SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_C_DVAC6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		3 ALA A 396
VAL A 392
TRP A 393
 None
 1.00A 1gmkC-1cjyA:
undetectable
1gmkD-1cjyA:
undetectable		 1gmkC-1cjyA:
2.69
1gmkD-1cjyA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 ALA A 121
VAL A 118
TRP A 182
 None
 0.91A 1gmkC-1e43A:
undetectable
1gmkD-1e43A:
undetectable		 1gmkC-1e43A:
4.90
1gmkD-1e43A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3y DIADENOSINE
5',5'''-P1,P4-TETRAP
HOSPHATE HYDROLASE

(Lupinus
angustifolius) 		PF00293
(NUDIX) 		3 ALA A 104
VAL A  17
TRP A 107
 None
 0.95A 1gmkC-1f3yA:
undetectable
1gmkD-1f3yA:
undetectable		 1gmkC-1f3yA:
9.09
1gmkD-1f3yA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR

(Drosophila
melanogaster) 		PF00447
(HSF_DNA-bind) 		3 ALA A  60
VAL A  57
TRP A  68
 None
 1.00A 1gmkC-1hktA:
undetectable
1gmkD-1hktA:
undetectable		 1gmkC-1hktA:
17.02
1gmkD-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 ALA A 335
VAL A 338
TRP A 378
 None
 0.96A 1gmkC-1kfwA:
undetectable
1gmkD-1kfwA:
undetectable		 1gmkC-1kfwA:
3.19
1gmkD-1kfwA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		3 ALA A 646
VAL A 547
TRP A 642
 None
 0.89A 1gmkC-1l1lA:
undetectable
1gmkD-1l1lA:
undetectable		 1gmkC-1l1lA:
2.70
1gmkD-1l1lA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ma1 SUPEROXIDE DISMUTASE

(Methanothermobacter
thermautotrophicus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 122
VAL A 133
TRP A 131
 None
 0.88A 1gmkC-1ma1A:
undetectable
1gmkD-1ma1A:
undetectable		 1gmkC-1ma1A:
10.42
1gmkD-1ma1A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		3 ALA M 238
VAL M 241
TRP M 186
 None
PID  M 624 (-4.2A)
PID  M 624 ( 3.6A)
 0.95A 1gmkC-1pprM:
undetectable
1gmkD-1pprM:
undetectable		 1gmkC-1pprM:
7.10
1gmkD-1pprM:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ALA A 215
VAL A 190
TRP A 227
 None
 0.86A 1gmkC-1q5nA:
undetectable
1gmkD-1q5nA:
undetectable		 1gmkC-1q5nA:
4.14
1gmkD-1q5nA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		3 ALA A 370
VAL A 376
TRP A 349
 None
 1.02A 1gmkC-1r47A:
undetectable
1gmkD-1r47A:
undetectable		 1gmkC-1r47A:
4.24
1gmkD-1r47A:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 ALA A 214
VAL A 189
TRP A 226
 None
 0.83A 1gmkC-1re5A:
undetectable
1gmkD-1re5A:
undetectable		 1gmkC-1re5A:
5.05
1gmkD-1re5A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ALA A 255
VAL A 250
TRP A 627
 None
 0.99A 1gmkC-1tmoA:
undetectable
1gmkD-1tmoA:
undetectable		 1gmkC-1tmoA:
1.88
1gmkD-1tmoA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME

(Thermus
thermophilus) 		PF08443
(RimK) 		3 ALA A  85
VAL A  94
TRP A  90
 None
 0.95A 1gmkC-1uc8A:
undetectable
1gmkD-1uc8A:
undetectable		 1gmkC-1uc8A:
10.31
1gmkD-1uc8A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		3 ALA B   9
VAL B  11
TRP B 107
 None
 0.99A 1gmkC-1y43B:
undetectable
1gmkD-1y43B:
undetectable		 1gmkC-1y43B:
6.13
1gmkD-1y43B:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apj PUTATIVE ESTERASE

(Arabidopsis
thaliana) 		PF03629
(SASA) 		3 ALA A  34
VAL A  92
TRP A  50
 SEB  A  31 ( 3.8A)
None
None
 0.98A 1gmkC-2apjA:
undetectable
1gmkD-2apjA:
undetectable		 1gmkC-2apjA:
6.17
1gmkD-2apjA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ar1 HYPOTHETICAL PROTEIN

(Leishmania
major) 		PF01878
(EVE) 		3 ALA A 148
VAL A 146
TRP A  14
 None
 0.97A 1gmkC-2ar1A:
undetectable
1gmkD-2ar1A:
undetectable		 1gmkC-2ar1A:
15.49
1gmkD-2ar1A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  85
VAL A 101
TRP A 102
 None
None
MPD  A   1 ( 3.9A)
 1.02A 1gmkC-2d4wA:
undetectable
1gmkD-2d4wA:
undetectable		 1gmkC-2d4wA:
4.98
1gmkD-2d4wA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 ALA A 294
VAL A 113
TRP A  94
 None
 0.83A 1gmkC-2dw6A:
undetectable
1gmkD-2dw6A:
undetectable		 1gmkC-2dw6A:
4.09
1gmkD-2dw6A:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erv HYPOTHETICAL PROTEIN
PAER03002360

(Pseudomonas
aeruginosa) 		PF09411
(PagL) 		3 ALA A  55
VAL A  93
TRP A  48
 None
 0.70A 1gmkC-2ervA:
undetectable
1gmkD-2ervA:
undetectable		 1gmkC-2ervA:
9.18
1gmkD-2ervA:
9.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eve HYPOTHETICAL PROTEIN
PSPTO5229

(Pseudomonas
syringae group
genomosp. 3) 		PF01878
(EVE) 		3 ALA A 139
VAL A 137
TRP A   4
 None
 0.99A 1gmkC-2eveA:
undetectable
1gmkD-2eveA:
undetectable		 1gmkC-2eveA:
31.25
1gmkD-2eveA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		3 ALA A 279
VAL A 281
TRP A 230
 None
 0.99A 1gmkC-2f5xA:
undetectable
1gmkD-2f5xA:
undetectable		 1gmkC-2f5xA:
6.80
1gmkD-2f5xA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g37 PROLINE
DEHYDROGENASE/DELTA-
1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF01619
(Pro_dh) 		3 ALA A  44
VAL A  36
TRP A 282
 None
 0.92A 1gmkC-2g37A:
undetectable
1gmkD-2g37A:
undetectable		 1gmkC-2g37A:
5.00
1gmkD-2g37A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggj N-ACYLAMINO ACID
RACEMASE

(Deinococcus
radiodurans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 286
VAL A 265
TRP A 294
 None
 1.01A 1gmkC-2ggjA:
undetectable
1gmkD-2ggjA:
undetectable		 1gmkC-2ggjA:
4.64
1gmkD-2ggjA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iir ACETATE KINASE

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		3 ALA A 291
VAL A 301
TRP A 297
 None
 0.95A 1gmkC-2iirA:
undetectable
1gmkD-2iirA:
undetectable		 1gmkC-2iirA:
4.23
1gmkD-2iirA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 ALA A 190
VAL A 170
TRP A 134
 None
 1.01A 1gmkC-2j7cA:
undetectable
1gmkD-2j7cA:
undetectable		 1gmkC-2j7cA:
2.35
1gmkD-2j7cA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4q MAJOR TAIL PROTEIN V

(Escherichia
virus Lambda) 		PF16461
(Phage_TTP_12) 		3 ALA A  80
VAL A 149
TRP A 126
 None
 0.67A 1gmkC-2k4qA:
undetectable
1gmkD-2k4qA:
undetectable		 1gmkC-2k4qA:
10.20
1gmkD-2k4qA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpw LAMIN-B1

(Homo sapiens) 		PF00932
(LTD) 		3 ALA A  80
VAL A  78
TRP A  72
 None
 0.95A 1gmkC-2kpwA:
undetectable
1gmkD-2kpwA:
undetectable		 1gmkC-2kpwA:
4.92
1gmkD-2kpwA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgz DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT STT3

(Saccharomyces
cerevisiae) 		no annotation 3 ALA A  28
VAL A  24
TRP A  23
 None
 0.87A 1gmkC-2lgzA:
undetectable
1gmkD-2lgzA:
undetectable		 1gmkC-2lgzA:
3.66
1gmkD-2lgzA:
3.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ock VALACYCLOVIR
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		3 ALA A 235
VAL A 222
TRP A 145
 None
 0.79A 1gmkC-2ockA:
undetectable
1gmkD-2ockA:
undetectable		 1gmkC-2ockA:
6.82
1gmkD-2ockA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		3 ALA C 249
VAL C 208
TRP C 219
 None
 0.76A 1gmkC-2p9nC:
undetectable
1gmkD-2p9nC:
undetectable		 1gmkC-2p9nC:
3.52
1gmkD-2p9nC:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 ALA A1033
VAL A1027
TRP A1193
 None
 0.98A 1gmkC-2pffA:
undetectable
1gmkD-2pffA:
undetectable		 1gmkC-2pffA:
1.22
1gmkD-2pffA:
1.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 ALA A 371
VAL A 373
TRP A 368
 None
 1.01A 1gmkC-2yfqA:
undetectable
1gmkD-2yfqA:
undetectable		 1gmkC-2yfqA:
3.15
1gmkD-2yfqA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak1 SUPEROXIDE DISMUTASE
[MN/FE]

(Aeropyrum
pernix) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ALA A 121
VAL A 132
TRP A 130
 None
 0.93A 1gmkC-3ak1A:
undetectable
1gmkD-3ak1A:
undetectable		 1gmkC-3ak1A:
5.14
1gmkD-3ak1A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-ACETYLTRANSFERASE

(Enterococcus
faecalis) 		PF00132
(Hexapep)
PF08503
(DapH_N)
PF14602
(Hexapep_2) 		3 ALA A  74
VAL A  19
TRP A  51
 None
 0.93A 1gmkC-3cj8A:
undetectable
1gmkD-3cj8A:
undetectable		 1gmkC-3cj8A:
7.96
1gmkD-3cj8A:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		3 ALA A 258
VAL A 175
TRP A 173
 None
 0.73A 1gmkC-3enkA:
undetectable
1gmkD-3enkA:
undetectable		 1gmkC-3enkA:
8.72
1gmkD-3enkA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum) 		PF00132
(Hexapep) 		3 ALA A 195
VAL A 178
TRP A 239
 None
 0.95A 1gmkC-3fscA:
undetectable
1gmkD-3fscA:
undetectable		 1gmkC-3fscA:
13.89
1gmkD-3fscA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		3 ALA B 349
VAL B 344
TRP B 323
 None
 1.01A 1gmkC-3it4B:
undetectable
1gmkD-3it4B:
undetectable		 1gmkC-3it4B:
8.93
1gmkD-3it4B:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP1
VP3

(Parechovirus B;
Parechovirus B) 		no annotation
PF00073
(Rhv) 		3 ALA C  44
VAL A 181
TRP A 150
 None
 0.94A 1gmkC-3jb4C:
undetectable
1gmkD-3jb4C:
undetectable		 1gmkC-3jb4C:
13.58
1gmkD-3jb4C:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3jd5 28S RIBOSOMAL
PROTEIN S10,
MITOCHONDRIAL
PENTATRICOPEPTIDE
REPEAT
DOMAIN-CONTAINING
PROTEIN 3,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00338
(Ribosomal_S10)
PF00312
(Ribosomal_S15) 		3 ALA J 153
VAL J 155
TRP o  65
 None
 0.92A 1gmkC-3jd5J:
undetectable
1gmkD-3jd5J:
undetectable		 1gmkC-3jd5J:
31.25
1gmkD-3jd5J:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 3 ALA B 400
VAL B 405
TRP B 126
 None
 0.95A 1gmkC-3jruB:
undetectable
1gmkD-3jruB:
undetectable		 1gmkC-3jruB:
3.02
1gmkD-3jruB:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju1 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Shewanella
oneidensis) 		PF16113
(ECH_2) 		3 ALA A  66
VAL A  68
TRP A  59
 None
 0.99A 1gmkC-3ju1A:
undetectable
1gmkD-3ju1A:
undetectable		 1gmkC-3ju1A:
5.15
1gmkD-3ju1A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		3 ALA A 186
VAL A 188
TRP A  56
 None
 1.00A 1gmkC-3luyA:
undetectable
1gmkD-3luyA:
undetectable		 1gmkC-3luyA:
3.92
1gmkD-3luyA:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1u PUTATIVE
GAMMA-D-GLUTAMYL-L-D
IAMINO ACID
ENDOPEPTIDASE

(Desulfovibrio
vulgaris) 		PF00877
(NLPC_P60)
PF12912
(N_NLPC_P60)
PF12913
(SH3_6)
PF12914
(SH3_7) 		3 ALA A 106
VAL A 104
TRP A 214
 None
 0.95A 1gmkC-3m1uA:
undetectable
1gmkD-3m1uA:
undetectable		 1gmkC-3m1uA:
4.01
1gmkD-3m1uA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		3 ALA A 260
VAL A 262
TRP A 399
 None
 0.92A 1gmkC-3mktA:
undetectable
1gmkD-3mktA:
undetectable		 1gmkC-3mktA:
3.16
1gmkD-3mktA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqy ALPHA CHAIN OF THE
6218-TCR

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ALA D 197
VAL D 147
TRP D 190
 None
 0.77A 1gmkC-3pqyD:
undetectable
1gmkD-3pqyD:
undetectable		 1gmkC-3pqyD:
7.50
1gmkD-3pqyD:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz4 ENDO-1,4-BETA-XYLANA
SE D

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		3 ALA A 219
VAL A 164
TRP A 179
 UNX  A 334 ( 4.9A)
None
None
 0.63A 1gmkC-3qz4A:
undetectable
1gmkD-3qz4A:
undetectable		 1gmkC-3qz4A:
10.34
1gmkD-3qz4A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rby UNCHARACTERIZED
PROTEIN YLR301W

(Saccharomyces
cerevisiae) 		PF16815
(HRI1) 		3 ALA A   3
VAL A 132
TRP A 175
 None
 1.00A 1gmkC-3rbyA:
undetectable
1gmkD-3rbyA:
undetectable		 1gmkC-3rbyA:
6.17
1gmkD-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tat TYROSINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 ALA A 314
VAL A 309
TRP A 319
 None
 0.85A 1gmkC-3tatA:
undetectable
1gmkD-3tatA:
undetectable		 1gmkC-3tatA:
3.58
1gmkD-3tatA:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		3 ALA A 150
VAL A 152
TRP A 105
 None
 0.96A 1gmkC-3tfoA:
undetectable
1gmkD-3tfoA:
undetectable		 1gmkC-3tfoA:
4.67
1gmkD-3tfoA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3th6 TRIOSEPHOSPHATE
ISOMERASE

(Rhipicephalus
microplus) 		PF00121
(TIM) 		3 ALA A 198
VAL A 196
TRP A 157
 None
 0.84A 1gmkC-3th6A:
undetectable
1gmkD-3th6A:
undetectable		 1gmkC-3th6A:
5.19
1gmkD-3th6A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		3 ALA A 394
VAL A 388
TRP A 397
 None
 0.91A 1gmkC-3ut2A:
undetectable
1gmkD-3ut2A:
undetectable		 1gmkC-3ut2A:
3.08
1gmkD-3ut2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		3 ALA A  52
VAL A  55
TRP A 363
 None
 0.74A 1gmkC-3wwxA:
undetectable
1gmkD-3wwxA:
undetectable		 1gmkC-3wwxA:
8.15
1gmkD-3wwxA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxl HIAXHD3

(Humicola
insolens) 		PF04616
(Glyco_hydro_43) 		3 ALA A 102
VAL A 104
TRP A 108
 None
None
B3P  A1560 (-3.6A)
 1.02A 1gmkC-3zxlA:
undetectable
1gmkD-3zxlA:
undetectable		 1gmkC-3zxlA:
2.92
1gmkD-3zxlA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0k CULLIN-4A

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 ALA A 320
VAL A 375
TRP A 340
 None
 0.93A 1gmkC-4a0kA:
undetectable
1gmkD-4a0kA:
undetectable		 1gmkC-4a0kA:
6.47
1gmkD-4a0kA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 401
VAL A 366
TRP A 509
 None
 1.00A 1gmkC-4e1jA:
undetectable
1gmkD-4e1jA:
undetectable		 1gmkC-4e1jA:
2.80
1gmkD-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ALA A 313
VAL A 317
TRP A 282
 None
 1.02A 1gmkC-4gi2A:
undetectable
1gmkD-4gi2A:
undetectable		 1gmkC-4gi2A:
5.09
1gmkD-4gi2A:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		3 ALA A 275
VAL A 280
TRP A 353
 None
 1.00A 1gmkC-4gklA:
undetectable
1gmkD-4gklA:
undetectable		 1gmkC-4gklA:
4.47
1gmkD-4gklA:
4.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		3 ALA A 241
VAL A 246
TRP A 137
 None
 1.00A 1gmkC-4gmfA:
undetectable
1gmkD-4gmfA:
undetectable		 1gmkC-4gmfA:
4.39
1gmkD-4gmfA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hi4 AEROTAXIS TRANSDUCER
AER2

(Pseudomonas
aeruginosa) 		PF13188
(PAS_8) 		3 ALA A 184
VAL A 202
TRP A 283
 None
 0.93A 1gmkC-4hi4A:
undetectable
1gmkD-4hi4A:
undetectable		 1gmkC-4hi4A:
8.74
1gmkD-4hi4A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		3 ALA A1373
VAL A1371
TRP A1402
 None
 0.86A 1gmkC-4iglA:
undetectable
1gmkD-4iglA:
undetectable		 1gmkC-4iglA:
0.96
1gmkD-4iglA:
0.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0x RIBOSOMAL
RNA-PROCESSING
PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 ALA A 517
VAL A 520
TRP A 492
 None
 1.02A 1gmkC-4j0xA:
undetectable
1gmkD-4j0xA:
undetectable		 1gmkC-4j0xA:
4.73
1gmkD-4j0xA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpq UNCHARACTERIZED
PROTEIN

(Bacteroides
uniformis) 		PF16011
(CBM9_2) 		3 ALA A 101
VAL A 103
TRP A 185
 None
 0.77A 1gmkC-4jpqA:
undetectable
1gmkD-4jpqA:
undetectable		 1gmkC-4jpqA:
8.11
1gmkD-4jpqA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdr 3-DEMETHYLUBIQUINONE
-9
3-METHYLTRANSFERASE

(Escherichia
coli) 		PF13489
(Methyltransf_23) 		3 ALA A  98
VAL A  93
TRP A  27
 None
 0.94A 1gmkC-4kdrA:
undetectable
1gmkD-4kdrA:
undetectable		 1gmkC-4kdrA:
9.48
1gmkD-4kdrA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		3 ALA A 293
VAL A 111
TRP A  92
 None
 0.83A 1gmkC-4kemA:
undetectable
1gmkD-4kemA:
undetectable		 1gmkC-4kemA:
5.70
1gmkD-4kemA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		3 ALA A 217
VAL A 219
TRP A  26
 None
 0.92A 1gmkC-4lmvA:
undetectable
1gmkD-4lmvA:
undetectable		 1gmkC-4lmvA:
9.17
1gmkD-4lmvA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m64 MELIBIOSE CARRIER
PROTEIN

(Salmonella
enterica) 		PF13347
(MFS_2) 		3 ALA A 242
VAL A 376
TRP A 342
 None
 0.82A 1gmkC-4m64A:
undetectable
1gmkD-4m64A:
undetectable		 1gmkC-4m64A:
4.00
1gmkD-4m64A:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbr HYPOTHETICAL
3-OXOACYL-(ACYL-CARR
IER PROTEIN)
REDUCTASE

(Brucella
abortus) 		PF13561
(adh_short_C2) 		3 ALA A 119
VAL A 115
TRP A 116
 None
 1.00A 1gmkC-4nbrA:
undetectable
1gmkD-4nbrA:
undetectable		 1gmkC-4nbrA:
5.74
1gmkD-4nbrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		3 ALA A  29
VAL A  40
TRP A  42
 None
 1.01A 1gmkC-4nbwA:
undetectable
1gmkD-4nbwA:
undetectable		 1gmkC-4nbwA:
4.78
1gmkD-4nbwA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2h PROTEIN BCAM1869

(Burkholderia
cenocepacia) 		PF16245
(DUF4902) 		3 ALA A  34
VAL A 129
TRP A  77
 None
 1.01A 1gmkC-4o2hA:
undetectable
1gmkD-4o2hA:
undetectable		 1gmkC-4o2hA:
10.08
1gmkD-4o2hA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obt TRIOSEPHOSPHATE
ISOMERASE, CYTOSOLIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		3 ALA A 199
VAL A 197
TRP A 158
 None
 0.93A 1gmkC-4obtA:
undetectable
1gmkD-4obtA:
undetectable		 1gmkC-4obtA:
6.35
1gmkD-4obtA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN

(Orthohepevirus
A) 		PF03014
(SP2) 		3 ALA A 507
VAL A 503
TRP A 472
 None
 0.99A 1gmkC-4pljA:
undetectable
1gmkD-4pljA:
undetectable		 1gmkC-4pljA:
16.07
1gmkD-4pljA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		3 ALA A 190
VAL A 170
TRP A 134
 None
 0.96A 1gmkC-4ptxA:
undetectable
1gmkD-4ptxA:
undetectable		 1gmkC-4ptxA:
2.50
1gmkD-4ptxA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkc AROMATIC AMINO ACID
AMINOTRANSFERASE

(Psychrobacter
sp. B6) 		PF00155
(Aminotran_1_2) 		3 ALA A 302
VAL A 297
TRP A 307
 None
 0.77A 1gmkC-4rkcA:
undetectable
1gmkD-4rkcA:
undetectable		 1gmkC-4rkcA:
2.62
1gmkD-4rkcA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz5 PUTATIVE SECRETED
PROTEIN

(Streptomyces
sp. SirexAA-E) 		no annotation 3 ALA A 190
VAL A 172
TRP A 170
 None
 0.93A 1gmkC-4tz5A:
undetectable
1gmkD-4tz5A:
undetectable		 1gmkC-4tz5A:
3.34
1gmkD-4tz5A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		3 ALA A 302
VAL A 297
TRP A 307
 None
 0.77A 1gmkC-4wd2A:
undetectable
1gmkD-4wd2A:
undetectable		 1gmkC-4wd2A:
3.93
1gmkD-4wd2A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		3 ALA A  60
VAL A 165
TRP A  11
 None
 0.87A 1gmkC-4x0oA:
undetectable
1gmkD-4x0oA:
undetectable		 1gmkC-4x0oA:
3.51
1gmkD-4x0oA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhb SIALIDASE B

(Streptococcus
pneumoniae) 		PF02012
(BNR)
PF02973
(Sialidase)
PF13088
(BNR_2) 		3 ALA A  78
VAL A 142
TRP A 134
 None
 0.82A 1gmkC-4xhbA:
undetectable
1gmkD-4xhbA:
undetectable		 1gmkC-4xhbA:
1.92
1gmkD-4xhbA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		3 ALA A 227
VAL A 222
TRP A 232
 None
 0.98A 1gmkC-5bp8A:
undetectable
1gmkD-5bp8A:
undetectable		 1gmkC-5bp8A:
2.94
1gmkD-5bp8A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c08 1E6 TCR ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		3 ALA D 183
VAL D 133
TRP D 176
 None
 0.87A 1gmkC-5c08D:
undetectable
1gmkD-5c08D:
undetectable		 1gmkC-5c08D:
5.75
1gmkD-5c08D:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c30 RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF02026
(RyR) 		3 ALA A1002
VAL A 995
TRP A1005
 None
 0.98A 1gmkC-5c30A:
undetectable
1gmkD-5c30A:
undetectable		 1gmkC-5c30A:
5.56
1gmkD-5c30A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		3 ALA A 275
VAL A 392
TRP A 391
 None
 0.93A 1gmkC-5c9iA:
undetectable
1gmkD-5c9iA:
undetectable		 1gmkC-5c9iA:
2.18
1gmkD-5c9iA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cc8 THIAMINE-MONOPHOSPHA
TE KINASE

(Acinetobacter
baumannii) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ALA A 131
VAL A  39
TRP A 134
 None
 0.95A 1gmkC-5cc8A:
undetectable
1gmkD-5cc8A:
undetectable		 1gmkC-5cc8A:
5.83
1gmkD-5cc8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		3 ALA B 573
VAL B 593
TRP B 589
 None
 1.02A 1gmkC-5do7B:
undetectable
1gmkD-5do7B:
undetectable		 1gmkC-5do7B:
2.71
1gmkD-5do7B:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		3 ALA A 159
VAL A 172
TRP A 152
 None
 0.75A 1gmkC-5e5uA:
undetectable
1gmkD-5e5uA:
undetectable		 1gmkC-5e5uA:
5.08
1gmkD-5e5uA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A 575
VAL A 577
TRP A 568
 None
 0.99A 1gmkC-5erbA:
undetectable
1gmkD-5erbA:
undetectable		 1gmkC-5erbA:
2.86
1gmkD-5erbA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyw TRIOSEPHOSPHATE
ISOMERASE

(Litopenaeus
vannamei) 		PF00121
(TIM) 		3 ALA A 199
VAL A 197
TRP A 158
 None
 1.00A 1gmkC-5eywA:
undetectable
1gmkD-5eywA:
undetectable		 1gmkC-5eywA:
6.42
1gmkD-5eywA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guw NITRIC OXIDE
REDUCTASE SUBUNIT C

(Pseudomonas
aeruginosa) 		PF00034
(Cytochrom_C) 		3 ALA A 126
VAL A  49
TRP A 131
 None
 0.98A 1gmkC-5guwA:
undetectable
1gmkD-5guwA:
undetectable		 1gmkC-5guwA:
8.51
1gmkD-5guwA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ALA H  33
VAL H  93
TRP H  36
 None
 0.77A 1gmkC-5ihuH:
undetectable
1gmkD-5ihuH:
undetectable		 1gmkC-5ihuH:
5.56
1gmkD-5ihuH:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		3 ALA A 494
VAL A 489
TRP A 108
 None
 0.86A 1gmkC-5j90A:
undetectable
1gmkD-5j90A:
undetectable		 1gmkC-5j90A:
3.64
1gmkD-5j90A:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		3 ALA A 572
VAL A 570
TRP A 602
 None
 0.99A 1gmkC-5jbgA:
undetectable
1gmkD-5jbgA:
undetectable		 1gmkC-5jbgA:
2.18
1gmkD-5jbgA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 3 ALA A 123
VAL A 115
TRP A 172
 None
 0.94A 1gmkC-5jnmA:
undetectable
1gmkD-5jnmA:
undetectable		 1gmkC-5jnmA:
3.09
1gmkD-5jnmA:
3.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		3 ALA A 313
VAL A 361
TRP A 440
 None
 0.90A 1gmkC-5l9wA:
undetectable
1gmkD-5l9wA:
undetectable		 1gmkC-5l9wA:
2.05
1gmkD-5l9wA:
2.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly3 ACTIN/ACTIN FAMILY
PROTEIN

(Pyrobaculum
calidifontis) 		PF00022
(Actin) 		3 ALA A 158
VAL A 127
TRP A 125
 None
 1.00A 1gmkC-5ly3A:
undetectable
1gmkD-5ly3A:
undetectable		 1gmkC-5ly3A:
3.57
1gmkD-5ly3A:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 ALA A  27
VAL A  95
TRP A 100
 None
 0.99A 1gmkC-5mchA:
undetectable
1gmkD-5mchA:
undetectable		 1gmkC-5mchA:
3.08
1gmkD-5mchA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		3 ALA A  51
VAL A 182
TRP A  48
 None
 1.01A 1gmkC-5szsA:
undetectable
1gmkD-5szsA:
undetectable		 1gmkC-5szsA:
1.75
1gmkD-5szsA:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvs ALCOHOL
DEHYDROGENASE

(candidate
divison MSBL1
archaeon
SCGC-AAA259E19) 		no annotation 3 ALA A 145
VAL A 182
TRP A  29
 None
 1.00A 1gmkC-5yvsA:
undetectable
1gmkD-5yvsA:
undetectable		 1gmkC-5yvsA:
undetectable
1gmkD-5yvsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 3 ALA A 245
VAL A 193
TRP A 285
 None
 0.93A 1gmkC-5zctA:
undetectable
1gmkD-5zctA:
undetectable		 1gmkC-5zctA:
undetectable
1gmkD-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 3 ALA A  54
VAL A  44
TRP A  46
 None
 1.01A 1gmkC-5zmyA:
undetectable
1gmkD-5zmyA:
undetectable		 1gmkC-5zmyA:
undetectable
1gmkD-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT OST5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 ALA 5  29
VAL 5  76
TRP 1 245
 None
 0.99A 1gmkC-6c265:
undetectable
1gmkD-6c265:
undetectable		 1gmkC-6c265:
undetectable
1gmkD-6c265:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 3 ALA A 221
VAL A 226
TRP A 260
 None
 1.02A 1gmkC-6cf8A:
undetectable
1gmkD-6cf8A:
undetectable		 1gmkC-6cf8A:
undetectable
1gmkD-6cf8A:
undetectable