SIMILAR PATTERNS OF AMINO ACIDS FOR 1GMK_A_DVAA8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		3 VAL A 315
TRP A 120
TRP A 314
 None
 1.33A 1gmkA-1cn3A:
undetectable
1gmkB-1cn3A:
undetectable		 1gmkA-1cn3A:
4.64
1gmkB-1cn3A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 VAL A 429
TRP A 434
TRP A 436
 None
 1.22A 1gmkA-1dnpA:
undetectable
1gmkB-1dnpA:
undetectable		 1gmkA-1dnpA:
3.23
1gmkB-1dnpA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eqc EXO-(B)-(1,3)-GLUCAN
ASE

(Candida
albicans) 		PF00150
(Cellulase) 		3 VAL A  14
TRP A 131
TRP A 360
 None
 1.03A 1gmkA-1eqcA:
undetectable
1gmkB-1eqcA:
undetectable		 1gmkA-1eqcA:
4.33
1gmkB-1eqcA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 VAL A 431
TRP A 370
TRP A 375
 None
 1.38A 1gmkA-1ex0A:
undetectable
1gmkB-1ex0A:
undetectable		 1gmkA-1ex0A:
1.69
1gmkB-1ex0A:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g5i MITOCHONDRIAL DNA
POLYMERASE ACCESSORY
SUBUNIT

(Mus musculus) 		PF03129
(HGTP_anticodon) 		3 VAL A  94
TRP A 236
TRP A  89
 None
 1.27A 1gmkA-1g5iA:
undetectable
1gmkB-1g5iA:
undetectable		 1gmkA-1g5iA:
5.37
1gmkB-1g5iA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idt MINOR FMN-DEPENDENT
NITROREDUCTASE

(Escherichia
coli) 		PF00881
(Nitroreductase) 		3 VAL A 143
TRP A 138
TRP A  46
 None
 1.23A 1gmkA-1idtA:
undetectable
1gmkB-1idtA:
undetectable		 1gmkA-1idtA:
7.91
1gmkB-1idtA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		3 VAL A  58
TRP A 367
TRP A  59
 None
 1.37A 1gmkA-1j5sA:
undetectable
1gmkB-1j5sA:
undetectable		 1gmkA-1j5sA:
5.24
1gmkB-1j5sA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji8 DISSIMILATORY
SIROHEME-SULFITE
REDUCTASE

(Pyrobaculum
aerophilum) 		PF04358
(DsrC) 		3 VAL A 101
TRP A  63
TRP A  30
 None
 0.98A 1gmkA-1ji8A:
undetectable
1gmkB-1ji8A:
undetectable		 1gmkA-1ji8A:
16.13
1gmkB-1ji8A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		3 VAL A 338
TRP A 332
TRP A 378
 None
 1.27A 1gmkA-1kfwA:
undetectable
1gmkB-1kfwA:
undetectable		 1gmkA-1kfwA:
3.19
1gmkB-1kfwA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mus TN5 TRANSPOSASE

(Escherichia
coli) 		PF01609
(DDE_Tnp_1)
PF02281
(Dimer_Tnp_Tn5)
PF14706
(Tnp_DNA_bind) 		3 VAL A 361
TRP A 450
TRP A  12
 None
EDO  A 483 (-4.5A)
None
 1.09A 1gmkA-1musA:
undetectable
1gmkB-1musA:
undetectable		 1gmkA-1musA:
4.17
1gmkB-1musA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		3 VAL A 102
TRP A  99
TRP A 311
 None
 1.28A 1gmkA-1pz3A:
undetectable
1gmkB-1pz3A:
undetectable		 1gmkA-1pz3A:
3.71
1gmkB-1pz3A:
3.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0p COMPLEMENT FACTOR B

(Homo sapiens) 		PF00092
(VWA) 		3 VAL A 310
TRP A 296
TRP A 309
 None
 1.37A 1gmkA-1q0pA:
undetectable
1gmkB-1q0pA:
undetectable		 1gmkA-1q0pA:
17.02
1gmkB-1q0pA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1q SULFOTRANSFERASE
FAMILY, CYTOSOLIC,
2B, MEMBER 1 ISOFORM
A

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 139
TRP A 174
TRP A 266
 NHE  A 353 ( 4.0A)
None
None
 1.27A 1gmkA-1q1qA:
undetectable
1gmkB-1q1qA:
undetectable		 1gmkA-1q1qA:
7.43
1gmkB-1q1qA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		3 VAL A 310
TRP A 296
TRP A 309
 None
 1.39A 1gmkA-1rtkA:
undetectable
1gmkB-1rtkA:
undetectable		 1gmkA-1rtkA:
4.00
1gmkB-1rtkA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shm ANTIBODY RIG

(Lama glama) 		PF07686
(V-set) 		3 VAL A  48
TRP A  99
TRP A  36
 None
 1.16A 1gmkA-1shmA:
undetectable
1gmkB-1shmA:
undetectable		 1gmkA-1shmA:
8.55
1gmkB-1shmA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te1 ENDO-1,4-XYLANASE

(Talaromyces
funiculosus) 		PF00457
(Glyco_hydro_11) 		3 VAL B  84
TRP B 137
TRP B  78
 None
 1.37A 1gmkA-1te1B:
undetectable
1gmkB-1te1B:
undetectable		 1gmkA-1te1B:
6.67
1gmkB-1te1B:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1te5 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF13230
(GATase_4) 		3 VAL A 245
TRP A 180
TRP A 244
 None
 1.39A 1gmkA-1te5A:
undetectable
1gmkB-1te5A:
undetectable		 1gmkA-1te5A:
7.88
1gmkB-1te5A:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		3 VAL A 140
TRP A 173
TRP A 113
 None
 1.19A 1gmkA-1tisA:
undetectable
1gmkB-1tisA:
undetectable		 1gmkA-1tisA:
7.47
1gmkB-1tisA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn6 HYPOTHETICAL PROTEIN
BC4709

(Bacillus cereus) 		PF08327
(AHSA1) 		3 VAL A  83
TRP A 104
TRP A  76
 None
 1.25A 1gmkA-1xn6A:
undetectable
1gmkB-1xn6A:
undetectable		 1gmkA-1xn6A:
6.12
1gmkB-1xn6A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylococcus
capsulatus) 		PF02461
(AMO) 		3 VAL B  61
TRP B 152
TRP B  60
 None
 1.15A 1gmkA-1yewB:
undetectable
1gmkB-1yewB:
undetectable		 1gmkA-1yewB:
16.05
1gmkB-1yewB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		3 VAL A 131
TRP A 171
TRP A 108
 None
 0.97A 1gmkA-1yulA:
undetectable
1gmkB-1yulA:
undetectable		 1gmkA-1yulA:
7.25
1gmkB-1yulA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fz5 FLAVODOXIN

(Megasphaera
elsdenii) 		PF00258
(Flavodoxin_1) 		3 VAL A  66
TRP A 100
TRP A   7
 None
 1.15A 1gmkA-2fz5A:
undetectable
1gmkB-2fz5A:
undetectable		 1gmkA-2fz5A:
11.00
1gmkB-2fz5A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2giy GLYCOPROTEIN E

(Human
alphaherpesvirus
1) 		PF02480
(Herpes_gE) 		3 VAL A 261
TRP A 370
TRP A 302
 None
 1.43A 1gmkA-2giyA:
undetectable
1gmkB-2giyA:
undetectable		 1gmkA-2giyA:
6.88
1gmkB-2giyA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hva HEME-BINDING PROTEIN
1

(Mus musculus) 		PF04832
(SOUL) 		3 VAL A 130
TRP A  18
TRP A 186
 None
 1.03A 1gmkA-2hvaA:
undetectable
1gmkB-2hvaA:
undetectable		 1gmkA-2hvaA:
6.78
1gmkB-2hvaA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		3 VAL A 512
TRP A 571
TRP A 578
 None
 1.35A 1gmkA-2jh9A:
undetectable
1gmkB-2jh9A:
undetectable		 1gmkA-2jh9A:
5.85
1gmkB-2jh9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opk HYPOTHETICAL PROTEIN

(Cupriavidus
pinatubonensis) 		PF07883
(Cupin_2) 		3 VAL A 106
TRP A 103
TRP A  55
 None
UNL  A 112 (-3.5A)
None
 0.73A 1gmkA-2opkA:
undetectable
1gmkB-2opkA:
undetectable		 1gmkA-2opkA:
13.98
1gmkB-2opkA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 128
TRP A 163
TRP A 254
 None
 1.33A 1gmkA-2qp4A:
undetectable
1gmkB-2qp4A:
undetectable		 1gmkA-2qp4A:
4.62
1gmkB-2qp4A:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reo PUTATIVE
SULFOTRANSFERASE 1C3

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 146
TRP A 181
TRP A 273
 None
 1.30A 1gmkA-2reoA:
undetectable
1gmkB-2reoA:
undetectable		 1gmkA-2reoA:
3.64
1gmkB-2reoA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		3 VAL A 142
TRP A 166
TRP A 141
 None
 1.29A 1gmkA-2vrkA:
undetectable
1gmkB-2vrkA:
undetectable		 1gmkA-2vrkA:
2.41
1gmkB-2vrkA:
2.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 3 VAL A 191
TRP A 203
TRP A 200
 None
 1.18A 1gmkA-3a0fA:
undetectable
1gmkB-3a0fA:
undetectable		 1gmkA-3a0fA:
2.16
1gmkB-3a0fA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3avs LYSINE-SPECIFIC
DEMETHYLASE 6A

(Homo sapiens) 		PF02373
(JmjC) 		3 VAL A1168
TRP A1194
TRP A1166
 None
 1.35A 1gmkA-3avsA:
undetectable
1gmkB-3avsA:
undetectable		 1gmkA-3avsA:
3.33
1gmkB-3avsA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		3 VAL A 663
TRP A 640
TRP A 552
 None
 1.30A 1gmkA-3c10A:
undetectable
1gmkB-3c10A:
undetectable		 1gmkA-3c10A:
7.64
1gmkB-3c10A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckl SULFOTRANSFERASE
FAMILY CYTOSOLIC 1B
MEMBER 1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 138
TRP A 173
TRP A 265
 None
 1.30A 1gmkA-3cklA:
undetectable
1gmkB-3cklA:
undetectable		 1gmkA-3cklA:
5.33
1gmkB-3cklA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		3 VAL A 127
TRP A 135
TRP A  43
 None
 1.21A 1gmkA-3d34A:
undetectable
1gmkB-3d34A:
undetectable		 1gmkA-3d34A:
9.30
1gmkB-3d34A:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoi PILM

(Escherichia
coli) 		PF07419
(PilM) 		3 VAL A 119
TRP A 122
TRP A  70
 None
 1.36A 1gmkA-3eoiA:
undetectable
1gmkB-3eoiA:
undetectable		 1gmkA-3eoiA:
8.47
1gmkB-3eoiA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3et5 OUTER MEMBRANE
PROTEIN P4, NADP
PHOSPHATASE

(Haemophilus
influenzae) 		PF03767
(Acid_phosphat_B) 		3 VAL A  95
TRP A  78
TRP A  91
 None
 1.08A 1gmkA-3et5A:
undetectable
1gmkB-3et5A:
undetectable		 1gmkA-3et5A:
4.33
1gmkB-3et5A:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd9 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF16806
(ExsD) 		3 VAL A 235
TRP A 240
TRP A 131
 None
 1.09A 1gmkA-3fd9A:
undetectable
1gmkB-3fd9A:
undetectable		 1gmkA-3fd9A:
4.74
1gmkB-3fd9A:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgy UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Paraburkholderia
xenovorans) 		PF12680
(SnoaL_2) 		3 VAL A 103
TRP A  35
TRP A 102
 None
PEG  A 136 (-4.9A)
UNL  A 135 ( 4.0A)
 1.41A 1gmkA-3fgyA:
undetectable
1gmkB-3fgyA:
undetectable		 1gmkA-3fgyA:
8.26
1gmkB-3fgyA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 VAL A 567
TRP A 533
TRP A 564
 None
 1.41A 1gmkA-3gitA:
undetectable
1gmkB-3gitA:
undetectable		 1gmkA-3gitA:
3.93
1gmkB-3gitA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2) 		3 VAL A 254
TRP A 251
TRP A 255
 None
FAD  A1000 (-3.7A)
None
 1.19A 1gmkA-3gyxA:
undetectable
1gmkB-3gyxA:
undetectable		 1gmkA-3gyxA:
2.61
1gmkB-3gyxA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		3 VAL A  87
TRP A  66
TRP A  90
 None
 1.38A 1gmkA-3hoaA:
undetectable
1gmkB-3hoaA:
undetectable		 1gmkA-3hoaA:
2.78
1gmkB-3hoaA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzn OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Salmonella
enterica) 		PF00881
(Nitroreductase) 		3 VAL A 143
TRP A 138
TRP A  46
 None
 1.20A 1gmkA-3hznA:
undetectable
1gmkB-3hznA:
undetectable		 1gmkA-3hznA:
5.74
1gmkB-3hznA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 VAL A 766
TRP A 772
TRP A 740
 None
None
U  P  22 ( 4.7A)
 1.11A 1gmkA-3jb9A:
undetectable
1gmkB-3jb9A:
undetectable		 1gmkA-3jb9A:
1.94
1gmkB-3jb9A:
1.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkj AMINE OXIDASE,
FLAVIN-CONTAINING

(Pseudomonas
syringae group
genomosp. 3) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		3 VAL A  78
TRP A  81
TRP A 103
 None
 1.34A 1gmkA-3kkjA:
undetectable
1gmkB-3kkjA:
undetectable		 1gmkA-3kkjA:
4.19
1gmkB-3kkjA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxe TOXIN PROTEIN PARE-1

(Caulobacter
vibrioides) 		PF05016
(ParE_toxin) 		3 VAL A  27
TRP A  25
TRP A  18
 None
 1.36A 1gmkA-3kxeA:
undetectable
1gmkB-3kxeA:
undetectable		 1gmkA-3kxeA:
6.93
1gmkB-3kxeA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		3 VAL A 335
TRP A 342
TRP A 334
 None
 1.36A 1gmkA-3lm3A:
undetectable
1gmkB-3lm3A:
undetectable		 1gmkA-3lm3A:
3.05
1gmkB-3lm3A:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		3 VAL A 208
TRP A 113
TRP A 139
 None
 0.85A 1gmkA-3m3pA:
undetectable
1gmkB-3m3pA:
undetectable		 1gmkA-3m3pA:
10.37
1gmkB-3m3pA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pct CLASS C ACID
PHOSPHATASE

(Pasteurella
multocida) 		PF03767
(Acid_phosphat_B) 		3 VAL A  94
TRP A  77
TRP A  90
 None
 1.08A 1gmkA-3pctA:
undetectable
1gmkB-3pctA:
undetectable		 1gmkA-3pctA:
5.18
1gmkB-3pctA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		3 VAL A 137
TRP A 172
TRP A 264
 None
 1.30A 1gmkA-3qvuA:
undetectable
1gmkB-3qvuA:
undetectable		 1gmkA-3qvuA:
4.78
1gmkB-3qvuA:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rby UNCHARACTERIZED
PROTEIN YLR301W

(Saccharomyces
cerevisiae) 		PF16815
(HRI1) 		3 VAL A  71
TRP A 102
TRP A  99
 None
None
PGE  A 701 (-4.1A)
 1.24A 1gmkA-3rbyA:
undetectable
1gmkB-3rbyA:
undetectable		 1gmkA-3rbyA:
6.17
1gmkB-3rbyA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 VAL A 337
TRP A 343
TRP A 319
 SO4  A 554 (-3.9A)
None
None
 0.99A 1gmkA-3rcnA:
undetectable
1gmkB-3rcnA:
undetectable		 1gmkA-3rcnA:
3.88
1gmkB-3rcnA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Cryptococcus
neoformans) 		PF01239
(PPTA) 		3 VAL A 287
TRP A 326
TRP A 231
 None
 1.38A 1gmkA-3sfyA:
undetectable
1gmkB-3sfyA:
undetectable		 1gmkA-3sfyA:
6.56
1gmkB-3sfyA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4a JMB19063

(compost
metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 VAL A 143
TRP A 400
TRP A 140
 None
 1.35A 1gmkA-3u4aA:
undetectable
1gmkB-3u4aA:
undetectable		 1gmkA-3u4aA:
1.89
1gmkB-3u4aA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
ALPHA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		3 VAL A 138
TRP A  53
TRP A  61
 None
 1.32A 1gmkA-3vsjA:
undetectable
1gmkB-3vsjA:
undetectable		 1gmkA-3vsjA:
12.75
1gmkB-3vsjA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w95 GENOME POLYPROTEIN

(Enterovirus A) 		PF00947
(Pico_P2A) 		3 VAL A  32
TRP A  28
TRP A  33
 None
 1.18A 1gmkA-3w95A:
undetectable
1gmkB-3w95A:
undetectable		 1gmkA-3w95A:
8.21
1gmkB-3w95A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 3 VAL A  28
TRP A  22
TRP A  29
 None
SO4  A 501 (-4.8A)
None
 1.26A 1gmkA-3wvrA:
undetectable
1gmkB-3wvrA:
undetectable		 1gmkA-3wvrA:
5.12
1gmkB-3wvrA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A 143
TRP A 178
TRP A 140
 None
CU  A 602 ( 4.9A)
None
 1.23A 1gmkA-3zx1A:
undetectable
1gmkB-3zx1A:
undetectable		 1gmkA-3zx1A:
5.08
1gmkB-3zx1A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ao7 ESTERASE

(unidentified) 		PF12146
(Hydrolase_4) 		3 VAL A  70
TRP A 141
TRP A  36
 None
 1.31A 1gmkA-4ao7A:
undetectable
1gmkB-4ao7A:
undetectable		 1gmkA-4ao7A:
9.45
1gmkB-4ao7A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dve BIOTIN TRANSPORTER
BIOY

(Lactococcus
lactis) 		PF02632
(BioY) 		3 VAL A 133
TRP A 140
TRP A  96
 None
None
BTN  A 201 ( 4.8A)
 1.31A 1gmkA-4dveA:
undetectable
1gmkB-4dveA:
undetectable		 1gmkA-4dveA:
14.46
1gmkB-4dveA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9x MULTICOPPER OXIDASE

(uncultured
bacterium) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 VAL A1064
TRP A1102
TRP A1061
 None
CU  A1402 (-4.2A)
None
 0.99A 1gmkA-4e9xA:
undetectable
1gmkB-4e9xA:
undetectable		 1gmkA-4e9xA:
4.50
1gmkB-4e9xA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 VAL A 484
TRP A 290
TRP A 297
 None
 0.62A 1gmkA-4fffA:
undetectable
1gmkB-4fffA:
undetectable		 1gmkA-4fffA:
4.67
1gmkB-4fffA:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmg VP1

(Human
polyomavirus 5) 		PF00718
(Polyoma_coat) 		3 VAL A 318
TRP A 123
TRP A 317
 None
 1.34A 1gmkA-4fmgA:
undetectable
1gmkB-4fmgA:
undetectable		 1gmkA-4fmgA:
5.18
1gmkB-4fmgA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls9 DHH FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 VAL A 295
TRP A 258
TRP A 293
 None
 1.22A 1gmkA-4ls9A:
undetectable
1gmkB-4ls9A:
undetectable		 1gmkA-4ls9A:
5.06
1gmkB-4ls9A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		3 VAL A  87
TRP A  79
TRP A  90
 None
PEG  A 401 ( 4.6A)
None
 1.12A 1gmkA-4mdyA:
undetectable
1gmkB-4mdyA:
undetectable		 1gmkA-4mdyA:
7.32
1gmkB-4mdyA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlz PERIPLASMIC BINDING
PROTEIN

(Jonesia
denitrificans) 		PF01497
(Peripla_BP_2) 		3 VAL A 246
TRP A 296
TRP A 273
 None
 1.26A 1gmkA-4mlzA:
undetectable
1gmkB-4mlzA:
undetectable		 1gmkA-4mlzA:
5.19
1gmkB-4mlzA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		3 VAL A 172
TRP A 183
TRP A 206
 None
 1.09A 1gmkA-4noxA:
undetectable
1gmkB-4noxA:
undetectable		 1gmkA-4noxA:
8.11
1gmkB-4noxA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A

(Mus musculus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 VAL A  39
TRP A 168
TRP A  68
 None
 1.26A 1gmkA-4pirA:
undetectable
1gmkB-4pirA:
undetectable		 1gmkA-4pirA:
4.05
1gmkB-4pirA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pm4 IRON COMPLEX
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Mycobacterium
tuberculosis) 		PF01497
(Peripla_BP_2) 		3 VAL A  66
TRP A  58
TRP A  69
 None
 1.16A 1gmkA-4pm4A:
undetectable
1gmkB-4pm4A:
undetectable		 1gmkA-4pm4A:
8.50
1gmkB-4pm4A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 VAL B 628
TRP B 631
TRP B 463
 None
 1.35A 1gmkA-4qiwB:
undetectable
1gmkB-4qiwB:
undetectable		 1gmkA-4qiwB:
0.98
1gmkB-4qiwB:
0.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE

(Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 VAL A 895
TRP A 883
TRP A 570
 None
 1.37A 1gmkA-4qiwA:
undetectable
1gmkB-4qiwA:
undetectable		 1gmkA-4qiwA:
2.30
1gmkB-4qiwA:
2.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7k HYPOTHETICAL PROTEIN
JHP0584

(Helicobacter
pylori) 		no annotation 3 VAL A  85
TRP A  13
TRP A  99
 None
 1.15A 1gmkA-4r7kA:
undetectable
1gmkB-4r7kA:
undetectable		 1gmkA-4r7kA:
12.35
1gmkB-4r7kA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF08662
(eIF2A) 		3 VAL A 463
TRP A 499
TRP A 515
 None
 1.18A 1gmkA-4u1fA:
undetectable
1gmkB-4u1fA:
undetectable		 1gmkA-4u1fA:
3.50
1gmkB-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri) 		PF00318
(Ribosomal_S2) 		3 VAL b 529
TRP b 565
TRP b 581
 None
 1.14A 1gmkA-4uerb:
undetectable
1gmkB-4uerb:
undetectable		 1gmkA-4uerb:
2.02
1gmkB-4uerb:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		3 VAL A 463
TRP A 421
TRP A 395
 None
 1.22A 1gmkA-4y93A:
undetectable
1gmkB-4y93A:
undetectable		 1gmkA-4y93A:
2.60
1gmkB-4y93A:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		3 VAL A  32
TRP A  37
TRP A  35
 None
 1.00A 1gmkA-4ymgA:
undetectable
1gmkB-4ymgA:
undetectable		 1gmkA-4ymgA:
6.39
1gmkB-4ymgA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 VAL B 120
TRP B 262
TRP B 115
 None
 1.19A 1gmkA-4ztuB:
undetectable
1gmkB-4ztuB:
undetectable		 1gmkA-4ztuB:
4.63
1gmkB-4ztuB:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 VAL B 120
TRP B 262
TRP B 115
 None
 1.19A 1gmkA-5c53B:
undetectable
1gmkB-5c53B:
undetectable		 1gmkA-5c53B:
2.09
1gmkB-5c53B:
2.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 VAL A 439
TRP A 465
TRP A 663
 SO4  A 801 (-3.8A)
None
SO4  A 801 (-4.4A)
 1.37A 1gmkA-5f56A:
undetectable
1gmkB-5f56A:
undetectable		 1gmkA-5f56A:
2.35
1gmkB-5f56A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		3 VAL A 655
TRP A 660
TRP A 658
 None
 1.05A 1gmkA-5hb3A:
undetectable
1gmkB-5hb3A:
undetectable		 1gmkA-5hb3A:
2.68
1gmkB-5hb3A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iw4 NADH PYROPHOSPHATASE

(Escherichia
coli) 		PF00293
(NUDIX)
PF09297
(zf-NADH-PPase) 		3 VAL A  57
TRP A 112
TRP A  55
 None
 1.07A 1gmkA-5iw4A:
undetectable
1gmkB-5iw4A:
undetectable		 1gmkA-5iw4A:
5.02
1gmkB-5iw4A:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8d OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Enterobacter
cloacae) 		PF00881
(Nitroreductase) 		3 VAL A 143
TRP A 138
TRP A  46
 None
 1.21A 1gmkA-5j8dA:
undetectable
1gmkB-5j8dA:
undetectable		 1gmkA-5j8dA:
5.21
1gmkB-5j8dA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 VAL A 291
TRP A 254
TRP A 289
 None
 1.34A 1gmkA-5jjuA:
undetectable
1gmkB-5jjuA:
undetectable		 1gmkA-5jjuA:
4.90
1gmkB-5jjuA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel C13C6 VARIABLE FAB
DOMAIN HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		3 VAL C  35
TRP C  47
TRP C  52
 None
 1.23A 1gmkA-5kelC:
undetectable
1gmkB-5kelC:
undetectable		 1gmkA-5kelC:
18.18
1gmkB-5kelC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m58 C-METHYLTRANSFERASE
COUO

(Streptomyces
rishiriensis) 		PF13649
(Methyltransf_25) 		3 VAL A 162
TRP A 170
TRP A 161
 None
 1.03A 1gmkA-5m58A:
undetectable
1gmkB-5m58A:
undetectable		 1gmkA-5m58A:
7.91
1gmkB-5m58A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m77 ALPHA-1,6-MANNANASE

(Bacillus
circulans) 		PF03422
(CBM_6)
PF03663
(Glyco_hydro_76) 		3 VAL A  74
TRP A  79
TRP A 128
 None
 1.07A 1gmkA-5m77A:
undetectable
1gmkB-5m77A:
undetectable		 1gmkA-5m77A:
2.97
1gmkB-5m77A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgz 8-DEMETHYLNOVOBIOCIC
ACID
C(8)-METHYLTRANSFERA
SE

(Streptomyces
niveus) 		PF13649
(Methyltransf_25) 		3 VAL A 162
TRP A 170
TRP A 161
 None
 1.09A 1gmkA-5mgzA:
undetectable
1gmkB-5mgzA:
undetectable		 1gmkA-5mgzA:
7.26
1gmkB-5mgzA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 VAL B  17
TRP B  22
TRP B  14
 None
 1.28A 1gmkA-5mkkB:
undetectable
1gmkB-5mkkB:
undetectable		 1gmkA-5mkkB:
3.48
1gmkB-5mkkB:
3.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 3 VAL A 104
TRP A 110
TRP A 132
 None
 0.95A 1gmkA-5no5A:
undetectable
1gmkB-5no5A:
undetectable		 1gmkA-5no5A:
undetectable
1gmkB-5no5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 VAL A 171
TRP A 437
TRP A 168
 None
 1.30A 1gmkA-5tf0A:
undetectable
1gmkB-5tf0A:
undetectable		 1gmkA-5tf0A:
1.58
1gmkB-5tf0A:
1.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 VAL B 284
TRP B 335
TRP B  49
 None
 1.21A 1gmkA-5up2B:
undetectable
1gmkB-5up2B:
undetectable		 1gmkA-5up2B:
1.82
1gmkB-5up2B:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2b SULFOTRANSFERASE

(Mus musculus) 		no annotation 3 VAL D 123
TRP D 158
TRP D 252
 None
 1.33A 1gmkA-5x2bD:
undetectable
1gmkB-5x2bD:
undetectable		 1gmkA-5x2bD:
undetectable
1gmkB-5x2bD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 VAL A 169
TRP A 435
TRP A 166
 None
 1.28A 1gmkA-5xxoA:
undetectable
1gmkB-5xxoA:
undetectable		 1gmkA-5xxoA:
undetectable
1gmkB-5xxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 3 VAL A 160
TRP A 422
TRP A 157
 None
 1.23A 1gmkA-5z9sA:
undetectable
1gmkB-5z9sA:
undetectable		 1gmkA-5z9sA:
undetectable
1gmkB-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 3 VAL A 132
TRP A 129
TRP A  40
 None
 0.98A 1gmkA-5zu5A:
undetectable
1gmkB-5zu5A:
undetectable		 1gmkA-5zu5A:
undetectable
1gmkB-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu6 CBM32 DOMAIN

(Vibrio) 		no annotation 3 VAL A 132
TRP A 129
TRP A  40
 None
 0.94A 1gmkA-5zu6A:
undetectable
1gmkB-5zu6A:
undetectable		 1gmkA-5zu6A:
undetectable
1gmkB-5zu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmo CHIMERA PROTEIN OF
SOLUBLE CYTOCHROME
B562 AND RHODOPSIN

(Escherichia
coli;
Homo sapiens) 		no annotation 3 VAL R 129
TRP R 265
TRP R 126
 None
 1.29A 1gmkA-6cmoR:
undetectable
1gmkB-6cmoR:
undetectable		 1gmkA-6cmoR:
undetectable
1gmkB-6cmoR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czp OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Vibrio
vulnificus) 		no annotation 3 VAL A 143
TRP A 138
TRP A  46
 None
 1.36A 1gmkA-6czpA:
undetectable
1gmkB-6czpA:
undetectable		 1gmkA-6czpA:
undetectable
1gmkB-6czpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et8 -

(-) 		no annotation 3 VAL A 200
TRP A 162
TRP A 203
 None
BWH  A 301 (-4.5A)
None
 1.42A 1gmkA-6et8A:
undetectable
1gmkB-6et8A:
undetectable		 1gmkA-6et8A:
undetectable
1gmkB-6et8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k POLYSULPHIDE
REDUCTASE NRFD

(Rhodothermus
marinus) 		no annotation 3 VAL C  73
TRP C  84
TRP C 419
 None
 1.29A 1gmkA-6f0kC:
undetectable
1gmkB-6f0kC:
undetectable		 1gmkA-6f0kC:
undetectable
1gmkB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 3 VAL M  27
TRP M  16
TRP M  24
 None
3PE  M 505 ( 4.3A)
None
 1.39A 1gmkA-6g2jM:
undetectable
1gmkB-6g2jM:
undetectable		 1gmkA-6g2jM:
undetectable
1gmkB-6g2jM:
undetectable