SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_B_DVAB6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		4 VAL A  96
TRP A 112
ALA A   8
VAL A 123
 None
 1.30A 1gmkA-1dp2A:
undetectable
1gmkB-1dp2A:
undetectable		 1gmkA-1dp2A:
4.86
1gmkB-1dp2A:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kmq TRANSFORMING PROTEIN
RHOA

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A  79
TRP A  58
ALA A  56
VAL A   9
 None
 1.41A 1gmkA-1kmqA:
undetectable
1gmkB-1kmqA:
undetectable		 1gmkA-1kmqA:
6.36
1gmkB-1kmqA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE
SUBUNIT C2

(Methylococcus
capsulatus) 		PF04896
(AmoC) 		4 VAL C 139
TRP C 137
ALA C 191
VAL C 136
 None
 1.38A 1gmkA-1yewC:
undetectable
1gmkB-1yewC:
undetectable		 1gmkA-1yewC:
5.63
1gmkB-1yewC:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 VAL A1358
TRP A1368
ALA A1370
VAL A1360
 None
 1.20A 1gmkA-2bruA:
undetectable
1gmkB-2bruA:
undetectable		 1gmkA-2bruA:
3.11
1gmkB-2bruA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a58 GTP-BINDING PROTEIN
RHO1

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 VAL B  84
TRP B  63
ALA B  61
VAL B  14
 None
 1.37A 1gmkA-3a58B:
undetectable
1gmkB-3a58B:
undetectable		 1gmkA-3a58B:
11.88
1gmkB-3a58B:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaj PUTATIVE
RING-CLEAVING
DIOXYGENASE MHQO

(Bacillus
subtilis) 		PF00903
(Glyoxalase) 		4 VAL A  86
TRP A  95
ALA A 150
VAL A  87
 None
 1.41A 1gmkA-3oajA:
undetectable
1gmkB-3oajA:
undetectable		 1gmkA-3oajA:
4.72
1gmkB-3oajA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ub0 NON-STRUCTURAL
PROTEIN 6, NSP6,

(Alphacoronavirus
1) 		PF08717
(nsp8) 		4 VAL A 141
TRP A 154
ALA A 152
VAL A 147
 None
 1.18A 1gmkA-3ub0A:
undetectable
1gmkB-3ub0A:
undetectable		 1gmkA-3ub0A:
5.88
1gmkB-3ub0A:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 VAL A 150
TRP A 247
ALA A 196
VAL A 193
 None
 1.46A 1gmkA-3w6mA:
undetectable
1gmkB-3w6mA:
undetectable		 1gmkA-3w6mA:
3.53
1gmkB-3w6mA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ibn RIBONUCLEASE H

(uncultured
organism) 		PF00075
(RNase_H) 		4 VAL A 213
TRP A 116
ALA A 112
VAL A 214
 None
 1.39A 1gmkA-4ibnA:
undetectable
1gmkB-4ibnA:
undetectable		 1gmkA-4ibnA:
10.53
1gmkB-4ibnA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		4 VAL A 140
TRP A 146
ALA A 333
VAL A 143
 None
 1.33A 1gmkA-4tw0A:
undetectable
1gmkB-4tw0A:
undetectable		 1gmkA-4tw0A:
7.48
1gmkB-4tw0A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 VAL B 389
TRP B 528
ALA B 527
VAL B 388
 None
 1.12A 1gmkA-5b3gB:
undetectable
1gmkB-5b3gB:
undetectable		 1gmkA-5b3gB:
5.75
1gmkB-5b3gB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SCARECROW

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 VAL A 520
TRP A 649
ALA A 648
VAL A 519
 None
 1.13A 1gmkA-5b3hA:
undetectable
1gmkB-5b3hA:
undetectable		 1gmkA-5b3hA:
9.76
1gmkB-5b3hA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		4 VAL B 389
TRP B 528
ALA B 527
VAL B 388
 None
 1.16A 1gmkA-5b3hB:
undetectable
1gmkB-5b3hB:
undetectable		 1gmkA-5b3hB:
5.75
1gmkB-5b3hB:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2k TRANSFORMING PROTEIN
RHOA,RAC
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00071
(Ras)
PF00620
(RhoGAP) 		4 VAL A  79
TRP A  58
ALA A  56
VAL A   9
 None
 1.39A 1gmkA-5c2kA:
undetectable
1gmkB-5c2kA:
undetectable		 1gmkA-5c2kA:
3.06
1gmkB-5c2kA:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		4 VAL A 488
TRP A 557
ALA A 554
VAL A 484
 None
 1.40A 1gmkA-5ejjA:
undetectable
1gmkB-5ejjA:
undetectable		 1gmkA-5ejjA:
5.08
1gmkB-5ejjA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 VAL A1060
TRP A1186
ALA A1057
VAL A1059
 None
 1.26A 1gmkA-5fxvA:
undetectable
1gmkB-5fxvA:
undetectable		 1gmkA-5fxvA:
2.78
1gmkB-5fxvA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcp ARF-GAP WITH RHO-GAP
DOMAIN, ANK REPEAT
AND PH
DOMAIN-CONTAINING
PROTEIN
3,LINKER,TRANSFORMIN
G PROTEIN RHOA

(Homo sapiens;
synthetic
construct) 		no annotation 4 VAL B  79
TRP B  58
ALA B  56
VAL B   9
 None
 1.42A 1gmkA-5jcpB:
undetectable
1gmkB-5jcpB:
undetectable		 1gmkA-5jcpB:
3.05
1gmkB-5jcpB:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 VAL A  80
TRP A  86
ALA A  83
VAL A  81
 None
 1.32A 1gmkA-5olpA:
undetectable
1gmkB-5olpA:
undetectable		 1gmkA-5olpA:
8.80
1gmkB-5olpA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY

(Vibrio cholerae) 		PF00939
(Na_sulph_symp) 		4 VAL A 401
TRP A 217
ALA A 207
VAL A 405
 None
 1.35A 1gmkA-5uldA:
undetectable
1gmkB-5uldA:
undetectable		 1gmkA-5uldA:
2.97
1gmkB-5uldA:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5k NETRIN RECEPTOR DCC

(Rattus
norvegicus) 		no annotation 4 VAL A 190
TRP A 173
ALA A 196
VAL A 191
 None
 1.40A 1gmkA-5z5kA:
undetectable
1gmkB-5z5kA:
undetectable		 1gmkA-5z5kA:
undetectable
1gmkB-5z5kA:
undetectable