC-2opkA:
13.98
1gmkD-2opkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0x ABIOTIC ATP-BINDING,
FOLDING OPTIMIZED
PROTEIN

(-) 		no annotation 3 VAL A  50
TRP A  18
TRP A  52
 None
 1.05A 1gmkC-2p0xA:
undetectable
1gmkD-2p0xA:
undetectable		 1gmkC-2p0xA:
13.04
1gmkD-2p0xA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		3 VAL A 294
TRP A 289
TRP A 295
 None
 1.43A 1gmkC-2q14A:
undetectable
1gmkD-2q14A:
undetectable		 1gmkC-2q14A:
2.98
1gmkD-2q14A:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 VAL A 393
TRP A 332
TRP A 337
 None
 1.37A 1gmkC-2q3zA:
undetectable
1gmkD-2q3zA:
undetectable		 1gmkC-2q3zA:
3.47
1gmkD-2q3zA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 VAL A 387
TRP A 274
TRP A 389
 None
 1.40A 1gmkC-2qjfA:
undetectable
1gmkD-2qjfA:
undetectable		 1gmkC-2qjfA:
5.19
1gmkD-2qjfA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 VAL A 466
TRP A 461
TRP A 468
 PEG  A1782 ( 3.7A)
None
None
 1.07A 1gmkC-2wdaA:
undetectable
1gmkD-2wdaA:
undetectable		 1gmkC-2wdaA:
2.06
1gmkD-2wdaA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wm4 PUTATIVE CYTOCHROME
P450 124

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 VAL A 305
TRP A 311
TRP A 293
 None
 1.37A 1gmkC-2wm4A:
undetectable
1gmkD-2wm4A:
undetectable		 1gmkC-2wm4A:
3.35
1gmkD-2wm4A:
3.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyv TYROSINE-ESTER
SULFOTRANSFERASE

(Mus musculus) 		PF00685
(Sulfotransfer_1) 		3 VAL X 135
TRP X 264
TRP X 172
 None
 1.33A 1gmkC-2zyvX:
undetectable
1gmkD-2zyvX:
undetectable		 1gmkC-2zyvX:
4.63
1gmkD-2zyvX:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 VAL A 179
TRP A 200
TRP A 142
 None
 1.27A 1gmkC-3a0fA:
undetectable
1gmkD-3a0fA:
undetectable		 1gmkC-3a0fA:
2.16
1gmkD-3a0fA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkx SAM-DEPENDENT
METHYLTRANSFERASE

(Lactobacillus
paracasei) 		PF13649
(Methyltransf_25) 		3 VAL A 156
TRP A 159
TRP A  38
 None
 1.30A 1gmkC-3bkxA:
undetectable
1gmkD-3bkxA:
undetectable		 1gmkC-3bkxA:
5.52
1gmkD-3bkxA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 VAL A 663
TRP A 640
TRP A 552
 None
 1.18A 1gmkC-3c10A:
undetectable
1gmkD-3c10A:
undetectable		 1gmkC-3c10A:
7.64
1gmkD-3c10A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c64 PFEMP1 VARIANT 2 OF
STRAIN MC

(Plasmodium
falciparum) 		PF03011
(PFEMP) 		3 VAL A  56
TRP A  63
TRP A  55
 None
 1.45A 1gmkC-3c64A:
undetectable
1gmkD-3c64A:
undetectable		 1gmkC-3c64A:
13.56
1gmkD-3c64A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 136
TRP A 265
TRP A 173
 None
 1.39A 1gmkC-3cklA:
undetectable
1gmkD-3cklA:
undetectable		 1gmkC-3cklA:
5.33
1gmkD-3cklA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		3 VAL A 127
TRP A 135
TRP A  43
 None
 1.07A 1gmkC-3d34A:
undetectable
1gmkD-3d34A:
undetectable		 1gmkC-3d34A:
9.30
1gmkD-3d34A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4v NADH:FMN
OXIDOREDUCTASE LIKE
PROTEIN

(Methylobacillus
flagellatus) 		PF01613
(Flavin_Reduct) 		3 VAL A  73
TRP A 145
TRP A 118
 None
 1.38A 1gmkC-3e4vA:
undetectable
1gmkD-3e4vA:
undetectable		 1gmkC-3e4vA:
10.22
1gmkD-3e4vA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek9 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 2

(Mus musculus) 		PF00622
(SPRY) 		3 VAL A 106
TRP A 131
TRP A  91
 None
 1.34A 1gmkC-3ek9A:
undetectable
1gmkD-3ek9A:
undetectable		 1gmkC-3ek9A:
11.65
1gmkD-3ek9A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 VAL A 254
TRP A 251
TRP A 255
 None
FAD  A1000 (-3.7A)
None
 0.97A 1gmkC-3gyxA:
undetectable
1gmkD-3gyxA:
undetectable		 1gmkC-3gyxA:
2.61
1gmkD-3gyxA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4i 1,3-1,4-BETA-GLUCANA
SE

(uncultured
murine large
bowel bacterium
BAC 14) 		PF00722
(Glyco_hydro_16) 		3 VAL A 176
TRP A 105
TRP A 153
 None
 1.41A 1gmkC-3i4iA:
undetectable
1gmkD-3i4iA:
undetectable		 1gmkC-3i4iA:
6.19
1gmkD-3i4iA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxe TOXIN PROTEIN PARE-1

(Caulobacter
vibrioides) 		PF05016
(ParE_toxin) 		3 VAL A  27
TRP A  25
TRP A  18
 None
 1.44A 1gmkC-3kxeA:
undetectable
1gmkD-3kxeA:
undetectable		 1gmkC-3kxeA:
6.93
1gmkD-3kxeA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15

(Homo sapiens) 		PF06337
(DUSP) 		3 VAL A 101
TRP A  41
TRP A  97
 None
 0.69A 1gmkC-3lmnA:
undetectable
1gmkD-3lmnA:
undetectable		 1gmkC-3lmnA:
11.67
1gmkD-3lmnA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		3 VAL A 208
TRP A 113
TRP A 139
 None
 0.97A 1gmkC-3m3pA:
undetectable
1gmkD-3m3pA:
undetectable		 1gmkC-3m3pA:
10.37
1gmkD-3m3pA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m94 TRANSLATION
INITIATION FACTOR 4E

(Ascaris suum) 		PF01652
(IF4E) 		3 VAL A 176
TRP A 179
TRP A 143
 None
 1.44A 1gmkC-3m94A:
undetectable
1gmkD-3m94A:
undetectable		 1gmkC-3m94A:
8.27
1gmkD-3m94A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 LIGHT CHAIN
ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN

(Homo sapiens;
Mus musculus;
Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 VAL A  48
TRP B 103
TRP A  35
 None
 1.44A 1gmkC-3mnzA:
undetectable
1gmkD-3mnzA:
undetectable		 1gmkC-3mnzA:
10.38
1gmkD-3mnzA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 3 VAL A  55
TRP A  44
TRP A 108
 None
 1.38A 1gmkC-3oukA:
undetectable
1gmkD-3oukA:
undetectable		 1gmkC-3oukA:
6.96
1gmkD-3oukA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		3 VAL A  62
TRP A 153
TRP A 175
 None
 1.31A 1gmkC-3ps9A:
undetectable
1gmkD-3ps9A:
undetectable		 1gmkC-3ps9A:
2.20
1gmkD-3ps9A:
2.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rby UNCHARACTERIZED
PROTEIN YLR301W

(Saccharomyces
cerevisiae) 		PF16815
(HRI1) 		3 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.29A 1gmkC-3rbyA:
undetectable
1gmkD-3rbyA:
undetectable		 1gmkC-3rbyA:
6.17
1gmkD-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A 207
TRP A 272
TRP A 209
 None
 1.37A 1gmkC-3t9wA:
undetectable
1gmkD-3t9wA:
undetectable		 1gmkC-3t9wA:
5.16
1gmkD-3t9wA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		3 VAL A 174
TRP A  54
TRP A 175
 None
 1.11A 1gmkC-3umvA:
undetectable
1gmkD-3umvA:
undetectable		 1gmkC-3umvA:
5.24
1gmkD-3umvA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		3 VAL A 627
TRP A 640
TRP A 347
 None
RAM  A1202 (-3.7A)
None
 1.37A 1gmkC-3w5nA:
undetectable
1gmkD-3w5nA:
undetectable		 1gmkC-3w5nA:
2.27
1gmkD-3w5nA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 VAL A 273
TRP A 471
TRP A 205
 None
 1.34A 1gmkC-3wq4A:
undetectable
1gmkD-3wq4A:
undetectable		 1gmkC-3wq4A:
2.41
1gmkD-3wq4A:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		3 VAL A 485
TRP A 457
TRP A 581
 None
 1.34A 1gmkC-3wstA:
undetectable
1gmkD-3wstA:
undetectable		 1gmkC-3wstA:
2.69
1gmkD-3wstA:
2.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 3 VAL A 173
TRP A 215
TRP A 243
 None
 1.40A 1gmkC-3zphA:
undetectable
1gmkD-3zphA:
undetectable		 1gmkC-3zphA:
34.78
1gmkD-3zphA:
34.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drr OUTER CAPSID PROTEIN
VP4

(Rotavirus sp.) 		no annotation 3 VAL A 199
TRP A 102
TRP A 167
 None
 1.35A 1gmkC-4drrA:
undetectable
1gmkD-4drrA:
undetectable		 1gmkC-4drrA:
8.41
1gmkD-4drrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		3 VAL A 133
TRP A 140
TRP A  96
 None
None
BTN  A 201 ( 4.8A)
 1.18A 1gmkC-4dveA:
undetectable
1gmkD-4dveA:
undetectable		 1gmkC-4dveA:
14.46
1gmkD-4dveA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 484
TRP A 290
TRP A 297
 None
 0.86A 1gmkC-4fffA:
undetectable
1gmkD-4fffA:
undetectable		 1gmkC-4fffA:
4.67
1gmkD-4fffA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		3 VAL A 230
TRP A 247
TRP A 134
 None
 1.38A 1gmkC-4gpgA:
undetectable
1gmkD-4gpgA:
undetectable		 1gmkC-4gpgA:
4.92
1gmkD-4gpgA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2h MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Salipiger
bermudensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 VAL A  52
TRP A  28
TRP A 295
 0XW  A 403 ( 4.6A)
None
None
 1.38A 1gmkC-4h2hA:
undetectable
1gmkD-4h2hA:
undetectable		 1gmkC-4h2hA:
3.88
1gmkD-4h2hA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iml CROSSED HEAVY CHAIN
(VH-CKAPPA)
CROSSED LIGHT CHAIN
(VL-CH1)

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 VAL L  47
TRP H 119
TRP L  34
 None
 1.42A 1gmkC-4imlL:
undetectable
1gmkD-4imlL:
undetectable		 1gmkC-4imlL:
4.41
1gmkD-4imlL:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 VAL A 157
TRP A 309
TRP A 143
 None
 1.41A 1gmkC-4j3qA:
undetectable
1gmkD-4j3qA:
undetectable		 1gmkC-4j3qA:
4.87
1gmkD-4j3qA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
LIGHT CHAIN OF
ANTIBODY VRC-PG20

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 VAL L  48
TRP H 103
TRP L  35
 None
 1.44A 1gmkC-4lsuL:
undetectable
1gmkD-4lsuL:
undetectable		 1gmkC-4lsuL:
5.03
1gmkD-4lsuL:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly7 RIBONUCLEASE H

(unidentified) 		PF00075
(RNase_H) 		3 VAL A 101
TRP A  81
TRP A  90
 None
 1.23A 1gmkC-4ly7A:
undetectable
1gmkD-4ly7A:
undetectable		 1gmkC-4ly7A:
10.26
1gmkD-4ly7A:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 VAL A 259
TRP A 267
TRP A  51
 None
 1.31A 1gmkC-4mniA:
undetectable
1gmkD-4mniA:
undetectable		 1gmkC-4mniA:
5.36
1gmkD-4mniA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		3 VAL A 230
TRP A 247
TRP A 134
 None
 1.35A 1gmkC-4nsyA:
undetectable
1gmkD-4nsyA:
undetectable		 1gmkC-4nsyA:
4.38
1gmkD-4nsyA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		3 VAL A  31
TRP A 224
TRP A  33
 None
GOL  A 622 (-4.5A)
None
 1.45A 1gmkC-4pspA:
undetectable
1gmkD-4pspA:
undetectable		 1gmkC-4pspA:
2.60
1gmkD-4pspA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		3 VAL A 463
TRP A 499
TRP A 515
 None
 0.69A 1gmkC-4u1fA:
undetectable
1gmkD-4u1fA:
undetectable		 1gmkC-4u1fA:
3.50
1gmkD-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri) 		PF00318
(Ribosomal_S2) 		3 VAL b 529
TRP b 565
TRP b 581
 None
 0.58A 1gmkC-4uerb:
undetectable
1gmkD-4uerb:
undetectable		 1gmkC-4uerb:
2.02
1gmkD-4uerb:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8j PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 VAL A1018
TRP A1156
TRP A 991
 None
 1.09A 1gmkC-4w8jA:
undetectable
1gmkD-4w8jA:
undetectable		 1gmkC-4w8jA:
1.83
1gmkD-4w8jA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		3 VAL A 467
TRP A 456
TRP A 509
 None
 1.38A 1gmkC-4wd1A:
undetectable
1gmkD-4wd1A:
undetectable		 1gmkC-4wd1A:
4.07
1gmkD-4wd1A:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		3 VAL A 230
TRP A 235
TRP A 227
 None
 1.08A 1gmkC-4wisA:
undetectable
1gmkD-4wisA:
undetectable		 1gmkC-4wisA:
2.36
1gmkD-4wisA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 VAL A 610
TRP A 645
TRP A 617
 None
 1.34A 1gmkC-4wz9A:
undetectable
1gmkD-4wz9A:
undetectable		 1gmkC-4wz9A:
2.23
1gmkD-4wz9A:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		3 VAL A 463
TRP A 421
TRP A 395
 None
 1.01A 1gmkC-4y93A:
undetectable
1gmkD-4y93A:
undetectable		 1gmkC-4y93A:
2.60
1gmkD-4y93A:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		3 VAL A  32
TRP A  37
TRP A  35
 None
 1.10A 1gmkC-4ymgA:
undetectable
1gmkD-4ymgA:
undetectable		 1gmkC-4ymgA:
6.39
1gmkD-4ymgA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 VAL B 120
TRP B 262
TRP B 115
 None
 1.41A 1gmkC-4ztuB:
undetectable
1gmkD-4ztuB:
undetectable		 1gmkC-4ztuB:
4.63
1gmkD-4ztuB:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4n F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		3 VAL A 294
TRP A 209
TRP A 295
 None
 1.45A 1gmkC-5b4nA:
undetectable
1gmkD-5b4nA:
undetectable		 1gmkC-5b4nA:
4.43
1gmkD-5b4nA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 VAL B 120
TRP B 262
TRP B 115
 None
 1.42A 1gmkC-5c53B:
undetectable
1gmkD-5c53B:
undetectable		 1gmkC-5c53B:
2.09
1gmkD-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb7 OUTER CAPSID PROTEIN
VP4

(Rotavirus A) 		no annotation 3 VAL A 199
TRP A 102
TRP A 167
 None
 1.19A 1gmkC-5cb7A:
undetectable
1gmkD-5cb7A:
undetectable		 1gmkC-5cb7A:
10.99
1gmkD-5cb7A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 3 VAL B 115
TRP B 119
TRP B 138
 None
 1.18A 1gmkC-5dl8B:
undetectable
1gmkD-5dl8B:
undetectable		 1gmkC-5dl8B:
7.24
1gmkD-5dl8B:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esa ANTI-HCV E2
GLYCOPROTEIN FAB
HEAVY CHAIN
ANTI-HCV E2
GLYCOPROTEIN FAB
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 VAL B  47
TRP A 109
TRP B  34
 None
 1.45A 1gmkC-5esaB:
undetectable
1gmkD-5esaB:
undetectable		 1gmkC-5esaB:
6.83
1gmkD-5esaB:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		3 VAL B  63
TRP B  49
TRP B  18
 None
 1.44A 1gmkC-5exeB:
undetectable
1gmkD-5exeB:
undetectable		 1gmkC-5exeB:
3.52
1gmkD-5exeB:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guw NITRIC OXIDE
REDUCTASE SUBUNIT C

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C) 		3 VAL A  49
TRP A  56
TRP A 131
 None
 1.14A 1gmkC-5guwA:
undetectable
1gmkD-5guwA:
undetectable		 1gmkC-5guwA:
8.51
1gmkD-5guwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		3 VAL A 655
TRP A 660
TRP A 658
 None
 1.25A 1gmkC-5hb3A:
undetectable
1gmkD-5hb3A:
undetectable		 1gmkC-5hb3A:
2.68
1gmkD-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		3 VAL A  43
TRP A  49
TRP A  44
 None
 1.44A 1gmkC-5htpA:
undetectable
1gmkD-5htpA:
undetectable		 1gmkC-5htpA:
10.16
1gmkD-5htpA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 VAL A 281
TRP A 272
TRP A 335
 None
 1.11A 1gmkC-5i2hA:
undetectable
1gmkD-5i2hA:
undetectable		 1gmkC-5i2hA:
7.89
1gmkD-5i2hA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 VAL A 291
TRP A 254
TRP A 289
 None
 1.30A 1gmkC-5jjuA:
undetectable
1gmkD-5jjuA:
undetectable		 1gmkC-5jjuA:
4.90
1gmkD-5jjuA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT ALPHA

(Methylobacillus
flagellatus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 VAL A 399
TRP A 391
TRP A 395
 None
 1.20A 1gmkC-5ks8A:
undetectable
1gmkD-5ks8A:
undetectable		 1gmkC-5ks8A:
3.53
1gmkD-5ks8A:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 VAL B  17
TRP B  22
TRP B  14
 None
 1.36A 1gmkC-5mkkB:
undetectable
1gmkD-5mkkB:
undetectable		 1gmkC-5mkkB:
3.48
1gmkD-5mkkB:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 VAL A 171
TRP A 437
TRP A 168
 None
 1.27A 1gmkC-5tf0A:
undetectable
1gmkD-5tf0A:
undetectable		 1gmkC-5tf0A:
1.58
1gmkD-5tf0A:
1.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u22 N2152

(Neocallimastix
frontalis) 		PF01229
(Glyco_hydro_39) 		3 VAL A 158
TRP A 160
TRP A 118
 None
None
BTB  A 501 (-3.6A)
 1.34A 1gmkC-5u22A:
undetectable
1gmkD-5u22A:
undetectable		 1gmkC-5u22A:
4.12
1gmkD-5u22A:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 VAL A 169
TRP A 435
TRP A 166
 None
 1.25A 1gmkC-5xxoA:
undetectable
1gmkD-5xxoA:
undetectable		 1gmkC-5xxoA:
undetectable
1gmkD-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 3 VAL A 160
TRP A 422
TRP A 157
 None
 1.14A 1gmkC-5z9sA:
undetectable
1gmkD-5z9sA:
undetectable		 1gmkC-5z9sA:
undetectable
1gmkD-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 VAL B  61
TRP B 152
TRP B  60
 None
 1.34A 1gmkC-6cxhB:
undetectable
1gmkD-6cxhB:
undetectable		 1gmkC-6cxhB:
undetectable
1gmkD-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et8 -

(-) 		no annotation 3 VAL A 200
TRP A 162
TRP A 203
 None
BWH  A 301 (-4.5A)
None
 1.03A 1gmkC-6et8A:
undetectable
1gmkD-6et8A:
undetectable		 1gmkC-6et8A:
undetectable
1gmkD-6et8A:
undetectable